FlyBase Gene Report: Dmel\Ubc2

General Information

Symbol

Dmel\Ubc2

Species

D. melanogaster

Name

Ubiquitin conjugating enzyme 2

Annotation Symbol

CG6720

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015320

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

E2 ubiquitin-conjugating enzyme (2.3.2.23)

Gene Summary

Catalyzes the covalent attachment of ubiquitin to other proteins. (UniProt, P52485)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

UbcD2, l(2)k13206

Key Links

Genomic Location

Cytogenetic map

32A5-32A5

Sequence location

2L:10,765,010..10,768,006 [-]

Recombination map

2-43

RefSeq locus

NT_033779 REGION:10765010..10768006

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ubiquitin-protein transferase activity

inferred from genetic interaction with SGD:S000000286

(Matuschewski et al., 1996)

inferred from genetic interaction with SGD:S000002466

(Matuschewski et al., 1996)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables ubiquitin conjugating enzyme activity

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

enables ubiquitin-protein transferase activity

inferred from sequence or structural similarity with SGD:S000000286

(Matuschewski et al., 1996)

inferred from sequence or structural similarity with SGD:S000002466

(Matuschewski et al., 1996)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in lipid storage

inferred from direct assay

(Beller et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein polyubiquitination

inferred from sequence or structural similarity with SGD:S000002466

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES

Protein Family (UniProt)

Belongs to the ubiquitin-conjugating enzyme family. (P52485)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ubiquitin conjugating enzyme activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine (2.3.2.23)

Summaries

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES -: Ubiquitin-conjugating (E2) enzymes accept activated ubiquitin from ubiquitin-activating (E1) enzymes via thioester bond with a conserved catalytic cysteine. E2s then interact with ubiquitin ligases (E3) to directly or indirectly ubiquitinate target proteins. E2s are characterised by a 200 amino acid ubiquitin-conjugating (UBC) domain which interacts with E1 and E3s and acts catalytically. (Adapted from PMID:19940261.)

Protein Function (UniProtKB)

Catalyzes the covalent attachment of ubiquitin to other proteins.

(UniProt, P52485)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ubc2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P52485)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ubc2-RA

FBtr0080115

NM_057789

1558

232

Ubc2-RB

FBtr0080116

NM_164943

1349

232

Ubc2-RC

FBtr0333492

NM_001273433

2111

232

Ubc2-RD

FBtr0345437

NM_001298885

1625

232

Additional Transcript Data and Comments

Reported size (kB)

1.5 (northern blot)

(Matuschewski et al., 1996)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ubc2-PA

FBpp0079704

24.4

232

8.47

FBpp0079705

24.4

232

8.47

FBpp0305676

24.4

232

8.47

FBpp0311562

24.4

232

8.47

P52485

NP_001285814

AHN54328

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

232 aa isoforms: Ubc2-PA, Ubc2-PB, Ubc2-PC, Ubc2-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

232 (aa); 24.5 (kD predicted)

(Matuschewski et al., 1996)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ubc2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.65

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ubc2 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ubc2

View exonic expression by tissue for Dmel\Ubc2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015320

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34487/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015320

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015320

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015320

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6720

Flygut - An atlas of the Drosophila adult midgut

FBgn0015320

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Ubc2

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ubc2

Transgenic constructs containing regulatory region of Ubc2

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)BSC32

(Deal and Cook, 2003.7.11)

Df(2L)BSC214

(Christensen and Cook, 2006.8.30)

