FlyBase Allele Report: Dmel\dpp[d12]

Somatic dpp^d12 mutant clones at the anterior/posterior (A/P) compartmental boundary do not interfere with cell growth and proliferation of adjacent cell populations in third instar larval wing disc. Inducing the mutant clones in a Minute background gives them a growth advantage and in some such discs the A/P stripe of dpp expression is almost completely lacking, yet the cell proliferation in the wing pouch is unperturbed. Severely reduced wing discs are observed only when the mutant clones are induced very early in development.

(Akiyama and Gibson, 2015)

The wings of dpp^d8/dpp^d12 mutants do not develop at all, only rudimentary stubs are formed, this can be rescued by expression of Ecol\lexA^LG.dpp>dpp^{lexAop.cHa.EGFP} : the wings of these adults display venation defects (extra vein material at the anterior crossvein, loss of distal part of L4) and the have slightly elongated shape but their sizes are comparable to that of control wings. The wing size of these rescued flies can in turn be reduced again by hindering the spreading of the dpp morphogen: completely blocking it by co-expressing Zzzz\vhhGFP4^{Ecol\lexAop.morphotrap.ext.T:Disc\RFP-mCherry} at the source, i.e. within the dpp expression domain or reducing it by expressing Zzzz\vhhGFP4^{Scer\UAS.morphotrap.ext.T:Disc\RFP-mCherry} under the control of Scer\GAL4^hh.PU (i.e. in the posterior compartment). The former blocks the wing blade development completely, with the latter the blade size is strongly decreased and the patterning in its posterior part is lost.

Blocking dpp spreading at its source however does not interfere with the uniform proliferation pattern in larval imaginal discs as the density of mitotic cells (pH3-positive) is comparable between the rescue and morphotrap discs. Clonal growth rates are also not generally affected (assessed by utilizing the Raeppli tissue-labelling tool), but in the morphotrap wing discs low numbers of very small clones (1-3) are found next to the A/P boundary and these are not observed in the control discs.

In wing discs where dpp spreading is blocked within the dpp expression domain, the growth of the lateral part of the wing compartments shows similar width increase and similar growth rate as in the control discs with dpp spreading unhindered. However, the proliferation of the medial cell population (marked by low brk) is abolished, so the overall size of wing disc is visibly decreased compared to controls.

Similarly, hindering the dpp spreading at its (anterior) source reduces the size of the posterior wing pouch by more than 60%, blocking the dpp spreading in the posterior compartment (by expressing the morphotrap under the control of Scer\GAL4^hh.PU) decreased the posterior pouch size by about 40%.

(Harmansa et al., 2015)

The wings of dpp^d5/dpp^d12 mutants are so small that the identification of patterning defects is obscured.

(Bangi and Wharton, 2006)

dpp^d12/dpp^d6 flies show a considerable loss of taste bristles but do not show a loss of pseudotrachae or a significant change in gross mediproboscis morphology.

(Yasunaga et al., 2006)

The size of the capitellum of the haltere is reduced in dpp^d5/dpp^d12 adults compared to wild type.

(de Navas et al., 2006)

dpp^d5/dpp^d12 females have normal vaginal plates and tergite eight, showing discretely reduced analia in a few cases. dpp^d5/dpp^d12 males have extensively reduced terminalia and the penis apparatus can be duplicated or triplicated.

(Gorfinkiel et al., 2003)

The genital disc is severely reduced in dpp^d12/dpp^d14 larvae.

(Keisman and Baker, 2001)

The wing blade is almost entirely missing in dpp^d8/dpp^d12 animals. Some wing hinge structures are present.

(Teleman and Cohen, 2000)

dpp^d8/dpp^d12 flies have rudimentary wings.

(Jazwinska et al., 1999)

dpp^d6/dpp^d12 flies have a reduced number of ommatidia. The adults are weak, short-lived (live for 2-3 days) and have abnormalities in the wing, leg, antenna and external genitalia. The tarsal and meta-tarsal segments of all legs are abnormal in dpp^d6/dpp^d12 flies, due to loss of claws and fusion of the tarsal segments. The dorsal parts of the leg are sometimes ventralised. The tibia and femur are progressively less affected, while the trochanter and coxa are almost wild type. The number of sex comb bristles is generally higher than normal. dpp^d6/dpp^d12 flies have defects in the distal segments of the antenna. The arista is usually absent and a conical projection is present on the third segment (which presumably represents the fused 4th, 5th and 6th antennal segments). The leg and antennal discs of dpp^d6/dpp^d12 larvae are deformed. Most dpp^d6/dpp^d12 males completely lack external genitalia while some have abnormal external genitalia. There is little effect on the female genitalia.

