FlyBase Gene Report: Dmel\Mdr49

General Information

Symbol

Dmel\Mdr49

Species

D. melanogaster

Name

Multi drug resistance 49

Annotation Symbol

CG3879

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004512

Gene Model Status

Current

Stock Availability

10 publicly available

Enzyme Name (EC)

ABC-type xenobiotic transporter (7.6.2.2)

Gene Summary

Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. [Date last reviewed: 2018-09-06] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Mes5

Key Links

Genomic Location

Cytogenetic map

49E1-49E4

Sequence location

2R:12,940,323..12,946,347 [-]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12940323..12946347

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (7 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

enables ABC-type transporter activity

inferred from electronic annotation with InterPro:IPR011527

(InterPro Project Members, 2004-)

enables ABC-type xenobiotic transporter activity

inferred from sequence or structural similarity with UniProtKB:Q00748

(Gene Ontology Curators, 2002-)

enables ATP binding

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR011527, InterPro:IPR017871, InterPro:IPR036640

(InterPro Project Members, 2004-)

enables ATP hydrolysis activity

inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871

(InterPro Project Members, 2004-)

enables ATPase-coupled transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(GO Reference Genome Project, 2011-)

enables efflux transmembrane transporter activity

inferred from sequence or structural similarity with UniProtKB:Q00748

(Gene Ontology Curators, 2002-)

enables xenobiotic transmembrane transporter activity

non-traceable author statement

(Wu et al., 1991)

Biological Process (8 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in germ cell migration

inferred from mutant phenotype

(Ricardo and Lehmann, 2009)

involved_in renal tubular secretion

inferred from expression pattern

(Chahine and O'Donnell, 2009)

involved_in response to hypoxia

inferred from expression pattern

(Azad et al., 2009)

inferred from mutant phenotype

(Azad et al., 2009)

involved_in response to insecticide

inferred from mutant phenotype

(Denecke et al., 2017)

involved_in response to toxic substance

inferred from expression pattern

(Chahine and O'Donnell, 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in transmembrane transport

inferred from biological aspect of ancestor with PANTHER:PTN000657189

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR011527

(InterPro Project Members, 2004-)

involved_in xenobiotic transmembrane transport

non-traceable author statement

(Wu et al., 1991)

involved_in xenobiotic transport

inferred from sequence or structural similarity with UniProtKB:Q00748

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

part_of ATP-binding cassette (ABC) transporter complex

inferred from sequence or structural similarity with UniProtKB:Q00748

(Gene Ontology Curators, 2002-)

is_active_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN002517083

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from electronic annotation with InterPro:IPR011527, InterPro:IPR036640

(InterPro Project Members, 2004-)

located_in plasma membrane

non-traceable author statement

(Wu et al., 1991)

inferred from sequence or structural similarity with UniProtKB:Q00748

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS

Protein Family (UniProt)

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (Q00449)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ABC-type xenobiotic transporter activity

ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2 (7.6.2.2)

RHEA 33147: ATP hydrolysis activity
RHEA 13065:

Summaries

Gene Snapshot

Multi drug resistance 49 (Mdr49) encodes drug transmembrane transporter that belongs to the ABCB transporter subfamily and contributes to insecticide resistance. [Date last reviewed: 2018-09-06]

Gene Group (FlyBase)

ABCB ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY - FULL TRANSPORTERS -: The ATP-binding cassette (ABC) transporter family are primary active transporters that use ATP hydrolysis to drive the transport of substrates across the membrane. The ABCB full transporters encode the functional transporter in one polypeptide. (Adapted from FBrf0224053).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Mdr49 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q00449)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Mdr49-RA

FBtr0087801

NM_079000

4240

1302

Mdr49-RB

FBtr0302198

NM_001169661

3624

1101

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Mdr49-PA

FBpp0086914

142.7

1302

6.69

FBpp0291408

120.6

1101

7.21

E1JH49

NP_001163132

ACZ94407

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mdr49 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.50

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

head mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

trunk mesoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 5

mesoderm anlage

(Stathopoulos et al., 2002)

embryonic stage 5 -- 10

mesoderm

(Ricardo and Lehmann, 2009)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

trunk mesoderm

(Fisher et al., 2012)

wandering third instar larval stage

larval brain | restricted

(Tapadia and Lakhotia, 2005)

wing disc | restricted

(Tapadia and Lakhotia, 2005)

Additional Descriptive Data

Mdr49 expression is seen in mesodermal tissues.

