FlyBase Gene Report: Dmel\fw

General Information

Symbol

Dmel\fw

Species

D. melanogaster

Name

furrowed

Annotation Symbol

CG1500

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001083

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

wr, wrinkled

Key Links

Genomic Location

Cytogenetic map

11A1-11A1

Sequence location

X:11,992,915..12,003,914 [-]

Recombination map

1-38

RefSeq locus

NC_004354 REGION:11992915..12003914

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables carbohydrate binding

inferred from sequence or structural similarity with FLYBASE:Lectin-galC1; FB:FBgn0016675

(Tanji et al., 2006)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Chin and Mlodzik, 2013)

involved_in homophilic cell-cell adhesion

inferred from direct assay

(Chin and Mlodzik, 2013)

involved_in imaginal disc-derived wing hair organization

inferred from mutant phenotype

(Chin and Mlodzik, 2013)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Leshko-Lindsay and Corces, 1997)

involved_in protein stabilization

inferred from mutant phenotype

(Chin and Mlodzik, 2013)

involved_in sensory organ development

inferred from mutant phenotype

(Leshko-Lindsay and Corces, 1997)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in apical junction complex

inferred from direct assay

(Chin and Mlodzik, 2013)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

furrowed (fw) encodes a selectin that mediates the interaction of planar cell polarity proteins by stabilizing the product of fz. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

C-TYPE LECTIN-LIKE -: C-type lectins are Ca²⁺-dependent carbohydrate-binding proteins. They possess a C-type lectin fold, that is also present in proteins that do not bind carbohydrates. (Adapted from PMID:20301263.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

fw: furrowed

Eyes with vertical fold and furrows. Head and scutellum shortened. Bristles gnarled and shortened, especially the postscutellars. Best classification character is short, blunt notopleurals. RK2. Phenotype can become nearly wild type on inbreeding (Lefevre).

*fw2

Extreme fw. Female sterile. RK2A.

fw34e

Originally showed eye surface medium folded; bristles much gnarled. Schultz and Curry report that stock in 1940 showed gnarled bristles and eye small but no vertical fold. RK2.

fw49c

Eyes furrowed; distal portions of aristal branches hooked; wings divergent and often stringy; scutellar groove reduced. Bristles split, bent, and often erect; acrostichal hair pattern distributed with whorls and naked areas. Late hatching, poorly viable, and mostly sterile. fw49c/fw phenotypically intermediate but more like fw/fw than fw49c/fw49c. RK3.

fw59

Eyes rough and creased; facets irregular, 15% fewer than normal. Eyes browner than normal; pterine concentration reduced in the eyes and, except for isoxanthopterine, increased in testis sheath. Riboflavin accumulates in Malpighian tubules. Large bristles of head and thorax short, thick, angled, blunt, and occasionally reduced to stumps. Arista thick with contorted and supernumerary branches. Scutellum small with groove between it and thorax reduced. Hatchability and larval development normal; larval anal plates swollen and surrounded by melanotic halo. Melanotic anal region persists in pupa; pupa also has melanotic spots elsewhere that may result in nonpigmented areas on the imaginal integument. Extrusion of anterior and posterior spiracles in prepupa incomplete. Many fw59 flies die either after 24-30 hr of pupal development or at the time of eclosion. Fecundity of female reduced owing to reduced number of ovarioles. RK2.

fw60

Like fw59 but with lower penetrance and expressivity. RK2.

*fww: furrowed-weak

Affects only bristles, particularly the scutellars and postalars. Eyes normal. Normal fertility and viability. RK2.

fwwr: furrowed-wrinkled

Eye surface in folds. Some bristles shortened, thickened, or curved; many doubled and may be fused. Viability low. RK2.

