FlyBase Gene Report: Dmel\shv

General Information

Symbol

Dmel\shv

Species

D. melanogaster

Name

shriveled

Annotation Symbol

CG4164

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031256

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

shriveled (shv) encodes a secreted protein that activates integrin signaling. It is involved in synapse maturation regulation and stem cell maintenance. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

21C2-21C2

Sequence location

2L:453,108..454,654 [+]

Recombination map

2-0.7

RefSeq locus

NT_033779 REGION:453108..454654

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables receptor ligand activity

inferred from direct assay

(Lee et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables misfolded protein binding

inferred from biological aspect of ancestor with PANTHER:PTN001181597

(GO Reference Genome Project, 2011-)

enables unfolded protein binding

inferred from biological aspect of ancestor with PANTHER:PTN001181597

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR008971

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in germ-line stem-cell niche homeostasis

inferred from mutant phenotype

(Lee et al., 2016)

involved_in male germ-line stem cell population maintenance

inferred from mutant phenotype

(Lee et al., 2016)

involved_in positive regulation of integrin-mediated signaling pathway

inferred from mutant phenotype

(Lee et al., 2017, Lee et al., 2016)

involved_in positive regulation of synapse maturation

inferred from mutant phenotype

(Lee et al., 2017)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in protein folding

inferred from electronic annotation with InterPro:IPR008971

(InterPro Project Members, 2004-)

involved_in protein maturation

inferred from biological aspect of ancestor with PANTHER:PTN001181597

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Lee et al., 2017, Lee et al., 2016)

located_in neuromuscular junction

inferred from direct assay

(Lee et al., 2017)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN001181597

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES

UNCLASSIFIED RECEPTOR LIGANDS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

shriveled (shv) encodes a secreted protein that activates integrin signaling. It is involved in synapse maturation regulation and stem cell maintenance. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

HEAT SHOCK PROTEIN 40/DNAJ CO-CHAPERONES -: The Heat Shock Protein 40 (Hsp40) family of co-chaperones are essential factors in the Hsp70 chaperone cycle. The Hsp40 family is diverse in size and structure, but a number of them are about 40kDa and have been identified as products of heat shock genes. Their defining feature is the DnaJ or J-domain corresponding to the N-terminal 70 amino acids of the Escherichia coli co-chaperone DnaJ. (Adapted from FBrf0173155).
UNCLASSIFIED RECEPTOR LIGANDS -: This group comprises receptor ligands that do not classify under other groups in FlyBase.

Protein Function (UniProtKB)

Maintains stem cell niche architecture in the testes. Activates an extracellular integrin beta-PS pathway which regulates DE-cadherin (shg) levels in somatic hub cells, and is essential for maintaining the number of germline stem cells and the structure and localization of hub cells.

(UniProt, Q9VPQ2)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\shv for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VPQ2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

shv-RA

FBtr0078060

NM_134681

1488

354

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

shv-PA

FBpp0077720

40.2

354

5.36

Q9VPQ2

NP_608525

AAF51493

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VPQ2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\shv using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG4164_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.18

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

garland cell primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval garland cell

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval salivary gland

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic/larval plasmatocyte

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

adult stage | male

male germline stem cell

(Lee et al., 2016)

(Lee et al., 2016)

(Lee et al., 2016)

(Lee et al., 2016)

(Lee et al., 2016)

Additional Descriptive Data

shv is ubiquitously expressed in several cell types in the male testis. Low levels are seen in hub cells, cyst progenitor cells and germline stem cells, and high levels are found in speratocytes and cyst cells.

(Lee et al., 2016)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

hub cell

(Lee et al., 2016)

cyst progenitor cell

(Lee et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Low levels of shv protein are observed in hub cells and in cyst progenitor cells.

(Lee et al., 2016)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in extracellular space

inferred from direct assay

(Lee et al., 2017, Lee et al., 2016)

located_in neuromuscular junction

inferred from direct assay

(Lee et al., 2017)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\shv in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\shv

View exonic expression by tissue for Dmel\shv

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031256

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33220/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031256

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031256

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031256

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4164

Flygut - An atlas of the Drosophila adult midgut

FBgn0031256

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\shv

Stages(s) 1-3
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of shv

Transgenic constructs containing regulatory region of shv

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal

shv⁹⁸⁰³

partially lethal - majority die | recessive

shv⁹⁸⁰³

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

shv^GD12785

viable, with Scer\GAL4^Mef2.PR

shv^GD12785

viable, with Scer\GAL4^pnr-MD237

shv^GD12785

viable, with Scer\GAL4^tin.CΔ4

shv^GD12785

Sterility

Allele

male sterile

shv¹

Other Phenotypes

Allele

abnormal neuroanatomy | third instar larval stage

shv¹

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^nSyb.PS

shv^KK101364

abnormal neurophysiology | third instar larval stage

shv¹

atrophy | adult stage

shv¹

decreased cell number | adult stage | male

shv¹

decreased cell number | adult stage | male (with shv¹)

decreased cell number | adult stage | male (with shv⁹⁸⁰³)

shv¹

decreased cell number | adult stage | male (with shv^c00496)

shv¹

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

shv^GD12785

Phenotype manifest in

Allele

cyst progenitor cell

shv¹

germinal proliferation center hub

germinal proliferation center hub (with shv¹)

germinal proliferation center hub (with shv⁹⁸⁰³)

shv¹

germinal proliferation center hub (with shv^c00496)

