FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\vkg
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General Information
Symbol
Dmel\vkg
Species
D. melanogaster
Name
viking
Annotation Symbol
CG16858
Feature Type
protein_coding_gene
FlyBase ID
FBgn0016075
Gene Model Status
Current
Stock Availability
28 publicly available
Gene Summary
viking (vkg) encodes a subunit of Collagen IV and a major component of basement membranes. It is secreted by haemocytes and fat body cells and is required for the normal morphogenesis of many tissues. It also contributes to TGF-beta signalling in the early embryo and the developing Malpighian tubules. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

collagen IV, collagen IV α2, l(2)01209, DmColA2, colIV

Key Links
Genomic Location
Cytogenetic map
25C1-25C1
Sequence location
Recombination map
2-15
RefSeq locus
NT_033779 REGION:5012144..5028191
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables extracellular matrix structural constituent conferring tensile strength
inferred from biological aspect of ancestor with PANTHER:PTN001166351
(GO Reference Genome Project, 2011-)
enables extracellular matrix structural constituent
inferred by curator from GO:0005604
(Devergne et al., 2017)
inferred from electronic annotation with InterPro:IPR001442, InterPro:IPR036954
(InterPro Project Members, 2004-)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in anterior Malpighian tubule development
inferred from mutant phenotype
(Bunt et al., 2010)
involved_in basement membrane organization
inferred from mutant phenotype
(Dai et al., 2018)
involved_in Malpighian tubule morphogenesis
inferred from mutant phenotype
(Bunt et al., 2010)
involved_in somatic muscle development
inferred from mutant phenotype
(Junion et al., 2007)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in extracellular matrix organization
inferred from biological aspect of ancestor with PANTHER:PTN002770636
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
is_active_in basement membrane
inferred from direct assay
(Díaz de la Loza et al., 2017)
located_in basement membrane
inferred from direct assay
(Dai et al., 2018, Devergne et al., 2017)
located_in extracellular matrix
inferred from high throughput direct assay
(Sarov et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of collagen trimer
inferred from electronic annotation with InterPro:IPR001442, InterPro:IPR036954
(InterPro Project Members, 2004-)
part_of collagen type IV trimer
non-traceable author statement
(Hynes and Zhao, 2000)
is_active_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN008390299
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
viking (vkg) encodes a subunit of Collagen IV and a major component of basement membranes. It is secreted by haemocytes and fat body cells and is required for the normal morphogenesis of many tissues. It also contributes to TGF-beta signalling in the early embryo and the developing Malpighian tubules. [Date last reviewed: 2019-03-21]
Gene Group (FlyBase)
COLLAGENS -
Collagens are major structural components of extracellular matrix. (Adapted from FBrf0230242.)
Summary (Interactive Fly)

along with Collagen IV, the main component of basement membranes - synthesized by the fat body, secreted to the hemolymph, and incorporated into the basement membrane - determines organ shape - regulates BMP signaling

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\vkg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VMV5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
vkg-RA
FBtr0079036
NM_057842
6376
1940
vkg-RB
FBtr0333540
NM_001273142
6355
1940
vkg-RC
FBtr0333541
NM_001273143
6430
1940
Additional Transcript Data and Comments
Reported size (kB)

6.337 (longest cDNA)

(Yasothornsrikul et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
vkg-PA
FBpp0078672
193.8
1940
6.36
Q9VMV5
NP_477190
AAF52203
vkg-PB
FBpp0305720
193.8
1940
6.36
Q9VMV5
NP_001260071
AGB92607
vkg-PC
FBpp0305721
193.8
1940
6.36
Q9VMV5
NP_001260072
AGB92608
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1940 aa isoforms: vkg-PA, vkg-PB, vkg-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

1761 (aa)

(Yasothornsrikul et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\vkg using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.99

Transcript Expression
distribution deduced from reporter
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15 -- 16
embryonic/larval hemocyte
(Bunt et al., 2010)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
cardiogenic mesoderm
(Fisher et al., 2012)
pericardial cell primordium

Comment: reported as pericardial cell specific anlage

(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
embryonic stage 13 -- 16
larval circulatory system
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
larval pericardial cell
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
embryonic stage 15 -- 16
embryonic/larval hemocyte
(Yasothornsrikul et al., 1997)
embryonic stage 16 -- 17
embryonic/larval fat body
(Yasothornsrikul et al., 1997)
first instar larval stage
embryonic/larval fat body
(Yasothornsrikul et al., 1997)
oogenesis stage S7 -- S8 & adult stage | female
follicle cell
(Lerner et al., 2013)
nurse cell
(Lerner et al., 2013)
Additional Descriptive Data

vkg and Col4a1 transcripts are both detected in fat bodies and hemocytes in late embryogenesis, and fat bodies in first larval instar.

