FB2026_03 , released September 17, 2026
Gene: Dmel\Snoo
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General Information
Symbol
Dmel\Snoo
Species
D. melanogaster
Name
Sno oncogene
Annotation Symbol
CG34421
Feature Type
protein_coding_gene
FlyBase ID
FBgn0085450
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Sno oncogene (Snoo) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. It specifically binds the product of Med and switches its affinity from the products of Mad to Smox, resulting in antagonism of the product of dpp and facilitation of Activin signaling. Snoo overexpression antagonizes both pathways. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dSno, SnoN, dSki, l(2)SH1402

Key Links
Genomic Location
Cytogenetic map
28D2-28D3
Sequence location
Recombination map
2-29
RefSeq locus
NT_033779 REGION:7891187..7984196
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables co-SMAD binding
inferred from direct assay
(Takaesu et al., 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
enables SMAD binding
inferred from electronic annotation with InterPro:IPR014890
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
involved_in negative regulation of BMP signaling pathway
inferred from mutant phenotype
(Barrio et al., 2007, Ramel et al., 2007)
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Takaesu et al., 2006)
involved_in positive regulation of activin receptor signaling pathway
inferred from mutant phenotype
(Takaesu et al., 2006)
involved_in regulation of SMAD protein signal transduction
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Takaesu et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in negative regulation of BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Barrio et al., 2007)
located_in nucleus
inferred from direct assay
(Barrio et al., 2007)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
part_of transcription regulator complex
inferred from biological aspect of ancestor with PANTHER:PTN000000299
(GO Reference Genome Project, 2011-)
Gene Group / Complex (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Sno oncogene (Snoo) encodes a protein that belongs to the highly conserved Sno/Ski family of Smad binding proteins. It specifically binds the product of Med and switches its affinity from the products of Mad to Smox, resulting in antagonism of the product of dpp and facilitation of Activin signaling. Snoo overexpression antagonizes both pathways. [Date last reviewed: 2019-03-14]
Gene Group / Complex (FlyBase)
UNCLASSIFIED DNA BINDING DOMAIN TRANSCRIPTION FACTORS -
This group comprises DNA-binding transcription factors that do not classify under other domain-based transcription factor groups in FlyBase.
Pathway (FlyBase)
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
POSITIVE REGULATORS OF ACTIVIN SIGNALING PATHWAY -
Positive regulators of activin signaling up-regulate the pathway, ultimately resulting in the increased nuclear activity of the Smox/Med transcription factor complex.
Summary (Interactive Fly)

mediator of Baboon signaling - antagonizes Dpp signaling - physically interacts with Medea - inhibits growth when overexpressed - belongs to the highly conserved Sno/Ski family of Smad binding proteins - Medea and switches its affinity from Mad to Smox, resulting in antagonism of dpp and facilitation of Activin signaling

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Snoo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry A8DYX1)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Transposable element inserted into 5' UTR may affect transcription start sites.

Gene model reviewed during 5.52

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Snoo-RB
FBtr0112717
NM_001103645
5201
1223
Snoo-RC
FBtr0112718
NM_001103646
7131
1223
Snoo-RD
FBtr0112719
NM_001103647
6336
1223
Snoo-RG
FBtr0343409
NM_135320
7205
1223
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Snoo-PB
FBpp0111629
135.1
1223
5.87
Q00G30
NP_001097115
ABV53643
Snoo-PC
FBpp0111630
135.1
1223
5.87
Q00G30
NP_001097116
ABV53644
Snoo-PD
FBpp0111631
135.1
1223
5.87
Q00G30
NP_001097117
ABV53645
Snoo-PG
FBpp0310055
135.1
1223
5.87
Q00G30
NP_609164
AAF52579
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1223 aa isoforms: Snoo-PB, Snoo-PC, Snoo-PD, Snoo-PG
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Snoo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.09

Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Barrio et al., 2007)
located_in nucleus
inferred from direct assay
(Barrio et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Snoo in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 48 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Snoo
Transgenic constructs containing regulatory region of Snoo
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene partially disrupted in
Df(2L)snoN
(Barrio et al., 2007)
Inferred from location ( 7 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act.PU
lethal, with Scer\GAL4Tub.PU
lethal (with SnooEX8B)
lethal (with SnooEX9B)
lethal (with SnooEX10B)
lethal (with SnooEX34A)
lethal (with SnooEX71B)
lethal (with SnooEX95A)
lethal (with SnooSH1402)
lethal | recessive
lethal - all die before end of first instar larval stage (with SnooEX4B)
lethal - all die before end of first instar larval stage (with SnooSH1402)
lethal - all die before end of larval stage (with SnooEX4B)
lethal - all die before end of larval stage (with SnooEX17B)
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage (with SnooEX17B)
lethal - all die before end of pupal stage (with SnooSH1402)
lethal - all die before end of pupal stage | male, with Scer\GAL4MD-638
lethal - all die before end of pupal stage | recessive
partially lethal (with SnooBSC41)
partially lethal (with SnooEX4B)
partially lethal (with SnooEX17B)
partially lethal (with SnooEX34A)
partially lethal (with SnooEX71B)
partially lethal (with SnooEX95A)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Act.PU
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4Tub.PU
viable (with Df(2L)snoN)
viable (with SnooBSC41)
viable (with SnooEX8B)
viable (with SnooEX9B)
viable (with SnooEX10B)
viable (with SnooSH1402)
Sterility
Allele
female fertile (with SnooBSC41)
female fertile (with SnooEX8B)
female fertile (with SnooEX9B)
female fertile (with SnooEX10B)
female fertile (with SnooEX71B)
female fertile (with SnooSH1402)
female semi-fertile
female semi-sterile (with SnooBSC41)
female semi-sterile (with SnooEX34A)
female semi-sterile (with SnooEX95A)
female sterile (with SnooBSC41)
female sterile (with SnooEX4B)
female sterile (with SnooEX17B)
fertile | female (with Df(2L)snoN)
Other Phenotypes
Allele
abnormal neuroanatomy, with Scer\GAL4ppk.1.9
abnormal neuroanatomy (with SnooEX4B)
abnormal neuroanatomy (with SnooSH1402)
abnormal neuroanatomy | adult stage, with Scer\GAL4Fer2.2359
decreased cell number | adult stage, with Scer\GAL4Fer2.2359
some die during first instar larval stage (with SnooEX4B)
some die during first instar larval stage (with SnooSH1402)
some die during pupal stage (with SnooEX17B)
some die during pupal stage (with SnooSH1402)
some die during pupal stage | male, with Scer\GAL4MD-638
some die during pupal stage | recessive
some die during third instar larval stage (with SnooEX4B)
some die during third instar larval stage (with SnooEX17B)
some die during third instar larval stage | recessive
visible, with Scer\GAL432B
visible, with Scer\GAL4A9
visible, with Scer\GAL4Act.PU
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4dpp.3KK
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4Tub.PU
visible | dominant
Phenotype manifest in
Allele
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
adult dopaminergic PAM neuron | adult stage | decreased number, with Scer\GAL4Fer2.2359
crossvein, with Scer\GAL432B
crossvein, with Scer\GAL4A9
dorsal appendage
dorsal appendage, with Scer\GAL4CY2
egg operculum
egg operculum, with Scer\GAL4CY2
eye, with Scer\GAL4GMR.PF
imaginal disc, with Scer\GAL432B
lamina (with SnooEX4B)
lamina (with SnooSH1402)
lamina plexus (with SnooEX4B)
lamina plexus (with SnooSH1402)
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
leg, with Scer\GAL4Dll-md23
medulla (with SnooEX4B)
medulla (with SnooSH1402)
medulla anlage (with SnooEX4B)
medulla anlage (with SnooSH1402)
mesonotum, with Scer\GAL4ap-md544
mesonotum, with Scer\GAL4pnr-MD237
mesonotum, with Scer\GAL4ptc-559.1
ommatidium, with Scer\GAL4GMR.PF
photoreceptor cell R7 & axon (with SnooEX4B)
photoreceptor cell R7 & axon (with SnooSH1402)
photoreceptor cell R8 & axon (with SnooEX4B)
photoreceptor cell R8 & axon (with SnooSH1402)
wing, with Scer\GAL4A9
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4nub-AC-62
wing, with Scer\GAL4salm-459.2
wing, with Scer\GAL4T80
wing | female, with Scer\GAL4MD-638
wing blade, with Scer\GAL432B
wing blade, with Scer\GAL4Bx-MS1096
wing blade posterior compartment, with Scer\GAL4en-e16E
wing disc, with Scer\GAL4A9
wing vein, with Scer\GAL432B
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4dpp.3KK
wing vein, with Scer\GAL4nub-AC-62
wing vein, with Scer\GAL4salm-459.2
wing vein (with Snoo1D1), with Scer\GAL4MD-638
wing vein (with SnooF3), with Scer\GAL4MD-638
wing vein (with SnooK2), with Scer\GAL4MD-638
wing vein (with SnooM67), with Scer\GAL4MD-638
wing vein (with SnooR102), with Scer\GAL4MD-638
wing vein (with SnooS2), with Scer\GAL4MD-638
wing vein (with SnooV2), with Scer\GAL4MD-638
wing vein | ectopic
wing vein | ectopic, with Scer\GAL4Act.PU
wing vein | ectopic, with Scer\GAL4Tub.PU
wing vein | female, with Scer\GAL4MD-638
wing vein L3, with Scer\GAL4A9
wing vein L4, with Scer\GAL4A9
wing vein L4, with Scer\GAL4nub-AC-62
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\SKI
7 of 14
Yes
Yes
Hsap\SKIL
6 of 14
No
Yes
Hsap\SKOR1
3 of 14
No
No
1  
Hsap\SKOR2
3 of 14
No
No
1  
Hsap\DACH1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (4)
Rnor\Skil
6 of 14
Yes
Yes
Rnor\Ski
6 of 14
Yes
Yes
Rnor\Skor1
3 of 14
No
No
Rnor\Skor2
3 of 14
No
No
Mus musculus (laboratory mouse) (6)
Mmus\Ski
7 of 14
Yes
Yes
Mmus\Skil
6 of 14
No
Yes
Mmus\Skor1
3 of 14
No
No
Mmus\Skor2
3 of 14
No
No
Mmus\Dach1
1 of 14
No
No
Mmus\Dach2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (5)
Xtro\skil
5 of 13
Yes
Yes
Xtro\ski
5 of 13
Yes
Yes
Xtro\skor1
2 of 13
No
No
Xtro\dach2
1 of 13
No
No
Xtro\skor2
1 of 13
No
No
Danio rerio (Zebrafish) (11)
Drer\skia
8 of 14
Yes
Yes
Drer\skib
8 of 14
Yes
Yes
Drer\skilb
7 of 14
No
Yes
Drer\skila
6 of 14
No
Yes
Drer\skor1a
2 of 14
No
No
Drer\skor1b
2 of 14
No
No
Drer\dacha
1 of 14
No
No
Drer\dachb
1 of 14
No
No
Drer\dachc
1 of 14
No
No
Drer\dachd
1 of 14
No
No
Drer\skor2
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
Cele\daf-5
3 of 14
Yes
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP007776
3 of 12
Yes
Yes
Agam\AgaP_AGAP004306
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Snoo. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (1)
fuss
2 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    SKI; SKI proto-oncogene
    model of  craniosynostosis
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SKI; SKI proto-oncogene
    7 of 14
    164780
    SKIL; SKI like proto-oncogene
    6 of 14
    165340
        SKOR1; SKI family transcriptional corepressor 1
        3 of 14
        611273
             
