v(2)k16105, Female-lethal (2)d, female-lethal(2)d
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.50
2.5 (northern blot); 2.2 (longest cDNA)
539, 412 (aa); 80 (kD observed); 59 (kD predicted)
The protein contains stretches of histidine (H) and glutamine (Q) residues, which may account for the discrepancy between the predicted and observed sizes of the protein.
Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755). The MAC subcomplex is composed of Ime4/Mettl3 and Mettl14 (PubMed:29535189, PubMed:29555755). The MACOM subcomplex is composed of fl(2)d, Flacc/Xio, Hakai, vir, and, in some cases of nito (PubMed:27919077, PubMed:28675155, PubMed:29535189, PubMed:29555755). Interacts with vir and msk (PubMed:12444081). Part of a complex containing fl(2)d, Sxl and vir (PubMed:12444081).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fl(2)d using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\fl(2)d in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: fl(2)d v(2)k16105
Nonsense-mediated mRNA decay (NMD) down-regulates a distinct splice isoform(s) of this gene.