Summary (Interactive Fly)

selectin (carbohydrate binding protein) - mutants have defects in eye patterning and in cell determination of the ommatidia and bristles - mediates intercellular planar cell polarity interactions via Frizzled stabilization

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\fw for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VYR4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

fw-RA

FBtr0073580

NM_078581

4698

1174

fw-RB

FBtr0112806

NM_001103491

3938

755

fw-RC

FBtr0342733

NM_001298217

4318

1174

Additional Transcript Data and Comments

Reported size (kB)

4.5, 4.0 (northern blot)

(Leshko-Lindsay and Corces, 1997)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

fw-PA

FBpp0073424

128.1

1174

5.59

FBpp0111718

82.2

755

5.28

FBpp0309601

128.1

1174

5.59

Q9VYR4

NP_001285146

AHN59616

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1174 aa isoforms: fw-PA, fw-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

974 (aa); 110 (kD observed)

(Leshko-Lindsay and Corces, 1997)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\fw using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.85

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Leshko-Lindsay and Corces, 1997)

first instar larval stage -- third instar larval stage

embryonic/larval proventriculus | restricted

(Leshko-Lindsay and Corces, 1997)

larval brain | restricted

(Leshko-Lindsay and Corces, 1997)

Additional Descriptive Data

The 4.0 and 4.5 kb fw transcripts are detected in all developmental stages.

(Leshko-Lindsay and Corces, 1997)

fw transcript is expressed in all imaginal discs. In the eye imaginal disc, expression is strongest in the dorsal and ventral margins. In the wing disc, expression is higher in cells of the prospective dorsal and ventral wing surfaces, ventral pleura and the notum. All cells in the haltere, leg, antennal, labial, clypeo-labral, humeral and genital discs express fw. Lower levels of fw expression are also seen in parts of the digestive system, the proventriculus, the gastric caecae, and parts of the larval brain.

(Leshko-Lindsay and Corces, 1997)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage -- third instar larval stage

embryonic/larval proventriculus | restricted

(Leshko-Lindsay and Corces, 1997)

larval brain | restricted

(Leshko-Lindsay and Corces, 1997)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

The pattern of fw protein expression closely matches that of fw transcript expression. fw protein accumulates in all imaginal discs, in the pattern seen for fw transcript. Additional strong staining is seen in posterior to the morphogenetic furrow in the eye disc. fw protein is also expressed in parts of the digestive system, the proventriculus, and the gastric caecae, as well as in the larval brain.

(Leshko-Lindsay and Corces, 1997)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical junction complex

inferred from direct assay

(Chin and Mlodzik, 2013)

Expression Deduced from Reporters

Reporter: P{GawB}fw^POc2.1

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye | restricted

(Mollereau et al., 2000)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\fw in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\fw

View exonic expression by tissue for Dmel\fw

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001083

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001083

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001083

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001083

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1500

Flygut - An atlas of the Drosophila adult midgut

FBgn0001083

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 29 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of fw

Transgenic constructs containing regulatory region of fw

Aberrations (Deficiencies and Duplications) ( 24 )

Inferred from experimentation ( 24 )

Gene not disrupted in

Df(1)244

(Patterson, 1932)

Df(1)247a

(Patterson, 1932)

Df(1)KA6

(Craymer and Roy, 1980)

Df(1)RA47

(Craymer and Roy, 1980)

T(1;2)v^267-4

Gene not duplicated in

Dp(1;2)m^v

(Lefevre, 1969)

Dp(1;Y)y⁺v⁺Bar^S#3

(Schalet, 1969)

Gene duplicated in

Dp(1;2)v⁺63i

(Lefevre, 1981)

Dp(1;2)v⁺65b

(Lefevre, 1981, Lefevre, 1969)

Dp(1;3)DC247

(Popodi et al., 2010-, Venken et al., 2010)

Dp(1;Y)BSC1

(Cook et al., 2010, Gornek et al., 2000.2.4)

Dp(1;Y)BSC2

(Cook et al., 2010, Gornek et al., 2000.2.4)

Tp(1;2)v⁺65b

(Craymer and Roy, 1980)