            SKOR2; SKI family transcriptional corepressor 2
            3 of 14
            617138
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            Interaction Browsers
            View in FlyBase Interactions Browser   View in MIST tool (external link)
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Snoo
            suppressible
            babo
            (Ramel et al., 2007)
            Snoo
            suppressible
            dpp
            (Ramel et al., 2007)
            Snoo
            suppressible
            Mad
            (Barrio et al., 2007, Takaesu et al., 2006)
            Snoo
            enhanceable
            Mad
            (Takaesu et al., 2006)
            Snoo
            suppressible
            Med
            (Barrio et al., 2007, Takaesu et al., 2006)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            babo
            suppressible
            Snoo
            (Barrio et al., 2007, Ramel et al., 2007)
            fzr
            suppressible
            Snoo
            (Neuert et al., 2017)
            Mad
            suppressible
            Snoo
            (Barrio et al., 2007)
            tkv
            suppressible
            Snoo
            (Barrio et al., 2007, Ramel et al., 2007, Takaesu et al., 2006)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            FlyBase
            External Links
            External Data
            Linkouts
            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
            Class of Gene
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-29
            Cytogenetic map
            28D2-28D3
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            28D2-28D3
            Limits computationally determined from genome sequence between P{PZ}mts02496 and P{EP}CG7231EP2510; Left limit from in situ hybridisation (FBrf0157097) Right limit from in situ hybridisation (FBrf0157097)
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            28D3-28D3
            (Oh et al., 2003)
            Experimentally Determined Recombination Data
            Location

            2-29

            (FlyBase, 2016)

            2-25.6

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (15)
            Genomic Clones (59)
            cDNA Clones (36)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Cell Line Information
            Publicly Available Cell Lines
             
              Other Stable Cell Lines
               
                Other Comments

                snoN has limited function in development, inhibiting TGF-β-induced wing vein formation during pupation.

                (Ramel et al., 2007)

                The Snoo locus contains a recent retrotransposon insertion (297{}323) that may be essential for Snoo function; a recovered cDNA sequence suggests that a possible Snoo promoter may reside within the 297{}323 element and animals in which the insertion is deleted show lethality.

                (Takaesu et al., 2006)

                1 allele of l(2)SH1402 recovered in a P-insertion screen.

