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Reference
Citation
Lacin, H., Chen, H.M., Long, X., Singer, R.H., Lee, T., Truman, J.W. (2019). Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS.  eLife 8(): e43701.
FlyBase ID
FBrf0242251
Publication Type
Research paper
Abstract

The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages, which are clusters of lineally related neurons. Neurons in these hemilineages use one of the three fast-acting neurotransmitters (acetylcholine, GABA, or glutamate) for communication. We generated a comprehensive neurotransmitter usage map for the entire ventral nerve cord. We did not find any cases of neurons using more than one neurotransmitter, but found that the acetylcholine specific gene ChAT is transcribed in many glutamatergic and GABAergic neurons, but these transcripts typically do not leave the nucleus and are not translated. Importantly, our work uncovered a simple rule: All neurons within a hemilineage use the same neurotransmitter. Thus, neurotransmitter identity is acquired at the stem cell level. Our detailed transmitter- usage/lineage identity map will be a great resource for studying the developmental basis of behavior and deciphering how neuronal circuits function to regulate behavior.

PubMed ID
PubMed Central ID
PMC6504232 (PMC) (EuropePMC)
Related Publication(s)
Note

A question of lineage.
Sen, 2019, eLife 8: e47162 [FBrf0242316]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (62)
    Genes (21)
    Sequence Features (2)
    Natural transposons (1)
    Insertions (28)
    Experimental Tools (2)
    Transgenic Constructs (38)
    Transcripts (2)