FlyBase Allele Report: Dmel\Rheb[UAS.cPa]

Expression of Rheb^UAS.cPa under the control of Scer\GAL4^Su(H).GBE (in combination with tub-Gal80[ts] to restrict expression to the adult stage) leads to an increase in the cell size of enteroblasts in adult guts when compared to controls.

(Rojas Villa et al., 2019)

Third instar larvae expressing Rheb^UAS.cPa under the control of Scer\GAL4^AB1 do not show significant changes in the size of salivary gland cells, as compared to controls.

(Sharma et al., 2019)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^insc-Mz1407 is capable of driving central brain neuroblast reactivation in the absence of dietary amino acids.

(Li et al., 2017)

The expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^en-e16E leads to a significant increase in the wing posterior compartment area, as compared to controls.

(Liu et al., 2017)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^phm.PO leads to decreased number of autophagic vesicles (marked with Atg8a protein).

(Danielsen et al., 2016)

The expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^{E(spl)m6-BFM.PF} leads to significantly increased numbers of abdominal lateral and dorsal, but not ventral, adult muscle precursor cells in third instar larvae, as compared to controls; this expression does not affect the number of mitotic adult muscle precursor cells at embryonic stages, as compared to controls.

(Aradhya et al., 2015)

Expression via Scer\GAL4^wor.PA and Scer\GAL80^ase.PN does not prevent the normal shrinkage and disappearance of pupal neuroblasts.

(Homem et al., 2014)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^da.G32 results in an increase in larval body weight compared to controls.

(Gupta et al., 2013)

Flies expressing Rheb^Scer\UAS.cPa in the midgut, under the control of Scer\GAL4^esg-NP5130 and Scer\GAL80^ts.αTub84B at the restrictive temperature of 29[o]C for two weeks, results in considerably fewer epithelial midgut cells, accounting for 10.4% of the total population. Some of the remaining intestinal stem cells are larger.

(Quan et al., 2013)

Overexpression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^GMR.PF increases S6k phosphorylation.

(Shin et al., 2013)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^Mef2.PR is able to completely suppress the formation of autophagosomes in the muscles of chloroquine-treated larvae starved on low-nutrient food for 6 hours.

(Zirin et al., 2013)

Scer\GAL4^elav.PLu-mediated expression of Rheb^Scer\UAS.cPa produces phototaxis deficits and a significantly lower phototaxis index. It also results in a failure of some R7 and R8 photoreceptors to terminate at their proper locations, produces substantial synaptic overgrowth at the larval neuromuscular junction, and increased excitatory junctional potentials.

The Scer\GAL4^elav.PLu, Rheb^Scer\UAS.cPa phototaxis deficits are significantly rescued when flies are reared on a yeast-restricted or calorie-restricted diet.

Raised at 25[o]C, the Scer\GAL4^elav.PLu, Rheb^Scer\UAS.cPa axon guidance phenotype is significantly rescued when flies are reared on a yeast-restricted or calorie-restricted or sugar-restricted diet.

Raised at 21[o]C, the Scer\GAL4^elav-C155, Rheb^Scer\UAS.cPa flies show a mild axon guidance phenotype that is significantly rescued when flies are reared on a yeast-restricted or calorie-restricted diet.

The Scer\GAL4^elav.PLu, Rheb^Scer\UAS.cPa synaptic overgrowth and increased excitatory junctional potential phenotypes cannot be rescued by dietary restriction. Flies raised on a sugar restricted diet actually show an increase in synaptic overgrowth.

(Dimitroff et al., 2012)

Expression of Rheb^Scer\UAS.cPa in mushroom body γ-neurons, under the control of Scer\GAL4^Tab2-201Y does not affect mushroom body morphology.

(Yaniv et al., 2012)

Overexpression of Rheb^Scer\UAS.cPa using either Scer\GAL4^elav-C155 or Scer\GAL4^P2.4.Pdf increases ethanol sensitivity.

