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General Information
Name
thyroid carcinoma, familial medullary
FlyBase ID
FBhh0000025
Disease Ontology Term
Parent Disease
Overview

Medullary thyroid carcinoma (MTC) occurs sporadically (~75%) or as a component of the multiple endocrine neoplasia (MEN) type 2; see reports for multiple endocrine neoplasia, type IIA (FBhh0000013) and multiple endocrine neoplasia, type IIB (FBhh0000014). There are two human genes implicated in this disease, RET (OMIM:164761) and NTRK1 (OMIM:191315), both of which are implicated in other diseases, as well. There is a single fly ortholog, Dmel\Ret, of RET; there is no gene with significant orthology to NTRK1 in Drosophila.

Variant(s) implicated in human disease tested (as analogous mutation in fly gene): M955T in the fly Ret gene (corresponds to M918T in the human RET gene); this variant is implicated in MEN2B.

[updated Oct. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: thyroid carcinoma, familial medullary
OMIM report

[THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC](https://omim.org/entry/155240)

Human gene(s) implicated

[REARRANGED DURING TRANSFECTION PROTOONCOGENE; RET](https://omim.org/entry/164761)

Symptoms and phenotype

Medullary thyroid carcinoma (MTC) is a malignant tumor of the calcitonin-secreting parafollicular C cells of the thyroid; it can occur sporadically or as a component of multiple endocrine neoplasia (MEN) type 2 [from OMIM:155240; 2015.02.17].

For additional information on classification and genetics see http://www.thyroidcancer.com/thyroid-cancer/medullary/genetics.

Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
MTC
FMTC
MTC1
Search term: thyroid cancer
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    D. melanogaster ortholog (based on DIOPT)
    Comments on ortholog(s)

    One to one: 1 human to 1 Drosophila.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Gene Snapshot
      Ret oncogene (Ret) encodes a cell surface receptor mediating dendrite development of class IV dendritic arborization sensory neurons. It interacts with integrins and mediates rac1 signaling to promote dendrite adhesion to the extracellular matrix. [Date last reviewed: 2019-03-14]
      Gene Groups / Pathways
      Comments on ortholog(s)
      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      Synthetic Gene(s) Used (0)
      Summary of Physical Interactions (2 groups)
      protein-protein
      Interacting group
      Assay
      References
      pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot, molecular weight estimation by staining
      anti tag coimmunoprecipitation, anti tag western blot
      Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
      Genetic Tools, Stocks and Reagents
      Sources of Stocks
      Contact lab of origin for a reagent not available from a public stock center.
      Bloomington Stock Center Disease Page
      Selected mammalian transgenes
      Allele
      Transgene
      Publicly Available Stocks
      Selected Drosophila transgenes
      Allele
      Transgene
      Publicly Available Stocks
      RNAi constructs available
      Allele
      Transgene
      Publicly Available Stocks
      Selected Drosophila classical alleles
      Allele
      Allele class
      Mutagen
      Publicly Available Stocks
      amorphic allele - molecular evidence
      ends-out gene targeting
      amorphic allele - molecular evidence
      CRISPR/Cas9
      amorphic allele - molecular evidence
      CRISPR/Cas9
      amorphic allele - molecular evidence
      CRISPR/Cas9
      References (11)