FlyBase Gene Report: Dmel\frac

General Information

Symbol

Dmel\frac

Species

D. melanogaster

Name

faulty attraction

Annotation Symbol

CG7526

Feature Type

protein_coding_gene

FlyBase ID

FBgn0035798

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

faulty attraction (frac) encodes an extracellular matrix protein that acts via an LIMK1- dependent BMP pathway to promote axon target recognition. The product of frac might be a proteolytic substrate of the matrix metalloproteinase encoded by Mmp2. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

CT16044

Key Links

Genomic Location

Cytogenetic map

66A5-66A5

Sequence location

3L:7,562,610..7,569,499 [+]

Recombination map

3-21

RefSeq locus

NT_037436 REGION:7562610..7569499

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in axon target recognition

inferred from mutant phenotype

(Miller et al., 2011)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN001170088

(GO Reference Genome Project, 2011-)

located_in extracellular matrix

inferred from sequence or structural similarity with UniProtKB:P35555

(Miller et al., 2011)

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN001170088

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\frac for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VS89)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

frac-RC

FBtr0290277

NM_001144433

5069

1618

frac-RD

FBtr0301221

NM_206292

5122

1618

frac-RE

FBtr0301222

NM_139880

5438

1618

frac-RF

FBtr0331839

NM_001274602

4549

1427

frac-RG

FBtr0331840

NM_001274603

4496

1427

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

frac-PC

FBpp0288716

177.1

1618

4.34

FBpp0290439

177.1

1618

4.34

FBpp0290440

177.1

1618

4.34

FBpp0304223

156.7

1427

4.45

FBpp0304224

156.7

1427

4.45

M9PHP7

NP_001261532

AGB94227

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1618 aa isoforms: frac-PC, frac-PD, frac-PE

1427 aa isoforms: frac-PF, frac-PG

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\frac using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

frac_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.40

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 14

somatic trunk mesoderm

(Miller et al., 2011)

embryonic stage 13 -- 16

dorsal head epidermis

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

larval visceral muscle cell

(Fisher et al., 2012)

embryonic stage 15

larval muscle system

(Miller et al., 2011)

Additional Descriptive Data

frac transcripts are expressed strongly at embryonic stage 13 in ventral mesoderm adjacent to the CNS and at lower levels in more dorsal mesoderm. By stage 15, it is present in all embryonic musculature.

(Miller et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 14

somatic trunk mesoderm

(Miller et al., 2011)

embryonic stage 15 -- 17

larval muscle system

(Miller et al., 2011)

embryonic stage 17

muscle attachment site

(Miller et al., 2011)

Additional Descriptive Data

frac protein is observed in ventral mesoderm adjacent to the CNS at embryonic stage 14. By stage 15, it is expressed throughout the embryonic musculature. It continues to be expressed in the musculature until late stage 17, when the protein concentrates at muscle attachment sites.

(Miller et al., 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\frac in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\frac

View exonic expression by tissue for Dmel\frac

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035798

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38850/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035798

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035798

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035798

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7526

Flygut - An atlas of the Drosophila adult midgut

FBgn0035798

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\frac

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of frac

Transgenic constructs containing regulatory region of frac

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Sterility

Allele

fertile

Other Phenotypes

Allele

abnormal neuroanatomy | embryonic stage

abnormal neuroanatomy | embryonic stage, with Scer\GAL4^how-24B

frac^UAS.cMa

abnormal neuroanatomy | embryonic stage (with Df(3L)pbl-X1)

Phenotype manifest in

Allele

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage, with Scer\GAL4^how-24B

frac^UAS.cMa

larval intersegmental nerve branch ISNb of A1-7 | embryonic stage (with Df(3L)pbl-X1)

larval segmental nerve branch SNa of A1-7 | embryonic stage

larval segmental nerve branch SNa of A1-7 | embryonic stage (with Df(3L)pbl-X1)

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (81)

Hsap\FBN1

5 of 14

Yes

Hsap\FBN3

5 of 14

Yes

Hsap\FBN2

4 of 14

Yes

Hsap\FBLN7

3 of 14

Yes

Hsap\LTBP1

3 of 14

Hsap\LTBP2

3 of 14

Hsap\LTBP3

3 of 14

Yes

Hsap\LTBP4

3 of 14

Hsap\CCBE1

2 of 14

Yes

Hsap\CD93

2 of 14

Yes

Hsap\CRELD1

2 of 14

Hsap\EFEMP1

2 of 14

Yes

Hsap\EFEMP2

2 of 14

Hsap\EGFL8

2 of 14

Hsap\FBLN5

2 of 14

Yes

Hsap\HMCN1

2 of 14

Hsap\LRP8

2 of 14

Hsap\MATN2

2 of 14

Yes

Hsap\MATN4

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Hsap\CLEC14A

1 of 14

Yes

Hsap\COL4A2

1 of 14

Hsap\COL6A3

1 of 14

Hsap\COL6A5

1 of 14

Yes

Hsap\COL14A1

1 of 14

Yes

Hsap\COL17A1

1 of 14

Yes

Hsap\COL20A1

1 of 14

Yes

Hsap\COL21A1

1 of 14

Yes

Hsap\COL22A1

1 of 14

Yes

Hsap\COL24A1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\GP2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\MEGF11

