FlyBase Gene Report: Dmel\vih

General Information

Symbol

Dmel\vih

Species

D. melanogaster

Name

vihar

Annotation Symbol

CG10682

Feature Type

protein_coding_gene

FlyBase ID

FBgn0264848

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

E2 ubiquitin-conjugating enzyme (2.3.2.23)

Gene Summary

vihar (vih) encodes a protein that belongs to the ubiquitin-conjugating (E2) enzyme family with a direct role in protein ubiquitylation. The product of vih accepts activated ubiquitin from the ubiquitin-activating (E1) enzyme via thioester bond with a conserved catalytic cysteine, then interacts with the APC/C ubiquitin ligase (E3) to directly ubiquitinate target proteins. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

69C4-69C4

Sequence location

3L:12,504,292..12,505,821 [+]

Recombination map

3-38

RefSeq locus

NT_037436 REGION:12504292..12505821

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ubiquitin conjugating enzyme activity

inferred from direct assay

(Mathe et al., 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ubiquitin conjugating enzyme activity

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from direct assay

(Mathe et al., 2004)

inferred from mutant phenotype

(Williamson et al., 2009)

involved_in exit from mitosis

inferred from mutant phenotype

(Williamson et al., 2009)

involved_in positive regulation of mitotic metaphase/anaphase transition

inferred from mutant phenotype

(Mathe et al., 2004)

involved_in positive regulation of protein catabolic process

inferred from mutant phenotype

(Mathe et al., 2004)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000630584

(GO Reference Genome Project, 2011-)

involved_in protein polyubiquitination

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

involved_in regulation of mitotic metaphase/anaphase transition

inferred from biological aspect of ancestor with PANTHER:PTN000630584

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Mathe et al., 2004)

colocalizes_with spindle pole centrosome

inferred from direct assay

(Mathe et al., 2004)

part_of ubiquitin conjugating enzyme complex

inferred from direct assay

(Nagy et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002514495

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES

Protein Family (UniProt)

Belongs to the ubiquitin-conjugating enzyme family. (Q9VTY6)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ubiquitin conjugating enzyme activity

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L- cysteine (2.3.2.23)

Summaries

Gene Snapshot

Gene Group (FlyBase)

E2 UBIQUITIN CONJUGATING ENZYMES -: Ubiquitin-conjugating (E2) enzymes accept activated ubiquitin from ubiquitin-activating (E1) enzymes via thioester bond with a conserved catalytic cysteine. E2s then interact with ubiquitin ligases (E3) to directly or indirectly ubiquitinate target proteins. E2s are characterised by a 200 amino acid ubiquitin-conjugating (UBC) domain which interacts with E1 and E3s and acts catalytically. (Adapted from PMID:19940261.)

Protein Function (UniProtKB)

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

(UniProt, Q9VTY6)

Summary (Interactive Fly)

E2 ubiquitin-conjugating enzyme - contributes to the spatiotemporal control of Cyclin B degradation that occurs first during mitosis at the spindle poles

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\vih for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VTY6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

vih-RA

FBtr0075958

NM_140325

1464

178

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

vih-PA

FBpp0075690

19.8

178

6.67

Q9VTY6

NP_648582

AAF49909

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the APC/C complex.

(UniProt, Q9VTY6)

Post Translational Modification

Ubiquitinated by the APC/C complex, leading to its degradation at the metaphase-anaphase transition.

(UniProt, Q9VTY6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vih using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

vih_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.52

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism | intense | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

organism | intense | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Mathe et al., 2004)

colocalizes_with spindle pole centrosome

inferred from direct assay

(Mathe et al., 2004)

part_of ubiquitin conjugating enzyme complex

inferred from direct assay

(Nagy et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\vih in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\vih

View exonic expression by tissue for Dmel\vih

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264848

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

44118/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264848

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027936

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264848

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of vih

Transgenic constructs containing regulatory region of vih

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(3L)E44

(Mathe et al., 2004)

Df(3L)F10

(Mathe et al., 2004)

Df(3L)iro-2

(Mathe et al., 2004)

Gene not disrupted in

Df(3L)vin7

(Mathe et al., 2004)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | embryonic stage | maternal effect | recessive

vih¹

lethal | recessive

lethal - all die before end of P-stage

vih^S110501

lethal - all die before end of P-stage | recessive

vih^S110501

lethal - all die during embryonic stage | maternal effect | recessive

vih²

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

vih^GD7061

viable, with Scer\GAL4^Mef2.PR

vih^GD7061

viable, with Scer\GAL4^pnr-MD237

vih^GD7061

viable, with Scer\GAL4^tin.CΔ4

vih^GD7061

Sterility

Allele

female semi-fertile

sterile

vih²

Other Phenotypes

Allele

abnormal mitotic cell cycle

vih¹

decreased fecundity | mated female

some die during embryonic stage | recessive | maternal effect | recessive

vih²

some die during pharate adult stage

vih^S110501

some die during pharate adult stage | recessive

vih^S110501

some die during P-stage | recessive

vih¹

wild-type, with Scer\GAL4^{VP16.mat.αTub67C}

Phenotype manifest in

Allele

centrosome | oogenesis

vih^ΔN-9

egg chamber

female germline cyst

microtubule | oogenesis

vih^ΔN-9

mitosis & nuclear chromosome

vih¹

mitosis & nuclear chromosome | maternal effect

vih¹

plasma membrane | oogenesis

spindle | maternal effect

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\UBE2C

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Ube2c

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Ube2c

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (18)

