FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\FoxK
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General Information
Symbol
Dmel\FoxK
Species
D. melanogaster
Name
Forkhead box K
Annotation Symbol
CG11799
Feature Type
protein_coding_gene
FlyBase ID
FBgn0036134
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
Forkhead box K (FoxK) encodes a transcription factor in the Fork Head family. It is a direct target of Dpp/BMP signaling during midgut development, and in turn regulates the homeobox gene lab to determine endoderm differentiation. It also regulates antiviral gene expression. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Mnf, fd68A

Key Links
Genomic Location
Cytogenetic map
68A7-68A7
Sequence location
Recombination map
3-34
RefSeq locus
NT_037436 REGION:11114169..11120783
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN009188255
(GO Reference Genome Project, 2011-)
enables DNA-binding transcription factor activity
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN009188255
(GO Reference Genome Project, 2011-)
enables sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in cellular response to virus
inferred from mutant phenotype
(Panda et al., 2015)
involved_in defense response to virus
inferred from mutant phenotype
(Panda et al., 2015)
involved_in midgut development
inferred from mutant phenotype
(Casas-Tinto et al., 2008)
involved_in positive regulation of gene expression
inferred from mutant phenotype
(Panda et al., 2015)
involved_in visceral mesoderm-endoderm interaction involved in midgut development
inferred from mutant phenotype
(Casas-Tinto et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in regulation of DNA-templated transcription
inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456
(InterPro Project Members, 2004-)
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN009188255
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN009188255
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Forkhead box K (FoxK) encodes a transcription factor in the Fork Head family. It is a direct target of Dpp/BMP signaling during midgut development, and in turn regulates the homeobox gene lab to determine endoderm differentiation. It also regulates antiviral gene expression. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
FORK HEAD BOX TRANSCRIPTION FACTORS -
The forkhead box family of transcription factors are sequence-specific DNA binding proteins that regulate transcription. They are characterized by approximately 110 amino acid DNA-binding domain known as the forkhead or winged helix. (Adapted from FBrf0173142).
Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\FoxK for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry M9PF47)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.42

Gene model reviewed during 5.45

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.55

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FoxK-RG
FBtr0300783
NM_140183
3281
746
FoxK-RH
FBtr0300784
NM_168444
3463
746
FoxK-RI
FBtr0300785
NM_168445
3159
746
FoxK-RJ
FBtr0300786
NM_168446
3338
746
FoxK-RK
FBtr0301967
NM_168443
3364
740
FoxK-RN
FBtr0332652
NM_001274772
3382
760
FoxK-RO
FBtr0332653
NM_001274773
3379
745
FoxK-RP
FBtr0332654
NM_001274774
3278
745
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
FoxK-PG
FBpp0290007
80.6
746
7.97
Q8IQE9
NP_648440
AAN11900
FoxK-PH
FBpp0290008
80.6
746
7.97
Q8IQE9
NP_729673
AAF50093
FoxK-PI
FBpp0290009
80.6
746
7.97
Q8IQE9
NP_729674
AAN11901
FoxK-PJ
FBpp0290010
80.6
746
7.97
Q8IQE9
NP_729675
AAF50094
FoxK-PK
FBpp0291179
80.0
740
7.97
Q0E8F8
NP_729672
AAF50092
FoxK-PN
FBpp0304898
82.2
760
8.77
M9PF47
NP_001261701
AGB94395
FoxK-PO
FBpp0304899
80.4
745
7.97
M9PI07
NP_001261702
AGB94396
FoxK-PP
FBpp0304900
80.5
745
7.97
M9PC64
NP_001261703
AGB94397
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

746 aa isoforms: FoxK-PG, FoxK-PH, FoxK-PI, FoxK-PJ
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\FoxK using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.90

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
organism | ubiquitous | uniform

Comment: maternally deposited

(Lee and Frasch, 2004)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 4 -- 13
organism | uniform
(Lee and Frasch, 2004)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
gonad
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
larval ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14 -- 17
larval central nervous system
(Lee and Frasch, 2004)
embryonic stage 15 -- 16
embryonic/larval midgut
(Casas-Tinto et al., 2008)
embryonic stage 16
parasegment 3
(Casas-Tinto et al., 2008)
parasegment 7
(Casas-Tinto et al., 2008)
Additional Descriptive Data

fd68A is uniformly in expressed in embryos through embryonic stage 13, after which transcript restricted to the central nervous system.

