FlyBase Gene Report: Dmel\αCOP

General Information

Symbol

Dmel\αCOP

Species

D. melanogaster

Name

Coat Protein (coatomer) α

Annotation Symbol

CG7961

Feature Type

protein_coding_gene

FlyBase ID

FBgn0025725

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

α-COP

Key Links

Genomic Location

Cytogenetic map

62A9-62A9

Sequence location

3L:1,641,066..1,645,199 [-]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1641066..1645199

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables structural molecule activity

inferred from electronic annotation with InterPro:IPR006692, InterPro:IPR010714

(InterPro Project Members, 2004-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in male meiosis cytokinesis

inferred from mutant phenotype

(Kitazawa et al., 2012)

involved_in protein localization to cleavage furrow

inferred from mutant phenotype

(Kitazawa et al., 2012)

involved_in regulation of lipid storage

inferred from direct assay

(Beller et al., 2008)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

involved_in endoplasmic reticulum to Golgi vesicle-mediated transport

inferred from electronic annotation with InterPro:IPR016391

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in intra-Golgi vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in intracellular protein transport

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR006692, InterPro:IPR010714, InterPro:IPR016391

(InterPro Project Members, 2004-)

involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

involved_in vesicle-mediated transport

non-traceable author statement

(Sisson et al., 2000)

inferred from electronic annotation with InterPro:IPR006692, InterPro:IPR010714

(InterPro Project Members, 2004-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from direct assay

(Stuart et al., 2007)

located_in endoplasmic reticulum-Golgi intermediate compartment

inferred from direct assay

(Kitazawa et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from biological aspect of ancestor with PANTHER:PTN000458798

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR010714, InterPro:IPR016391

(InterPro Project Members, 2004-)

part_of membrane coat

inferred from electronic annotation with InterPro:IPR006692

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

COAT PROTEIN COMPLEX I -: The Coat Protein Complex I (COPI or coatomer) is responsible for retrograde transport from the Golgi to ER. It is composed of seven subunits: the α, β, δ and γ subunits form the cargo adaptor and the β', ε and ζ form the vesicle cage. (Adapted from PMID:22160157).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\αCOP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W0B8)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

αCOP-RA

FBtr0072812

NM_058047

4078

1234

αCOP-RB

FBtr0072811

NM_167908

3970

1234

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

αCOP-PA

FBpp0072694

139.3

1234

7.68

FBpp0072693

139.3

1234

7.68

Q9W0B8

NP_728648

AAF47535

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1234 aa isoforms: αCOP-PA, αCOP-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\αCOP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

alphaCOP_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.38

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

amnioserosa

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

(Fisher et al., 2012)

tracheal primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male & spermatogenesis

primary spermatocyte

• endoplasmic reticulum-Golgi intermediate compartment

(Kitazawa et al., 2012)

meiotic primary spermatocyte

• COPI-coated vesicle

(Kitazawa et al., 2012)

onion stage spermatid

• acroblast

(Kitazawa et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

αCOP is localized to the endoplasmic reticulum-Golgi intermediate compartment in premeiotic spermatocytes, to COPI vesicles associated with astral microtubules in meiotic primary spermatocytes, and to the acroblast in onion stage spermatids.

(Kitazawa et al., 2012)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of COPI vesicle coat

inferred from direct assay

(Stuart et al., 2007)

located_in endoplasmic reticulum-Golgi intermediate compartment

inferred from direct assay

(Kitazawa et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\αCOP in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\αCOP

View exonic expression by tissue for Dmel\αCOP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025725