(Ricardo and Lehmann, 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Mdr49 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Mdr49

View exonic expression by tissue for Dmel\Mdr49

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004512

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36428/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004512

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004512

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004512

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3879

Flygut - An atlas of the Drosophila adult midgut

FBgn0004512

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Mdr49

Stages(s) 4-6
Stages(s) 7-8

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Mdr49

Transgenic constructs containing regulatory region of Mdr49

Aberrations (Deficiencies and Duplications) ( 13 )

Inferred from experimentation ( 13 )

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Mdr49^GD542

viable, with Scer\GAL4^Mef2.PR

Mdr49^GD542

viable, with Scer\GAL4^pnr-MD237

Mdr49^GD542

viable, with Scer\GAL4^tin.CΔ4

Mdr49^GD542

Other Phenotypes

Allele

increased mortality during development

Mdr49^KO

Phenotype manifest in

Allele

germline cell | embryonic stage 14

Mdr49^KG08611

ovariole

Mdr49^MB04959

ovariole, with Scer\GAL4^bab1-Pgal4-2

Mdr49^KK106585

ovariole, with Scer\GAL4^tj.PU

Mdr49^KK106585

primordial germ cell

primordial germ cell (with Df(2R)Exel7123)

primordial germ cell (with Mdr49^KG08611)

Mdr49^δ3.16

primordial germ cell (with Mdr49^δ3.16)

Mdr49^KG08611

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (26)

Hsap\ABCB1

9 of 14

Yes

Hsap\ABCB4

9 of 14

Yes

Hsap\ABCB5

9 of 14

Yes

7 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Abcb1b

10 of 14

Yes

9 of 14

9 of 14

8 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (13)

Mmus\Abcb1b

10 of 14

Yes

9 of 14

9 of 14

9 of 14

7 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (18)

Xtro\LOC100485969

7 of 13

Yes

Xtro\LOC100494753

7 of 13

Yes

6 of 13

6 of 13

4 of 13

4 of 13

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (15)

Drer\abcb5

9 of 14

Yes

8 of 14

8 of 14

7 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tap1

1 of 14

Drer\tap2a

1 of 14

Drer\tap2t

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (36)

Cele\pgp-1

11 of 14

Yes

Cele\pgp-2

11 of 14

Yes

Cele\pgp-9

11 of 14

Yes

Cele\pgp-3

10 of 14

Yes

Cele\pgp-7

9 of 14

Yes

Cele\pgp-8

9 of 14

Yes

Cele\pgp-12

9 of 14

Yes

Cele\pgp-13

9 of 14

Yes

Cele\pgp-14

9 of 14

Yes

Cele\pgp-4

8 of 14

Cele\pgp-5

8 of 14

Yes

Cele\pgp-6

8 of 14

Yes

Cele\pgp-11

8 of 14

Yes

Cele\pgp-10

7 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP005639

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (46)

Atha\ABCB2

13 of 13

Yes

Atha\ABCB1

12 of 13

Yes

Atha\ABCB3

12 of 13

Yes

Atha\ABCB4

12 of 13

Yes

Atha\ABCB5

12 of 13

Yes

Atha\ABCB7

12 of 13

Yes

Atha\ABCB9

12 of 13

Yes

Atha\ABCB11

12 of 13

Yes

Atha\ABCB12

12 of 13

Yes

Atha\ABCB13

12 of 13

Yes

Atha\ABCB14

12 of 13

Yes

Atha\ABCB15

12 of 13

Yes

Atha\ABCB17

12 of 13

Yes

Atha\ABCB18

12 of 13

Yes

Atha\ABCB19

12 of 13

Yes

Atha\ABCB21

12 of 13

Yes

Atha\ABCB22

12 of 13

Yes

Atha\PGP10

12 of 13

Yes

Atha\ABCB16

11 of 13

Yes

Atha\ABCB6

8 of 13

Yes

Atha\ABCB20

7 of 13

Yes

Atha\AT3G30875

6 of 13

Yes

Atha\ABCB27

2 of 13

Atha\ABCB28

2 of 13

Yes

Atha\ABCI10

2 of 13

Atha\ABCI11

2 of 13

Yes

Atha\ABCI13

2 of 13

Yes

Atha\ABCI17

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (12)

Scer\STE6

7 of 13

Yes

3 of 13

3 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\pmd1

10 of 12

Yes

4 of 12

3 of 12

2 of 12

1 of 12

Escherichia coli (enterobacterium) (12)

Ecol\msbA

6 of 11

Yes

Ecol\mdlB

2 of 11

Ecol\cydD

1 of 11

Yes

Ecol\glnQ

1 of 11

Ecol\gsiA

1 of 11

Yes

1 of 11

1 of 11

1 of 11

1 of 11

Yes

Ecol\pstB

1 of 11

Yes

Ecol\ybhR

1 of 11

Ecol\yphE

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Mdr49. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (20)