(Lee and Frasch, 2004)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15
embryonic/larval midgut
(Casas-Tinto et al., 2008)
embryonic stage 16
embryonic midgut constriction
(Casas-Tinto et al., 2008)
larval ventral nerve cord
(Casas-Tinto et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\FoxK in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of FoxK
Transgenic constructs containing regulatory region of FoxK
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (51)
Hsap\FOXK1
11 of 14
Yes
Yes
Hsap\FOXK2
11 of 14
Yes
Yes
Hsap\FOXD1
4 of 14
No
No
Hsap\FOXD2
4 of 14
No
No
Hsap\FOXD3
4 of 14
No
No
1  
Hsap\FOXD4
4 of 14
No
No
Hsap\FOXD4L1
4 of 14
No
No
Hsap\FOXD4L3
4 of 14
No
No
Hsap\FOXD4L4
4 of 14
No
No
Hsap\FOXD4L5
4 of 14
No
No
Hsap\FOXD4L6
4 of 14
No
No
Hsap\FOXE1
4 of 14
No
No
Hsap\FOXE3
4 of 14
No
No
Hsap\FOXG1
4 of 14
No
No
Hsap\FOXI1
4 of 14
No
No
Hsap\FOXI2
4 of 14
No
No
Hsap\FOXI3
4 of 14
No
No
Hsap\FOXL1
4 of 14
No
No
Hsap\FOXS1
4 of 14
No
No
Hsap\FOXC1
3 of 14
No
No
Hsap\FOXC2
3 of 14
No
No
Hsap\FOXF1
3 of 14
No
No
Hsap\FOXH1
3 of 14
No
Yes
Hsap\FOXJ1
3 of 14
No
Yes
Hsap\FOXJ2
3 of 14
No
No
Hsap\FOXJ3
3 of 14
No
No
Hsap\FOXL2
3 of 14
No
No
Hsap\FOXM1
3 of 14
No
Yes
1  
Hsap\FOXQ1
3 of 14
No
Yes
Hsap\FOXA2
2 of 14
No
No
Hsap\FOXA3
2 of 14
No
No
Hsap\FOXB1
2 of 14
No
No
1  
Hsap\FOXB2
2 of 14
No
No
1  
Hsap\FOXF2
2 of 14
No
No
Hsap\FOXL3
2 of 14
No
No
Hsap\FOXL3-OT1
2 of 14
No
Yes
Hsap\FOXN1
2 of 14
No
No
1  
Hsap\FOXN2
2 of 14
No
No
Hsap\FOXN3
2 of 14
No
No
1  
Hsap\FOXN4
2 of 14
No
No
Hsap\FOXO1
2 of 14
No
No
0  
Hsap\FOXO3
2 of 14
No
No
2  
Hsap\FOXO4
2 of 14
No
No
Hsap\FOXR1
2 of 14
No
Yes
Hsap\FOXR2
2 of 14
No
Yes
Hsap\FOXA1
1 of 14
No
No
Hsap\FOXO6
1 of 14
No
No
Hsap\FOXP1
1 of 14
No
No
1  
Hsap\FOXP2
1 of 14
No
No
1  
Hsap\FOXP3
1 of 14
No
No
Hsap\UPK2
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (43)
Rnor\Foxk1
11 of 14
Yes
Yes
Rnor\Foxk2
9 of 14
No
Yes
Rnor\Foxc1
4 of 14
No
No
Rnor\Foxc2
4 of 14
No
No
Rnor\Foxe3
4 of 14
No
No
Rnor\Foxg1
4 of 14
No
No
Rnor\Foxi1
4 of 14
No
No
Rnor\Foxi3
4 of 14
No
No
Rnor\Foxl1
4 of 14
No
No
Rnor\Foxl2
4 of 14
No
No
Rnor\Foxs1
4 of 14
No
No
Rnor\Foxd1
3 of 14
No
No
Rnor\Foxe1
3 of 14
No
No
Rnor\Foxh1
3 of 14
No
Yes
Rnor\Foxj2
3 of 14
No
No
Rnor\Foxl3
3 of 14
No
No
Rnor\Foxm1
3 of 14
No
Yes
Rnor\Foxa2
2 of 14
No
No
Rnor\Foxa3
2 of 14
No
No
Rnor\Foxb2
2 of 14
No
No
Rnor\Foxd2
2 of 14
No
No
Rnor\Foxd3
2 of 14
No
No
Rnor\Foxd4
2 of 14
No
No
Rnor\Foxf1
2 of 14
No
No
Rnor\Foxi2
2 of 14
No
No
Rnor\Foxj1
2 of 14
No
Yes
Rnor\Foxj3
2 of 14
No
No
Rnor\Foxn1
2 of 14
No
No
Rnor\Foxn3
2 of 14
No
No
Rnor\Foxo1
2 of 14
No
No
Rnor\Foxo4
2 of 14
No
No
Rnor\Foxq1
2 of 14
No
Yes
Rnor\Foxr1
2 of 14
No
Yes
Rnor\Foxa1
1 of 14
No
No
Rnor\Foxn2
1 of 14
No
No
Rnor\Foxn4
1 of 14
No
No
Rnor\Foxo3
1 of 14
No
No
Rnor\Foxo6
1 of 14
No
No
Rnor\Foxp1
1 of 14
No
No
Rnor\Foxp2
1 of 14
No
No
Rnor\Foxp3
1 of 14
No
No
Rnor\Foxr2
1 of 14
No
Yes
Rnor\Upk2
1 of 14
No
Yes
Mus musculus (laboratory mouse) (46)
Mmus\Foxk1
11 of 14
Yes
Yes
Mmus\Foxk2
11 of 14
Yes
Yes
Mmus\Foxc1
4 of 14
No
No
Mmus\Foxc2
4 of 14
No
No
Mmus\Foxd2
4 of 14
No
No
Mmus\Foxd3
4 of 14
No
No
Mmus\Foxd4
4 of 14
No
No
Mmus\Foxe3
4 of 14
No
No
Mmus\Foxg1
4 of 14
No
No
Mmus\Foxi1
4 of 14
No
No
Mmus\Foxi2
