FlyBase Gene Report: Dmel\Taf12

General Information

Symbol

Dmel\Taf12

Species

D. melanogaster

Name

TBP-associated factor 12

Annotation Symbol

CG17358

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011290

Gene Model Status

Current

Stock Availability

7 publicly available

Gene Summary

TBP-associated factor 12 (Taf12) encodes a protein that forms part of the multisubunit basal transcription factor TFIID, and it is important for its stability. It forms a histone-like pair with Taf4. Taf12 is also an integral component of the Drosophila SAGA histone acetyltransferase complex. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Taf30α, TBP-associated factor 30kD subunit α, dTAF_II30α, TFIID, TAF_II30α

Key Links

Genomic Location

Cytogenetic map

86E15-86E15

Sequence location

3R:11,678,386..11,679,690 [-]

Recombination map

3-51

RefSeq locus

NT_033777 REGION:11678386..11679690

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

contributes_to RNA polymerase II general transcription initiation factor activity

inferred from direct assay

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000262707

(GO Reference Genome Project, 2011-)

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(InterPro Project Members, 2004-)

enables TBP-class protein binding

inferred from biological aspect of ancestor with PANTHER:PTN000262707

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in DNA-templated transcription initiation

inferred from electronic annotation with InterPro:IPR003228

(InterPro Project Members, 2004-)

involved_in RNA polymerase II preinitiation complex assembly

inferred from biological aspect of ancestor with PANTHER:PTN000262707

(GO Reference Genome Project, 2011-)

involved_in transcription initiation at RNA polymerase II promoter

inferred from sequence or structural similarity with SGD:S000002552

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with UniProtKB:Q16514

(Aoyagi and Wassarman, 2000)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006, Yokomori et al., 1993)

part_of SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

part_of transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of SAGA complex

inferred from electronic annotation with InterPro:IPR037794

(InterPro Project Members, 2004-)

part_of transcription factor TFIID complex

inferred from electronic annotation with InterPro:IPR003228, InterPro:IPR037794

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with SGD:S000002552

(Aoyagi and Wassarman, 2000)

inferred from sequence or structural similarity with UniProtKB:Q16514

(Aoyagi and Wassarman, 2000)

inferred from biological aspect of ancestor with PANTHER:PTN000262707

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SAGA COMPLEX

TRANSCRIPTION FACTOR II D

Protein Family (UniProt)

Belongs to the TAF12 family. (P49905)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

SAGA COMPLEX -: The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a chromatin modifying complex. SAGA can acetylate and deubiquitinate histone residues. Also SAGA has been shown to regulate the transcriptional activation of a subset of genes. (Adapted from FBrf0228923, FBrf0219841 and FBrf0233349).
TRANSCRIPTION FACTOR II D -: The general transcription factor complex Transcription factor II D (TFIID) plays an important role in recruiting the transcription machinery to core promoters. TFIID is a complex composed of TBP and several TBP-associated factors. (Adapted from FBrf0125116 and FBrf0156065).

Protein Function (UniProtKB)

TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

(UniProt, P49905)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Taf12 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P49905)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Taf12-RA

FBtr0082442

NM_079596

1234

196

Taf12-RB

FBtr0082440

NM_169420

1066

196

Taf12-RD

FBtr0290205

NM_169421

852

160

Taf12-RE

FBtr0335213

NM_001275550

897

160

Additional Transcript Data and Comments

Reported size (kB)

0.8 (longest cDNA)

(Kokubo et al., 1994)

1.4 (northern blot)

(Yokomori et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Taf12-PA

FBpp0081918

21.5

196

7.15

FBpp0081916

21.5

196

7.15

FBpp0288644

17.6

160

9.47

FBpp0307200

17.6

160

9.47

A0A0B4KFN0

NP_001262479

AGB95861

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

196 aa isoforms: Taf12-PA, Taf12-PB

160 aa isoforms: Taf12-PD, Taf12-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

196, 160 (aa); 28, 22 (kD observed); 22, 18 (kD predicted)

(Kokubo et al., 1994)

196 (aa); 22 (kD predicted)

(Yokomori et al., 1993)

32 (kD)

(Dynlacht et al., 1991)

Comments

External Data

Subunit Structure (UniProtKB)

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Tbp, Taf2 and Taf4.

(UniProt, P49905)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Taf12 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf12_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.79

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006, Yokomori et al., 1993)

part_of SAGA complex

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

part_of transcription factor TFIID complex

inferred from direct assay

(Yokomori et al., 1993)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Taf12 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Taf12

View exonic expression by tissue for Dmel\Taf12

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011290

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41406/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011290

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011290

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011290

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17358

Flygut - An atlas of the Drosophila adult midgut

FBgn0011290

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Taf12

Transgenic constructs containing regulatory region of Taf12

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3R)Exel7309

(Ryder, 2004.4.26)

