FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\ttm50
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General Information
Symbol
Dmel\ttm50
Species
D. melanogaster
Name
tiny tim 50
Annotation Symbol
CG2713
Feature Type
protein_coding_gene
FlyBase ID
FBgn0250874
Gene Model Status
Current
Stock Availability
3 publicly available
Gene Summary
tiny tim 50 (ttm50) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. It plays active roles in regulating metabolic levels for modulation of growth in development. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

EG:95B7.3 , Gp99

Key Links
Genomic Location
Cytogenetic map
3B3-3B3
Sequence location
Recombination map
1-1.5
RefSeq locus
NC_004354 REGION:2730077..2732190
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables cysteine-type endopeptidase activator activity
inferred from direct assay
(Metwally et al., 2021)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in mitochondrion organization
inferred from mutant phenotype
(Sugiyama et al., 2007)
involved_in protein localization to endoplasmic reticulum
inferred from direct assay
(Metwally et al., 2021)
involved_in protein localization to Golgi apparatus
inferred from direct assay
(Metwally et al., 2021)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in mitochondrial membrane organization
inferred from sequence or structural similarity with UniProtKB:Q3ZCQ8
(Gene Ontology Curators, 2002-)
involved_in protein import into mitochondrial matrix
inferred from biological aspect of ancestor with PANTHER:PTN002639282
(GO Reference Genome Project, 2011-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
is_active_in endoplasmic reticulum
inferred from direct assay
(Metwally et al., 2021)
is_active_in Golgi apparatus
inferred from direct assay
(Metwally et al., 2021)
located_in mitochondrion
inferred from direct assay
(Sugiyama et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in mitochondrial inner membrane
inferred from experiment
(Metwally et al., 2021)
located_in mitochondrial inner membrane
inferred from sequence or structural similarity with UniProtKB:Q3ZCQ8
(Gene Ontology Curators, 2002-)
part_of TIM23 mitochondrial import inner membrane translocase complex
traceable author statement
(Metwally et al., 2021)
inferred from biological aspect of ancestor with PANTHER:PTN002639282
(GO Reference Genome Project, 2011-)
inferred from sequence or structural similarity with UniProtKB:Q3ZCQ8
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TIM50 family. (Q9W4V8)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
tiny tim 50 (ttm50) encodes a mitochondrial inner membrane protein that is involved in mitochondrial protein translocation and maintenance of mitochondrial membrane potential. It plays active roles in regulating metabolic levels for modulation of growth in development. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
PSEUDOPHOSPHATASES -
Pseudophosphatases are proteins that are evolutionary related to phosphatases but lack relevant catalytic activity. Proposed functions of pseudophosphatases include: (i) being part of scaffolding signaling complexes; (ii) acting as 'antiphosphatases' that protect specific substrates from other active phosphatases; and (iii) working as functional inhibitors of their substrate. (Adapted from FBrf0227974.)
TIM50 PRESEQUENCE RECEPTOR SUBUNITS -
TIM50 is a core subunit of the TIM23 complex. It is the receptor for mitochondrial presequence-containing precursor proteins, binding them in the mitochondrial intermembrane space and directing them to the channel in the inner membrane. (Adapted from PMID:30765764.)
TIM23 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE MOTOR COMPLEX -
The TIM23 MOTOR (or TIM23 PAM) complex mediates import of mitochondrial presequence-containing proteins into the mitochondrial matrix. Following translocation of proteins across the outer mitochondrial membrane by the TOM complex, presequence-containing proteins are passed to the TIM23 MOTOR complex and transported across the inner membrane. This requires the ATPase-activity of the matrix subcomplex, the presequence translocase-associated motor (PAM). (Adapted from PMID:32074073,PMID:38828998 and PMID:19884344.)
TIM23 MITOCHONDRIAL IMPORT INNER MEMBRANE SORT COMPLEX -
The TIM23 SORT complex mediates the import and lateral insertion of mitochondrial presequence-containing proteins into the inner mitochondrial membrane. Following translocation of proteins across the outer mitochondrial membrane by the TOM complex, presequence-containing proteins are passed to the TIM23 complex. In the TIM23 SORT variant, TIMM21 replaces the presequence translocase-associated motor (of the TIM23 MOTOR complex, that mediates import into the matrix) and facilitates lateral insertion of proteins into the inner membrane. Lateral insertion is independent of ATP-hydrolysis and dependent on membrane potential. (Adapted from PMID:32074073,PMID:38828998 and PMID:19884344.)
Protein Function (UniProtKB)
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
(UniProt, Q9W4V8)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\ttm50 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W4V8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 6.02

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
ttm50-RA
FBtr0070497
NM_130671
1728
428
ttm50-RB
FBtr0347024
NM_001316628
1868
428
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
ttm50-PA
FBpp0070474
49.7
428
7.48
Q9W4V8
NP_570027
AAF45820
ttm50-PB
FBpp0312448
49.7
428
7.48
Q9W4V8
NP_001303557
ALI51141
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

428 aa isoforms: ttm50-PA, ttm50-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50.