4 of 14
No
No
Mmus\Foxl1
4 of 14
No
No
Mmus\Foxl2
4 of 14
No
No
Mmus\Foxl3
4 of 14
No
No
Mmus\Foxd1
3 of 14
No
No
Mmus\Foxe1
3 of 14
No
No
Mmus\Foxf1
3 of 14
No
No
Mmus\Foxf2
3 of 14
No
No
Mmus\Foxh1
3 of 14
No
Yes
Mmus\Foxi3
3 of 14
No
No
Mmus\Foxj1
3 of 14
No
Yes
Mmus\Foxj2
3 of 14
No
No
Mmus\Foxj3
3 of 14
No
No
Mmus\Foxm1
3 of 14
No
Yes
Mmus\Foxq1
3 of 14
No
Yes
Mmus\Foxs1
3 of 14
No
No
Mmus\Foxa2
2 of 14
No
No
Mmus\Foxa3
2 of 14
No
No
Mmus\Foxb1
2 of 14
No
No
Mmus\Foxb2
2 of 14
No
No
Mmus\Foxn1
2 of 14
No
No
Mmus\Foxn2
2 of 14
No
No
Mmus\Foxn4
2 of 14
No
No
Mmus\Foxo1
2 of 14
No
No
2  
Mmus\Foxo4
2 of 14
No
No
Mmus\Foxo6
2 of 14
No
No
Mmus\Foxr1
2 of 14
No
Yes
Mmus\Foxr2
2 of 14
No
Yes
Mmus\Foxa1
1 of 14
No
No
Mmus\Foxn3
1 of 14
No
No
Mmus\Foxo3
1 of 14
No
No
Mmus\Foxp1
1 of 14
No
No
Mmus\Foxp2
1 of 14
No
No
Mmus\Foxp3
1 of 14
No
No
Mmus\Foxp4
1 of 14
No
No
Mmus\Upk2
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (54)
Xtro\foxk2
7 of 13
Yes
Yes
Xtro\brap
3 of 13
No
No
Xtro\foxc1
3 of 13
No
No
Xtro\foxc2
3 of 13
No
No
Xtro\foxd1
3 of 13
No
No
Xtro\foxd2
3 of 13
No
No
Xtro\foxd3
3 of 13
No
No
Xtro\foxd4l1.1
3 of 13
No
No
Xtro\foxd4l1.2
3 of 13
No
No
Xtro\foxg1
3 of 13
No
No
Xtro\foxi1
3 of 13
No
No
Xtro\foxi2
3 of 13
No
No
Xtro\foxi4.1
3 of 13
No
No
Xtro\foxi4.2
3 of 13
No
No
Xtro\foxl1
3 of 13
No
No
Xtro\foxl2
3 of 13
No
No
Xtro\crip2
2 of 13
No
No
Xtro\foxa2
2 of 13
No
No
Xtro\foxa4
2 of 13
No
No
Xtro\foxb1
2 of 13
No
No
Xtro\foxe1
2 of 13
No
Yes
Xtro\foxe3
2 of 13
No
No
Xtro\foxf1
2 of 13
No
No
Xtro\foxh1
2 of 13
No
No
Xtro\foxj1
2 of 13
No
Yes
Xtro\foxj2
2 of 13
No
No
Xtro\foxl3-ot1
2 of 13
No
Yes
Xtro\foxm1
2 of 13
No
Yes
Xtro\gcdh
2 of 13
No
No
Xtro\nr2f6
2 of 13
No
No
Xtro\qrich2
2 of 13
No
No
Xtro\arhgap5
1 of 13
No
No
Xtro\ctsw
1 of 13
No
No
Xtro\erh
1 of 13
No
No
Xtro\esrra
1 of 13
No
No
Xtro\fam161a
1 of 13
No
No
Xtro\foxa1
1 of 13
No
No
Xtro\foxb2
1 of 13
No
No
Xtro\foxf2
1 of 13
No
No
Xtro\foxj1.2
1 of 13
No
Yes
Xtro\foxj3
1 of 13
No
No
Xtro\foxn1
1 of 13
No
No
Xtro\foxn2
1 of 13
No
No
Xtro\foxn3
1 of 13
No
No
Xtro\foxo1
1 of 13
No
No
Xtro\foxo3
1 of 13
No
No
Xtro\foxo4
1 of 13
No
No
Xtro\foxp3
1 of 13
No
No
Xtro\foxq1
1 of 13
No
Yes
Xtro\foxr1
1 of 13
No
Yes
Xtro\LOC101730723
1 of 13
No
Yes
Xtro\nop2
1 of 13
No
No
Xtro\ppard
1 of 13
No
Yes
Xtro\vegfd
1 of 13
No
No
Danio rerio (Zebrafish) (65)
Drer\foxk1
11 of 14
Yes
Yes
Drer\foxk2a
11 of 14
Yes
Yes
Drer\foxk2b
11 of 14
Yes
Yes
Drer\foxc1a
4 of 14
No
No
Drer\foxc1b
4 of 14
No
No
Drer\foxd1
4 of 14
No
No
Drer\foxd2
4 of 14
No
No
Drer\foxd3
4 of 14
No
No
Drer\foxd5
4 of 14
No
No
Drer\foxd7
4 of 14
No
No
Drer\foxe1
4 of 14
No
No
Drer\foxe3
4 of 14
No
No
Drer\foxg1a
4 of 14
No
No
Drer\foxg1b
4 of 14
No
No
Drer\foxg1c
4 of 14
No
No
Drer\foxg1d
4 of 14
No
No
Drer\foxi2
4 of 14
No
No
Drer\foxi3a
4 of 14
No
No
Drer\foxi3b
4 of 14
No
No
Drer\foxj2
4 of 14
No
No
Drer\foxl1
4 of 14
No
No
Drer\foxl2a
4 of 14
No
No
Drer\foxl2b
4 of 14
No
No
Drer\foxl2l
4 of 14
No
No
Drer\foxl3
4 of 14
No
No
Drer\foxq2
4 of 14
No
No
Drer\foxf1
3 of 14
No
No
Drer\foxf2a
3 of 14
No
No
Drer\foxf2b
3 of 14
No
No
Drer\foxh1
3 of 14
No
No
Drer\foxi1
3 of 14
No
No
Drer\foxj1b
3 of 14
No
Yes
Drer\foxj3
3 of 14
No
No
Drer\foxm1
3 of 14
No
Yes
Drer\si:ch211-145o7.3
