FlyBase Gene Report: Dmel\Fsn

General Information

Symbol

Dmel\Fsn

Species

D. melanogaster

Name

F-box synaptic protein

Annotation Symbol

CG4643

Feature Type

protein_coding_gene

FlyBase ID

FBgn0043010

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

F-box synaptic protein (Fsn) encodes an F-box protein that forms a ubiquitin ligase complex with the E3 ligase and the Skp protein encoded by hiw and SkpA, respectively. Its key substrates are the products of wnd and Nmnat. [Date last reviewed: 2018-11-08] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

DFsn, BEST:GH20696

Key Links

Genomic Location

Cytogenetic map

49F10-49F10

Sequence location

2R:13,220,939..13,222,459 [-]

Recombination map

2-68

RefSeq locus

NT_033778 REGION:13220939..13222459

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9NB71

(Wu et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables ubiquitin-like ligase-substrate adaptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000956493

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in negative regulation of gene expression

inferred from mutant phenotype

(Kugler et al., 2010)

involved_in negative regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Wu et al., 2007)

involved_in neuromuscular synaptic transmission

inferred from mutant phenotype

(Wu et al., 2007)

involved_in positive regulation of protein catabolic process

inferred from mutant phenotype

(Kugler et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in proteasome-mediated ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000956493

(GO Reference Genome Project, 2011-)

involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

inferred from sequence model

(FlyBase Curators, 2011-)

involved_in synapse assembly involved in innervation

inferred from biological aspect of ancestor with PANTHER:PTN000261681

(GO Reference Genome Project, 2011-)

Cellular Component (7 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

located_in cell cortex

inferred from direct assay

(Kugler et al., 2010)

located_in cytoplasm

inferred from direct assay

(Kugler et al., 2010)

located_in neuromuscular junction

inferred from direct assay

(Wu et al., 2007)

located_in nucleus

inferred from direct assay

(Kugler et al., 2010)

located_in pole plasm

inferred from direct assay

(Kugler et al., 2010)

part_of SCF ubiquitin ligase complex

inferred from direct assay

(Kugler et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of SCF ubiquitin ligase complex

inferred from biological aspect of ancestor with PANTHER:PTN001387175

(GO Reference Genome Project, 2011-)

inferred from sequence model

(FlyBase Curators, 2011-)

is_active_in synapse

inferred from biological aspect of ancestor with PANTHER:PTN000261681

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

F BOX ONLY PROTEINS

Protein Family (UniProt)

Belongs to the FBXO45/Fsn family. (Q9V6L9)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

F BOX ONLY PROTEINS -: F box only proteins (FBXO) are F box proteins which do not contain WD40 repeats or leucine-rich repeats, but may contain other domains. F box proteins are the variable substrate adapters for Skp, Cullin, F-box (SCF) E3 ubiquitin ligase complexes. (Adapted from FBrf0225076).

Protein Function (UniProtKB)

Required in the presynaptic motoneuron to down-regulate the levels of wnd and restrain synaptic terminal growth at the neuromuscular junction (NMJ). Negatively regulates the localization of vas to the posterior pole of the oocyte. Involved in primordial germ cell formation.

(UniProt, Q9V6L9)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fsn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V6L9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fsn-RA

FBtr0087762

NM_137005

1287

255

Fsn-RB

FBtr0087763

NM_165973

1280

255

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Fsn-PA

FBpp0086875

28.8

255

6.50

FBpp0086876

28.8

255

6.50

Q9V6L9

NP_725266

AAM68601

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

255 aa isoforms: Fsn-PA, Fsn-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of an E3 ubiquitin ligase complex composed of hiw and Fsn (PubMed:17697379, PubMed:21874015). Interacts with Rae1, probably as part of the hiw-Fsn complex (PubMed:21874015). Interacts (via B30.2/SPRY domain) with vas (PubMed:20123973). Interacts with Cul1 (PubMed:20123973).