(Mandal and Lakhotia, 1999)

The external genitalia of dpp^d6/dpp^d12 and dpp^d8/dpp^d12 males are reduced to a small ring like structure. The external genitalia of dpp¹⁰⁶³⁸/dpp^d12 males are highly defective and the penis apparatus is less defective. dpp^d6/dpp^d12 and dpp¹⁰⁶³⁸/dpp^d12 females show duplication of the thorn bristles accompanied by an absence of long bristles. dpp^d8/dpp^d12 females show a complete duplication of the thorn bristles of the vaginal plate.

(Emerald and Roy, 1998)

Heterozygotes are phenotypically wild-type.

(Khalsa et al., 1998)

Homozygous clones induced in first instar larvae produce abnormalities in the dorsal side of the leg. Pattern elements from the dorsal side are missing, and may or may not be replaced with a duplicate version of the remaining ventral part of the leg. Duplications are arranged as mirror images. Homozygous clones doubly mutant for dpp^d12 and wg^l-17 show defects in both the ventral and dorsal sides of the leg. The frequency of duplications is reduced compared to the single mutant homozygous dpp^d12 or wg^l-17 clones.

(Held and Heup, 1996)

dpp^d8/dpp^d12 dics wing pouch is small, almost no wing tissue remains, except structures for the proximal hinge region. The proximal costa remains in the anterior compartment and a reduced alula in the posterior. Partial rescue of the wing phenotype is achieved by tkv^{Q253D.Scer\UAS.cLa} expression driven by Scer\GAL4^dpp.blk1.

(Lecuit et al., 1996)

Mutation partially suppresses the penetrance of the hh^Mrt phenotype.

(Felsenfeld and Kennison, 1995)

Heterozygotes with dpp^d5 have reduced wings. dpp^d5/dpp^d12 heterozygotes have reduced wings. Some dpp^d12 ptc^G20/dpp^d5 ptc¹⁶ individuals eclose and show a partial rescue of the ptc phenotype (decrease in the numbers of bristles on the notum, legs and antennae and number of teeth in the male sex comb and a reduction in size of overgrown structures).

(Capdevila et al., 1994)

Heterozygotes of dpp^d12 and dpp^d14 have the distal leg structures missing.

(Diaz-Benjumea et al., 1994)

A posterior clone runs along the antero-posterior boundary until it reaches a gap in wing vein 4 (a region sensitive to lack of dpp) where the border of the clone becomes irregular.

(Hidalgo, 1994)

medulla neuropil ommatidia In dpp^d12/dpp^d6 or dpp^d12/dpp^d14 flies the medulla neuropil is reduced to a size similar to that produced by inactivating wg prior to 44hr AEL. The number of ommatidia is correspondingly reduced.

(Kaphingst and Kunes, 1994)

Rudimentary imaginal discs.

(St. Johnston et al., 1990)

In dpp^d12/dpp^d14 heterozygotes all imaginal discs are extremely reduced, die as early pupae. Imaginal disc transplantation demonstrates that only the anterior notum and most of the proximal anterior wing margin are produced. Wing discs do not have regenerative capacities.

(Bryant, 1988)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Df(2L)JS17/+, dpp^d12 has visible | dominant phenotype, enhanceable by sax[+]/sax¹

(Twombly et al., 2009)

dpp^d6/dpp^d12 has visible phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

Suppressed by

Statement

Reference

dpp^d5/dpp^d12 has visible phenotype, suppressible | partially by Ubx¹³⁰/Ubx[+]

(de Navas et al., 2006)

Enhancer of

Statement

Reference

dpp^d12 is an enhancer of visible | recessive phenotype of gbb⁴

(Khalsa et al., 1998)

NOT Enhancer of

Statement

Reference

dpp^d12/dpp[+] is a non-enhancer of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Suppressor of

Statement

Reference

dpp^d12 is a suppressor | partially of increased size | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

dpp^d12 is a suppressor of increased cell number | adult stage phenotype of mir-958^KO

(Mukherjee et al., 2021)

dpp^d12/dpp[+] is a suppressor of abnormal neuroanatomy phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d12 is a suppressor of increased cell number | somatic clone phenotype of BacA\p35^UAS.cHa, Scer\GAL4^Tub.PU

(Perez-Garijo et al., 2005)

dpp^d12 is a suppressor of visible phenotype of upd1^GMR.PB

(Bach et al., 2003)