3 of 14
No
No
Drer\foxa2
2 of 14
No
No
Drer\foxa3
2 of 14
No
No
Drer\foxa
2 of 14
No
No
Drer\foxb1a
2 of 14
No
No
Drer\foxb1b
2 of 14
No
No
Drer\foxb2
2 of 14
No
No
Drer\foxj1a
2 of 14
No
Yes
Drer\foxn1
2 of 14
No
No
Drer\foxn2a
2 of 14
No
No
Drer\foxn2b
2 of 14
No
No
Drer\foxn3
2 of 14
No
No
Drer\foxn4
2 of 14
No
No
Drer\foxo1b
2 of 14
No
No
Drer\foxo4
2 of 14
No
No
Drer\foxo6b
2 of 14
No
No
Drer\foxq1a
2 of 14
No
Yes
Drer\foxq1b
2 of 14
No
Yes
Drer\foxr1
2 of 14
No
Yes
Drer\si:rp71-45k5.2
2 of 14
No
No
Drer\zgc:113424
2 of 14
No
No
Drer\ches1
1 of 14
No
No
Drer\foxa1
1 of 14
No
No
Drer\foxo1a
1 of 14
No
No
Drer\foxo3a
1 of 14
No
No
Drer\foxo6a
1 of 14
No
No
Drer\foxp1a
1 of 14
No
No
Drer\foxp1b
1 of 14
No
No
Drer\foxp2
1 of 14
No
No
Drer\foxp3a
1 of 14
No
No
Drer\foxp3b
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (16)
Cele\fkh-10
4 of 14
Yes
No
Cele\let-381
4 of 14
Yes
No
Cele\pha-4
4 of 14
Yes
No
Cele\unc-130
4 of 14
Yes
No
Cele\fkh-2
3 of 14
No
No
Cele\fkh-6
3 of 14
No
No
Cele\lin-31
3 of 14
No
No
Cele\pes-1
3 of 14
No
No
Cele\fkh-5
2 of 14
No
No
Cele\fkh-8
2 of 14
No
No
Cele\fkh-9
2 of 14
No
No
Cele\C29F7.10
1 of 14
No
Yes
Cele\daf-16
1 of 14
No
No
Cele\fkh-3
1 of 14
No
No
Cele\fkh-4
1 of 14
No
No
Cele\fkh-7
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (19)
Agam\AgaP_AGAP000662
7 of 12
Yes
Yes
Agam\AgaP_AGAP000069
4 of 12
No
No
Agam\AgaP_AGAP005804
4 of 12
No
Yes
Agam\AgaP_AGAP005902
4 of 12
No
No
Agam\AgaP_AGAP009147
4 of 12
No
No
Agam\AgaP_AGAP002903
3 of 12
No
No
Agam\AgaP_AGAP003940
3 of 12
No
No
Agam\AgaP_AGAP006786
3 of 12
No
No
Agam\AgaP_AGAP008155
3 of 12
No
No
Agam\AgaP_AGAP008606
3 of 12
No
Yes
Agam\AgaP_AGAP013178
3 of 12
No
No
Agam\AgaP_AGAP001577
2 of 12
No
No
Agam\AgaP_AGAP001671
2 of 12
No
No
Agam\AgaP_AGAP002460
2 of 12
No
No
Agam\AgaP_AGAP012976
2 of 12
No
No
Agam\AgaP_AGAP013032
2 of 12
No
No
Agam\AgaP_AGAP013297
2 of 12
No
No
Agam\AgaP_AGAP000569
1 of 12
No
No
Agam\AgaP_AGAP005903
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (2)
Atha\AT3G07260
1 of 13
Yes
Yes
Atha\FHA2
1 of 13
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\FKH2
8 of 13
Yes
Yes
Scer\FKH1
7 of 13
No
Yes
Scer\FHL1
4 of 13
No
Yes
Scer\HCM1
4 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\fhl1
6 of 12
Yes
Yes
Spom\fkh2
6 of 12
Yes
Yes
Spom\mei4
4 of 12
No
No
Spom\sep1
3 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:FoxK. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
croc
7 of 13
fd19B
7 of 13
FoxL1
7 of 13
slp1
7 of 13
slp2
7 of 13
fd59A
6 of 13
fd96Ca
5 of 13
fd96Cb
5 of 13
fd102C
5 of 13
fkh
5 of 13
CHES-1-like
4 of 13
jumu
4 of 13
bin
3 of 13
CG32006
3 of 13
foxo
3 of 13
FoxP
2 of 13
fd3F
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    FOXJ1; forkhead box J1
    model of  primary ciliary dyskinesia 43
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FOXK1; forkhead box K1
    11 of 14
    616302
        FOXK2; forkhead box K2
        11 of 14
        147685
            FOXD1; forkhead box D1
            4 of 14
            601091
                FOXD2; forkhead box D2
                4 of 14
                602211
                    FOXD3; forkhead box D3
                    4 of 14
                    611539
                       