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025725

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025725

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025725

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7961

Flygut - An atlas of the Drosophila adult midgut

FBgn0025725

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\αCOP

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of αCOP

Transgenic constructs containing regulatory region of αCOP

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

αCOP²⁷⁵⁰

lethal, with Scer\GAL4^pnr-MD237

αCOP^GD12332

lethal, with Scer\GAL4^tin.CΔ4

αCOP^GD12332

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

αCOP^GD12332

viable

αCOP^EY09064

Sterility

Allele

fertile

αCOP^EY09064

Other Phenotypes

Allele

abnormal neuroanatomy | adult stage | progressive | somatic clone

αCOP²⁷⁵⁰

abnormal neurophysiology | adult stage | somatic clone

αCOP²⁷⁵⁰

Phenotype manifest in

Allele

adult neuromuscular junction

αCOP²⁷⁵⁰

astral microtubule | male, with Scer\GAL4^VP16.bam

αCOP^GD12332

axon | adult stage | somatic clone

αCOP²⁷⁵⁰

combined L1-L3 nerve | adult stage | somatic clone

αCOP²⁷⁵⁰

embryonic/larval fat body | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

αCOP^GLC01632

endoplasmic reticulum | adult stage | decreased number | somatic clone

αCOP²⁷⁵⁰

endosome | adult stage | decreased number | somatic clone

αCOP²⁷⁵⁰

extracellular matrix | third instar larval stage, with Scer\GAL4^{SPARC-MI00329-GAL4}

αCOP^GLC01632

leg muscle motor neuron | adult stage

αCOP²⁷⁵⁰

mitochondrion | adult stage | decreased number | somatic clone

αCOP²⁷⁵⁰

onion stage spermatid, with Scer\GAL4^VP16.bam

αCOP^GD12332

peroxisome | adult stage | increased number | somatic clone

αCOP²⁷⁵⁰

spindle microtubule | male, with Scer\GAL4^VP16.bam

αCOP^GD12332

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\COPA

14 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\EML6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\WDR76

1 of 14

Yes

Hsap\WDR86

1 of 14

Hsap\WRAP53

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (20)

Rnor\Copa

14 of 14

Yes

Rnor\Copb2

2 of 14

Rnor\Apaf1

1 of 14

Rnor\Ddb2

1 of 14

Yes

Rnor\Eml6

1 of 14

Rnor\Fbxw10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (20)

Mmus\Copa

13 of 14

Yes

Mmus\Copb2

2 of 14

Mmus\Apaf1

1 of 14

Mmus\Ddb2

1 of 14

Yes

Mmus\Eml6

1 of 14

Mmus\Fbxw10

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (20)

Xtro\copa

11 of 13

Yes

Xtro\copb2

2 of 13

Xtro\cdrt1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (25)

Drer\copa

13 of 14

Yes

Drer\copb2

2 of 14

Drer\ahi1

1 of 14

Yes

Drer\chaf1b

1 of 14

Drer\daw1

1 of 14

Drer\ddb2

1 of 14

Yes

Drer\eml1

1 of 14

Drer\eml5

1 of 14

Drer\eml6

1 of 14

Yes

Drer\ercc8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\copa-1

14 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP010251

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (28)

Atha\AT1G62020

13 of 13

Yes

Atha\AT2G21390

13 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\DRS1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\TRM82

1 of 13

Atha\WDR5b

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (14)

Scer\COP1

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\SPBPJ4664.04

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:αCOP. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

β'COP

4 of 13

ago

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Nle

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

COPA; coat protein complex I subunit alpha

model of autoimmune interstitial lung, joint, and kidney disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COPA; coat protein complex I subunit alpha

14 of 14

601924

AUTOINFLAMMATION AND AUTOIMMUNITY, SYSTEMIC, WITH IMMUNE DYSREGULATION 1; AIAISD1

autoimmune interstitial lung, joint, and kidney disease

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

αCOP - Akt

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - Arf1

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

αCOP - Arf4

pull down, peptide massfingerprinting

(Christis and Munro, 2012)

αCOP - CG7878

experimental knowledge based

(Guruharsha et al., 2011)

αCOP - Lkb1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - Mfap1

anti bait coimmunoprecipitation, peptide massfingerprinting

(Andersen and Tapon, 2008)

αCOP - Prp38

anti bait coimmunoprecipitation, peptide massfingerprinting

(Andersen and Tapon, 2008)

αCOP - S6k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - foxo

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - gig

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - sau

pull down, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry

(Sechi et al., 2021, Frappaolo et al., 2017)

αCOP - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

αCOP - β'COP

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

αCOP

suppressible

Drp1

(Maddison et al., 2023)

αCOP

suppressible

Marf

(Maddison et al., 2023)

αCOP

suppressible

Miro

(Maddison et al., 2023)

αCOP

suppressible

Vap33

(Maddison et al., 2023)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63733

DroID - A comprehensive database of gene and protein interactions.