(Eddison et al., 2011)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^sca.PU in the adult thorax leads to an increase in the frequency of bristle twinning, and delay or premature arrest of the cell cycle, as compared to controls.

(Karbowniczek et al., 2010)

Overexpression of Rheb^Scer\UAS.cPa via Scer\GAL4^GMR.PF causes a hyperplastic phenotype in the eye.

(Lee et al., 2010)

Expression of Rheb^Scer\UAS.cPa in the developing eye under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype with bristle disorganization.

(Doumanis et al., 2009)

Expression of Rheb^Scer\UAS.cPa driven by Scer\GAL4^ap-md544 in the dorsal epithelial of the wing disc results in enlargement of the dorsal compartment, which causes the wing to curve downwards. When expression of Rheb^Scer\UAS.cPa is driven by Scer\GAL4^ap-md544 in the posterior compartment of the wing, the posterior area is increased but cell density is lower and total cell number is not significantly different to wild type. Therefore, cell size is increased. The anterior compartment of these wings is reduced compared to wild type, while the cell density is increased.

(Patel et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neurophysiology phenotype, enhanceable by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Suppressed by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^Su(H).GBE has increased cell size | adult stage phenotype, suppressible by zfh2^GD4506, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

Rheb^UAS.cPa, Scer\GAL4^Su(H).GBE has increased cell size | adult stage phenotype, suppressible by zfh2^HMC03043, Scer\GAL4^Su(H).GBE

(Rojas Villa et al., 2019)

Rheb^UAS.cPa, Scer\GAL4^en-e16E has abnormal size | adult stage phenotype, suppressible by nclb^NIG.6751R, Scer\GAL4^en-e16E

(Liu et al., 2017)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by mTor^Δ6B/Tor[+]

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal phototaxis phenotype, suppressible by mTor^Δ6B/Tor[+]

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal phototaxis phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by raptor^GD5138, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, suppressible by S6k^GD6646, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^GMR.PF has visible phenotype, suppressible by Sesn^d04539, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT suppressed by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by rictor^Δ2/rictor^Δ1

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has abnormal neuroanatomy phenotype, non-suppressible by Sin1^e03756/Sin1^e03756

(Dimitroff et al., 2012)

Enhancer of

Statement

Reference

Scer\GAL4^ci.PC/Rheb^UAS.cPa is an enhancer of increased cell death | larval stage | somatic clone phenotype of RpS23^R67K

(Recasens-Alvarez et al., 2021)

Rheb^UAS.cPa/Scer\GAL4^ppk.PG is an enhancer of abnormal neuroanatomy | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

Rheb^UAS.cPa, Scer\GAL4^elav-C155 is an enhancer of abnormal neuroanatomy phenotype of Hsap\HTT^{98Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^elav-C155

(Doumanis et al., 2009)

Suppressor of

Statement

Reference

Rheb^UAS.cPa/Scer\GAL4^pHCl-2.PR is a suppressor of abnormal developmental rate phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Rheb^UAS.cPa/Scer\GAL4^pHCl-2.PR is a suppressor of decreased rate of feeding behavior | larval stage phenotype of pHCl-2^pTV-Cherry

(Redhai et al., 2020)

Rheb^UAS.cPa/Scer\GAL4^Tab2-201Y is a suppressor | partially of abnormal neuroanatomy | somatic clone phenotype of Hr51^LL04325

(Yaniv et al., 2012)

NOT Suppressor of

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^NP0001 is a non-suppressor of increased cell size phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Rheb^UAS.cPa/Scer\GAL4^ppk.PG is a non-suppressor of abnormal neuroanatomy | larval stage phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

Rheb^UAS.cPa, Scer\GAL4^elav-C155 is a non-suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Other

Statement

Reference

PIP4K²⁹, Rheb^UAS.cPa, Scer\GAL4^AB1 has increased cell size | third instar larval stage phenotype