NOT Suppressor of

Statement

Reference

dpp^d12 is a non-suppressor of abnormal cell death | somatic clone phenotype of BacA\p35^UAS.cHa, Scer\GAL4^Tub.PU

(Perez-Garijo et al., 2005)

dpp^d12/dpp[+] is a non-suppressor of increased body size phenotype of Scer\GAL4^29BD, dally^{sec.UAS.Tag:MYC}

(Takeo et al., 2005)

dpp^d12/dpp[+] is a non-suppressor of visible phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

dpp^d12 is a non-suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

Other

Statement

Reference

dpp^d5/dpp^d12, ix¹ has neoplasia phenotype

(Chatterjee et al., 2015)

dpp^d12, gbb⁴ has partially lethal phenotype

(Khalsa et al., 1998)

dpp^d12, nub¹ has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12, nub² has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub¹ has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub² has visible phenotype

(Cifuentes and Garcia-Bellido, 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has visible | dominant phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has visible | dominant phenotype

(Jackson et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

Df(2L)JS17/+, dpp^d12 has unguis phenotype, enhanceable by sax[+]/sax¹

(Twombly et al., 2009)

Df(2L)JS17/+, dpp^d12 has wing vein phenotype, enhanceable by sax[+]/sax¹

(Twombly et al., 2009)

dpp^d6/dpp^d12 has antenna phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has fourth segment of antenna phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has fifth segment of antenna phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has arista phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has femur phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has leg phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has male genitalia phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has ommatidium phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has sex comb | increased number phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has tarsal segment phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

dpp^d6/dpp^d12 has tibia phenotype, enhanceable by Bar¹

(Mandal and Lakhotia, 1999)

Suppressed by

Statement

Reference

dpp^d5/dpp^d12 has capitellum phenotype, suppressible | partially by Ubx¹³⁰/Ubx[+]

(de Navas et al., 2006)

dpp^d12 has eye disc phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

dpp^d12 has ommatidium phenotype, suppressible by Scer\GAL4^dpp.blk1/eya^UAS.cBa

(Curtiss and Mlodzik, 2000)

Enhancer of

Statement

Reference

dpp^d12/dpp[+] is an enhancer of crossvein | somatic clone phenotype of gbb¹

(Bangi and Wharton, 2006)

dpp^d12/dpp[+] is an enhancer of wing vein L5 phenotype of gbb^5I/gbb⁴

(Bangi and Wharton, 2006)

dpp^d12/dpp[+] is an enhancer of wing vein L4 phenotype of gbb^5I/gbb⁴

(Bangi and Wharton, 2006)

dpp^d12 is an enhancer of wing vein L4 phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of anterior crossvein phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L2 phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L4 phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L2 phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L3 phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L5 phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing cell phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L3 phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of submarginal wing cell phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of second posterior wing cell phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of discal wing cell phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of second basal wing cell phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of anterior crossvein phenotype of gbb¹

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing vein L5 phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of wing cell phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of submarginal wing cell phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of second posterior wing cell phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of discal wing cell phenotype of gbb⁴

(Khalsa et al., 1998)

dpp^d12 is an enhancer of second basal wing cell phenotype of gbb⁴

(Khalsa et al., 1998)

NOT Enhancer of

Statement

Reference

dpp^d12/dpp[+] is a non-enhancer of wing vein L5 | somatic clone phenotype of gbb¹

(Bangi and Wharton, 2006)

dpp^d12/dpp[+] is a non-enhancer of wing phenotype of Moe^C858

(Molnar and de Celis, 2006)

dpp^d12/dpp[+] is a non-enhancer of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

Suppressor of

Statement

Reference

dpp^d12 is a suppressor | partially of wing disc anterior compartment | larval stage phenotype of Scer\GAL4^hh-Gal4, hh^UAS.cIa

(Gore et al., 2021)

dpp^d12 is a suppressor of intestinal stem cell | increased number | adult stage phenotype of mir-958^KO

(Mukherjee et al., 2021)

dpp^d12/dpp[+] is a suppressor of eye disc phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d12/dpp[+] is a suppressor of glial cell phenotype of spin¹⁰⁴⁰³

(Yuva-Aydemir et al., 2011)

dpp^d12 is a suppressor of arista | increased number phenotype of obk¹

(Atallah et al., 2004)

dpp^d12 is a suppressor of eye phenotype of upd1^GMR.PB

(Bach et al., 2003)

dpp^d-ho/dpp^d12 is a suppressor of eye phenotype of CycE^JP

(Horsfield et al., 1998)

dpp^d5/dpp^d12 is a suppressor | partially of phenotype of ptc¹⁶/ptc^G20

(Capdevila et al., 1994)