Xtro\ube2c

7 of 13

Yes

6 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ube2w

1 of 13

Danio rerio (Zebrafish) (31)

Drer\ube2c

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Drer\si:ch1073-205c8.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (18)

Cele\let-70

2 of 14

Yes

Cele\ubc-13

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (23)

Agam\AgaP_AGAP006238

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (38)

Atha\UBC19

13 of 13

Yes

Atha\UBC20

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (12)

Scer\UBC11

12 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (11)

Spom\ubc11

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:vih. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (31)

ben

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

eff

2 of 13

lwr

2 of 13

morgue

2 of 13

peo

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Kua

1 of 13

Ubc10

1 of 13

Ubc84D

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

UBE2C; ubiquitin conjugating enzyme E2 C

14 of 14

605574

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

vih - lmgA

protein three hybrid

(Nagy et al., 2012)

vih - mr

protein three hybrid

(Nagy et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

vih

suppressible

(Braun et al., 2021)

vih

suppressible

polo

(Braun et al., 2021)

vih

enhanceable

Sas-4

(Braun et al., 2021)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of the APC/C complex.

(UniProt, Q9VTY6 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0264848

MIST (protein-protein) - An integrated Molecular Interaction Database

44118

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VTY6

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-38

Cytogenetic map

69C4-69C4

Sequence location

3L:12,504,292..12,505,821 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69C4-69C4

Limits computationally determined from genome sequence between P{PZ}l(3)05088⁰⁵⁰⁸⁸ and P{PZ}l(3)06924⁰⁶⁹²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

69C-69D

(determined by in situ hybridisation)

(Mathe et al., 2004)

69C-69C

(Mathe and Glover, 1999)

69C-69C

(determined by in situ hybridisation)

(Deak et al., 1997)

Experimentally Determined Recombination Data

Location

3-38

(FlyBase, 2016)

3-31.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

36198

y¹ w^*; Mi{MIC}vih^MI03119

16570

y¹ w^67c23; P{EPgy2}vih^EY03666

14254

y¹; P{SUPor-P}vih^KG02013 ry⁵⁰⁶/TM3, Sb¹ Ser¹

Kyoto

111589

y^d2 w¹¹¹⁸ P{ey-FLP.N}2 P{5xglBS-lacZ.38-1}TPN1; P{SUPor-P}vih^KG02013 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb¹

VDRC

v107720

P{KK102343}VIE-260B

v27306

w¹¹¹⁸; P{GD7061}v27306

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (57)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP01717

Other clones

DPiM_IP01717

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0264848

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R⁺ cells.

(Boutros et al., 2004)

Reduction of vih function results in an accumulation of cells in a metaphase-like state.

(Mathe et al., 2004)

Centrosomes are released from the poles of both cleavage embryo and neuroblast spindles in vih mutants, but anastral and acentrosomal spindles remain relatively stable. These acentrosomal and anastral spindles develop two broad spindle poles, and the chromosomes become overcondensed and scattered throughout these barrel-like bipolar spindles.

(Mathe and Glover, 1999)

Relationship to Other Genes

Source for database merge of

Source for merge of: vih anon-WO0172774.54 anon-WO0172774.55 anon-WO0172774.56

(FlyBase, 1996-)

Source for merge of: vihar CG10682

(FlyBase, 1996-)

Source for merge of: vih l(3)S110501

(Nagy et al., 2012)

Additional comments

Source for merge of vih anon-WO0172774.54 anon-WO0172774.55 anon-WO0172774.56 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Source for merge of vihar CG10682 was sequence comparison ( date:011219 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

The gene is named "vihar" (Hungarian for "storm") after the characteristic mutant phenotype in which chromosomes are scattered throughout the mitotic spindle.

(Mathe et al., 2004)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

1105/01

(Deak et al., 1997)

CG10682

(Lin et al., 2018, Park et al., 2016, Hosono et al., 2015, Keleman et al., 2009.8.5, Boutros et al., 2004, Jones et al., 2002)

UbcH10

(Williamson et al., 2009)

anon-WO0172774.54

anon-WO0172774.55

anon-WO0172774.56

l(3)S110501

vih

(Braun et al., 2021, Fischer et al., 2015, Du et al., 2011, Franco et al., 2011)

vihar

(Michelle et al., 2009)

Name Synonyms

Vihar

(Williamson et al., 2009)

lethal (3) S110501

vihar

(Nagy et al., 2012, Li et al., 2007, Pines, 2006, Mathe et al., 2004, Mathe and Glover, 1999)

Secondary FlyBase IDs

FBgn0027936
FBgn0036293
FBgn0046375
FBgn0046376
FBgn0046377
FBgn0060486

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

44118

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VTY6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

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Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VTY6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0264848

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

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EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0264848

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0264848

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10682

MARRVEL_MODEL - MARRVEL (model organism gene)

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Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0264848

DroID - A comprehensive database of gene and protein interactions.

FBgn0264848

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

vih_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0027936

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0264848

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

protein ubiquitination

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0264848

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008974

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

MIST (protein-protein) - An integrated Molecular Interaction Database

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Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q9VTY6

References (50)

The following external sites may use different assemblies or annotations than FlyBase.

1.52

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