1 of 14

Hsap\NELL1

1 of 14

Yes

Hsap\NELL2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\PROS1

1 of 14

Yes

Hsap\SCARA5

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\VIT

1 of 14

Yes

Hsap\VWA2

1 of 14

Yes

Hsap\VWCE

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (58)

Rnor\Fbn1

7 of 14

Yes

Rnor\Fbn2

6 of 14

Yes

Rnor\Ltbp1

4 of 14

Yes

Rnor\Ltbp2

4 of 14

Yes

Rnor\Ltbp3

4 of 14

Yes

Rnor\Ltbp4

4 of 14

Yes

Rnor\Efemp1

3 of 14

Yes

Rnor\Efemp2

3 of 14

Yes

Rnor\Egfem1

3 of 14

Yes

Rnor\Fbln7

3 of 14

Yes

Rnor\Cd93

2 of 14

Yes

Rnor\Creld1

2 of 14

Rnor\Fbln1

2 of 14

Rnor\Fbln5

2 of 14

Yes

Rnor\Gas6

2 of 14

Yes

Rnor\Hmcn1

2 of 14

Rnor\Matn2

2 of 14

Yes

Rnor\Matn4

2 of 14

Yes

Rnor\Megf6

2 of 14

Rnor\Scube1

2 of 14

Yes

Rnor\Scube2

2 of 14

Yes

Rnor\Scube3

2 of 14

Yes

Rnor\Cd248

1 of 14

Yes

Rnor\Clec14a

1 of 14

Yes

Rnor\Col5a3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Megf11

1 of 14

Rnor\Nell1

1 of 14

Rnor\Nell2

1 of 14

Yes

Rnor\Notch2

1 of 14

Rnor\Notch3

1 of 14

Rnor\Oit3

1 of 14

Yes

Rnor\Pros1

1 of 14

Yes

Rnor\Prx

1 of 14

Yes

Rnor\Scara5

1 of 14

Yes

Rnor\Shbg

1 of 14

Yes

Rnor\Srpx2

1 of 14

Yes

Rnor\Srpx

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Umod

1 of 14

Yes

Rnor\Vldlr

1 of 14

Rnor\Vwce

1 of 14

Yes

Mus musculus (laboratory mouse) (62)

Mmus\Fbn2

6 of 14

Yes

Mmus\Fbn1

5 of 14

Yes

Mmus\Ltbp1

4 of 14

Yes

Mmus\Ltbp2

4 of 14

Yes

Mmus\Ltbp3

4 of 14

Yes

Mmus\Ltbp4

4 of 14

Yes

Mmus\Efemp1

3 of 14

Yes

Mmus\Fbln7

3 of 14

Yes

Mmus\Ccbe1

2 of 14

Yes

Mmus\Cd93

2 of 14

Yes

Mmus\Creld1

2 of 14

Mmus\Efemp2

2 of 14

Yes

Mmus\Egfem1

2 of 14

Yes

Mmus\Fbln1

2 of 14

Mmus\Fbln5

2 of 14

Yes

Mmus\Gas6

2 of 14

Yes

Mmus\Hmcn1

2 of 14

Mmus\Matn2

2 of 14

Yes

Mmus\Matn4

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Mmus\Clec14a

1 of 14

Yes

Mmus\Col24a1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Megf11

1 of 14

Mmus\Msr1

1 of 14

Yes

Mmus\Nell1

1 of 14

Yes

Mmus\Nell2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Proz

1 of 14

Mmus\Prx

1 of 14

Yes

Mmus\Scara5

1 of 14

Yes

Mmus\Scube1

1 of 14

Yes

Mmus\Scube2

1 of 14

Yes

Mmus\Scube3

1 of 14

Yes

Mmus\Shbg

1 of 14

Yes

Mmus\Slit1

1 of 14

Mmus\Srpx2

1 of 14

Yes

Mmus\Srpx

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Vldlr

1 of 14

Mmus\Vwce

1 of 14

Xenopus tropicalis (Western clawed frog) (61)