                      FOXD4; forkhead box D4
                      4 of 14
                      601092
                          FOXD4L1; forkhead box D4 like 1
                          4 of 14
                          611084
                              FOXD4L3; forkhead box D4 like 3
                              4 of 14
                              611086
                                  FOXD4L4; forkhead box D4 like 4
                                  4 of 14
                                  611085
                                      FOXD4L5; forkhead box D4 like 5
                                      4 of 14
                                          FOXD4L6; forkhead box D4 like 6
                                          4 of 14
                                              FOXE1; forkhead box E1
                                              4 of 14
                                              602617
                                              FOXE3; forkhead box E3
                                              4 of 14
                                              601094
                                              FOXG1; forkhead box G1
                                              4 of 14
                                              164874
                                              FOXI1; forkhead box I1
                                              4 of 14
                                              601093
                                              FOXI2; forkhead box I2
                                              4 of 14
                                              617202
                                                  FOXI3; forkhead box I3
                                                  4 of 14
                                                  612351
                                                    FOXL1; forkhead box L1
                                                    4 of 14
                                                    603252
                                                    FOXS1; forkhead box S1
                                                    4 of 14
                                                    602939
                                                        FOXC1; forkhead box C1
                                                        3 of 14
                                                        601090
                                                        FOXC2; forkhead box C2
                                                        3 of 14
                                                        602402
                                                        FOXF1; forkhead box F1
                                                        3 of 14
                                                        601089
                                                        FOXH1; forkhead box H1
                                                        3 of 14
                                                        603621
                                                            FOXJ1; forkhead box J1
                                                            3 of 14
                                                            602291
                                                            FOXJ2; forkhead box J2
                                                            3 of 14
                                                            619162
                                                                FOXJ3; forkhead box J3
                                                                3 of 14
                                                                616035
                                                                    FOXL2; forkhead box L2
                                                                    3 of 14
                                                                    605597
                                                                    FOXM1; forkhead box M1
                                                                    3 of 14
                                                                    602341
                                                                         