FBgn0025725

MIST (protein-protein) - An integrated Molecular Interaction Database

38199

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O77285

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-0.5

Cytogenetic map

62A9-62A9

Sequence location

3L:1,641,066..1,645,199 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A9-62A9

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

62A10-62B5

(determined by in situ hybridisation)

(Merdes, 1998.12.20)

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31702

y¹ v¹; P{TRiP.HM04008}attP2

81494

y¹ v¹; P{TKO.GS04824}attP40

17530

y¹ w^67c23; P{EPgy2}αCOP^EY09064

34923

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01272}attP2/TM3, Sb¹

FlyORF

F001833

M{UAS-αCOP.ORF.3xHA}ZH-86Fb

NIG-Fly

HMS01272

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01272}attP2/TM3, Sb¹

VDRC

v318793

PBac{fTRG01193.sfGFP-TVPTBF}VK00002

v35305

w¹¹¹⁸; P{GD12332}v35305/TM3

v35306

w¹¹¹⁸; P{GD12332}v35306/TM3

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (100)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD46584

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0025725

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0025725

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kitazawa et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

dsRNA made from templates generated with primers directed against αCop that is transfected into S2 treated with Listeria monocytogenes reveals αCop to be involved in Listeria monocytogenes entry and vacuolar escape.

(Cheng et al., 2005)

Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.

(Nybakken et al., 2005)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: αCOP αCop

(FlyBase, 2009-)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG7961

(Kolkhof et al., 2017, Hosono et al., 2015, Schertel et al., 2013, Christis and Munro, 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Andersen and Tapon, 2008, Ni et al., 2008, Sepp et al., 2008, Derré et al., 2007, Nybakken et al., 2005)

alpha-COP

(Merdes, 1998.9.27)

alphaCOP

(Pang et al., 2021, Kolkhof et al., 2017, Transgenic RNAi Project members, 2017-, Gonzalez et al., 2014, Aikin et al., 2012, Lindquist et al., 2011, Cherry et al., 2006)

alphaCop

(Laflamme et al., 2017, Sarov et al., 2016, Dent et al., 2015, Mukherjee et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Friedman et al., 2011, Lindquist et al., 2011, Sepp et al., 2008, Derré et al., 2007, Giot et al., 2003)

α-COP

(D'Ambrosio and Vale, 2010, Sisson et al., 2000)

αCOP

(Ascencio et al., 2023, Heigwer et al., 2023, Hodgson et al., 2022, Frappaolo et al., 2017, Zhang et al., 2016, Vedanayagam and Garrigan, 2015, Christis and Munro, 2012, Kitazawa et al., 2012, Wendler et al., 2010, Beller et al., 2008, Grieder et al., 2005, Nybakken et al., 2005)

αCop

(Maddison et al., 2023, Costello et al., 2009, Beller et al., 2008, Guo et al., 2008, Sepp et al., 2008, Stuart et al., 2007, Stroschein-Stevenson et al., 2006)

Name Synonyms

COPI α subunit

(Neumann et al., 2010)

Coat Protein (coatomer) α

coatomer I

(Bonke et al., 2013)

α-coatomer protein

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38199

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W0B8

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W0B8

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0025725

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38199/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0025725

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0025725

FlyMine - An integrated database for Drosophila genomics

FBgn0025725

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7961

MARRVEL_MODEL - MARRVEL (model organism gene)

38199

Linkouts

BioGRID - A database of protein and genetic interactions.

63733

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0025725

DroID - A comprehensive database of gene and protein interactions.

FBgn0025725

DRSC - Results frm RNAi screens

FBgn0025725

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

alphaCOP_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0025725

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0025725

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7961

Flygut - An atlas of the Drosophila adult midgut

FBgn0025725

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0025725

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC016033

MIST (protein-protein) - An integrated Molecular Interaction Database

38199

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O77285

References (87)

The following external sites may use different assemblies or annotations than FlyBase.

-0.38

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