FlyBase Gene Report: Dmel\Ctdnep1

General Information

Symbol

Dmel\Ctdnep1

Species

D. melanogaster

Name

CTD nuclear envelope phosphatase 1

Annotation Symbol

CG1696

Feature Type

protein_coding_gene

FlyBase ID

FBgn0029067

Gene Model Status

Current

Stock Availability

9 publicly available

Enzyme Name (EC)

protein-serine/threonine phosphatase (3.1.3.16)

Gene Summary

CTD nuclear envelope phosphatase 1 (Ctdnep1) encodes a putative protein phosphatase of the Haloacid Dehalogenase family. It has a negative effect on BMP signaling-dependent wing vein formation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dd, l(1)G0269, Dullard, ddd

Key Links

Genomic Location

Cytogenetic map

19F4-19F4

Sequence location

X:21,319,791..21,324,009 [-]

Recombination map

1-65

RefSeq locus

NC_004354 REGION:21319791..21324009

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables phosphatase activator activity

inferred from genetic interaction with FLYBASE:Lpin; FB:FBgn0263593

(Jacquemyn et al., 2021)

enables protein serine/threonine phosphatase activity

inferred from mutant phenotype

(Urrutia et al., 2016)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables phosphatase activity

inferred from electronic annotation with InterPro:IPR011948

(InterPro Project Members, 2004-)

enables phosphoprotein phosphatase activity

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

enables protein serine/threonine phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN002639497

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with UniProtKB:O95476

(Jacquemyn et al., 2021, Gene Ontology Curators, 2002-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Liu et al., 2011)

involved_in negative regulation of BMP signaling pathway

inferred from mutant phenotype

(Liu et al., 2011)

inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716

(Urrutia et al., 2016)

acts_upstream_of nuclear membrane biogenesis

inferred from expression pattern

(Jacquemyn et al., 2021)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in nuclear envelope organization

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

involved_in positive regulation of triglyceride biosynthetic process

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from direct assay

(Jacquemyn et al., 2021)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

located_in endoplasmic reticulum membrane

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

part_of Nem1-Spo7 phosphatase complex

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

located_in nuclear envelope

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

located_in nuclear membrane

inferred from sequence or structural similarity with UniProtKB:O95476

(Gene Ontology Curators, 2002-)

part_of protein serine/threonine phosphatase complex

traceable author statement

(Jacquemyn et al., 2021)

Gene Group (FlyBase)

CTD FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES

Pathway (FlyBase)

NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY

Protein Family (UniProt)

Belongs to the dullard family. (Q9VRG7)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein serine/threonine phosphatase activity

(1) O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate (3.1.3.16)

(2) O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate (3.1.3.16)

phosphoprotein phosphatase activity

Summaries

Gene Snapshot

Pathway (FlyBase)

NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -: Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.

Gene Group (FlyBase)

CTD FAMILY PROTEIN SERINE/THREONINE PHOSPHATASES -: Prototypical RNA polymerase C-terminal domain (CTD) family phosphatases dephosphorylate specific serine residues in the carboxyl-terminal tail of the RNA polymerase catalytic subunit, a feature essential for the reinitiation of transcription by the RNA polymerase. However, other members of this family have diversified to have other substrates, such as nuclear pore complex proteins. (Adapted from FBrf0228712.)

Protein Function (UniProtKB)

Serine/threonine protein phosphatase that may dephosphorylate and activate lipin-like phosphatases. Lipins are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol (By similarity).

(UniProt, Q9VRG7)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ctdnep1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VRG7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 6.61

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ctdnep1-RA

FBtr0077226

NM_134605

3043

243

Ctdnep1-RB

FBtr0339623

NM_001298586

3034

240

Ctdnep1-RC

FBtr0339624

NM_001298587

2860

182

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ctdnep1-PA

FBpp0076921

28.5

243

9.92

FBpp0308686

28.1

240

9.92

FBpp0308687

21.4

182

10.56

X2JEK6

NP_001285516

AHN59986

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ctdnep1 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.05

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from direct assay

(Jacquemyn et al., 2021)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ctdnep1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ctdnep1

View exonic expression by tissue for Dmel\Ctdnep1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029067

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33107/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029067

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029067

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029067

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1696

Flygut - An atlas of the Drosophila adult midgut

FBgn0029067

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ctdnep1

Transgenic constructs containing regulatory region of Ctdnep1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 24 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | pharate adult stage

