FlyBase Gene Report: Dmel\Ir21a

General Information

Symbol

Dmel\Ir21a

Species

D. melanogaster

Name

Ionotropic receptor 21a

Annotation Symbol

CG2657

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031209

Gene Model Status

Current

Stock Availability

13 publicly available

Gene Summary

Integral part of a neural sensory system in the antenna that provides the neural basis for the response to environmental changes in temperature (thermosensation) (PubMed:27126188, PubMed:27656904). Together with Ir25a and Ir93a, mediates the response of the dorsal organ cool cells, a trio of cool-responsive neurons, to cooling and is required for cool avoidance behavior (PubMed:27126188, PubMed:27656904). (UniProt, Q9VPI2)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

21A4-21B1

Sequence location

2L:21,823..25,155 [-]

Recombination map

2-0.5

RefSeq locus

NT_033779 REGION:21823..25155

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables glutamate receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

enables ligand-gated monoatomic ion channel activity

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in detection of chemical stimulus involved in sensory perception

inferred from expression pattern

(Benton et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in modulation of chemical synaptic transmission

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

involved_in synaptic transmission, glutamatergic

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR001320

(InterPro Project Members, 2004-)

inferred from sequence model

(Benton et al., 2009)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000437926

(GO Reference Genome Project, 2011-)

is_active_in postsynaptic density membrane

inferred from biological aspect of ancestor with PANTHER:PTN001826301

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ANTENNAL IONOTROPIC RECEPTORS

Protein Family (UniProt)

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (Q9VPI2)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

ANTENNAL IONOTROPIC RECEPTORS -: Ionotropic Receptors (IR) expressed in antennal sensory neurons in Drosophila are largely thought to act as odor-responsive ion channels. IRs are a subfamily of ionotropic glutamate receptors that do not bind glutamate. Some only form functional receptors in the presence of coreceptor IRs. The profile of expression of IRs, together with broadly expressed co-receptors underlies the precise odor-responsiveness of subpopulations of antennal neurons. (Adapted from FBrf0222310).

Protein Function (UniProtKB)

(UniProt, Q9VPI2)

Summary (Interactive Fly)

mediator of heat seeking in the malaria vector Anopheles gambiae - Ir21a mediates heat avoidance in Drosophila - antenna

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ir21a for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPI2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.41

Gene model reviewed during 5.44

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ir21a-RB

FBtr0113008

NM_001103573

2629

842

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ir21a-PB

FBpp0111921

95.6

842

7.93

Q9VPI2

NP_001097043

AAF51569

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VPI2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ir21a using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir21a_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

sacculus | restricted

Comment: neurons surrounding the third chamber of the sacculus

(Benton et al., 2009)

adult sense organ

(Benton et al., 2009)

neuron of coeloconic sensillum of antennal segment 3

(Benton et al., 2009)

neuron of aristal sensillum

(Benton et al., 2009)

Additional Descriptive Data

Ir21a transcript is expressed in the neurons of the sensillum coeloconicum of antennal segment 3 located near the third chamber of the sacculus and in the neurons of the arista.

(Benton et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

aristal sensory neuron VP3

(Budelli et al., 2019)

aristal sensory neuron VP2

(Budelli et al., 2019)

Additional Descriptive Data

Ir21a protein is detected in cold cell sensory endings.

(Budelli et al., 2019)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{Ir21a-Gal4.K}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

dorsal organ cool cell

(Knecht et al., 2016, Ni et al., 2016)

larval brain | restricted

(Ni et al., 2016)

larval ventral nerve cord | restricted

(Ni et al., 2016)

sensory neuron | subset

(Ni et al., 2016)

third instar larval stage

gustatory receptor neuron of the dorsal organ

(Sánchez-Alcañiz et al., 2018)

adult stage

adult antennal olfactory receptor neuron | subset

(Sánchez-Alcañiz et al., 2018)

Reporter: P{Ir40a-GAL4.3011}

Stage

Tissue/Position (including subcellular localization)

Reference

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ir21a in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ir21a

View exonic expression by tissue for Dmel\Ir21a

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33157/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031209

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031209

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031209

Flygut - An atlas of the Drosophila adult midgut

FBgn0031209

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ir21a

Transgenic constructs containing regulatory region of Ir21a

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene partially disrupted in

Df(2L)Ir21a^Δ1

(Ni et al., 2016)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Ir21a^GD773

viable

Ir21a^c02720

viable, with Dcr-2^UAS.cDa, Scer\GAL4^e22c, Scer\GAL4^sqh.PW

Ir21a^GD773

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ir21a^GD773

viable, with Scer\GAL4^Mef2.PR

Ir21a^GD773

Sterility

Allele

fertile

Ir21a^c02720

Other Phenotypes

Allele

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ir21a^GD773

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (18)

Hsap\GRIA1

3 of 14

Yes

Hsap\GRIA2

3 of 14

Yes

Hsap\GRIA3

3 of 14

Yes

Hsap\GRIA4

3 of 14

Yes

Hsap\GRIK4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Gria3

3 of 14

Yes

Rnor\Gria4

3 of 14

Yes

Rnor\Grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (17)

Mmus\Gria1

3 of 14

Yes

Mmus\Gria2

3 of 14

Yes

Mmus\Gria3

3 of 14

Yes

Mmus\Gria4

3 of 14

Yes

Mmus\Grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (13)

Xtro\dedd2

2 of 13

Yes

Xtro\grik4

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (32)