Df(2L)Exel8026

(Ryder, 2004.4.26)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

Ubc2^k13206

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ubc2^GD14776

viable, with Scer\GAL4^Mef2.PR

Ubc2^GD14776

viable, with Scer\GAL4^pnr-MD237

Ubc2^GD14776

viable, with Scer\GAL4^tin.CΔ4

Ubc2^GD14776

Other Phenotypes

Allele

abnormal eye color, with Scer\GAL4^GMR.PF

Ubc2^GD14776

abnormal neuroanatomy | somatic clone

Ubc2^k13206

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Ubc2^GD14776

visible, with Scer\GAL4^pnr-MD237

Ubc2^GD14776

visible, with Scer\GAL4^sca-537.4

Ubc2^EP2146b

visible | adult stage, with Scer\GAL4^GMR.PF

Ubc2^GD14776

Phenotype manifest in

Allele

macrochaeta

Ubc2^L32BC

mesonotum, with Scer\GAL4^pnr-MD237

Ubc2^GD14776

neuroblast | somatic clone

Ubc2^k13206

scutellar bristle, with Scer\GAL4^sca-537.4

Ubc2^EP2146b

tormogen cell, with Scer\GAL4^sca-537.4

Ubc2^EP2146b

trichogen cell | ectopic, with Scer\GAL4^sca-537.4

Ubc2^EP2146b

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (34)

Hsap\UBE2E2

13 of 14

Yes

Hsap\UBE2E1

12 of 14

Yes

Hsap\UBE2E3

12 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Ube2e1

11 of 14

Yes

Rnor\Ube2e2

7 of 14

Yes

Rnor\Ube2e3

7 of 14

Yes

5 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (23)

Mmus\Ube2e2

13 of 14

Yes

Mmus\Ube2e1

12 of 14

Yes

Mmus\Ube2e3

11 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (19)

Xtro\ube2e3

10 of 13

Yes

Xtro\ube2e1

6 of 13

Yes

3 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\ube2e2

13 of 14

Yes

Drer\ube2e3

12 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (20)

Cele\let-70

4 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (21)

Agam\AgaP_AGAP007952

12 of 12

Yes

Agam\AgaP_AGAP012754

10 of 12

Yes

4 of 12

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (43)

Atha\FUS9

6 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Yes

4 of 13

4 of 13

4 of 13

3 of 13

Yes

Atha\UBC31

3 of 13

Yes

Atha\UBC35

3 of 13

Atha\UBC36

3 of 13

Atha\PEX4

2 of 13

Yes

Atha\UBC19

2 of 13

Atha\UBC20

2 of 13

Atha\UBC37

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\UBC4

3 of 13

Yes

Scer\UBC5

3 of 13

Yes

Scer\UBC13

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (10)

Spom\ubc4

3 of 12

Yes

Spom\ubc13

3 of 12

Yes

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ubc2. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (28)

CG2574

5 of 13

CG5440

5 of 13

eff

5 of 13

CG10862

4 of 13

ben

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

vih

2 of 13

CG7656

1 of 13

CG10254

1 of 13

CG40045

1 of 13

lwr

1 of 13

Ubc6

1 of 13

Ubc7

1 of 13

Ubc87F

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UBE2E2; ubiquitin conjugating enzyme E2 E2

13 of 14

602163

UBE2E1; ubiquitin conjugating enzyme E2 E1

12 of 14

602916

UBE2E3; ubiquitin conjugating enzyme E2 E3

12 of 14

604151

UBE2D1; ubiquitin conjugating enzyme E2 D1

4 of 14

602961

UBE2D2; ubiquitin conjugating enzyme E2 D2

4 of 14

602962

UBE2D3; ubiquitin conjugating enzyme E2 D3

4 of 14

602963

UBE2D4; ubiquitin conjugating enzyme E2 D4

4 of 14

UBE2N; ubiquitin conjugating enzyme E2 N

3 of 14

603679

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ubc2 - CG44251

two hybrid

(Hu et al., 2017.6.13)

Ubc2 - Iru

two hybrid

(Hu et al., 2017.6.13)

Ubc2 - Su(dx)

two hybrid

(Hu et al., 2017.6.13)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enc

enhanceable

Ubc2

(Ohlmeyer and Schupbach, 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

60561

DroID - A comprehensive database of gene and protein interactions.