(Yasothornsrikul et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S7 -- S8 & adult stage | female
follicle cell
(Lerner et al., 2013)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
extracellular matrix
(Zhou et al., 2013)
Subcellular Localization
CV Term
Evidence
References
is_active_in basement membrane
inferred from direct assay
(Díaz de la Loza et al., 2017)
located_in basement membrane
inferred from direct assay
(Dai et al., 2018, Devergne et al., 2017)
located_in extracellular matrix
inferred from high throughput direct assay
(Sarov et al., 2016)
Expression Deduced from Reporters
Reporter: P{lacW}vkgk07138
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hemocyte
(Rodriguez et al., 1996)
embryonic stage -- larval stage & adult stage
fat body
(Rodriguez et al., 1996)
adult stage
adult oenocyte
(Rodriguez et al., 1996)
Reporter: P{lacW}vkgk09511
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hemocyte
(Rodriguez et al., 1996)
embryonic stage -- larval stage & adult stage
fat body
(Rodriguez et al., 1996)
larval stage
larval central nervous system
(Rodriguez et al., 1996)
Reporter: P{lacW}vkgk13802
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hemocyte
(Rodriguez et al., 1996)
embryonic stage -- larval stage & adult stage
fat body
(Rodriguez et al., 1996)
larval stage
larval central nervous system
(Rodriguez et al., 1996)
Reporter: P{lacW}vkgk16721
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
embryonic/larval hemocyte
(Rodriguez et al., 1996)
embryonic stage -- larval stage & adult stage
fat body
(Rodriguez et al., 1996)
Reporter: P{PTT-GC}vkgCC00791
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult CNS glial cell
(DeSalvo et al., 2014)
adult brain surface glial cell
(DeSalvo et al., 2014)
adult brain neuropil glial cell
(DeSalvo et al., 2014)
adult brain cell body glial cell
(DeSalvo et al., 2014)
adult medulla neuropil associated glial cell
(DeSalvo et al., 2014)
adult lobula astrocyte-like glial cell
(DeSalvo et al., 2014)
adult lobula plate astrocyte-like glial cell
(DeSalvo et al., 2014)
adult optic chiasma glial cell
(DeSalvo et al., 2014)
Reporter: P{PTT-un}vkgG00454
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval lymph gland | restricted
(Jung et al., 2005)
embryonic stage 17
larval cardial cell
(Drechsler et al., 2013)
Reporter: P{PZ}vkg01209
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
gastric caecum
(Jackle and Janning, 1998.8.10)
embryonic/larval proventriculus
(Jackle and Janning, 1998.8.10)
larval pericardial cell
(Jackle and Janning, 1998.8.10)
embryonic/larval fat body
(Jackle and Janning, 1998.8.10)
embryonic/larval midgut
(Jackle and Janning, 1998.8.10)
embryonic/larval hemocyte
(Jackle and Janning, 1998.8.10)
embryonic/larval anterior midgut
(Jackle and Janning, 1998.8.10)
embryonic/larval posterior midgut
(Jackle and Janning, 1998.8.10)
mesoderm
(Jackle and Janning, 1998.8.10)
wandering third instar larval stage
ring gland
(Harvie et al., 1998)
embryonic/larval optic lobe
(Harvie et al., 1998)
larval ventral nerve cord
(Harvie et al., 1998)
Reporter: P{PZ}vkg06072a
Stage
Tissue/Position (including subcellular localization)
Reference
second instar larval stage -- third instar larval stage
embryonic/larval corpus allatum
(Harvie et al., 1998)
wandering third instar larval stage
embryonic/larval optic lobe
(Harvie et al., 1998)
larval ventral nerve cord
(Harvie et al., 1998)
eye disc
(Harvie et al., 1998)