                                                                        FOXQ1; forkhead box Q1
                                                                        3 of 14
                                                                        612788
                                                                            Functional Complementation Data
                                                                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                                            Interactions
                                                                            Summary of Physical Interactions
                                                                            Interaction Browsers
                                                                            View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                                            Please see the Physical Interaction reports below for full details
                                                                            protein-protein
                                                                            Physical Interaction
                                                                            Assay
                                                                            References
                                                                            FoxK - Ada2b
                                                                            anti tag coimmunoprecipitation, peptide massfingerprinting
                                                                            (Weake et al., 2011)
                                                                            FoxK - CG3457
                                                                            two hybrid
                                                                            (Hu et al., 2017.6.13)
                                                                            Summary of Genetic Interactions
                                                                            Interaction Browsers
                                                                            Starting gene(s)
                                                                            Interaction type
                                                                            Interacting gene(s)
                                                                            Reference
                                                                            Starting gene(s)
                                                                            Interaction type
                                                                            Interacting gene(s)
                                                                            Reference
                                                                            External Data
                                                                            Linkouts
                                                                            BioGRID - A database of protein and genetic interactions.
                                                                            DroID - A comprehensive database of gene and protein interactions.
                                                                            MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                            Pathways
                                                                            Signaling Pathways (FlyBase)
                                                                            Metabolic Pathways
                                                                            FlyBase
                                                                            External Links
                                                                            External Data
                                                                            Linkouts
                                                                            KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                            SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                                            Class of Gene
                                                                            Genomic Location and Detailed Mapping Data
                                                                            Chromosome (arm)
                                                                            3L
                                                                            Recombination map
                                                                            3-34
                                                                            Cytogenetic map
                                                                            68A7-68A7
                                                                            Sequence location
                                                                            FlyBase Computed Cytological Location
                                                                            Cytogenetic map
                                                                            Evidence for location
                                                                            68A7-68A7
                                                                            Limits computationally determined from genome sequence between P{PZ}l(3)0123901239&P{lacW}l(3)01239j9B4 and P{PZ}CycA02461&P{PZ}CycA03946
                                                                            Experimentally Determined Cytological Location
                                                                            Cytogenetic map
                                                                            Notes
                                                                            References
                                                                            Experimentally Determined Recombination Data
                                                                            Location