                (Oh et al., 2003)
                Relationship to Other Genes
                Source for database merge of

                Source for merge of: snoN CG7093

                (FlyBase Genome Annotators, 2007)

                Source for merge of: snoN CG7093 l(2)SH1402

                (Takaesu et al., 2006)

                Source for merge of: snoN l(2)SH1402

                (Ramel et al., 2007)
                Additional comments

                Annotations CG7233 and CG7093 merged as CG34421 in release 5.2 of the genome annotation.

                (FlyBase Genome Annotators, 2007)
                Nomenclature History
                Source for database identify of

                Source for identity of: snoN CG7233

                (Shravage, 2004.11.5)

                Source for identity of: Snoo snoN

                (Newfeld, 2007.2.25)
                Nomenclature comments
                Etymology
                Synonyms and Secondary IDs (22)
                Reported As
                Symbol Synonym
                CG34421
                (National Institute of Genetics Fly Stocks, 2022-, Neuert et al., 2017, Ni et al., 2010.12.1, Perkins et al., 2009, FlyBase Genome Annotators, 2007)
                CG7093
                (Barrio et al., 2007, FlyBase Genome Annotators, 2007, Newfeld, 2007.2.25, Takaesu et al., 2006)
                CG7233
                (Barrio et al., 2007, Newfeld, 2007.2.25, Shravage et al., 2007, Molnar et al., 2006, Takaesu et al., 2006, Shravage and Roth, 2003, Egger et al., 2002)
                DskiL
                (Barrio-Olano, 2006.6.2)
                Sno
                (Takaesu et al., 2012)
                SnoA
                (Takaesu and Newfeld, 2006.6.22)
                SnoI
                (Takaesu and Newfeld, 2006.6.28)
                SnoN
                (Newfeld, 2007.2.25, Ramel et al., 2007, Takaesu and Newfeld, 2006.6.29, Takaesu and Newfeld, 2006.6.29, Takaesu and Newfeld, 2006.6.29)
                SnoN2
                (Takaesu and Newfeld, 2006.6.28)
                Snoo
                (GenetiVision Corporation, 2026-, Larnerd et al., 2024, Liang and Luan, 2024, Ding et al., 2022, Miozzo et al., 2022, National Institute of Genetics Fly Stocks, 2022-, Pavlidaki et al., 2022, Philyaw et al., 2022, Saha et al., 2022, Spierer et al., 2021, Cho et al., 2020, Robinson et al., 2020, Highfill et al., 2019, Meltzer et al., 2019, Shokri et al., 2019, Gene Disruption Project members, 2018-, Rajpurohit et al., 2018, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Schleich et al., 2014, Chintapalli et al., 2013, de Celis et al., 2013.9.11, Iyer et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Rodriguez et al., 2012, Luo et al., 2011, Quijano et al., 2010, Newfeld, 2007.2.25)
                dSki
                (Barrio-Olano, 2006.6.2, Barrio-Olano, 2006.6.2, Barrio-Olano, 2006.6.2)
                dSno
                (Fischer et al., 2012, Quijano et al., 2010, Newfeld, 2007.2.25, Newfeld et al., 2007, Shravage et al., 2007, Takaesu et al., 2006)
                dSnoN
                (Barrio et al., 2007)
                dsno
                (Fischer et al., 2012)
                dsnoN
                (Barrio R. et al., 2007)
                l(2)SH1402
                (Ramel et al., 2007)
                l(2)SH2 1402
                (Oh et al., 2002.3.25)
                snoN
                (Ramel et al., 2007, Molnar et al., 2006)
                snoo
                (Meltzer, 2019-, Djabrayan and Casanova, 2016)
                Name Synonyms
                CG7093
                Sno oncogene
                (Pool et al., 2012, Takaesu et al., 2006)
                Sno-oncogene
                (Newfeld, 2007.2.25)
                lethal (2) SH1402
                snoN
                Secondary FlyBase IDs
                • FBgn0031967
                • FBgn0065450
                • FBgn0031965
                Datasets (0)
                Study focus (0)
                Experimental Role
                Project
                Project Type
                Title
                Study result (0)
                Result
                Result Type
                Title
                External Crossreferences and Linkouts ( 82 )
                Sequence Crossreferences
                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                Other crossreferences
                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                FlyMine - An integrated database for Drosophila genomics
                InterPro - A database of protein families, domains and functional sites
                KEGG Genes - Molecular building blocks of life in the genomic space.
                MARRVEL_MODEL - MARRVEL (model organism gene)
                Linkouts
                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                DroID - A comprehensive database of gene and protein interactions.
                DRSC - Results frm RNAi screens
                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                Flygut - An atlas of the Drosophila adult midgut
                FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                MIST (genetic) - An integrated Molecular Interaction Database
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                References (102)