(Sharma et al., 2019)

Rheb^UAS.cPa, Scer\GAL4^ppk.PG, path^A.UAS.GFP has abnormal neuroanatomy phenotype

(Lin et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, enhanceable by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

NOT Enhanced by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^sca.PU has mesothoracic bristle | adult stage | increased number phenotype, non-enhanceable by Rab11^UASp.YFP, Scer\GAL4^sca.PU

(Karbowniczek et al., 2010)

Rheb^UAS.cPa, Scer\GAL4^sca.PU has mesothoracic bristle | adult stage | increased number phenotype, non-enhanceable by nuf^EP3324, Scer\GAL4^sca.PU

(Karbowniczek et al., 2010)

Suppressed by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^insc-Mz1407 has neuroblast | third instar larval stage | nutrition conditional phenotype, suppressible by Chro^KK105370, Scer\GAL4^insc-Mz1407

(Li et al., 2017)

Rheb^UAS.cPa, Scer\GAL4^en-e16E has wing posterior compartment phenotype, suppressible by nclb^NIG.6751R, Scer\GAL4^en-e16E

(Liu et al., 2017)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, suppressible by mTor^Δ6B/Tor[+]

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, suppressible by mTor^Δ6B/Tor[+]

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, suppressible by mTor^Δ6B/Tor[+]

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, suppressible by AMPKα^TD.UAS, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, suppressible by raptor^GD5138, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, suppressible by raptor^GD5138, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, suppressible by S6k^GD6646, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, suppressible by S6k^GD6646, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, suppressible by rictor^Δ2/rictor^Δ1

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, suppressible by Sin1^e03756/Sin1^e03756

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^GMR.PF has eye phenotype, suppressible by Sesn^d04539, Scer\GAL4^GMR.PF

(Lee et al., 2010)

NOT suppressed by

Statement

Reference

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, non-suppressible by rictor^Δ2/rictor^Δ1

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, non-suppressible by rictor^Δ2/rictor^Δ1

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R7 phenotype, non-suppressible by Sin1^e03756/Sin1^e03756

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has photoreceptor cell R8 phenotype, non-suppressible by Sin1^e03756/Sin1^e03756

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, non-suppressible by raptor^GD5138, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Rheb^UAS.cPa, Scer\GAL4^elav.PLu has embryonic/larval neuromuscular junction phenotype, non-suppressible by S6k^GD6646, Scer\GAL4^elav.PLu

(Dimitroff et al., 2012)

Enhancer of

Statement

Reference

Scer\GAL4^ci.PC/Rheb^UAS.cPa is an enhancer of imaginal disc phenotype of RpS23^R67K

(Recasens-Alvarez et al., 2021)

Rheb^UAS.cPa/Scer\GAL4^ppk.PG is an enhancer of larval dorsal multidendritic neuron ddaC | pupal stage | somatic clone phenotype of Mical¹⁵²⁵⁶

(Wong et al., 2013)

Rheb^UAS.cPa, Scer\GAL4^sca.PU is an enhancer of mesothoracic bristle | adult stage | increased number phenotype of Scer\GAL4^sca.PU, l(2)gl^3A.UAS

(Karbowniczek et al., 2010)

Scer\GAL4^GMR.PF, Rheb^UAS.cPa is an enhancer of eye phenotype of Hsap\HTT^{152Q.Ex1.UAS.EGFP}, Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

(Doumanis et al., 2009)

Scer\GAL4^GMR.PF, Rheb^UAS.cPa is an enhancer of pigment cell phenotype of Hsap\HTT^{152Q.Ex1.UAS.EGFP}, Hsap\HTT^{48Q.Ex1.UAS.EGFP.Tag:NLS(Unk)}, Scer\GAL4^GMR.PF

(Doumanis et al., 2009)

Suppressor of

Statement

Reference

Scer\GAL4^ninaE.PU/Rheb^UAS.cPa is a suppressor of vesicle | pupal stage | conditional phenotype of PIP4K²⁹