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\vkg in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 43 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of vkg
Transgenic constructs containing regulatory region of vkg
Aberrations (Deficiencies and Duplications) ( 12 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (48)
Hsap\COL4A1
8 of 14
Yes
No
Hsap\COL4A6
8 of 14
Yes
No
Hsap\COL4A4
7 of 14
No
Yes
Hsap\COL4A5
7 of 14
No
No
Hsap\COL4A3
6 of 14
No
No
Hsap\COL4A2
5 of 14
No
No
Hsap\COL5A1
3 of 14
No
Yes
Hsap\COL5A2
3 of 14
No
Yes
Hsap\COL11A1
3 of 14
No
Yes
Hsap\COL1A1
2 of 14
No
Yes
Hsap\COL1A2
2 of 14
No
Yes
Hsap\COL2A1
2 of 14
No
Yes
Hsap\COL5A3
2 of 14
No
Yes
Hsap\COL7A1
2 of 14
No
Yes
Hsap\COL11A2
2 of 14
No
Yes
Hsap\MARCO
2 of 14
No
Yes
Hsap\ADIPOQ
1 of 14
No
Yes
1  
Hsap\C1QTNF9B
1 of 14
No
Yes
Hsap\C1QTNF9
1 of 14
No
Yes
Hsap\CCBE1
1 of 14
No
No
Hsap\COL3A1
1 of 14
No
No
Hsap\COL6A1
1 of 14
No
Yes
1  
Hsap\COL6A2
1 of 14
No
Yes
1  
Hsap\COL6A3
1 of 14
No
No
Hsap\COL6A5
1 of 14
No
Yes
Hsap\COL6A6
1 of 14
No
Yes
Hsap\COL9A1
1 of 14
No
Yes
Hsap\COL12A1
1 of 14
No
Yes
Hsap\COL13A1
1 of 14
No
No
Hsap\COL14A1
1 of 14
No
Yes
Hsap\COL15A1
1 of 14
No
No
Hsap\COL16A1
1 of 14
No
Yes
Hsap\COL17A1
1 of 14
No
Yes
Hsap\COL18A1
1 of 14
No
No
Hsap\COL19A1
1 of 14
No
Yes
Hsap\COL21A1
1 of 14
No
Yes
Hsap\COL22A1
1 of 14
No
Yes
Hsap\COL24A1
1 of 14
No
Yes
Hsap\COL25A1
1 of 14
No
Yes
Hsap\COL27A1
1 of 14
No
Yes
Hsap\COL28A1
1 of 14
No
Yes
Hsap\COLEC10
1 of 14
No
No
Hsap\EGFL8
1 of 14
No
No
Hsap\FBN1
1 of 14
No
No
Hsap\FBN3
1 of 14
No
No
Hsap\FCN1
1 of 14
No
No
Hsap\RPTN
1 of 14
No
No
Hsap\SCUBE2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (37)
Rnor\Col4a1
8 of 14
Yes
No
Rnor\Col4a5
7 of 14
No
No
Rnor\Col4a3
6 of 14
No
No
Rnor\Col4a6
6 of 14
No
Yes
Rnor\Col4a2
5 of 14
No
No
Rnor\Col4a4
4 of 14
No
No
Rnor\Col5a2
3 of 14
No
Yes
Rnor\Col2a1
2 of 14
No
Yes
Rnor\Col3a1
2 of 14
No
Yes
Rnor\Col5a1
2 of 14
No
Yes
Rnor\Col7a1
2 of 14
No
No
Rnor\Col11a1
2 of 14
No
Yes
Rnor\Col11a2
2 of 14
No
Yes
Rnor\Col1a1
1 of 14
No
Yes
Rnor\Col1a2
1 of 14
No
Yes
Rnor\Col5a3
1 of 14
No
Yes
Rnor\Col6a2
1 of 14
No
Yes
Rnor\Col6a4
1 of 14
No
No
Rnor\Col9a2
1 of 14
No
Yes
Rnor\Col13a1
1 of 14
No
No
Rnor\Col14a1
1 of 14
No
Yes
Rnor\Col15a1
1 of 14
No
No
Rnor\Col16a1
1 of 14
No
Yes
Rnor\Col17a1
1 of 14
No
Yes
Rnor\Col18a1
1 of 14
No
No
Rnor\Col19a1
1 of 14
No
Yes
Rnor\Col22a1
1 of 14
No
Yes
Rnor\Col24a1
1 of 14
No
Yes
Rnor\Col27a1
1 of 14
No
Yes
Rnor\Col28a1
1 of 14
No
No
Rnor\Fbn1
1 of 14
No
No
Rnor\Fcnb
1 of 14
No
No
Rnor\Marco
1 of 14
No
No
Rnor\Matn2
1 of 14
No
No
Rnor\Rptn
1 of 14
No
No
Rnor\Scube1
1 of 14
No
No
Rnor\Scube3
1 of 14
No
No
Mus musculus (laboratory mouse) (43)
Mmus\Col4a6
8 of 14
Yes
No
Mmus\Col4a1
7 of 14
No
No
Mmus\Col4a5
7 of 14
No
No
Mmus\Col4a2
6 of 14
No
No
Mmus\Col4a3
6 of 14
No
No
Mmus\Col4a4
6 of 14
No
Yes
Mmus\Col2a1
3 of 14
No
Yes
Mmus\Col5a2
3 of 14
No
Yes
Mmus\Col11a1
3 of 14
No
Yes
Mmus\Col1a1
2 of 14
No
Yes
Mmus\Col1a2
2 of 14
No
Yes
Mmus\Col5a1
2 of 14
No
Yes
Mmus\Col5a3
2 of 14
No
Yes
Mmus\Col7a1
2 of 14
No
Yes
Mmus\Col11a2
2 of 14
No
Yes
Mmus\Col22a1
2 of 14
No
Yes
Mmus\Col27a1
2 of 14
No
Yes
Mmus\Col28a1
2 of 14
No
Yes
Mmus\Ccbe1
1 of 14
No
No
Mmus\Col3a1
1 of 14
No
Yes
Mmus\Col6a2
1 of 14
No
Yes
Mmus\Col6a3
1 of 14
No
No
Mmus\Col6a4
1 of 14
No
Yes
Mmus\Col6a6
1 of 14
No
Yes
Mmus\Col8a2
1 of 14
No
Yes
Mmus\Col9a1
1 of 14
No
Yes
Mmus\Col12a1
1 of 14
No
Yes
Mmus\Col13a1
1 of 14
No
No
Mmus\Col14a1
1 of 14
No
Yes