Inferred from location ( 27 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | female | pupal stage

fw^34e

partially lethal

partially lethal | female

fw⁶⁷

partially lethal | male

fw⁶⁷

partially lethal - majority die, with Scer\GAL4^pnr-MD237

fw^GD3327

partially lethal - majority live

fw^wr

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

fw^GD3327

viable, with Scer\GAL4^Mef2.PR

fw^GD3327

viable, with Scer\GAL4^tin.CΔ4

fw^GD3327

Sterility

Allele

female fertile

fw⁶⁷

female sterile

fertile

fw^w

male fertile

semi-fertile

fw^51h

sterile

fw^49c

Other Phenotypes

Allele

abnormal eye color

fw⁵⁹

abnormal planar polarity

abnormal planar polarity, with Scer\GAL4^en.PU

fw^GD3327

abnormal planar polarity, with Scer\GAL4^sev.PU

fw^GD3327

abnormal planar polarity | somatic clone

fw⁴²

decreased fecundity | female

fw⁵⁹

some die during pupal stage, with Scer\GAL4^pnr-MD237

fw^GD3327

visible

visible, with Scer\GAL4^pnr-MD237

fw^GD3327

visible, with Scer\GAL4^sev.PU

fw^GD3327

visible | recessive

fw^wr

wild-type

fw^+t12.7

Phenotype manifest in

Allele

acrostichal bristle

fw^49c

adult head

arista

chaeta

fw⁴²

chaeta, with Scer\GAL4^pnr-MD237

fw^GD3327

cone cell

fw^U2

embryonic/larval anal pad

fw⁵⁹

eye

eye & macrochaeta

eye photoreceptor cell

eye photoreceptor cell, with Scer\GAL4^sev.PU

fw^GD3327

interommatidial bristle

lamina

fw^U2

macrochaeta

Malpighian tubule

fw⁵⁹

mesonotum

fw⁴²

mesonotum, with Scer\GAL4^pnr-MD237

fw^GD3327

microchaeta

notopleural bristle

fw¹

ommatidium

ommatidium, with Scer\GAL4^sev.PU

fw^GD3327

ovariole

fw⁵⁹

pigment cell

postalar bristle

fw^w

posterior scutellar bristle

fw¹

pupal spiracle

fw⁵⁹

retina

scutellar bristle

fw^w

scutellum

scutoscutellar suture

testis sheath

fw⁵⁹

trichogen cell, with Scer\GAL4^pnr-MD237

fw^GD3327

trichome

fw⁴²

trichome, with Scer\GAL4^pnr-MD237

fw^GD3327

wing

wing hair

fw⁴²

wing hair, with Scer\GAL4^en.PU

fw^GD3327

wing vein

fw⁶⁸

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (15)

Hsap\CR1

6 of 14

Yes

Hsap\SVEP1

5 of 14

Yes

Hsap\C4BPA

4 of 14

Yes

Hsap\CR1L

4 of 14

Yes

Hsap\CSMD2

4 of 14

Yes

Hsap\CSMD3

4 of 14

Yes

Hsap\CSMD1

3 of 14

Yes

Hsap\CR2

2 of 14

Hsap\SELE

2 of 14

Yes

Hsap\SELL

2 of 14

Hsap\SELP

2 of 14

Hsap\CD55

1 of 14

Yes

Hsap\FCER2

1 of 14

Hsap\LAYN

1 of 14

Yes

Hsap\MRC1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Csmd1

5 of 14

Yes

Rnor\Svep1

5 of 14

Yes

Rnor\Cr1l

4 of 14

Yes

Rnor\Cr2

4 of 14

Yes

Rnor\C4bpa

3 of 14

Yes

Rnor\Csmd2

3 of 14

Yes

Rnor\Zp3r

3 of 14

Yes

Rnor\Cfh

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Srpx

1 of 14

Yes

Mus musculus (laboratory mouse) (15)

Mmus\Svep1

6 of 14

Yes

Mmus\Csmd1

4 of 14

Yes

Mmus\Csmd2

4 of 14

Yes

Mmus\Csmd3

4 of 14

Yes

Mmus\Cr1l

3 of 14

Yes

Mmus\C4bp

2 of 14

Yes

Mmus\Cr2

2 of 14

Mmus\Zp3r

2 of 14

Yes

Mmus\Cd69

1 of 14

Yes

Mmus\Cfhr4

1 of 14

Yes

Mmus\F13b

1 of 14

Yes

Mmus\Pamr1

1 of 14

Yes

Mmus\Sele

1 of 14

Mmus\Sell

1 of 14

Mmus\Selp

1 of 14

Xenopus tropicalis (Western clawed frog) (36)