(UniProt, Q9W4V8)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ttm50 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.36

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in endoplasmic reticulum
inferred from direct assay
(Metwally et al., 2021)
is_active_in Golgi apparatus
inferred from direct assay
(Metwally et al., 2021)
located_in mitochondrion
inferred from direct assay
(Sugiyama et al., 2007)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\ttm50 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of ttm50
Transgenic constructs containing regulatory region of ttm50
Aberrations (Deficiencies and Duplications) ( 1 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PU
lethal | embryonic stage | maternal effect | recessive
lethal - all die before end of first instar larval stage
lethal - all die before end of larval stage
lethal - all die during embryonic stage
lethal - all die during P-stage, with Scer\GAL4Mef2.PR
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
male semi-fertile
Other Phenotypes
Allele
abnormal developmental rate
abnormal mitotic cell cycle
abnormal neuroanatomy | pupal stage, with Scer\GAL4ppk.PG
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4109(2)80
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4221
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4smid-C161
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
decreased body size
decreased body size | first instar larval stage
decreased body size | larval stage
decreased cell number | recessive | somatic clone
decreased cell size
decreased cell size | somatic clone | third instar larval stage
decreased occurrence of cell division | larval stage
decreased size | pupal stage, with Scer\GAL4ppk.PG
increased size | pupal stage, with Scer\GAL4ppk.PG
some die during first instar larval stage
some die during larval stage
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
abdominal dorsal multidendritic neuron ddaA | third instar larval stage, with Scer\GAL4smid-C161
abdominal dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4109(2)80
abdominal dorsal multidendritic neuron ddaE | third instar larval stage, with Scer\GAL4221
autophagosome | early third instar larval stage | somatic clone
dendrite | pupal stage, with Scer\GAL4ppk.PG
dendrite | third instar larval stage, with Scer\GAL4109(2)80
dendrite | third instar larval stage, with Scer\GAL4221
dendrite | third instar larval stage, with Scer\GAL4smid-C161
eye, with Scer\GAL4GMR.PF
fat cell | early third instar larval stage | somatic clone
imaginal disc | somatic clone
larval multidendritic class IV neuron | pupal stage, with Scer\GAL4ppk.PG
macrochaeta
mitochondrion
mitochondrion | somatic clone
mitochondrion | third instar larval stage, with Scer\GAL4109(2)80
rhabdomere of eye photoreceptor cell | adult stage | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\TIMM50
12 of 14
Yes
Yes
Hsap\CTDSP1
2 of 14
No
No
Hsap\CTDSP2
2 of 14
No
No
1  
Hsap\CTDSPL2
2 of 14
No
No
Hsap\CTDSPL
2 of 14
No
No
1  
Hsap\CTDNEP1
1 of 14
No
No
1  
Hsap\CTDP1
1 of 14
No
No
Hsap\UBLCP1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Timm50
13 of 14
Yes
Yes
Rnor\Ctdnep1
2 of 14
No
No
Rnor\Ctdsp1
2 of 14
No
No
Rnor\Ctdspl2
2 of 14
No
No
Rnor\Ctdsp2
1 of 14
No
No
Rnor\Ctdspl
1 of 14
No
No
Rnor\Ublcp1
1 of 14
No
No
Mus musculus (laboratory mouse) (8)
Mmus\Timm50
12 of 14
Yes
Yes
Mmus\Ctdnep1
2 of 14
No
No
Mmus\Ctdsp1
2 of 14
No
No
Mmus\Ctdsp2
2 of 14
No
No
Mmus\Ctdspl2
2 of 14
No
No
Mmus\Ctdspl
2 of 14
No
No
Mmus\Ctdp1
1 of 14
No
No
Mmus\Ublcp1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (7)
Xtro\timm50
8 of 13
Yes
Yes
Xtro\ctdnep1
1 of 13
No
No
Xtro\ctdsp2
1 of 13
No
No
Xtro\ctdspl2
1 of 13
No
No
Xtro\ctdspl
1 of 13
No
No
Xtro\LOC100488559
1 of 13
No
No
Xtro\XB5962940
1 of 13
No
No
Danio rerio (Zebrafish) (11)
Drer\timm50
13 of 14
Yes
Yes
Drer\ctdnep1a
2 of 14
No
No
Drer\ctdnep1b
2 of 14
No
No
Drer\ctdsp1
2 of 14
No
No
Drer\ctdsp2
2 of 14
No
No
Drer\ctdspl2a
2 of 14
No
No
Drer\ctdspl3
2 of 14
No
No
Drer\ctdspla
2 of 14
No
No
Drer\ctdspl2b
1 of 14
No
No
Drer\ctdsplb
1 of 14
No
No
Drer\ublcp1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\scpl-4
11 of 14
Yes
Yes
Cele\cnep-1
1 of 14
No
No
Cele\fcp-1
1 of 14
No
No
Cele\scpl-1
1 of 14
No
No
Cele\scpl-3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP001108
12 of 12
Yes
Yes
Agam\AgaP_AGAP006231
2 of 12
No
No
Agam\AgaP_AGAP011422
2 of 12
No
No
Agam\AgaP_AGAP004967
1 of 12
No
No
Agam\AgaP_AGAP005119
1 of 12
No
No
Agam\AgaP_AGAP005270
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (23)
Atha\TIM50
10 of 13
Yes
Yes
Atha\AT3G55960
2 of 13
No
No
Atha\AT5G45700
2 of 13
No
No
Atha\SSP4
2 of 13
No
No
Atha\SSP4b
2 of 13
No
No
Atha\SSP5
2 of 13
No
No
Atha\AT1G20320
1 of 13
No
No
Atha\AT1G29770
1 of 13
No
No
Atha\AT1G29780
1 of 13
No
No
Atha\AT1G43600
1 of 13
No
No
Atha\AT1G43610
1 of 13
No
No
Atha\AT2G02290
1 of 13
No
No
Atha\AT2G04930
1 of 13
No
No
Atha\AT3G17550
1 of 13
No
No
Atha\AT3G19595
1 of 13
No
No
Atha\AT4G06599
1 of 13
No
No
Atha\AT5G23470
1 of 13
No
No
Atha\AT5G54210
1 of 13
No
No
Atha\CPL1
1 of 13
No
No
Atha\CPL2
1 of 13
No
No
Atha\CPL3
1 of 13
No
No
Atha\CPL4
1 of 13
No
No
Atha\CPL5
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\TIM50
10 of 13
Yes
No
Scer\NEM1
2 of 13
No
No
Scer\PSR1
2 of 13
No
No
Scer\PSR2
2 of 13
No
No
Scer\FCP1
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (5)
Spom\tim50
9 of 12
Yes
No
Spom\nem1
2 of 12
No
No
Spom\SPAC2F7.02c
2 of 12
No
No
Spom\fcp1
1 of 12
No
No
Spom\SPBC1271.03c
1 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:ttm50. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (8)
ttm2
11 of 13
ttm3
11 of 13
CG8584
4 of 13
CG12078
4 of 13
Ctdnep1
4 of 13
hzg
4 of 13
Fcp1
1 of 13
Ublcp1
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    TIMM50; translocase of inner mitochondrial membrane 50
    12 of 14
    607381
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    Interaction Browsers
    View in FlyBase Interactions Browser   View in MIST tool (external link)
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    ttm50
    enhanceable
    Diap1
    (Sugiyama et al., 2007)
    ttm50
    suppressible
    hid
    (Sugiyama et al., 2007)
    ttm50
    suppressible
    PPP1R15
    (Tsuyama et al., 2017)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    CalpA
    suppressible
    ttm50
    (Metwally et al., 2021)
    External Data
    Subunit Structure (UniProtKB)
    Component of the TIM23 complex at least composed of Tim23, Tim17 (Tim17a1, Tim17a2 or Tim17b1) and a Tim50.
    (UniProt, Q9W4V8 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    FlyBase
    External Links
    External Data
    Linkouts
    Class of Gene
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-1.5
    Cytogenetic map
    3B3-3B3
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    3B3-3B3
    Limits computationally determined from genome sequence between P{EP}EP1362 and P{EP}dncEP1395
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    1-1.5