Drer\gria1a

3 of 14

Yes

Drer\gria1b

3 of 14

Yes

Drer\gria2a

3 of 14

Yes

Drer\gria2b

3 of 14

Yes

Drer\gria3a

3 of 14

Yes

Drer\gria3b

3 of 14

Yes

Drer\gria4b

3 of 14

Yes

Drer\grik4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch211-251b21.1

2 of 14

Drer\si:dkey-183j2.10

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\glr-1

3 of 14

Yes

Cele\glr-3

3 of 14

Yes

Cele\glr-5

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\T25E4.2

1 of 14

Cele\W02A2.5

1 of 14

Cele\ZK867.2

1 of 14

Anopheles gambiae (African malaria mosquito) (47)

Agam\AgaP_AGAP008511

11 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (20)

Atha\ATGLR1.2

3 of 13

Yes

Atha\GLR1.4

3 of 13

Yes

Atha\GLR2.1

3 of 13

Yes

Atha\GLR2.2

3 of 13

Yes

Atha\GLR2.5

3 of 13

Yes

Atha\GLR2.6

3 of 13

Yes

Atha\GLR2.7

3 of 13

Yes

Atha\GLR2.8

3 of 13

Yes

Atha\GLR2.9

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ir21a. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (51)

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

model of autosomal dominant intellectual developmental disorder 67

IEA

(FlyBase, 2019-)

model of autosomal recessive intellectual developmental disorder 76

IEA

(FlyBase, 2019-)

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

model of syndromic X-linked intellectual disability 94

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GRIA1; glutamate ionotropic receptor AMPA type subunit 1

3 of 14

138248

GRIA2; glutamate ionotropic receptor AMPA type subunit 2

3 of 14

138247

NEURODEVELOPMENTAL DISORDER WITH LANGUAGE IMPAIRMENT AND BEHAVIORAL ABNORMALITIES; NEDLIB

GRIA3; glutamate ionotropic receptor AMPA type subunit 3

3 of 14

305915

INTELLECTUAL DEVELOPMENTAL DISORDER, X-LINKED, SYNDROMIC, WU TYPE; MRXSW

syndromic X-linked intellectual disability 94

GRIA4; glutamate ionotropic receptor AMPA type subunit 4

3 of 14

138246

NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT SEIZURES AND GAIT ABNORMALITIES; NEDSGA

GRIK4; glutamate ionotropic receptor kainate type subunit 4

3 of 14

600282

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Dgat2

suppressible

Ir21a

(Deng et al., 2025)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0031209

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-0.5

Cytogenetic map

21A4-21B1

Sequence location

2L:21,823..25,155 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21A4-21B1

; Limits computationally determined from genome sequence between P{lacW}spen^k06805&P{lacW}l(2)k13604^k13604 and P{lacW}U2af38^k14504

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-0.5

(FlyBase, 2016)

2-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

98109

w^*; Ir21a^Δ1

17177

w¹¹¹⁸; P{EP}Ir21a^EP526

10975

w¹¹¹⁸; PBac{PB}Ir21a^c02720

64578

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05597}attP40

NIG-Fly

2657R-1

P{NIG.2657R}1

2657R-2

P{NIG.2657R}2

M2L-2590

y¹ w¹¹¹⁸; Ir21a^SK1 P{neoFRT}40A/CyO-Tb

M2L-2591

y¹ w¹¹¹⁸; Ir21a^SK6 P{neoFRT}40A/CyO-Tb

VDRC

v2471

w¹¹¹⁸ P{GD773}v2471

v2472

w¹¹¹⁸; P{GD773}v2472

v341930

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01201}attP40/CyO-GFP

v342097

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01559}attP40/CyO-GFP

More stocks available...

Genomic Clones (5)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031209

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031209

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ir21a CG2657

(Benton et al., 2009)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

21a

(Ni, 2020)

CG2657

(National Institute of Genetics Fly Stocks, 2022-, Japanese National Institute of Genetics, 2012.5.21, Tsubouchi et al., 2012, Croset et al., 2010, Benton et al., 2009, Lee et al., 2009, Perkins et al., 2009, Yamamoto et al., 2009.2.25, Firth and Baker, 2007, Grzeschik et al., 2007)

CT8983

(Littleton and Ganetzky, 2000)

DmelIR21a

(Croset et al., 2010)

IR21a

(Liu and Zhang, 2022, George and Stanewsky, 2021, Montell, 2021, Xiao and Xu, 2021, Ni, 2020, He et al., 2019, Rimal and Lee, 2018, Ahn et al., 2017, Menuz et al., 2014, Silbering et al., 2011, Croset et al., 2010, Benton et al., 2009)

Ir21a

(Budelli et al., 2025, Pandey et al., 2024, Sang and Lee, 2024, Sang et al., 2024, Suito and Tominaga, 2024, Corthals et al., 2023, Ali et al., 2022, McLaughlin et al., 2021, Hope et al., 2020, Li et al., 2020, Marin et al., 2020, Miller et al., 2020, Budelli et al., 2019, Ganguly et al., 2017, Enjin et al., 2016, Knecht et al., 2016, Ni et al., 2016, Kwon et al., 2013, Tsubouchi et al., 2012)

ir21a

(Riveron et al., 2013)

Name Synonyms

CG2657

Ionotropic receptor 21a

(Tsubouchi et al., 2012)

ionotropic receptor 21a

(Benton et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33157

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

CZ468165

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF51569

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPI2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VPI2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPI2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33157/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031209

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031209

FlyMine - An integrated database for Drosophila genomics

FBgn0031209

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2657

MARRVEL_MODEL - MARRVEL (model organism gene)

33157

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031209

DroID - A comprehensive database of gene and protein interactions.

FBgn0031209

DRSC - Results frm RNAi screens

FBgn0031209

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ir21a_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031209

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031209

Flygut - An atlas of the Drosophila adult midgut

FBgn0031209

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0031209

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031556

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

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