Xtro\svep1

4 of 13

Yes

Xtro\csmd2

3 of 13

Yes

Xtro\csmd3

3 of 13

Yes

Xtro\selp

3 of 13

Yes

Xtro\csmd1

2 of 13

Yes

Xtro\fucolectinloc100491211

2 of 13

Yes

Xtro\LOC100498436

2 of 13

Yes

Xtro\sell

2 of 13

Yes

Xtro\arc3

1 of 13

Xtro\asgr1

1 of 13

Xtro\c2

1 of 13

Yes

Xtro\c4bpa

1 of 13

Xtro\cfb

1 of 13

Yes

Xtro\clec4e

1 of 13

Xtro\clec4m

1 of 13

Xtro\fucolectin

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100493885

1 of 13

Yes

Xtro\LOC100494969

1 of 13

Xtro\LOC100496324

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (78)

Drer\svep1

5 of 14

Yes

Drer\csmd2

3 of 14

Yes

Drer\csmd3a

3 of 14

Yes

Drer\sele

3 of 14

Yes

Drer\selp

2 of 14

Yes

Drer\si:ch211-215k15.4

2 of 14

Yes

Drer\zgc:171424

2 of 14

Yes

Drer\bfb

1 of 14

Yes

Drer\cfb

1 of 14

Yes

Drer\cfbl

1 of 14

Yes

Drer\csmd1a

1 of 14

Yes

Drer\csmd3b

1 of 14

Yes

Drer\LOC100149796

1 of 14

Yes

Drer\LOC100331987

1 of 14

Yes

Drer\LOC100334521

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\rca2.2

1 of 14

Yes

Drer\sez6a

1 of 14

Yes

Drer\sez6b

1 of 14

Yes

Drer\sez6l2

1 of 14

Yes

Drer\si:cabz01083838.1

1 of 14

Drer\si:ch73-217n20.1

1 of 14

Yes

Drer\si:ch73-335d12.2

1 of 14

Drer\si:ch73-359m17.2

1 of 14

Yes

Drer\si:ch211-63p21.3

1 of 14

Drer\si:ch211-63p21.4

1 of 14

Drer\si:ch211-125e6.5

1 of 14

Drer\si:ch211-125e6.11

1 of 14

Drer\si:ch211-225k7.3

1 of 14

Drer\si:ch211-225k7.4

1 of 14

Drer\si:ch211-225k7.5

1 of 14

Drer\si:ch211-225k7.6

1 of 14

Drer\si:ch211-272h9.3

1 of 14

Drer\si:ch211-282j17.2

1 of 14

Drer\si:ch211-282j17.3

1 of 14

Drer\si:ch211-282j17.5

1 of 14

Drer\si:ch211-282j17.8

1 of 14

Drer\si:ch211-282j17.10

1 of 14

Drer\si:ch211-282j17.11

1 of 14

Drer\si:ch1073-376c22.1

1 of 14

Yes

Drer\si:dkey-11o15.4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-83f18.10

1 of 14

Drer\si:dkey-83f18.11

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-88n24.10

1 of 14

Drer\si:dkey-187j14.6

1 of 14

Yes

Drer\si:dkey-192d15.3

1 of 14

Drer\si:dkeyp-75b4.10

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\C54G4.4

6 of 14

Yes

Cele\lev-9

3 of 14

Cele\cfh-1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (5)

Agam\CTLSE1

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:fw. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

CG9095

6 of 13

Hasp

4 of 13

hig

2 of 13

CG12111

1 of 13

lectin-37Da

1 of 13

Sfp24F

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CR1; complement C3b/C4b receptor 1 (Knops blood group)

6 of 14

120620

SVEP1; sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

5 of 14

611691

C4BPA; complement component 4 binding protein alpha

4 of 14

120830

CR1L; complement C3b/C4b receptor 1 like

4 of 14

605886

CSMD2; CUB and Sushi multiple domains 2

4 of 14

608398

CSMD3; CUB and Sushi multiple domains 3

4 of 14

608399

CSMD1; CUB and Sushi multiple domains 1

3 of 14

608397

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

fw - fz

anti tag coimmunoprecipitation, anti tag western blot

(Chin and Mlodzik, 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chin and Mlodzik, 2013)

suppressible

stan

(Chin and Mlodzik, 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chin and Mlodzik, 2013)

sog

enhanceable

(Araujo et al., 2003)

stan

enhanceable

(Chin and Mlodzik, 2013)

