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FB2026_01
,
released March 12, 2026
Trg
transcription factor - brachyury homolog - essential for the development of hindgut, anal pads and Malpighian tubules - mediates specification of caudalbvisceral mesoderm
Please see the JBrowse view of Dmel\byn for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Gene model reviewed during 5.45
2.6 (longest cDNA)
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\byn using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Transcription of byn commences at the beginning of embryonic cycle 14 in the posterior terminal region from 0-20% egg length. During cellularization, transcripts recede from the pole and become confined to a ring of cells of which the ventral cells form the posterior part of the ventral furrow, while the dorsal and lateral cells form the primordia of the proctodeum and anal pads. The dorsal and lateral cells are internalized by the amnioproctodeal invagination during gastrulation. The proctodeum continues to express byn during germ band extension. Expression is maintained in the hindgut and anal pads until the end of embryogenesis.
byn protein is first detected in the blastoderm in a ring of cells mostly comprising the proctodeal primordium and in the primordia of the anal pads and the hindgut. During germ band extension, the protein is confined to the proctodeum. In the fully retracted germ band, it is found in the hindgut and anal pads.
Comment: posterior to zone of wg expression
Comment: posterior to zone of wg expression
JBrowse - Visual display of RNA-Seq signals
View Dmel\byn in JBrowse3-37
3-30.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
byn injected into Xenopus embryos exhibits a strong endoderm-inducing activity.
cad acts in hindgut development through fog, fkh and wg, but does not play a role in activating tll, hkb, byn and bowl which are also required for proper hindgut development. cad, fkh, byn and wg constitute a conserved constellation of genes that plays a required role in gastrulation and gut development.
Phenotypic analysis demonstrates byn is required to regulate specific gene activity in the primordia of the anal pads and hindgut. In the absence of byn activity, programmed cell death occurs in the primordia resulting in reduced and abnormal anal pads and hindgut. byn is also required for the formation of midgut restrictions and elongation of the Malpighian tubules. tll is necessary and sufficient to activate byn.
byn plays a key role in the development of tissues derived from the proctodeum.
byn is required for specification of the hindgut and anal pads.
Product is detected by an antibody against the mouse T gene.
Source for identity of: byn CG7260
The mutant phenotype and the similarity of the encoded gene product to the vertebrate Brachyury protein caused the gene named to be changed from "Trg" to "brachyenteron" ("byn"), or "short gut".