Mmus\Col15a1
1 of 14
No
No
Mmus\Col16a1
1 of 14
No
Yes
Mmus\Col17a1
1 of 14
No
Yes
Mmus\Col18a1
1 of 14
No
No
Mmus\Col19a1
1 of 14
No
Yes
Mmus\Col24a1
1 of 14
No
Yes
Mmus\Egfl8
1 of 14
No
No
Mmus\Fbn1
1 of 14
No
No
Mmus\Marco
1 of 14
No
No
Mmus\Matn2
1 of 14
No
No
Mmus\Rptn
1 of 14
No
No
Mmus\Rrbp1
1 of 14
No
No
Mmus\Scube2
1 of 14
No
Yes
Mmus\Vwce
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (33)
Xtro\col4a1
6 of 13
Yes
No
Xtro\col4a5
4 of 13
No
No
Xtro\col4a2
3 of 13
No
No
Xtro\col4a6
3 of 13
No
No
Xtro\col2a1
2 of 13
No
No
Xtro\col27a1
2 of 13
No
Yes
Xtro\med27
2 of 13
No
No
Xtro\ankle1
1 of 13
No
No
Xtro\ccbe1
1 of 13
No
No
Xtro\col1a1
1 of 13
No
Yes
Xtro\col1a2
1 of 13
No
Yes
Xtro\col3a1
1 of 13
No
Yes
Xtro\col5a2
1 of 13
No
Yes
Xtro\col5a3
1 of 13
No
Yes
Xtro\col6a5
1 of 13
No
No
Xtro\col11a2
1 of 13
No
Yes
Xtro\col13a1
1 of 13
No
No
Xtro\col17a1
1 of 13
No
Yes
Xtro\col19a1
1 of 13
No
Yes
Xtro\col21a1
1 of 13
No
Yes
Xtro\col22a1
1 of 13
No
Yes
Xtro\col28a1
1 of 13
No
Yes
Xtro\efemp1
1 of 13
No
No
Xtro\hmcn2
1 of 13
No
No
Xtro\ifnl3
1 of 13
No
Yes
Xtro\LOC100488932
1 of 13
No
Yes
Xtro\LOC100490088
1 of 13
No
Yes
Xtro\LOC100491712
1 of 13
No
Yes
Xtro\LOC100497103
1 of 13
No
Yes
Xtro\LOC100497990
1 of 13
No
Yes
Xtro\otol1
1 of 13
No
Yes
Xtro\raver2
1 of 13
No
Yes
Xtro\scara3
1 of 13
No
Yes
Danio rerio (Zebrafish) (56)
Drer\col4a5
7 of 14
Yes
No
Drer\col4a6
7 of 14
Yes
No
Drer\col4a1
6 of 14
No
No
Drer\col4a2
5 of 14
No
No
Drer\col4a3
5 of 14
No
Yes
Drer\col4a4
5 of 14
No
Yes
Drer\col5a2a
3 of 14
No
Yes
Drer\col2a1a
2 of 14
No
Yes
Drer\col5a1
2 of 14
No
Yes
Drer\col5a2b
2 of 14
No
Yes
Drer\col5a3a
2 of 14
No
Yes
Drer\col5a3b
2 of 14
No
Yes
Drer\col7a1
2 of 14
No
Yes
Drer\col11a1a
2 of 14
No
Yes
Drer\col27a1b
2 of 14
No
Yes
Drer\col28a1b
2 of 14
No
Yes
Drer\si:ch211-196i2.1
2 of 14
No
Yes
Drer\si:dkey-21p1.3
2 of 14
No
Yes
Drer\ccbe1
1 of 14
No
No
Drer\cd248a
1 of 14
No
Yes
Drer\col1a1a
1 of 14
No
Yes
Drer\col1a1b
1 of 14
No
Yes
Drer\col1a2
1 of 14
No
Yes
Drer\col2a1b
1 of 14
No
Yes
Drer\col6a1
1 of 14
No
Yes
Drer\col6a2
1 of 14
No
Yes
Drer\col7a1l
1 of 14
No
Yes
Drer\col9a1b
1 of 14
No
Yes
Drer\col9a3
1 of 14
No
No
Drer\col11a1b
1 of 14
No
Yes
Drer\col11a2
1 of 14
No
Yes
Drer\col12a1a
1 of 14
No
No
Drer\col12a1b
1 of 14
No
No
Drer\col14a1a
1 of 14
No
Yes
Drer\col15a1b
1 of 14
No
No
Drer\col16a1
1 of 14
No
Yes
Drer\col17a1a
1 of 14
No
Yes
Drer\col17a1b
1 of 14
No
Yes
Drer\col18a1a
1 of 14
No
No
Drer\col18a1b
1 of 14
No
No
Drer\col21a1
1 of 14
No
Yes
Drer\col22a1
1 of 14
No
Yes
Drer\col24a1
1 of 14
No
Yes
Drer\col27a1a
1 of 14
No
Yes
Drer\col28a1a
1 of 14
No
No
Drer\col28a2a
1 of 14
No
No
Drer\col28a2b
1 of 14
No
No
Drer\crybg1b
1 of 14
No
Yes
Drer\fbn2b
1 of 14
No
No
Drer\megf6a
1 of 14
No
No
Drer\si:ch211-106n13.3
1 of 14
No
Yes
Drer\si:dkey-61l1.4
1 of 14
No
Yes
Drer\si:dkey-163f14.6
1 of 14
No
No
Drer\si:dkey-225n22.4
1 of 14
No
Yes
Drer\zgc:113232
1 of 14
No
Yes
Drer\zmp:0000000760
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (112)
Cele\emb-9
9 of 14
Yes
Yes
Cele\let-2
4 of 14
No
No
Cele\col-135
2 of 14
No
No
Cele\bli-1
1 of 14
No
Yes
Cele\bli-6
1 of 14
No
Yes
Cele\cle-1
1 of 14
No
No
Cele\col-3
1 of 14
No
Yes
Cele\col-7
1 of 14
No
Yes
Cele\col-10
1 of 14
No
Yes
Cele\col-19
1 of 14
No
Yes
Cele\col-33
1 of 14
No
Yes
Cele\col-34
1 of 14
No
Yes
Cele\col-35
1 of 14
No
Yes
Cele\col-38
1 of 14
No
Yes
Cele\col-39
1 of 14
No
Yes
Cele\col-41
1 of 14
No
Yes
Cele\col-46
1 of 14
No
Yes
Cele\col-47