(Kamalesh et al., 2017)

Scer\GAL4^ninaE.PU/Rheb^UAS.cPa is a suppressor of multivesicular body | pupal stage | conditional phenotype of PIP4K²⁹

(Kamalesh et al., 2017)

Rheb^UAS.cPa/Scer\GAL4^Tab2-201Y is a suppressor | partially of gamma Kenyon cell | somatic clone phenotype of Hr51^LL04325

(Yaniv et al., 2012)

NOT Suppressor of

Statement

Reference

Rheb^UAS.cPa/Scer\GAL4^btl.PS is a non-suppressor of terminal tracheal cell | somatic clone | larval stage phenotype of Archease^dsj-169

(Francis et al., 2022)

Scer\GAL4^ninaE.PU/Rheb^UAS.cPa is a non-suppressor of photoreceptor neuron | pupal stage | conditional phenotype of PIP4K²⁹

(Kamalesh et al., 2017)

Rheb^UAS.cPa, Scer\GAL4^NP0001 is a non-suppressor of adult midgut epithelium phenotype of Atg9^HMS01246, Scer\GAL4^NP0001

(Wen et al., 2017)

Rheb^UAS.cPa/Scer\GAL4^bs.PM is a non-suppressor of terminal tracheal cell | somatic clone | third instar larval stage phenotype of Vha13^cnj-356

(Francis and Ghabrial, 2015)

Rheb^UAS.cPa/Scer\GAL4^ppk.PG is a non-suppressor of larval multidendritic class IV neuron phenotype of path^dg50/Df(3L)BSC773

(Lin et al., 2015)

Rheb^UAS.cPa, Scer\GAL4^elav-C155 is a non-suppressor of terminal bouton phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Other

Statement

Reference

PIP4K²⁹, Rheb^UAS.cPa, Scer\GAL4^AB1 has fat cell | third instar larval stage phenotype

(Sharma et al., 2019)

Rheb^UAS.cPa, Scer\GAL4^ppk.PG, path^A.UAS.GFP has larval multidendritic class IV neuron phenotype

(Lin et al., 2015)

Hr51^LL04325, Rheb^UAS.cPa, Scer\GAL4^Tab2-201Y has alpha/beta Kenyon cell | somatic clone phenotype

(Yaniv et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

PIP4K²⁹ third instar larvae expressing Rheb^UAS.cPa under the control of Scer\GAL4^AB1 show significantly bigger salivary gland cells, as compared to PIP4K²⁹ single mutants.

(Sharma et al., 2019)

The expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^ninaE.PU does not suppress the expansion in endosome-like vesicles and multivesicular bodies observed in the photoreceptors of PIP4K²⁹ homozygous late pupae reared in light conditions.

(Kamalesh et al., 2017)

The ability of Scer\GAL4^insc-Mz1407-driven expression of Rheb^Scer\UAS.cPa to induce central brain neuroblast reactivation in the absence of dietary amino acids is prevented by co-expression of Chro^KK105370.

(Li et al., 2017)

The increased wing posterior compartment area induced by the expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^en-e16E is suppressed by the co-expression of nclb^NIG.6751R.

(Liu et al., 2017)

The co-expression of Rheb^Scer\UAS.cPa does not suppress the increased midgut cell size resulting from the expression of Atg9^HMS01246 under the control of Scer\GAL4^{Myo31DF-NP0001}.

(Wen et al., 2017)

Scer\GAL4^ppk.PG-mediated co-expression of path^{A.Scer\UAS.T:Avic\GFP} and Rheb^Scer\UAS.cPa promote dendritic growth, whereas expression of either alone has no such effect.