FBgn0015320

MIST (protein-protein) - An integrated Molecular Interaction Database

34487

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P52485

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-43

Cytogenetic map

32A5-32A5

Sequence location

2L:10,765,010..10,768,006 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32A5-32A5

Limits computationally determined from genome sequence between P{PZ}dbf¹ and P{lacW}SCAR^k03107

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

32A-32A

(determined by in situ hybridisation)

(Abdelilah-Seyfried et al., 2000)

32A4-32A5

(determined by in situ hybridisation)

(Spradling et al., 1999)

32A-32B

(determined by in situ hybridisation)

(Matuschewski et al., 1996)

32A4-32A5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-43

(FlyBase, 2016)

2-36.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

11071

y¹ w^67c23; P{lacW}Ubc2^k13206/CyO

Kyoto

122055

w¹¹¹⁸; P{EP}Ubc2^EP2598

NIG-Fly

M2L-1316

y¹ w¹¹¹⁸; Ubc2^SK1 P{neoFRT}40A/CyO-Tb

M2L-1317

y¹ w¹¹¹⁸; Ubc2^SK3 P{neoFRT}40A/CyO-Tb

2LG-1052

y² VhaAC39-1^cho-1 v¹; P{U6-Ubc2.NIG.sgRNA}attP40/CyO

VDRC

v31158

w¹¹¹⁸; P{GD14776}v31158

Genomic Clones (33)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (130)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE74673

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015320

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015320

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

A UbcD2 cDNA has been cloned and sequenced.

(Matuschewski et al., 1996)

S.cerevisiae Scer\ubc4 Scer\ubc5 double mutants are partially functionally complemented by UbcD2.

(Matuschewski et al., 1996)

Relationship to Other Genes

Source for database merge of

Source for merge of: UbcD2 l(2)k13206

(Spradling et al., 1999)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ubc2 UbcD2

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'UbcD2' to 'Ubc2' as the 'D' indicates 'Drosophila' (which FlyBase nomenclature rules disallow) and to avoid the implication that this is the specific ortholog of human UBE2D2.

(FlyBase, 2009-)

Etymology

Named 'UbcD2' for 'ubiquitin-conjugating enzyme from Drosophila 2 (the numbering reflects the order of identification).

(Matuschewski et al., 1996)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG6720

(National Institute of Genetics Fly Stocks, 2022-, Chen et al., 2012, Zhang et al., 2011, Zhang et al., 2010, Norga et al., 2003)

UBCD2

(Daou et al., 2018)

Ubc2

(National Institute of Genetics Fly Stocks, 2022-, Hu et al., 2017.6.13)

UbcD2

(Hans et al., 2014, Gurudatta et al., 2012, Popkova et al., 2012, Abed et al., 2011, Barry et al., 2011, Du et al., 2011, Franco et al., 2011, Carbone et al., 2009, Michelle et al., 2009, Hoopfer et al., 2008, Altenhein et al., 2006, Christensen and Cook, 2006.8.30, Kuo et al., 2006, Jones et al., 2002, Matuschewski et al., 1996)

l(2)k13206

(Mesilaty-Gross et al., 1999, BDGP Project Members, 1994-1999)

ubcD2

(Kuo et al., 2006, Ryoo et al., 2002, Ryoo et al., 2002)

Name Synonyms

Ubiquitin conjugating enzyme 2

ubiquitin conjugating enzyme 2

(Beller et al., 2008)

Secondary FlyBase IDs

FBgn0021893

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 74 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34487

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P52485

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P52485

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q541C3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P52485

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015320

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34487/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015320

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015320

FlyMine - An integrated database for Drosophila genomics

FBgn0015320

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6720

MARRVEL_MODEL - MARRVEL (model organism gene)

34487

Linkouts

BioGRID - A database of protein and genetic interactions.

60561

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015320

DroID - A comprehensive database of gene and protein interactions.

FBgn0015320

DRSC - Results frm RNAi screens

FBgn0015320

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015320

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015320

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6720

Flygut - An atlas of the Drosophila adult midgut

FBgn0015320

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015320

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012100

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

MIST (protein-protein) - An integrated Molecular Interaction Database

34487

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P52485

References (72)

The following external sites may use different assemblies or annotations than FlyBase.

3.65

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