1 of 14
No
Yes
Cele\col-49
1 of 14
No
Yes
Cele\col-53
1 of 14
No
Yes
Cele\col-54
1 of 14
No
Yes
Cele\col-56
1 of 14
No
Yes
Cele\col-58
1 of 14
No
Yes
Cele\col-60
1 of 14
No
Yes
Cele\col-61
1 of 14
No
Yes
Cele\col-62
1 of 14
No
Yes
Cele\col-63
1 of 14
No
Yes
Cele\col-64
1 of 14
No
Yes
Cele\col-65
1 of 14
No
Yes
Cele\col-69
1 of 14
No
Yes
Cele\col-71
1 of 14
No
Yes
Cele\col-74
1 of 14
No
Yes
Cele\col-75
1 of 14
No
Yes
Cele\col-77
1 of 14
No
Yes
Cele\col-78
1 of 14
No
Yes
Cele\col-79
1 of 14
No
Yes
Cele\col-80
1 of 14
No
Yes
Cele\col-84
1 of 14
No
Yes
Cele\col-86
1 of 14
No
Yes
Cele\col-87
1 of 14
No
Yes
Cele\col-88
1 of 14
No
Yes
Cele\col-90
1 of 14
No
Yes
Cele\col-91
1 of 14
No
Yes
Cele\col-92
1 of 14
No
Yes
Cele\col-93
1 of 14
No
Yes
Cele\col-94
1 of 14
No
Yes
Cele\col-96
1 of 14
No
Yes
Cele\col-97
1 of 14
No
Yes
Cele\col-99
1 of 14
No
No
Cele\col-102
1 of 14
No
Yes
Cele\col-104
1 of 14
No
Yes
Cele\col-105
1 of 14
No
Yes
Cele\col-106
1 of 14
No
Yes
Cele\col-107
1 of 14
No
Yes
Cele\col-108
1 of 14
No
Yes
Cele\col-109
1 of 14
No
Yes
Cele\col-110
1 of 14
No
Yes
Cele\col-111
1 of 14
No
Yes
Cele\col-113
1 of 14
No
Yes
Cele\col-116
1 of 14
No
Yes
Cele\col-117
1 of 14
No
Yes
Cele\col-120
1 of 14
No
Yes
Cele\col-121
1 of 14
No
Yes
Cele\col-123
1 of 14
No
Yes
Cele\col-124
1 of 14
No
Yes
Cele\col-125
1 of 14
No
Yes
Cele\col-126
1 of 14
No
Yes
Cele\col-127
1 of 14
No
Yes
Cele\col-128
1 of 14
No
Yes
Cele\col-129
1 of 14
No
Yes
Cele\col-130
1 of 14
No
Yes
Cele\col-131
1 of 14
No
Yes
Cele\col-133
1 of 14
No
Yes
Cele\col-138
1 of 14
No
Yes
Cele\col-140
1 of 14
No
Yes
Cele\col-141
1 of 14
No
Yes
Cele\col-143
1 of 14
No
Yes
Cele\col-144
1 of 14
No
Yes
Cele\col-145
1 of 14
No
Yes
Cele\col-148
1 of 14
No
Yes
Cele\col-149
1 of 14
No
Yes
Cele\col-150
1 of 14
No
Yes
Cele\col-151
1 of 14
No
Yes
Cele\col-152
1 of 14
No
Yes
Cele\col-153
1 of 14
No
Yes
Cele\col-154
1 of 14
No
Yes
Cele\col-155
1 of 14
No
Yes
Cele\col-156
1 of 14
No
Yes
Cele\col-157
1 of 14
No
Yes
Cele\col-158
1 of 14
No
Yes
Cele\col-161
1 of 14
No
Yes
Cele\col-162
1 of 14
No
Yes
Cele\col-164
1 of 14
No
Yes
Cele\col-165
1 of 14
No
Yes
Cele\col-171
1 of 14
No
Yes
Cele\col-172
1 of 14
No
Yes
Cele\col-175
1 of 14
No
Yes
Cele\col-177
1 of 14
No
Yes
Cele\col-181
1 of 14
No
Yes
Cele\col-184
1 of 14
No
Yes
Cele\dpy-2
1 of 14
No
Yes
Cele\dpy-5
1 of 14
No
Yes
Cele\dpy-7
1 of 14
No
Yes
Cele\dpy-10
1 of 14
No
Yes
Cele\dpy-13
1 of 14
No
Yes
Cele\dpy-17
1 of 14
No
Yes
Cele\lon-3
1 of 14
No
Yes
Cele\mec-5
1 of 14
No
Yes
Cele\rol-1
1 of 14
No
Yes
Cele\rol-6
1 of 14
No
Yes
Cele\sqt-1
1 of 14
No
Yes
Cele\Y53C10A.24
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (9)
Agam\AgaP_AGAP009201
9 of 12
Yes
Yes
Agam\AgaP_AGAP009576
4 of 12
No
Yes
Agam\AgaP_AGAP009581
4 of 12
No
Yes
Agam\AgaP_AGAP009200
3 of 12
No
No
Agam\AgaP_AGAP011620
3 of 12
No
Yes
Agam\AgaP_AGAP001194
1 of 12
No
No
Agam\AgaP_AGAP006516
1 of 12
No
No
Agam\AgaP_AGAP012623
1 of 12
No
Yes
Agam\AgaP_AGAP012765
1 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\AT1G64455
2 of 13
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:vkg. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (5)
Col4a1
8 of 13
Mp
2 of 13
CG14089
1 of 13
CG42342
1 of 13
frac
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 11 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    COL4A1; collagen type IV alpha 1 chain
    8 of 14
    120130
    COL4A6; collagen type IV alpha 6 chain
    8 of 14
    303631
    COL4A4; collagen type IV alpha 4 chain
