Medullary thyroid carcinoma (MTC) occurs sporadically (~75%) or as a component of the multiple endocrine neoplasia (MEN) type 2; see reports for multiple endocrine neoplasia, type IIA (FBhh0000013) and multiple endocrine neoplasia, type IIB (FBhh0000014). There are two human genes implicated in this disease, RET (OMIM:164761) and NTRK1 (OMIM:191315), both of which are implicated in other diseases, as well. There is a single fly ortholog, Dmel\Ret, of RET; there is no gene with significant orthology to NTRK1 in Drosophila.
Variant(s) implicated in human disease tested (as analogous mutation in fly gene): M955T in the fly Ret gene (corresponds to M918T in the human RET gene); this variant is implicated in MEN2B.
[updated Oct. 2019 by FlyBase; FBrf0222196]
[THYROID CARCINOMA, FAMILIAL MEDULLARY; MTC](https://omim.org/entry/155240)
[REARRANGED DURING TRANSFECTION PROTOONCOGENE; RET](https://omim.org/entry/164761)
Medullary thyroid carcinoma (MTC) is a malignant tumor of the calcitonin-secreting parafollicular C cells of the thyroid; it can occur sporadically or as a component of multiple endocrine neoplasia (MEN) type 2 [from OMIM:155240; 2015.02.17].
For additional information on classification and genetics see http://www.thyroidcancer.com/thyroid-cancer/medullary/genetics.