Xtro\fbn1

4 of 13

Yes

Xtro\fbn2

4 of 13

Yes

Xtro\fbn3

4 of 13

Yes

Xtro\ltbp4

4 of 13

Yes

Xtro\ltbp1

3 of 13

Yes

Xtro\b3gat2

2 of 13

Xtro\ccbe1

2 of 13

Yes

Xtro\cd93

2 of 13

Yes

Xtro\creld1

2 of 13

Xtro\efemp1

2 of 13

Yes

Xtro\fbln7

2 of 13

Yes

Xtro\hmcn2

2 of 13

Yes

Xtro\LOC100497748

2 of 13

Yes

Xtro\ltbp3

2 of 13

Yes

Xtro\nell2

2 of 13

Yes

Xtro\thbd

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC108647649

1 of 13

Yes

Xtro\LOC116407732

1 of 13

Yes

Xtro\LOC116408843

1 of 13

Yes

Xtro\lrp1

1 of 13

Xtro\lrp2

1 of 13

Xtro\matn1

1 of 13

Yes

Xtro\megf6

1 of 13

Yes

Xtro\mylk4

1 of 13

Xtro\nell1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\panx1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\umod.1

1 of 13

Xtro\vldlr

1 of 13

Xtro\vwce

1 of 13

Yes

Xtro\XB5809687

1 of 13

Danio rerio (Zebrafish) (73)

Drer\fbn2b

4 of 14

Yes

Drer\fbln7

3 of 14

Yes

Drer\fbn2a

3 of 14

Drer\LOC100333499

3 of 14

Yes

Drer\ltbp1

3 of 14

Yes

Drer\matn4

3 of 14

Yes

Drer\megf6b

3 of 14

Drer\si:dkey-234i14.3

3 of 14

Yes

Drer\ccbe1

2 of 14

Yes

Drer\creld1

2 of 14

Drer\efemp2a

2 of 14

Yes

Drer\efemp2b

2 of 14

Yes

Drer\fbln1

2 of 14

Drer\fbln5

2 of 14

Yes

Drer\hmcn1

2 of 14

Drer\hmcn2

2 of 14

Drer\ltbp3

2 of 14

Yes

Drer\megf6a

2 of 14

Drer\megf6

2 of 14

Yes

Drer\si:ch73-173h19.3

2 of 14

Yes

Drer\adgrf6

1 of 14

Yes

Drer\bmp1a

1 of 14

Drer\bmp1b

1 of 14

Drer\cd248a

1 of 14

Yes

Drer\cd248b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\eys

1 of 14

Drer\fbln2

1 of 14

Drer\fbn1

1 of 14

Yes

Drer\gas6

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC110439193

1 of 14

Yes

Drer\LOC110439194

1 of 14

Yes

Drer\lrp5

1 of 14

Drer\marco

1 of 14

Yes

Drer\matn1

1 of 14

Drer\matn3a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\pros1

1 of 14

Yes

Drer\scara5

1 of 14

Yes

Drer\scube1

1 of 14

Yes

Drer\scube2

1 of 14

Yes

Drer\scube3

1 of 14

Yes

Drer\shbg

1 of 14

Yes

Drer\si:ch73-105b23.6

1 of 14

Drer\si:ch211-226h7.3

1 of 14

Yes

Drer\si:dkey-163f14.6

1 of 14

Drer\si:dkey-239b22.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\mup-4

5 of 14

Yes

Cele\mua-3

4 of 14

Yes

Cele\fbl-1

2 of 14

Cele\Y64G10A.7

2 of 14

Yes

Cele\B0393.5

1 of 14

Cele\bli-1

1 of 14

Yes

Cele\col-108

1 of 14

Yes

Cele\crld-1

1 of 14

Cele\cubn-1

1 of 14

Cele\dpy-13

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\slt-1

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP005714

8 of 12

Yes

Agam\AgaP_AGAP005713

4 of 12

Yes

Agam\AgaP_AGAP010021

3 of 12

Yes

3 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\PELPK2

1 of 13

Yes

Atha\WAK1

1 of 13

Yes

Atha\WAK3

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:frac. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

CG32373

5 of 13

CG31999

4 of 13

dpy

3 of 13

Creld

2 of 13

arr

1 of 13

crb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mgl

1 of 13

NimC1

1 of 13

NimC2

1 of 13

pwn

1 of 13

Ten-a

1 of 13

tld

1 of 13

uif

1 of 13

vkg

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 10 )

Human Ortholog

Disease

Evidence

References

FBN1; fibrillin 1

model of acromicric dysplasia

IEA

(FlyBase, 2019-)

model of Marfan syndrome

IEA

(FlyBase, 2019-)

model of Weill-Marchesani syndrome

IEA

(FlyBase, 2019-)

model of stiff skin syndrome

IEA

(FlyBase, 2019-)

model of autosomal dominant isolated ectopia lentis 1

IEA

(FlyBase, 2019-)

model of geleophysic dysplasia 2

IEA

(FlyBase, 2019-)