    7 of 14
    120131
    COL4A5; collagen type IV alpha 5 chain
    7 of 14
    303630
    COL4A3; collagen type IV alpha 3 chain
    6 of 14
    120070
    COL4A2; collagen type IV alpha 2 chain
    5 of 14
    120090
    COL5A1; collagen type V alpha 1 chain
    3 of 14
    120215
    COL5A2; collagen type V alpha 2 chain
    3 of 14
    120190
    COL11A1; collagen type XI alpha 1 chain
    3 of 14
    120280
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    vkg
    pull down, molecular weight estimation by staining, molecular sieving, Identification by mass spectrometry, western blot
    (Summers et al., 2023, Bhave et al., 2012)
    vkg - CG3008
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - CG7049
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - Col4a1
    x-ray crystallography, pull down, molecular sieving, experimental knowledge based, molecular weight estimation by staining, Identification by mass spectrometry
    (Summers et al., 2023, Guruharsha et al., 2011)
    vkg - Gbp2
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - Glt
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - LanB2
    anti tag coimmunoprecipitation, western blot, inferred by curator
    (Rotstein et al., 2018)
    vkg - Ndg
    anti tag coimmunoprecipitation, western blot
    (Rotstein et al., 2018)
    vkg - Pi3K68D
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - Pih1D1
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - Rb97D
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - Tet
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - boca
    experimental knowledge based
    (Guruharsha et al., 2011)
    vkg - dpp
    pull down, anti tag western blot
    (Sawala et al., 2012)
    vkg - mys
    proximity ligation assay, fluorescence microscopy
    (Hunter et al., 2020)
    vkg - prc
    anti tag coimmunoprecipitation, western blot
    (Rotstein et al., 2018)
    vkg - sog
    pull down, anti tag western blot
    (Sawala et al., 2012)
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    vkg
    suppressible
    Col4a1
    (Kelemen-Valkony et al., 2012)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    AdamTS-A
    suppressible
    vkg
    (Skeath et al., 2017)
    Col4a1
    suppressible
    vkg
    (Kelemen-Valkony et al., 2012)
    peb
    suppressible
    vkg
    (Wilk et al., 2004)
    peb
    enhanceable
    vkg
    (Wilk et al., 2004)
    Ras85D|scrib
    suppressible
    Col4a1|vkg
    (Bakopoulos et al., 2023)
    shi
    suppressible
    Col4a1|vkg
    (Zang et al., 2015)
    sli
    enhanceable
    vkg
    (MacMullin and Jacobs, 2006)
    Tl
    suppressible
    Col4a1|vkg
    (Zang et al., 2015)
    trol
    suppressible
    vkg
    (Bonche et al., 2022)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2L
    Recombination map
    2-15
    Cytogenetic map
    25C1-25C1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    25C1-25C1
    Limits computationally determined from genome sequence between P{lacW}l(2)k10001k10001 and P{lacW}vkgk16721&P{lacW}Cg25Ck00405
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    25C-25C
    (Gellon et al., 1997, Chen et al., 1996, Dearolf, 1996.7.26, Kimbrell, 1996.4.28)
    25C1-25C2
    (determined by in situ hybridisation)
    (Spradling et al., 1999)
    25C-25C
    (determined by in situ hybridisation)
    (Rodriguez et al., 1996)
    25C1-25C2
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-15