(UniProt, Q9V6L9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V6L9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fsn using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fsn_1
Fsn_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.18

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cell cortex

inferred from direct assay

(Kugler et al., 2010)

located_in cytoplasm

inferred from direct assay

(Kugler et al., 2010)

located_in neuromuscular junction

inferred from direct assay

(Wu et al., 2007)

located_in nucleus

inferred from direct assay

(Kugler et al., 2010)

located_in pole plasm

inferred from direct assay

(Kugler et al., 2010)

part_of SCF ubiquitin ligase complex

inferred from direct assay

(Kugler et al., 2010)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fsn in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fsn

View exonic expression by tissue for Dmel\Fsn

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043010

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36460/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0043010

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0043010

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0043010

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4643

Flygut - An atlas of the Drosophila adult midgut

FBgn0043010

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fsn

Transgenic constructs containing regulatory region of Fsn

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel7124

(Kugler et al., 2010, Ryder, 2004.4.26)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority live | maternal effect (with Df(2R)Exel7124)

Fsn^f06595

viable

Fsn^f06595

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fsn^GD11383

viable, with Scer\GAL4^Mef2.PR

Fsn^GD11383

viable, with Scer\GAL4^pnr-MD237

Fsn^GD11383

viable, with Scer\GAL4^tin.CΔ4

Fsn^GD11383

viable, with Scer\GAL4^{VP16.nanos.UTR}

viable (with Df(2R)Exel7124)

Fsn^f06595

Sterility

Allele

male sterile

Fsn^f06595

male sterile (with Df(2R)Exel7124)

Fsn^f06595

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Fsn^GD11383

abnormal neuroanatomy | third instar larval stage

Fsn^f06595

abnormal neuroanatomy | third instar larval stage (with Df(2R)Exel7124)

Fsn^f06595

abnormal neurophysiology | third instar larval stage (with Df(2R)Exel7124)

Fsn^f06595

Phenotype manifest in

Allele

embryonic/larval neuromuscular junction

Fsn^f06595

embryonic/larval neuromuscular junction (with Df(2R)Exel7124)

Fsn^f06595

mesonotum, with Scer\GAL4^pnr-MD237

Fsn^GD11383

primordial germ cell | maternal effect, with Df(2R)Exel7124, Scer\GAL4^{VP16.nanos.UTR}

Fsn^UAS.Tag:HA

primordial germ cell | maternal effect, with Fsn^f06595, Scer\GAL4^{VP16.nanos.UTR}

Fsn^UAS.Tag:HA

primordial germ cell | maternal effect, with Fsn^UAS.Tag:HA, Scer\GAL4^{VP16.nanos.UTR}

Fsn^f06595

primordial germ cell | maternal effect, with Scer\GAL4^{VP16.nanos.UTR}

type I bouton | increased number | third instar larval stage

Fsn^f06595

type I bouton | increased number | third instar larval stage (with Df(2R)Exel7124)

Fsn^f06595

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\FBXO45

14 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\TRIM25

1 of 14

Yes

Hsap\TRIM39

1 of 14

Yes

Hsap\TRIM67

1 of 14

Hsap\TRIM72

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (22)

Rnor\Fbxo45

12 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Trim25

1 of 14

Yes

Rnor\Trim39

1 of 14

Rnor\Trim65

1 of 14

Yes

Rnor\Trim67

1 of 14

Rnor\Trim72

1 of 14

Yes

Rnor\Trim80

1 of 14

Yes

Mus musculus (laboratory mouse) (23)

Mmus\Fbxo45

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Trim14

1 of 14

Yes

Mmus\Trim25

1 of 14

Yes

Mmus\Trim30a

1 of 14

Yes

Mmus\Trim39

1 of 14

Yes

Mmus\Trim65

1 of 14

Yes

Mmus\Trim67

1 of 14

Mmus\Trim72

1 of 14

Yes

Mmus\Trim80

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (13)

Xtro\fbxo45

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\trim47

1 of 13

Yes

Xtro\XB5729975

1 of 13

Xtro\znf208

1 of 13

Danio rerio (Zebrafish) (42)

Drer\fbxo45

14 of 14

Yes

Drer\si:ch1073-228j22.2

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ftr61

1 of 14

Yes

Drer\ftr66

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\ftr83

1 of 14

Yes

Drer\ftr84

1 of 14

Yes

Drer\ftr86

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch73-106l15.3

1 of 14

Yes

Drer\si:ch211-107m4.1

1 of 14

Drer\si:ch211-114c12.5

1 of 14

Yes

Drer\si:dkey-23n7.10

1 of 14

Drer\si:dkey-219e21.2

1 of 14

Yes

Drer\si:dkey-264f17.2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\trim65

1 of 14

Yes

Drer\trim67

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\fsn-1

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (6)

Agam\FBSP1_ANOGA

12 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC1259.12c

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Fsn. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

CG10516

4 of 13

gus

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Fsn^GD11383

model of chromosome 3q29 microdeletion syndrome

CEA with Cbp20^KK109448

(Singh et al., 2020)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FBXO45; F-box protein 45