Df(3R)Exel8154

(Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Taf12^GD4149

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Taf12^GD4149

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Taf12^GD4149

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Taf12^GD4149

viable, with Scer\GAL4^tin.CΔ4

Taf12^GD4149

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

Taf12^GD4149

some die during pupal stage, with Scer\GAL4^pnr-MD237

Taf12^GD4149

Phenotype manifest in

Allele

embryonic/larval fat body | wandering third instar larval stage, with Scer\GAL4^ppl.PP

Taf12^GD4149

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

Taf12^GD4149

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

Taf12^GD4149

lipid droplet | wandering third instar larval stage, with Scer\GAL4^ppl.PP

Taf12^GD4149

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (1)

Hsap\TAF12

12 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\Taf12

11 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\Taf12

11 of 14

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\taf12

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (3)

Drer\taf12

11 of 14

Yes

Drer\si:dkey-23a13.22

1 of 14

Drer\si:dkey-261m9.19

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\taf-12

7 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP003135

11 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\TAF12

8 of 13

Yes

Atha\EER4

7 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\TAF12

9 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\taf12

8 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Taf12. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

Taf12L

2 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TAF12; TATA-box binding protein associated factor 12

12 of 14

600773

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Taf12 - Hrb27C

anti bait coimmunoprecipitation, quantitative reverse transcription pcr

(Blanchette et al., 2009)

protein-protein

Physical Interaction

Assay

References

Taf12

anti tag coimmunoprecipitation, autoradiography

(Yokomori et al., 1993)

Taf12 - Ada1-2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf12 - Ada2b

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Torres-Zelada et al., 2019, Weake et al., 2011, Weake et al., 2009)

Taf12 - Atxn7

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mohan et al., 2014)

Taf12 - GATAe

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Rhee et al., 2014)

Taf12 - Saf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf12 - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Taf12 - Sgf29

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf12 - Spt20

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Taf12 - Spt3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Taf12 - Taf1

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation

(Yokomori et al., 1993)

Taf12 - Taf4

pull down, anti tag western blot, anti tag coimmunoprecipitation, autoradiography

(Hiller et al., 2004, Yokomori et al., 1993)

Taf12 - Taf5

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf12 - Taf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Taf12 - Taf9

anti bait coimmunoprecipitation, western blot

(Yokomori et al., 1993)

Taf12 - Tbp

anti bait coimmunoprecipitation, molecular weight estimation by staining, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Chen et al., 1994, Verrijzer et al., 1994, Yokomori et al., 1993)

Taf12 - wda

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2009)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Belongs to the TFIID complex which is composed of TATA binding protein (Tbp) and a number of TBP-associated factors (TAFs). Interacts with Tbp, Taf2 and Taf4.

(UniProt, P49905 )

Linkouts

BioGRID - A database of protein and genetic interactions.

66532

DroID - A comprehensive database of gene and protein interactions.

FBgn0011290

MIST (protein-protein) - An integrated Molecular Interaction Database

41406

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Basal transcription factors

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-51

Cytogenetic map

86E15-86E15

Sequence location

3R:11,678,386..11,679,690 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

86E15-86E15

Limits computationally determined from genome sequence between P{PZ}tho¹&P{PZ}l(3)04629⁰⁵²⁷⁵ and P{EP}Lk6^EP886

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

86F1-86F2

(Yokomori, 1994.2.25)

Experimentally Determined Recombination Data

Location

3-51

(FlyBase, 2016)

3-48.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

80176

y¹ sc^* v¹ sev²¹; P{TOE.GS02153}attP40

34852

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00170}attP2

FlyORF

F003185

M{UAS-Taf12.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

HMS00170

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00170}attP2

VDRC

v110628

P{KK108054}VIE-260B

v12654

w¹¹¹⁸; P{GD4149}v12654

v318745

PBac{fTRG01079.sfGFP-TVPTBF}VK00002

Genomic Clones (9)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (39)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD36256

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011290

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011290

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Yokomori et al., 1993)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Marr et al., 2006)

The proteins encoded by Taf4, Taf5, Taf6, e(y)1 and Taf12 form a core sub-complex of TFIID.

(Wright et al., 2006)

Does not interact, in vitro, with human thryroid-hormone receptor-β.

(Petty et al., 1996)

The assembly and purification of various functional Tbp TAF complexes demonstrate that Tbp plus the TAFs is sufficient to replace endogenous TFIID to support activated transcription in vitro.

(Chen et al., 1994)

The 28kD and 22kD proteins are products of the same gene, with the smaller being an N-truncated version of the larger. TFIID subunit proteins and the Tbp protein can interact in pairwise combinations with several subunits in a network of interactions within TFIID.

(Kokubo et al., 1994)

A number of polypeptides (encoded by Taf1, Taf4, Taf5, Taf6, e(y)1 and Taf12) that are tightly associated with Tbp and are native TFIID components have been purified. Protein blotting experiments suggest that one of these proteins, Taf1, interacts directly with Tbp, while the association between Tbp and the other proteins is either weak or is an indirect association via Taf1.

(Kokubo et al., 1993)

Taf12 and Taf11 join the TfIID complex through interaction with one or more of the larger subunits and only Taf12 may be in contact with Tbp.