    (FlyBase, 2016)

    2-16.5

    (Comeron et al., 2012)

    2-

    (Chen et al., 1996)
    Left of (cM)
    Right of (cM)
    Notes

    Maps immediately 5' to Cg25C.

    (Chen et al., 1996)
    Stocks and Reagents
    Stocks (28)
    Genomic Clones (14)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (42)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Hirooka et al., 2025, Van De Bor et al., 2021, McCall et al., 2014)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

          (Harvie et al., 1998)

          Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype.

          (Gellon et al., 1997)

          vkg has been cloned and characterised.

          (Yasothornsrikul et al., 1997)

          May be the same as Cg25C.

          (Chen et al., 1996)

          Identified in an enhancer-trap screen for insertions expressed in the fat body and haemocytes. May encode a collagen.

          (Chen et al., 1996)

          vkg encodes a collagen IV α2 protein.

          (Kimbrell, 1996.4.28)

          vkg is a member of the haemocyte and fat body enhancer detector strains.

          (Rodriguez et al., 1996)
          Relationship to Other Genes
          Source for database merge of
          Additional comments
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology

          The expression in immune tissues that are involved in both attack and defense, and the persistence of the few survivors as larvae led to the gene being named "viking".

          (Rodriguez et al., 1996)
          Synonyms and Secondary IDs (36)
          Reported As
          Symbol Synonym
          1209
          (Harvie et al., 1998)
          6072
          (Harvie et al., 1998)
          CG16858
          (National Institute of Genetics Fly Stocks, 2022-, Palu and Thummel, 2016, Christis and Munro, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Mosallanejad et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Quinones-Coello, 2007, Fakhouri et al., 2006)
          COL4A2
          (Wang et al., 2023)
          CT25584
          (Hynes and Zhao, 2000)
          Col IV
          (Matsubayashi et al., 2017)
          Col4
          (Ku and Bilder, 2025)
          Col4a2
          (Nichols et al., 2025)
          ColIV
          (Zhou et al., 2023, Wilmes et al., 2018)
          ColIVα2
          (Crest et al., 2017)
          Coll IV
          (Devergne et al., 2017)
          Coll IVα2
          (Denef et al., 2008)
          DmColA2
          (Dearolf, 1996.7.26)
          Vkg
          (Karling and Weavers, 2025, Lancaster et al., 2025, Lee et al., 2025, Sui and Dahmann, 2024, Guss et al., 2023, Khalili et al., 2023, Reinhardt et al., 2023, Kharrat et al., 2022, Liu et al., 2022, Hoshino and Niwa, 2021, Luo et al., 2021, Van De Bor et al., 2021, Hughes et al., 2020, Nematbakhsh et al., 2020, Rani et al., 2020, Zheng et al., 2020, Sauerwald et al., 2019, Li et al., 2018, Rotstein et al., 2018, Devergne et al., 2017, Hughes and Jacobs, 2017, Sessions et al., 2017, Pearson et al., 2016, Sarov et al., 2016, Drechsler et al., 2013, Weavers and Skaer, 2013, Akhouayri et al., 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Kallappagoudar et al., 2010, Alves-Silva et al., 2008, Denef et al., 2008)
          VkgC
          (Sawala et al., 2012)
          col4a2
          (Kelemen-Valkony et al., 2012)
          colIV
          (Ku et al., 2023, Cerqueira Campos et al., 2020)
          coll-IV
          (Khan et al., 2013)
          coll. IV
          (Fakhouri et al., 2006)
          collagen-IV
          (Khan et al., 2013)
          collagenIV
          (Soans and Norden, 2021)
          l(2)01209
          (Halsell and Kiehart, 1998)
          veg
          (Park et al., 2019)
          vkg
