FlyBase Gene Report: Dmel\abs

(Schmucker et al., 2000)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 13 -- 16

(Fisher et al., 2012)

wandering third instar larval stage

(Fisher et al., 2012)

Additional Descriptive Data

abs transcripts are expressed at a very low level throughout development and in all tissues.

(Schmucker et al., 2000)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of catalytic step 2 spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

part_of precatalytic spliceosome

inferred from high throughput direct assay

(Herold et al., 2009)

Expression Deduced from Reporters

Reporter: P{PZ}abs⁰⁰⁶²⁰

Stage

Tissue/Position (including subcellular localization)

Reference

gonad

(Meister and Braun, 1995.10)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\abs in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\abs

View exonic expression by tissue for Dmel\abs

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015331

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40530/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015331

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015331

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015331

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG14637

Flygut - An atlas of the Drosophila adult midgut

FBgn0015331

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 18 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of abs

Transgenic constructs containing regulatory region of abs

Aberrations (Deficiencies and Duplications) ( 13 )

Inferred from experimentation ( 13 )

Gene disrupted in

Df(3R)2-2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(3R)7B-90

(Honda, 2019.6.5)

Df(3R)231-5

(Irion and Leptin, 1999)

Df(3R)XM3

(Honda, 2019.6.5)

Gene not disrupted in

Df(3L)6B-29+Df(3R)6B-29

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

(Honda, 2019.6.5)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | heat sensitive

abs^33B

lethal | larval stage | heat sensitive

abs^E2

lethal | pharate adult stage

abs^E2

lethal | recessive

lethal | recessive | heat sensitive

abs^14B

lethal - all die before end of larval stage (with abs^45LR7)

abs^E2

lethal - all die before end of larval stage (with abs^E2)

abs^45LR7

Other Phenotypes

Allele

abnormal cell death | recessive | heat sensitive

abs^14B

some die during third instar larval stage (with abs^45LR7)

abs^E2

some die during third instar larval stage (with abs^E2)

abs^45LR7

wild-type

Phenotype manifest in

Allele

Bolwig nerve

abs^unspecified

Bolwig nerve (with abs^45LR7)

abs^II-F1

Bolwig nerve (with abs^II-F1)

abs^45LR7

central nervous system

egg chamber | heat sensitive

abs^14B

embryo | embryonic stage 5 | ventral | heat sensitive

abs^14B

embryonic head | heat sensitive

abs^14B

embryonic neuroblast | heat sensitive

abs^14B

follicle cell | heat sensitive

abs^14B

larval longitudinal connective

larval RP2 motor neuron | ectopic | heat sensitive (with Df(3R)231-5)

abs^14B

melanotic mass | ectopic (with abs^45LR7)

abs^E2

melanotic mass | ectopic (with abs^E2)

abs^45LR7

mesoderm | heat sensitive

abs^14B

mitotic cell cycle | heat sensitive

abs^14B

muscle cell of A1-7 dorsal acute muscle 1 | ectopic | heat sensitive (with Df(3R)231-5)

abs^14B

neurite | heat sensitive

abs^14B

neuroblast | heat sensitive (with Df(3R)231-5)

abs^14B

nurse cell | heat sensitive

abs^14B

ommatidium (with abs^45LR7)

abs^E2

ommatidium (with abs^E2)

abs^45LR7

oocyte nucleus | heat sensitive

abs^14B

photoreceptor neuron (with abs^45LR7)

abs^E2

photoreceptor neuron (with abs^E2)

abs^45LR7

photoreceptor neuron | ectopic (with abs^45LR7)

abs^E2

photoreceptor neuron | ectopic (with abs^E2)

abs^45LR7

primordial germ cell | heat sensitive

abs^14B

retina

retina & axon (with abs^45LR7)

abs^E2

retina & axon (with abs^E2)

abs^45LR7

RP2sib neuron | heat sensitive (with Df(3R)231-5)

abs^14B

spindle | heat sensitive

abs^14B

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (32)

Hsap\DDX41

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Ddx41

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (25)

Mmus\Ddx41

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\ddx41

11 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (23)

Drer\LOC108179221

6 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (32)

Cele\sacy-1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (24)

Agam\AgaP_AGAP004711

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (51)

Atha\AT4G33370

13 of 13

Yes

Atha\AT5G51280

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\emb1138

2 of 13

Atha\PDE340

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (15)

Scer\DBP1

2 of 13

Yes

Scer\DBP2

2 of 13

Yes

Scer\DBP8

2 of 13

Yes

Scer\DED1

2 of 13

Yes

Scer\DRS1

2 of 13

Yes

Scer\MAK5

2 of 13

Yes

Scer\RRP3

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (13)

Spom\dbp2

2 of 12

Yes

Spom\sum3

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\deaD

1 of 11

Yes

Ecol\rhlE

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:abs. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (34)

CG10077

4 of 13

CG10333

4 of 13

mahe

4 of 13

bel

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

vas

3 of 13

ais

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Rs1

2 of 13

Blm

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pit

1 of 13

RecQ5

1 of 13

SoYb

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

abs^KK101165

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.Tag:HA

(Fortuna et al., 2021)

modeled by Hsap\FUS^{R518K.UAS.Tag:HA}

(Fortuna et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DDX41; DEAD-box helicase 41

13 of 14

608170

MYELOPROLIFERATIVE/LYMPHOPROLIFERATIVE NEOPLASMS, FAMILIAL (MULTIPLE TYPES), SUSCEPTIBILITY TO; MPLPF

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

abs - Acsx3

(Guruharsha et al., 2011)

abs - ApepP

(Guruharsha et al., 2011)

abs - CG10657

(Guruharsha et al., 2011)

abs - CG3107

(Guruharsha et al., 2011)

abs - CG4119

(Guruharsha et al., 2011)

abs - Coq6

(Guruharsha et al., 2011)

abs - Nagk

(Guruharsha et al., 2011)

abs - Ssb-c31a

(Guruharsha et al., 2011)

abs - asl

(Guruharsha et al., 2011)

abs - snRNP-U1-70K