(Lin et al., 2015)

Expression of Rheb^Scer\UAS.cPa does not suppress the enlarged bouton phenotype seen when Vap-33A^{P58S.cRa.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Deivasigamani et al., 2014)

Expression of Rheb^Scer\UAS.cPa under the control of Scer\GAL4^ppk.PG enhances the dendrite pruning defects seen in Mical¹⁵²⁵⁶ mutant ddaC neuron clones at 16 hours after puparium formation.

(Wong et al., 2013)

Heterozygosity for Tor^Δ6B in a Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu background rescues the phototaxis phenotype and photoreceptor axon guidance abnormalities to almost control levels, and causes a significant rescue of the synapse overgrowth phenotype.

Co-expression of SNF1A^TD.Scer\UAS significantly rescues the phototaxis and axon guidance phenotypes, while it enhances the synapse overgrowth and excitatory junctional potential phenotypes, of Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu flies.

Co-expression of raptor^GD5138 or S6k^GD6646 significantly rescues the axon guidance phenotypes of Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu flies.

The axon guidance phenotypes of Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu flies are not significantly rescued in a rictor^Δ1/rictor^Δ2 or Sin1^e03756/Sin1^e03756 background.

Co-expression of raptor^GD5138 or S6k^GD6646 does not rescue the Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu synapse overgrowth phenotype.

The Rheb^Scer\UAS.cPa, Scer\GAL4^elav.PLu synapse overgrowth phenotype is significantly rescued in a rictor^Δ1/rictor^Δ2 or Sin1^e03756/Sin1^e03756 background.

(Dimitroff et al., 2012)

Expression of Rheb^Scer\UAS.cPa in Hr51^LL04325 MARCM neuroblast clones partially suppresses the developmental regrowth defect. In addition these double mutants exhibit severe axon guidance defects. In these clones, γ axons do not occupy the entire adult lobe but instead grow to the dorsal and ventral extremities of the adult γ-lobe and in some cases only to its ventral portion.

(Yaniv et al., 2012)

Co-expression of Rab11^{Scer\UAS.P\T.T:Avic\GFP-YFP} or nuf^EP3324 does not enhance the bristle twinning phenotype of flies expressing Rheb^Scer\UAS.cPa under the control of Scer\GAL4^sca.PU.

Co-expression of Rheb^Scer\UAS.cPa enhances the bristle twinning phenotype seen in flies expressing l(2)gl^3A.Scer\UAS under the control of Scer\GAL4^sca.PU.

(Karbowniczek et al., 2010)

Co-expression of Sesn^d04539 with Rheb^Scer\UAS.cPa via Scer\GAL4^GMR.PF suppresses the Rheb^Scer\UAS.cPa hyperplastic eye phenotype.

(Lee et al., 2010)

Xenogenetic Interactions

Statement

Reference

Overexpression of Rheb^Scer\UAS.cPa in the developing eye enhances the phenotype seen in mutant flies co-expressing Hsap\HTT^{152Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP} and Hsap\HTT^{48Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} under the control of Scer\GAL4^GMR.PF, with a severe rough eye phenotype and enhancement of pigment cell loss.

Overexpression of Rheb^Scer\UAS.cPa in the developing eye of Hsap\HTT^{18Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} mutants (both transgene under the control of Scer\GAL4^GMR.PF results in a rough eye phenotype with bristle disorganization.

Co-expression of Rheb^Scer\UAS.cPa in a Hsap\HTT^{98Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} mutant brain (with both transgenes under the control of Scer\GAL4^elav-C155) does not significantly increase the average number of brain aggregate inclusions compared to flies expressing Hsap\HTT^{98Q.Ex1.Scer\UAS.T:Avic\GFP-EGFP.T:Zzzz\nls1} alone, but does increase the average aggregate size.

(Doumanis et al., 2009)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

9688

w^*; P{UAS-Rheb.Pa}2

9689

w^*; P{UAS-Rheb.Pa}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Rheb^Scer\UAS.cPa

Rheb^UAS.cPa

Name Synonyms

UAS construct a of Patel

(Patel et al., 2003)

Secondary FlyBase IDs

References (55)

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