Vang

enhanceable

(Chin and Mlodzik, 2013)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0001083

MIST (genetic) - An integrated Molecular Interaction Database

32162

MIST (protein-protein) - An integrated Molecular Interaction Database

32162

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-38

Cytogenetic map

11A1-11A1

Sequence location

X:11,992,915..12,003,914 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11A1-11A1

Limits computationally determined from genome sequence between P{EP}ATP7^EP308 and P{EP}EP1451&P{EP}EP1629

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

11A4-11A4

(Leshko-Lindsay, 1996.9.13)

Experimentally Determined Recombination Data

Location

1-38

(FlyBase, 2016)

1-37.1

(Comeron et al., 2012)

1-36.84

(Konrad et al., 1998)

1-36.85

(Lefevre, 1970)

1-38.3

(Kaufman, 1969, Edmondson, 1952, Hannah, 1952, Mickey, 1952)

Left of (cM)

Right of (cM)

(Konrad et al., 1998)

(Valencia, 1959)

Notes

97 of 129 recombinants between m and fw ocurred distal to cac. 5 of 8 recombinants between cac and fw were distal to gd. 2 of 10 gd/fw recombinants were distal to tsg.

(Konrad et al., 1998)

Stocks and Reagents

Stocks (17)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

141

v² fw¹

166

w^t fw¹

194

y^2S fw^34e

26620

w^* P{EP}fw^G1522

28307

y¹ v¹; P{TRiP.JF02938}attP2

38975

y¹ v¹; P{TRiP.HMS01891}attP40

Korea

10804

P{EP}fw^G1522

Kyoto

105755

v² fw¹

105764

w^t fw¹

105781

y^2S fw^34e

VDRC

v106656

P{KK109200}VIE-260B

v39575

w¹¹¹⁸; P{GD3327}v39575/TM3

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE10878

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001083

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001083

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Leshko-Lindsay and Corces, 1997)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

fw mutational analysis suggests the product is necessary for viability and is involved in wing morphogenesis and cell determination events within sensory organs.

(Leshko-Lindsay and Corces, 1997)

Eight new alleles of fw were generated in a screen for X-linked mutations affecting bristle morphology.

(Cant and Cooley, 1996)

Relationship to Other Genes

Source for database merge of

Additional comments

"l(1)G0214" may affect "fw".

(Peter et al., 2002)

Nomenclature History

Source for database identify of

Source for identity of: fw CG1500

(Zheng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG1500

(Lu et al., 2020, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Wu and Silverman, 2007)

CT3745

(Hynes and Zhao, 2000)

(Koca et al., 2022, Wang et al., 2022)

(Transgenic RNAi Project members, 2017-, Chin and Mlodzik, 2013, Legent et al., 2012, Cook et al., 2010, Popodi et al., 2010-, Venken et al., 2010, Christensen et al., 2008.6.11, Christensen et al., 2008.6.11, Christensen et al., 2008.6.11, Beltran et al., 2007, Buszczak et al., 2007, Tanji et al., 2006)

fw-like

(Hynes and Zhao, 2000)

(Valencia, 1959)

Name Synonyms

Furrowed

(Chin and Mlodzik, 2013)

furrowed

(Legent et al., 2012, Aonuma et al., 2007, Wu and Silverman, 2007)

wrinkled

(Valencia, 1959)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 57 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32162

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VYR4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VYR4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001083

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32162/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001083

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001083

FlyMine - An integrated database for Drosophila genomics

FBgn0001083

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1500

MARRVEL_MODEL - MARRVEL (model organism gene)

32162

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001083

DroID - A comprehensive database of gene and protein interactions.

FBgn0001083

DRSC - Results frm RNAi screens

FBgn0001083

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001083

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001083

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1500

Flygut - An atlas of the Drosophila adult midgut

FBgn0001083

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0001083

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC030754

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

32162

MIST (protein-protein) - An integrated Molecular Interaction Database

32162

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (94)

The following external sites may use different assemblies or annotations than FlyBase.

-0.85

Report Sections