          (Andrews et al., 2025, Hirooka et al., 2025, Ishikawa et al., 2025, Ku and Bilder, 2025, Mendoza Andrade et al., 2025, Isaacson et al., 2024, Lacin et al., 2024, Monticelli et al., 2024, Pignataro et al., 2024, Sutton et al., 2024, Walther et al., 2024, Huang et al., 2023, Ku et al., 2023, Takarada et al., 2023, Voutyraki et al., 2023, Bindhani et al., 2022, Cassella and Ephrussi, 2022, Hultmark and Andó, 2022, Jia et al., 2022, Khalid et al., 2022, Montanari et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Peng et al., 2022, Zajac and Horne-Badovinac, 2022, Bilder et al., 2021, Cattenoz et al., 2021, Girard et al., 2021, Moussalem et al., 2021, Sun et al., 2021, Wang et al., 2021, Brooks et al., 2020, Cho et al., 2020, Csordás et al., 2020, Krautz et al., 2020, Parra and Johnston, 2020, Pastor-Pareja, 2020, Töpfer and Holz, 2020, Walls et al., 2020, Blice-Baum et al., 2019, Cevik et al., 2019, Kanda et al., 2019, Proag et al., 2019, Ramos-Lewis and Page-McCaw, 2019, Story et al., 2019, Wolfstetter et al., 2019, Yang et al., 2019, Zhang et al., 2019, Dai et al., 2018, Gene Disruption Project members, 2018-, Grobler et al., 2018, Itoh et al., 2018, Ramos-Lewis et al., 2018, Díaz de la Loza et al., 2017, Hermle et al., 2017, Ríos-Barrera et al., 2017, Skeath et al., 2017, Ables et al., 2016, Ashe, 2016, Isabella and Horne-Badovinac, 2016, Sarov et al., 2016, Sawala et al., 2015, Van De Bor et al., 2015, Winstanley et al., 2015, Zang et al., 2015, Arefin et al., 2014, DeSalvo et al., 2014, Findlay et al., 2014, Jiang et al., 2014, Kim and Choe, 2014, McCall et al., 2014, Shen et al., 2014, Tian and Jiang, 2014, Zhou et al., 2014, Khan et al., 2013, Lerner et al., 2013, Petzoldt et al., 2013, Kelemen-Valkony et al., 2012, Vanderploeg et al., 2012, Wolfstetter and Holz, 2012, Friedman et al., 2011, Haigo and Bilder, 2011, Knox et al., 2011, Pastor-Pareja and Xu, 2011, Beebe et al., 2010, Bunt et al., 2010, Langer et al., 2010, Gilliland et al., 2009, Tang et al., 2008, Wang et al., 2008, Buszczak et al., 2007, Junion et al., 2007, Quinones-Coello, 2007, Beller et al., 2006, Christensen and Cook, 2006.8.29, MacMullin and Jacobs, 2006)
          α(IV)2/vkg
          (Hynes and Zhao, 2000)
          Name Synonyms
          Collagen IV
          (Gonçalves et al., 2025, Santillán et al., 2025, Banerjee et al., 2019, Sekiguchi and Yamada, 2018, Pasco et al., 2015, Zhang and Labouesse, 2012, Pastor-Pareja and Xu, 2011, Paddibhatla et al., 2010, Urbano et al., 2009, Stork et al., 2008)
          Collagen IVa2
          (Reinhardt et al., 2023)
          CollagenIV
          (Sauerwald et al., 2019)
          Type IV collagen
          (Yurchenco and O'Rear, 1994)
          Viking
          (Nelson et al., 2025, Li et al., 2024, Koehler and Huber, 2023, Reinhardt et al., 2023, Wang et al., 2023, Hughes et al., 2020, Hunter et al., 2020, Khadilkar et al., 2020, Ramond et al., 2020, Smith et al., 2020, Zhang and Cai, 2020, Sui et al., 2018, Wilmes et al., 2018, Devergne et al., 2017, Tiwari et al., 2015, Arefin et al., 2014, Weavers and Skaer, 2013, Bunt et al., 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Momota et al., 2011, Umulis et al., 2010, Guha et al., 2009, Weavers et al., 2009, Alves-Silva et al., 2008, Stork et al., 2008, Wang et al., 2008, Beaucher et al., 2007, Srivastava et al., 2007, Fakhouri et al., 2006)
          collagen IV
          (Sawala et al., 2015, Arefin et al., 2014, McCall et al., 2014, Weavers and Skaer, 2013, Bhave et al., 2012, Knox et al., 2011, Guha et al., 2009, Weavers et al., 2009, Alves-Silva et al., 2008, Mirth and Akam, 2002, Kramerov and Fessler, 2000)
          collagen IV α2
          (Pearson et al., 2016, Gates, 2012, Haigo and Bilder, 2011)
          collagenIV a2
          (Araujo et al., 2003)
          type IV collagen, α-chain
          (Myllharju and Kivirikko, 2004)
          type IV collagenS
          (Knox et al., 2011)
          viking
          (Santillán et al., 2025, Fortuna et al., 2021, Töpfer and Holz, 2020, Yadav et al., 2017, Ayyaz et al., 2015, Sawala et al., 2015, Winstanley et al., 2015, Shen et al., 2014, Bhave et al., 2012, Gates, 2012, Jaspers et al., 2012, Cammarato et al., 2011, Eliazer and Buszczak, 2011, Haigo and Bilder, 2011, Marcu et al., 2011, Pastor-Pareja and Xu, 2011, Xie and Auld, 2011, Bunt et al., 2010, Martinek et al., 2008, Gellon et al., 1997, Yasothornsrikul et al., 1997, Chen et al., 1996, Rodriguez et al., 1996)
          Secondary FlyBase IDs
          • FBgn0010477
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
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          Result
          Result Type
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          External Crossreferences and Linkouts ( 54 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (316)