11 of 13

11 of 13

10 of 13

5 of 13

4 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

ldd

1 of 13

osy

1 of 13

snu

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

ABCB4; ATP binding cassette subfamily B member 4

model of intrahepatic cholestasis of pregnancy 3

IEA

(FlyBase, 2019-)

model of cholecystitis

IEA

(FlyBase, 2019-)

model of progressive familial intrahepatic cholestasis 3

IEA

(FlyBase, 2019-)

ABCB1; ATP binding cassette subfamily B member 1

model of inflammatory bowel disease 13

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Mdr49^HMS00400

exacerbates neurodegenerative disease

modeled by Zzzz\CAG^{127Q.UAS.Tag:HA}

(Yadav and Tapadia, 2013)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ABCB1; ATP binding cassette subfamily B member 1

9 of 14

171050

inflammatory bowel disease 13

ABCB4; ATP binding cassette subfamily B member 4

9 of 14

171060

ABCB5; ATP binding cassette subfamily B member 5

9 of 14

611785

ABCB11; ATP binding cassette subfamily B member 11

7 of 14

603201

ABCB10; ATP binding cassette subfamily B member 10

3 of 14

605454

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Hmgcr

suppressible

Mdr49

(Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62198

DroID - A comprehensive database of gene and protein interactions.

FBgn0004512

MIST (genetic) - An integrated Molecular Interaction Database

36428

MIST (protein-protein) - An integrated Molecular Interaction Database

36428

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ABC transporters

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49E1-49E4

Sequence location

2R:12,940,323..12,946,347 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49E1-49E4

Limits computationally determined from genome sequence between P{PZ}l(2)01424⁰¹⁴²⁴ and P{lacW}Psc^k07834&P{lacW}Su(z)2^k06344

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49E-49F

(determined by in situ hybridisation)

(Wu et al., 1991)

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016)

2-71.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

24312

w¹¹¹⁸; Mi{ET1}Mdr49^MB04959

53221

y¹ w^*; Mi{MIC}Mdr49^MI10165

54524

y¹ w^*; Mi{MIC}Mdr49^MI10307/SM6a

605030

y¹ sc^* v¹ sev²¹; P{TOE.GS03110}attP40

Kyoto

126262

w¹¹¹⁸; P{RS5}Mdr49^5-SZ-3972

NIG-Fly

3879R-2

P{NIG.3879R}2

HMJ22239

y¹ v¹; P{TRiP.HMJ22239}attP40/CyO

HMS00400

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00400}attP2

VDRC

v108327

P{KK106585}VIE-260B

v42514

w¹¹¹⁸; P{GD542}v42514

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (70)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD10012

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004512

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004512

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA has been made from templates generated with primers directed against this gene.

(Pilot et al., 2006)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG3879

(Wang et al., 2025, Wang et al., 2024, National Institute of Genetics Fly Stocks, 2023-, Paulsen et al., 2013, Ni et al., 2010.12.1, Chahine and O'Donnell, 2009, Keleman et al., 2009.8.5, Dean et al., 2001)

Dm5

(Allikmets et al., 1993)

DmMdr49

(He et al., 2019)

MDR49

(Diaz et al., 2025, Denecke, 2022.6.8, Denecke et al., 2022, Seong et al., 2016, Steele et al., 2015, Chahine and O'Donnell, 2009, Nasonkin et al., 1999)

MDR5

(Bassett et al., 1997)

Mes5

(Saunders et al., 2013, Stathopoulos et al., 2002)

mdr49

(Deshpande et al., 2023, Frat et al., 2023, Saini et al., 2020, Yadav and Tapadia, 2016, Jones and Macdonald, 2015, Yadav and Tapadia, 2013, Ricardo and Lehmann, 2009, Ricardo and Lehmann, 2009, Tapadia and Lakhotia, 2005)

mrd49

(Ricardo and Lehmann, 2009)

Name Synonyms

Multi drug resistance 49

(Radyuk et al., 2012)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

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External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36428

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q00449

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q00449

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

E1JH49

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q00449

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0004512

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36428/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004512

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004512

FlyMine - An integrated database for Drosophila genomics

FBgn0004512

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3879

MARRVEL_MODEL - MARRVEL (model organism gene)

36428

Linkouts

BioGRID - A database of protein and genetic interactions.

62198

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004512

DroID - A comprehensive database of gene and protein interactions.

FBgn0004512

DRSC - Results frm RNAi screens

FBgn0004512

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004512

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004512

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3879

Flygut - An atlas of the Drosophila adult midgut

FBgn0004512

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

ABC transporters

MIST (genetic) - An integrated Molecular Interaction Database

36428

MIST (protein-protein) - An integrated Molecular Interaction Database

36428

References (97)

The following external sites may use different assemblies or annotations than FlyBase.

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