NOT Suppressor of

Statement

Reference

dpp^d12/dpp[+] is a non-suppressor of wing phenotype of Moe^C858

(Molnar and de Celis, 2006)

dpp^d12/dpp[+] is a non-suppressor of wing phenotype of I-2^{UAS.Tag:polyHis,Tag:MYC}, Scer\GAL4^vg.PM, put^UAS.cMa

(Bennett et al., 2003)

dpp^d12 is a non-suppressor of eye phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

dpp^d12 is a non-suppressor of eye photoreceptor cell phenotype of Scer\GAL4^hs.2sev, Tak1^UAS.cMa

(Mihaly et al., 2001)

Other

Statement

Reference

dpp^d5/dpp^d12, ix¹ has terminalia phenotype

(Chatterjee et al., 2015)

BacA\p35^UAS.cHa, Scer\GAL4^Tub.PU, dpp^d12 has wing disc | somatic clone phenotype

(Perez-Garijo et al., 2005)

Bar¹, dpp^d6/dpp^d12 has third segment of antenna phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has second segment of antenna phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has leg sensillum phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has antennal segment 2 sense organ phenotype

(Mandal and Lakhotia, 1999)

Bar¹, dpp^d6/dpp^d12 has antennal segment 3 sense organ phenotype

(Mandal and Lakhotia, 1999)

dpp^d12, gbb⁴/gbb¹ has prothoracic tarsal segment | male phenotype

(Khalsa et al., 1998)

dpp^d12, gbb¹ has prothoracic tarsal segment | male phenotype

(Khalsa et al., 1998)

dpp^d12, gbb⁴ has prothoracic tarsal segment | male phenotype

(Khalsa et al., 1998)

dpp^d12, nub¹ has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12, nub² has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub¹ has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dpp^d12/dpp^s8, nub² has wing phenotype

(Cifuentes and Garcia-Bellido, 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has antenna phenotype

(Jackson et al., 1997)

dally[+]/dally⁰⁶⁴⁶⁴, dpp^d12 has eye phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has eye phenotype

(Jackson et al., 1997)

dally^ΔP-188, dpp^d12/dpp[+] has antenna phenotype

(Jackson et al., 1997)

Additional Comments

Genetic Interactions

Statement

Reference

A high frequency of tumour growth occurs below the anal plates of the terminalia in chromosomally female flies homozygous for ix¹ and trans-heterozygous for dpp^d5/dpp^d12.

(Chatterjee et al., 2015)

The glial overmigration phenotype seen in spin¹⁰⁴⁰³ eye discs is significantly suppressed if the animals are also heterozygous for dpp^d12.

(Yuva-Aydemir et al., 2011)

sax¹/+ enhances the trans-heterozygous dpp^d12 Df(2L)JS17 phenotype characterised by missing tarsal claws and abnormal wing venation.

(Twombly et al., 2009)

gbb¹, dpp^d12/+ clones induced in the anterior of the wing leads to a greater loss of the L4-L5 intervein than gbb¹ clones but no greater loss of the L5 wing vein.

The wing pouch of dpp^d12/dpp^hr56 wing discs is reduced to essentially a dorsal/ventral margin with no detectable vein primordia.

(Bangi and Wharton, 2006)

The wing defects seen in Moe^c858 homozygotes are unnaffected by dpp^d12/+.

(Molnar and de Celis, 2006)

The reduced size of the capitellum seen in dpp^d5/dpp^d12 adults is partially suppressed by Ubx¹³⁰/+.

(de Navas et al., 2006)

dpp^d12 heterozygosity does not reduce animal size when dally^{sec.Scer\UAS.T:Hsap\MYC} is driven by Scer\GAL4^29BD.

(Takeo et al., 2005)

The small size of dpp^d-blk/dpp^d12 eye discs is partially rescued by eya^Scer\UAS.cBa expressed under the control of Scer\GAL4^dpp.blk1 and greater numbers of developing ommatidia are seen.

(Curtiss and Mlodzik, 2000)

brk^M68 clones induced in a dpp^d8/dpp^d12 background lead to outgrowths of wing blade material indicating that normal target gene activation occurs without normal dpp levels.