                                                                            3-34

                                                                            (FlyBase, 2016)

                                                                            3-28.7

                                                                            (Comeron et al., 2012)
                                                                            Left of (cM)
                                                                            Right of (cM)
                                                                            Notes
                                                                            Stocks and Reagents
                                                                            Stocks (15)
                                                                            Genomic Clones (26)
                                                                            cDNA Clones (55)
                                                                             

                                                                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                                            cDNA clones, fully sequenced
                                                                            BDGP DGC clones
                                                                            Other clones
                                                                              Drosophila Genomics Resource Center cDNA clones

                                                                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                                              cDNA Clones, End Sequenced (ESTs)
                                                                              BDGP DGC clones
                                                                              Other clones
                                                                              RNAi and Array Information
                                                                              Linkouts
                                                                              DRSC - Results frm RNAi screens
                                                                              Antibody Information
                                                                              Laboratory Generated Antibodies
                                                                               

                                                                              polyclonal

                                                                              (Casas-Tinto et al., 2008)
                                                                              Commercially Available Antibodies
                                                                               
                                                                              Cell Line Information
                                                                              Publicly Available Cell Lines
                                                                               
                                                                                Other Stable Cell Lines
                                                                                 
                                                                                  Other Comments

                                                                                  fd68A mutant embryos fail to generate midgut constrictions and lack lab in the endoderm.

                                                                                  (Casas-Tinto et al., 2008)

                                                                                  fd68A activity is required for the formation of the midgut constrictions and for the proper development of the midgut vesicles.