Ctdnep1^G0269

lethal | pupal stage

Ctdnep1^G0269

partially lethal - majority die | embryonic stage

Ctdnep1^G0269

partially lethal - majority die | embryonic stage | recessive

Ctdnep1^ex28

partially lethal - majority die | larval stage

Ctdnep1^G0269

partially lethal - majority die | pupal stage

Ctdnep1^G0269

partially lethal - majority die | pupal stage | recessive

Ctdnep1^ex28

partially lethal - majority die | recessive

Ctdnep1^G0269

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ctdnep1^GD4859

viable, with Scer\GAL4^Mef2.PR

Ctdnep1^GD4859

viable, with Scer\GAL4^pnr-MD237

Ctdnep1^GD4859

viable, with Scer\GAL4^tin.CΔ4

Ctdnep1^GD4859

Sterility

Allele

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

Phenotype manifest in

Allele

anterior crossvein

Ctdnep1^G0269

anterior crossvein, with Scer\GAL4^dpp.blk1

anterior crossvein, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

anterior crossvein | ectopic

Ctdnep1^G0269

anterior crossvein | heat sensitive, with Scer\GAL4^71B

Ctdnep1^UAS.cLa

endoplasmic reticulum, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

larval fat cell, with Scer\GAL4^r4

Ctdnep1^{UAS.mEGFP(L221K)}

lipid droplet, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

lipid droplet | increased number | larval stage, with Scer\GAL4^r4

Ctdnep1^{UAS.mEGFP(L221K)}

nuclear envelope | larval stage, with Scer\GAL4^r4

Ctdnep1^{UAS.mEGFP(L221K)}

nuclear membrane | larval stage, with Scer\GAL4^r4

Ctdnep1^{UAS.mEGFP(L221K)}

nuclear pore | larval stage, with Scer\GAL4^r4

Ctdnep1^{UAS.mEGFP(L221K)}

posterior crossvein

Ctdnep1^G0269

posterior crossvein, with Scer\GAL4^71B

Ctdnep1^UAS.Tag:HA

posterior crossvein, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

posterior crossvein | ectopic

Ctdnep1^G0269

posterior crossvein | heat sensitive, with Scer\GAL4^71B

Ctdnep1^UAS.cLa

wing

Ctdnep1^G0269

wing vein | ectopic, with Scer\GAL4^71B

Ctdnep1^GD4859

wing vein L2

Ctdnep1^G0269

wing vein L3

Ctdnep1^G0269

wing vein L4, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

wing vein L5, with Scer\GAL4^en-e16E

Ctdnep1^UAS.cLa

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\CTDNEP1

13 of 14

Yes

Hsap\CTDSP1

3 of 14

Hsap\CTDSP2

3 of 14

Hsap\CTDSPL2

3 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (7)

Rnor\Ctdnep1

14 of 14

Yes

Rnor\Ctdsp1

3 of 14

Rnor\Ctdspl2

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

Mus musculus (laboratory mouse) (8)

Mmus\Ctdnep1

14 of 14

Yes

Mmus\Ctdsp2

3 of 14

Mmus\Ctdspl2

3 of 14

Yes

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\ctdnep1

11 of 13

Yes

Xtro\ctdsp2

2 of 13

Xtro\ctdspl2

2 of 13

Yes

Xtro\ctdspl

2 of 13

Xtro\XB5962940

2 of 13

Yes

Xtro\ctdsp1

1 of 13

Xtro\LOC100488559

1 of 13

Danio rerio (Zebrafish) (11)

Drer\ctdnep1a

14 of 14

Yes

Drer\ctdnep1b

14 of 14

Yes

Drer\ctdsp1

3 of 14

Drer\ctdsp2

3 of 14

Drer\ctdspl2a

3 of 14

Yes

Drer\ctdspl3

3 of 14

Yes

Drer\ctdspla

3 of 14

Drer\ctdspl2b

2 of 14

Yes

Drer\ctdsplb

2 of 14

Drer\timm50

2 of 14

Drer\ublcp1

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\cnep-1

13 of 14

Yes

Cele\scpl-3

3 of 14

Yes

Cele\scpl-1

2 of 14

Cele\scpl-4

2 of 14

Cele\fcp-1

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\AgaP_AGAP006231

12 of 12

Yes

Agam\AgaP_AGAP011422

3 of 12

Agam\AgaP_AGAP001108

2 of 12

Agam\AgaP_AGAP004967

2 of 12

Yes

Agam\AgaP_AGAP005119

1 of 12

Agam\AgaP_AGAP005270

1 of 12

Arabidopsis thaliana (thale-cress) (23)

Atha\AT5G45700

5 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\NEM1

9 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\nem1

8 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ctdnep1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

CG8584

9 of 13

CG12078

8 of 13

hzg

6 of 13

4 of 13

4 of 13

4 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CTDNEP1; CTD nuclear envelope phosphatase 1

13 of 14

610684

CTDSP1; CTD small phosphatase 1

3 of 14

605323

CTDSP2; CTD small phosphatase 2

3 of 14

608711

CTDSPL2; CTD small phosphatase like 2

3 of 14

618739

CTDSPL; CTD small phosphatase like

3 of 14

608592

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ctdnep1 - Mad

anti tag coimmunoprecipitation, western blot

(Urrutia et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

suppressible

(Jacquemyn et al., 2021)

suppressible

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

suppressible

(Liu et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Torsin

suppressible

Ctdnep1

(Jacquemyn et al., 2021)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59385

DroID - A comprehensive database of gene and protein interactions.