FBN2; fibrillin 2

model of congenital contractural arachnodactyly

IEA

(FlyBase, 2019-)

LTBP3; latent transforming growth factor beta binding protein 3

model of brachyolmia-amelogenesis imperfecta syndrome

IEA

(FlyBase, 2019-)

model of geleophysic dysplasia 3

IEA

(FlyBase, 2019-)

LTBP2; latent transforming growth factor beta binding protein 2

model of Weill-Marchesani syndrome

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

5 of 14

5 of 14

4 of 14

congenital contractural arachnodactyly

FBLN7; fibulin 7

3 of 14

611551

LTBP1; latent transforming growth factor beta binding protein 1

3 of 14

150390

CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IIE; ARCL2E

LTBP2; latent transforming growth factor beta binding protein 2

3 of 14

602091

LTBP3; latent transforming growth factor beta binding protein 3

3 of 14

602090

LTBP4; latent transforming growth factor beta binding protein 4

3 of 14

604710

CUTIS LAXA, AUTOSOMAL RECESSIVE, TYPE IC; ARCL1C

autosomal recessive cutis laxa type IC

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

frac - Mmp2

two hybrid

(Miller et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

frac

suppressible

beat-Ia

(Miller et al., 2011)

frac

suppressible

gbb

(Miller et al., 2011)

frac

enhanceable

LIMK1

(Miller et al., 2011)

frac

enhanceable

Mmp2

(Miller et al., 2011)

frac

suppressible

sax

(Miller et al., 2011)

frac

suppressible

Sema1a

(Miller et al., 2011)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

LIMK1

enhanceable

frac

(Miller et al., 2011)

Mmp2

suppressible

frac

(Miller et al., 2011)

Mmp2

enhanceable

frac

(Miller et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64287

DroID - A comprehensive database of gene and protein interactions.

FBgn0035798

MIST (genetic) - An integrated Molecular Interaction Database

38850

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-21

Cytogenetic map

66A5-66A5

Sequence location

3L:7,562,610..7,569,499 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A5-66A5

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-21

(FlyBase, 2016)

3-17.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

29297

w¹¹¹⁸; Mi{ET1}frac^MB12360

31577

y¹ v¹; P{TRiP.JF01150}attP2

31578

y¹ v¹; P{TRiP.JF01151}attP2

62941

y¹ v¹; P{TRiP.HMJ30018}attP40

NIG-Fly

HMJ30018

y¹ v¹; P{TRiP.HMJ30018}attP40/CyO

VDRC

v330351

P{VSH330351}attP40

v104254

P{KK106367}VIE-260B

v342930

P{hsFLP}1, y1 w1118; P{HD_CFD02327}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (234)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI18763

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0035798

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE27274

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0035798

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Miller et al., 2011)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

frac is genetically downstream of Mmp2 in axon guidance.

(Miller et al., 2011)

frac acts via an LIMK1-dependent non-canonical BMP pathway to promote proper motor axon pathfinding.

(Miller et al., 2011)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: frac CG7526

(Miller et al., 2011)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG7526

(Liang and Luan, 2024, Meadows, 2017.1.11, Demontis et al., 2014, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2008, Junion et al., 2007)

CT16044

(Hynes and Zhao, 2000, Hynes and Zhao, 2000)

Frac

(Owings and Chow, 2024, Zhu et al., 2017)

frac

(Mendoza Andrade et al., 2025, Pignataro et al., 2024, Trujillo et al., 2024, Yamamoto et al., 2024, Zhang et al., 2023, Pang et al., 2021, Miller et al., 2011)

Name Synonyms

faulty attraction

(Miller et al., 2011)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38850

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VS89

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VS89

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0035798

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38850/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0035798

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0035798

FlyMine - An integrated database for Drosophila genomics

FBgn0035798

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG7526

MARRVEL_MODEL - MARRVEL (model organism gene)

38850

Linkouts

BioGRID - A database of protein and genetic interactions.

64287

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0035798

DroID - A comprehensive database of gene and protein interactions.

FBgn0035798

DRSC - Results frm RNAi screens

FBgn0035798

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

frac_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0035798

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0035798

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7526

Flygut - An atlas of the Drosophila adult midgut

FBgn0035798

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0035798

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC000086

MIST (genetic) - An integrated Molecular Interaction Database

38850

References (38)

The following external sites may use different assemblies or annotations than FlyBase.

-0.40

Report Sections