(Jazwinska et al., 1999)

The severity of the leg defects seen in dpp^d6/dpp^d16 flies is enhanced by B¹. There is an overall shortening in length along the proximal-distal axis of the leg and complete or partial fusion or even total loss of tarsal segments. The tibia and femur are deformed, showing shortening, bulging and disorganised bristle patterns. The coxa and trochanter are not so strongly affected. The sex comb of the prothoracic leg, when present, is always duplicated in these flies. The antenna phenotype of dpp^d6/dpp^d16 flies is enhanced by B¹; the arista, 4th and 5th segments are completely absent and the 2nd and 3rd segments are widened and deformed and have defects in the bristle pattern. B¹ ; dpp^d6/dpp^d16 flies completely lack ommatidia. All B¹ ; dpp^d6/dpp^d16 males completely lack external genitalia.

(Mandal and Lakhotia, 1999)

The gbb⁴/gbb⁴ and gbb¹/gbb⁴ phenotypes are dominantly enhanced by dpp^d12; there is a greater loss of wing vein L4, wing vein L2 and the anterior crossvein than in gbb single mutant flies. There is also loss of intervein tissue, especially between veins L2 and L3 and between veins L4 and L5, resulting in a reduction in the size of the wing. A gap at the distal end of vein L3 is seen in 3% of cases. A reduction in the loss of wing vein L5 is seen in these flies. Viability is reduced. gbb¹ dpp^d12/gbb⁴ + flies show truncations and/or fusions of the distal-most tarsal segments of the male prothoracic leg.

(Khalsa et al., 1998)

Double mutant clones with nub¹ or nub² cause dramatic reduction of cell number in the wing pouch.

(Cifuentes and Garcia-Bellido, 1997)

Flies heterozygous for both dally⁰⁶⁴⁶⁴ and dpp^d12 show eye and antenna abnormalities.

(Jackson et al., 1997)

dpp^d12 Pka-C1^E95 also fail to form veins in the anterior compartment.

(Jiang and Struhl, 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

dpp^d5/dpp^d12 is rescued by dpp^αTub84B.PG

(Gorfinkiel et al., 2003)

Partially rescued by

dpp^d14/dpp^d12 is partially rescued by dpp^UAS.E.EGFP/Scer\GAL4^dpp.blk1

(Entchev et al., 2000)

dpp^d12/dpp^d8 is partially rescued by dpp^UAS.T.EGFP/Scer\GAL4^dpp.blk1

(Teleman and Cohen, 2000)

Not rescued by

dpp^d14/dpp^d12 is not rescued by dpp^TnJMB7

(Masucci et al., 1990)

Comments

Expression of dpp^αTub84B.PG in clones in the male terminalia in a dpp^d5/dpp^d12 background results in the recovery of terminal structures. The degree of recovery depends on the developmental stage at which the clone is induced. Recovery of terminal structures is accompanied by reduced penis apparatus duplications. The rescue is non-autonomous.

(Gorfinkiel et al., 2003)

dpp^{Scer\UAS.T.T:Avic\GFP-EGFP} rescues the wing phenotype of dpp^d8/dpp^d12 flies when expressed under the control of Scer\GAL4^dpp.blk1; wing size and pattern are almost normal except that ectopic vein material is seen near vein 3 and the spacing between veins 3 and 4 is slightly increased.

(Teleman and Cohen, 2000)

Belongs to the disk-V class of alleles.

(St. Johnston et al., 1990)

Allele class: d-V

Images (0)

Mutant

Wild-type

Stocks (3)

2070

106650

101482

Notes on Origin

Discoverer

Comments

dpp class V allele.

(Segal and Gelbart, 1985)

Two copies fail to rescue defects of class V heterozygote dpp^d12/dpp^d14, individuals fail to form cuticle, most do not eclose from the pupal case, those that do have near full size wings and some legs are missing tarsal segments.

(Masucci et al., 1990)

Lacks disc function and retains shortvein function.

(Jiang and Struhl, 1995)

Remove most or all of the imaginal disc function of dpp.

(Lecuit et al., 1996)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Dpp12

(Van De Bor et al., 2015)

Dpp¹²

(Yuva-Aydemir et al., 2011)

Dpp^d12

(Dalui et al., 2020)

d12

(Stultz et al., 2005)

dpp¹²

(Li et al., 2013, Curtiss and Mlodzik, 2000, Chen et al., 1999, Sanchez et al., 1997, Segal and Gelbart, 1985)

dpp^D12

(Perez-Garijo et al., 2005, Mihaly et al., 2001, Moreno and Morata, 1999)

Name Synonyms

Secondary FlyBase IDs

References (83)

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