(Yokomori et al., 1993)

A TATA-dependent protein-DNA complex is found in fractionated embryonic nuclear extracts. DNase I footprint analysis identifies polypeptides (including Taf12, Tbp and RpII140) that require the Hsp70Bb TATA element for binding to regions of the Hsp70Bb promoter.

(Gilmour et al., 1990)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (43)

Reported As

Symbol Synonym

CG17358

(Fan et al., 2017, Stegeman et al., 2016, Fukuoh et al., 2014, Mohan et al., 2014, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Laszlo, 2002, Aoyagi and Wassarman, 2000)

T2DA_DROME

(Storm and Sonnhammer, 2003)

TAF

(Müller and Tora, 2004)

TAF12

(Cornelio-Parra et al., 2021, Helmlinger et al., 2021, Stegeman et al., 2016, Mohan et al., 2014, Xie et al., 2014, Weake et al., 2011, Weake et al., 2009, Wright and Tjian, 2009, Marr et al., 2006, Santoso and Kadonaga, 2006, Wright et al., 2006, Tora, 2002)

TAF30a

(Hansen et al., 1997)

TAF30α

(Hahn, 1998, Deak et al., 1997)

TAF30α/28

(Aoyagi and Wassarman, 2000)

TAF30α/28/22

(Green, 2000)

TAF_II

(Arnosti, 2002)

TAF_II230

(Tora, 2002)

TAF_II30α

(Wassarman and Sauer, 2001, Sauer et al., 1996, Hansen and Tjian, 1995)

TAF_II30α/28 TAF_II22

(Shen et al., 1998)

TAF_II30α/28/22

(Tansey and Herr, 1997)

TAF^II30α

(Kennett et al., 2002)

TAFII30α/22

(Berk, 1999)

TFIID

(Butler and Kadonaga, 2002, Gu et al., 2002, Hochheimer et al., 2002, Stathopoulos and Levine, 2002, Mizuguchi et al., 2001)

TFIID 22

(Nakatani, 1994.2.8)

TFIID 28

(Nakatani, 1994.2.8)

TFIID-p28

Taf12

(Torres-Zelada and Weake, 2021, Neves and Eisenman, 2019, Torres-Zelada et al., 2019, Transgenic RNAi Project members, 2017-, Sarov et al., 2016, Spedale et al., 2012, Grimberg et al., 2011, Neumüller et al., 2011, Rodriguez-Navarro, 2009, Zhou et al., 2008)

Taf22

Taf28

Taf30α

(Bell and Tora, 1999, Struhl and Moqtaderi, 1998, Verrijzer et al., 1995, Hori and Carey, 1994, Hoey et al., 1993, Yokomori et al., 1993, Dynlacht et al., 1991)

Taf32

Taf_II30α

(Chen et al., 1994)

d28/22

(Pugh, 2000)

dTAF12

(Guelman et al., 2006, Hiller et al., 2004)

dTAF22

(Hoffmann et al., 1996)

dTAF28

(Hoffmann et al., 1996)

dTAF_II30

(Mantovani, 1999, Burke and Kadonaga, 1997, Verrijzer et al., 1994)

dTAF_II30α

(Wright et al., 2006, Gangloff et al., 2001, Lively et al., 2001, Veenstra and Wolffe, 2001, Albright and Tjian, 2000, Zhou et al., 1998, Goodrich and Tjian, 1994)

dTAF_II30α/22

(Burley, 1998)

dTAFII30

(Deak et al., 1997)

dTAFII30 alpha

(Yokomori, 1994.2.25)

dTaf12

(Spedale et al., 2012)

dmTAF12

(Laszlo, 2002)

p22

(Kokubo et al., 1994, Kokubo et al., 1993)

p28

(Kokubo et al., 1994, Kokubo et al., 1993)

taf12

(Fan et al., 2017)

Name Synonyms

26kDa polypeptide

(Gilmour et al., 1990)

TBP-associated factor

(Schuettengruber et al., 2007)

TBP-associated factor 12

TBP-associated factor 30kD subunit α

(Bell and Tora, 1999, Struhl and Moqtaderi, 1998, Verrijzer et al., 1995, Hori and Carey, 1994, Hoey et al., 1993, Yokomori et al., 1993, Dynlacht et al., 1991)

Secondary FlyBase IDs

FBgn0011303
FBgn0011304

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

41406

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P49905

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P49905

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

A0A0B4KFN0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P49905

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011290

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

41406/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011290

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011290

FlyMine - An integrated database for Drosophila genomics

FBgn0011290

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG17358

MARRVEL_MODEL - MARRVEL (model organism gene)

41406

Linkouts

BioGRID - A database of protein and genetic interactions.

66532

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011290

DroID - A comprehensive database of gene and protein interactions.

FBgn0011290

DRSC - Results frm RNAi screens

FBgn0011290

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Taf12_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011290

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011290

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG17358

Flygut - An atlas of the Drosophila adult midgut

FBgn0011290

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011290

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007989

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Basal transcription factors

MIST (protein-protein) - An integrated Molecular Interaction Database

41406

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (110)

The following external sites may use different assemblies or annotations than FlyBase.

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