shv¹

germinal proliferation center hub | progressive

shv¹

hub cell

hub cell, with Scer\GAL4^{VP16.nanos.UTR}

shv^UAS.Tag:HA

hub cell (with shv¹)

hub cell (with shv⁹⁸⁰³)

shv¹

hub cell (with shv^c00496)

shv¹

hub cell | progressive

shv¹

hub cell | progressive, with Scer\GAL4^C833

shv^UAS.Tag:HA

hub cell | progressive, with Scer\GAL4^upd1.PU

shv^UAS.Tag:HA

male germline stem cell

male germline stem cell, with Scer\GAL4^C833

shv^UAS.Tag:HA

male germline stem cell (with shv¹)

male germline stem cell (with shv⁹⁸⁰³)

shv¹

male germline stem cell (with shv^c00496)

shv¹

male germline stem cell | progressive, with Scer\GAL4^upd1.PU

shv^UAS.Tag:HA

NMJ bouton | third instar larval stage

shv¹

NMJ bouton | third instar larval stage, with Scer\GAL4^nSyb.PS

shv^KK101364

testis | progressive

shv¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (30)

Hsap\DNAJB11

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (27)

Rnor\Dnajb11

14 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (28)

Mmus\Dnajb11

13 of 14

Yes

Mmus\Dnajc10

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (16)

Xtro\dnajb11

3 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (39)

Drer\dnajb11

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\dnj-20

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP008327

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (58)

Atha\ATERDJ3B

12 of 13

Yes

Atha\ARG1

2 of 13

Yes

Atha\ARL1

2 of 13

Yes

Atha\ARL2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT2G41000

1 of 13

Atha\AT2G42750

1 of 13

Yes

Atha\AT3G05345

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G25530

1 of 13

Atha\AT5G53150

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (10)

Scer\CAJ1

2 of 13

Yes

Scer\SCJ1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (8)

Spom\SPBC1347.05c

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Escherichia coli (enterobacterium) (2)

Ecol\cbpA

1 of 11

Yes

Ecol\dnaJ

1 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:shv. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

mrj

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Csp

1 of 13

DnaJ-60

1 of 13

DnaJ-H

1 of 13

Droj2

1 of 13

jdp

1 of 13

l(3)80Fg

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DNAJB11; DnaJ heat shock protein family (Hsp40) member B11

model of polycystic kidney disease 6

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DNAJB11; DnaJ heat shock protein family (Hsp40) member B11

13 of 14

611341

POLYCYSTIC KIDNEY DISEASE 6 WITH OR WITHOUT POLYCYSTIC LIVER DISEASE; PKD6

polycystic kidney disease 6

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

shv - Pdk1

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

shv - Raf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

shv - mys

anti tag coimmunoprecipitation, western blot, affinity technology, fluorescence microscopy, inferred by author, pull down

(Lee et al., 2017, Lee et al., 2016)

shv - orb2

anti bait coimmunoprecipitation, anti tag western blot

(Desai et al., 2024)

shv - sima

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Lee et al., 2016)

suppressible

(Lee et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

mys

suppressible

shv

(Lee et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

59476

DroID - A comprehensive database of gene and protein interactions.

FBgn0031256

MIST (protein-protein) - An integrated Molecular Interaction Database

33220

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-0.7

Cytogenetic map

21C2-21C2

Sequence location

2L:453,108..454,654 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21C2-21C2

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-0.7

(FlyBase, 2016)

2-0.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

54797

y¹ v¹; P{TRiP.HMJ21390}attP40

9803

y¹ w^*; P{UASp-YFP.Rab23}shv⁹⁸⁰³/CyO

37507

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01649}attP40

FlyORF

F003202

M{UAS-shv.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

4164R-1

P{NIG.4164R}1

2LG-0390

y² VhaAC39-1^cho-1 v¹; P{U6-shv.NIG.sgRNA}attP40/CyO

VDRC

v108576

P{KK101364}VIE-260B

v22997

w¹¹¹⁸; P{GD12785}v22997

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (61)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD30318

Other clones

DPiM_LD30318

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031256

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031256

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lee et al., 2016)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

shv is an activator of integrin signaling which is required for the maintenance of hub/niche identity in the testis.

(Lee et al., 2016)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: shv CG4164

(Lee et al., 2016)

Nomenclature comments

Etymology

The gene is named "shriveled" after the mutant phenotype of an age-dependent decrease in testis size.

(Lee et al., 2016)

Synonyms and Secondary IDs (3)

Reported As

Name Synonyms

shriveled

(Lee et al., 2016)

Secondary FlyBase IDs

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External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33220

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VPQ2

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VPQ2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VPQ2

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031256

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

33220/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031256

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031256

FlyMine - An integrated database for Drosophila genomics

FBgn0031256

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4164

MARRVEL_MODEL - MARRVEL (model organism gene)

33220

Linkouts

BioGRID - A database of protein and genetic interactions.

59476

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031256

DroID - A comprehensive database of gene and protein interactions.

FBgn0031256

DRSC - Results frm RNAi screens

FBgn0031256

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG4164_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031256

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031256

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4164

Flygut - An atlas of the Drosophila adult midgut

FBgn0031256

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC013491

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Protein processing in endoplasmic reticulum

MIST (protein-protein) - An integrated Molecular Interaction Database

33220

References (58)

The following external sites may use different assemblies or annotations than FlyBase.

1.18

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