                                                                                  (Casas-Tinto et al., 2008)
                                                                                  Relationship to Other Genes
                                                                                  Source for database merge of
                                                                                  Additional comments
                                                                                  Nomenclature History
                                                                                  Source for database identify of

                                                                                  Source for identity of: Mnf CG11799

                                                                                  (Casas-Tinto, 2004.2.23)

                                                                                  Source for identity of: FoxK fd68A

                                                                                  (Casas-Tinto et al., 2008)
                                                                                  Nomenclature comments
                                                                                  Etymology
                                                                                  Synonyms and Secondary IDs (14)
                                                                                  Reported As
                                                                                  Symbol Synonym
                                                                                  CG11799
                                                                                  (Ward and Moehring, 2021, Çiçek et al., 2016, Ponton et al., 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Bandyopadhyay et al., 2006, Mazet et al., 2006, Foley and O'Farrell, 2004, Lee and Frasch, 2004, van Steensel et al., 2003)
                                                                                  DmLD16137
                                                                                  (Mazet et al., 2003)
                                                                                  DmMNF
                                                                                  (Casas-Tinto and Granadino, 2004)
                                                                                  FoxK
                                                                                  (Ko et al., 2024, Li et al., 2024, Benoit et al., 2022, Janssen et al., 2022, Schomburg et al., 2022, Ward and Moehring, 2021, Funk et al., 2020, Gene Disruption Project members, 2018-, Swevers et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Clandinin and Owens, 2016-, Panda et al., 2015, Schertel et al., 2015, Casas-Tinto et al., 2008, Casas-Tinto et al., 2008, Casas-Tinto et al., 2007, Mazet et al., 2006, Lee and Frasch, 2004)
                                                                                  MNF
                                                                                  (Casas-Tinto et al., 2008, Casas-Tinto Sr and Granadino, 2005)
                                                                                  Mnf
                                                                                  (De Groef et al., 2024, Sarov et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Jungreis et al., 2011, Ponton et al., 2011, Carpenter et al., 2009, Buszczak et al., 2007)
                                                                                  dFoxK
                                                                                  (Casas-Tinto et al., 2008)
                                                                                  fd68A
                                                                                  (Van Bortle et al., 2015, Rhee et al., 2014, Weake et al., 2011, Lee and Frasch, 2004)
                                                                                  fork head transcription factor long isoform
                                                                                  (Casas-Tinto and Granadino Goenechea, 2004.10.20)
                                                                                  fork head transcription factor short isoform
                                                                                  (Casas-Tinto and Granadino Goenechea, 2004.10.20)
                                                                                  Name Synonyms
                                                                                  Forkhead box K
                                                                                  Mnf
                                                                                  fork head box K
                                                                                  (Casas-Tinto et al., 2008)
                                                                                  forkhead domain 68A
                                                                                  myocyte nuclear factor
                                                                                  (Casas-Tinto et al., 2008)
                                                                                  Secondary FlyBase IDs
                                                                                    Datasets (0)
                                                                                    Study focus (0)
                                                                                    Experimental Role
                                                                                    Project
                                                                                    Project Type
                                                                                    Title
                                                                                    Study result (0)
                                                                                    Result
                                                                                    Result Type
                                                                                    Title
                                                                                    External Crossreferences and Linkouts ( 86 )
                                                                                    Sequence Crossreferences
                                                                                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                                    UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                                    Other crossreferences
                                                                                    AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                                                    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                                    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                                    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                                    FlyMine - An integrated database for Drosophila genomics
                                                                                    InterPro - A database of protein families, domains and functional sites
                                                                                    KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                                    MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                                    Linkouts
                                                                                    BioGRID - A database of protein and genetic interactions.
                                                                                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                                                    DroID - A comprehensive database of gene and protein interactions.
                                                                                    DRSC - Results frm RNAi screens
                                                                                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                                                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                                    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                                    Flygut - An atlas of the Drosophila adult midgut
                                                                                    FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                                                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                                                                    MIST (protein-protein) - An integrated Molecular Interaction Database
                                                                                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                                    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                                                                                    References (79)