    (FlyBase, 2016)

    1-1.4

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (3)
    Genomic Clones (15)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (32)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    Antibody Information
    Laboratory Generated Antibodies
     

    polyclonal

    (Metwally et al., 2021)
    Commercially Available Antibodies
     
    Cell Line Information
    Publicly Available Cell Lines
     
      Other Stable Cell Lines
       
        Other Comments

        Gp99 encodes a novel peptide showing homology to a single shared domain in sequences reported in C.elegans, S.pombe and S.cerevisiae.

        (Sugiyama et al., 1997)

        Hypomorphic mutant shows delayed growth and reduced viability, phenotype is suppressed by Dsor1MAPKK.

        (Sugiyama et al., 1997)
        Relationship to Other Genes
        Source for database merge of
        Additional comments

        The CG6691 gene may have been derived from the CG2713 gene by retroposition.

        (Dai et al., 2006)

        FlyBase curator comment: the insertion in the "f08040" Exelixis line (PBac{WH}CG2712f08040) was originally assigned to the CG2713 gene in FBrf0179797, resulting in the "CG2713f08040" (FBal0161907) allele. However, FBrf0184340 shows that the insertion is actually within CG2712.

        (Bloomington Drosophila Stock Center, 2004.11.6)
        Nomenclature History
        Source for database identify of

        Source for identity of: EG:95B7.3 CG2713

        (Deng, 1999.11)

        Source for identity of: ttm50 CG2713 Gp99

        (Sugiyama et al., 2007)
        Nomenclature comments
        Etymology

        The gene name includes "tiny tim" due to the mutant phenotype and sequence homology to the S.cerevisiae "Tim50" gene.

        (Sugiyama et al., 2007)
        Synonyms and Secondary IDs (9)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 39 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        MIST (protein-protein) - An integrated Molecular Interaction Database
        References (45)