14 of 14

609112

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Fsn - Cul1

anti tag coimmunoprecipitation, western blot

(Kugler et al., 2010)

Fsn - Rae1

tandem affinity purification, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot

(Tian et al., 2011)

Fsn - SkpA

tandem affinity purification, Identification by mass spectrometry, experimental knowledge based

(Brace et al., 2014, Guruharsha et al., 2011)

Fsn - SkpB

experimental knowledge based

(Guruharsha et al., 2011)

Fsn - hiw

anti bait coimmunoprecipitation, anti tag western blot, tandem affinity purification, Identification by mass spectrometry, anti tag coimmunoprecipitation, western blot

(Tian et al., 2011, Wu et al., 2007)

Fsn - vas

anti bait coimmunoprecipitation, anti tag western blot

(Kugler et al., 2010)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Fsn

enhanceable

vas

(Kugler et al., 2010)

Fsn

suppressible

wnd

(Wu et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

gus

suppressible

Fsn

(Kugler et al., 2010)

hiw

enhanceable

Fsn

(Wu et al., 2007)

External Data

Subunit Structure (UniProtKB)

(UniProt, Q9V6L9 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62223

DroID - A comprehensive database of gene and protein interactions.

FBgn0043010

MIST (protein-protein) - An integrated Molecular Interaction Database

36460

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-68

Cytogenetic map

49F10-49F10

Sequence location

2R:13,220,939..13,222,459 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49F10-49F10

Limits computationally determined from genome sequence between P{EP}CG33182^EP728&P{lacW}Aats-val^k14804 and P{EP}Dp^EP358

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-68

(FlyBase, 2016)

2-71.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

31096

y¹ v¹; P{TRiP.JF01561}attP2

14562

y¹; P{SUPor-P}Fsn^KG08128/CyO; ry⁵⁰⁶

83482

y¹ sc^* v¹ sev²¹; P{TKO.GS04170}attP40

VDRC

v107315

P{KK108523}VIE-260B

v26578

w¹¹¹⁸; P{GD11383}v26578

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (131)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD47425

Other clones

DPiM_LD47425

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0043010

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0043010

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: BEST:GH20696 CG4643

(FlyBase, 1996-)

Additional comments

FlyBase curator comment: Correspondence with author Kugler revealed that 'Wals' = 'CG4643'.

(Kugler et al., 2008)

Source for merge of BEST:GH20696 CG4643 was a shared cDNA ( date:030206 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Fsn CG4643

(Wu et al., 2007)

Nomenclature comments

Etymology

Named 'Fsn' based on orthology to C. elegans 'fsn-1' (see FBrf0205388).

(FlyBase, 2009-)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

BEST:GH20696

(Myster et al., 2000)

CG4643

(Roberts et al., 2012, Keleman et al., 2009.8.5, Perkins et al., 2009, Skaar et al., 2009, Ni et al., 2008, Kugler and Lasko, 2007, Wu et al., 2007, Ho et al., 2006, Stanyon et al., 2004)

DFsn

(Grill et al., 2016, Brace et al., 2014, Po et al., 2010, Wu et al., 2007)

FBXO2

(Roberts et al., 2012)

FSN

(Barbosa et al., 2021)

Fsn

(Eickelberg et al., 2022, Singh et al., 2020, Yusuff et al., 2020, Rivera et al., 2019, Transgenic RNAi Project members, 2017-, Grice et al., 2015, Kugler et al., 2013, Du et al., 2011, Tian et al., 2011, Kugler et al., 2010)

Wals

(Kugler et al., 2008)

dFsn

(Skaar et al., 2009)

fsn

(Smibert et al., 2012)

Name Synonyms

CG4643

F-box synaptic protein

Wallenstein

(Kugler et al., 2008)

Secondary FlyBase IDs

FBgn0033811

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36460

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V6L9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V6L9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V6L9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0043010

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36460/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0043010

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0043010

FlyMine - An integrated database for Drosophila genomics

FBgn0043010

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4643

MARRVEL_MODEL - MARRVEL (model organism gene)

36460

Linkouts

BioGRID - A database of protein and genetic interactions.

62223

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0043010

DroID - A comprehensive database of gene and protein interactions.

FBgn0043010

DRSC - Results frm RNAi screens

FBgn0043010

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fsn_1
Fsn_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0043010

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0043010

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4643

Flygut - An atlas of the Drosophila adult midgut

FBgn0043010

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010464

MIST (protein-protein) - An integrated Molecular Interaction Database

36460

References (57)

The following external sites may use different assemblies or annotations than FlyBase.

4.18

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