FBgn0029067

MIST (genetic) - An integrated Molecular Interaction Database

33107

MIST (protein-protein) - An integrated Molecular Interaction Database

33107

Pathways

Signaling Pathways (FlyBase)

NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Depolymerization of the Nuclear Lamina

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-65

Cytogenetic map

19F4-19F4

Sequence location

X:21,319,791..21,324,009 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

19F4-19F4

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

19E-19E

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.12.14)

Experimentally Determined Recombination Data

Location

1-65

(FlyBase, 2016)

1-65.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

12290

w^67c23 P{lacW}Ctdnep1^G0269/FM7c

93339

w^* TI{CRIMIC.TG4.0}Ctdnep1^{CR60077-TG4.0}

604591

w^*; P{UASp-Ctdnep1.N-m9Venus}attP2/TM3, Sb¹

41840

y¹ v¹; P{TRiP.GL01268}attP2/TM3, Sb¹

13531

y¹ w^67c23 P{Mae-UAS.6.11}Ctdnep1^GG01124

11442

v104785

v12941

w¹¹¹⁸; P{GD4859}v12941

v342347

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02148}attP40/CyO-GFP

Genomic Clones (6)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (65)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD04380

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0029067

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0029067

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days.

(Claridge-Chang et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: l(1)G0269 CG1696

(Peter et al., 2002)

Source for merge of: CG1696 BcDNA:LD08201

(FlyBase, 1996-)

Source for merge of: l(1)G0269 anon-WO03040301.167

(FlyBase, 1996-)

Additional comments

The CG8584 gene may have been derived from the l(1)G0269 gene by retroposition.

(Dai et al., 2006)

Source for merge of CG1696 BcDNA:LD08201 was a shared cDNA ( date:020730 ).

(FlyBase, 1996-)

Source for merge of l(1)G0269 anon-WO03040301.167 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Dd l(1)G0269

(Liu et al., 2011)

Source for identity of: Ctdnep1 Dd

(FlyBoard ad hoc nomenclature committee, 2024.7.14)

Nomenclature comments

The original gene name "Dullard" (Dd) was changed to "CTD nuclear envelope phosphatase 1" (Ctdnep1) to reflect its homology to the human gene and eliminate its potentially offensive association with human conditions.

(FlyBoard ad hoc nomenclature committee, 2024.7.14)

Etymology

Named 'Dullard' after its vertebrate ortholog.

(Liu et al., 2011)

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

20151539

(Burroughs et al., 2006)

BcDNA:LD08201

CG1696

(Liu et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Dai et al., 2006, Claridge-Chang et al., 2001)

Ctdnep1

(FlyBoard ad hoc nomenclature committee, 2024.7.14, Jacquemyn et al., 2021)

(Arora and Ligoxygakis, 2020)

(Jacquemyn et al., 2021, Ostalé et al., 2021, Gene Disruption Project members, 2018-, Sopko et al., 2014)

anon-WO03040301.167

ddd

(Urrutia et al., 2016, Liu et al., 2011)

l(1)G0269

(Liu et al., 2011, Shigenobu et al., 2006)

Name Synonyms

CTD nuclear envelope phosphatase 1

(FlyBoard ad hoc nomenclature committee, 2024.7.14)

Dullard

(Akiyama et al., 2024, Urrutia et al., 2016)

d-dullard

(Liu et al., 2011)

lethal (1) G0269

Secondary FlyBase IDs

FBgn0031173
FBgn0063165
FBgn0066839

Datasets (0)

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External Crossreferences and Linkouts ( 49 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33107

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VRG7

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VRG7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VRG7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0029067

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33107/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0029067

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0029067

FlyMine - An integrated database for Drosophila genomics

FBgn0029067

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1696

MARRVEL_MODEL - MARRVEL (model organism gene)

33107

Linkouts

BioGRID - A database of protein and genetic interactions.

59385

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0029067

DroID - A comprehensive database of gene and protein interactions.

FBgn0029067

DRSC - Results frm RNAi screens

FBgn0029067

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0029067

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0029067

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1696

Flygut - An atlas of the Drosophila adult midgut

FBgn0029067

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0029067

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC011922

MIST (genetic) - An integrated Molecular Interaction Database

33107

MIST (protein-protein) - An integrated Molecular Interaction Database

33107

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Depolymerization of the Nuclear Lamina

References (44)

The following external sites may use different assemblies or annotations than FlyBase.

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