FlyBase Gene Report: Dmel\kz

General Information

Symbol

Dmel\kz

Species

D. melanogaster

Name

kurz

Annotation Symbol

CG3228

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001330

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

RNA helicase (3.6.4.13)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

EG:30B8.2 , l67

Key Links

Genomic Location

Cytogenetic map

2F1-2F1

Sequence location

X:2,237,858..2,242,035 [-]

Recombination map

1-0.9

RefSeq locus

NC_004354 REGION:2237858..2242035

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR011545

(InterPro Project Members, 2004-)

enables helicase activity

inferred from biological aspect of ancestor with PANTHER:PTN008360424

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity

(Lasko, 2000)

enables nucleic acid binding

inferred from electronic annotation with InterPro:IPR011545

(InterPro Project Members, 2004-)

enables RNA binding

inferred from biological aspect of ancestor with PANTHER:PTN008360424

(GO Reference Genome Project, 2011-)

enables RNA helicase activity

inferred from sequence or structural similarity with UniProtKB:Q04217

(Gene Ontology Curators, 2002-)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

inferred from biological aspect of ancestor with PANTHER:PTN000433605

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleolus

inferred from biological aspect of ancestor with PANTHER:PTN000433605

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

DEAH-BOX RNA HELICASES

Protein Family (UniProt)

Belongs to the DEAD box helicase family. DEAH subfamily. (O46072)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

RNA helicase activity

ATP + H2O = ADP + phosphate + H(+) (3.6.4.13)

Summaries

Gene Group (FlyBase)

DEAH-BOX RNA HELICASES -: DEAH-box RNA helicases belong to helicase superfamily 2 (SF2). They are characterized by the presence of nine conserved helicase motifs, including the DEAH sequence in motif II. (Adapted from PMID:21509200.)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

kz: kurz

In the viable allele kz1, bristle are shorter and finer, like a slight Minute (Stern, 1930, 1934). Postscutellars often absent. Mutant hatches somewhat late. Viability fair; both sexes fertile. Recessive lethal alleles are slow to develop. First or second instar larvae stop developing; larvae may survive up to one week in arrested state (Perrimon et al., 1984). All lethal alleles are cell lethal in germline clones. kz1 females, heterozygous for a deficiency for the locus or for a lethal allele, emerge occasionally, but only after a delay of several days (Perrimon et al., 1984).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\kz for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O46072)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 5.51

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

kz-RA

FBtr0070419

NM_057243

3927

1192

kz-RB

FBtr0342769

NM_001297886

3741

1192

Additional Transcript Data and Comments

Reported size (kB)

4.2 (northern blot)

(Haenlin et al., 1987)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

kz-PA

FBpp0070403

134.1

1192

7.46

FBpp0309621

134.1

1192

7.46

O46072

NP_001284815

AHN59286

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1192 aa isoforms: kz-PA, kz-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kz using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kz_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.19

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 11

Comment: reference states 0-6 hr AEL

(Haenlin et al., 1987)

oogenesis & adult stage | female

ovary

(Haenlin et al., 1987)

Additional Descriptive Data

kz transcript is detected in 0-6 hr embryos and in the ovary.

(Haenlin et al., 1987)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\kz in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\kz

View exonic expression by tissue for Dmel\kz

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31205/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001330

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001330

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001330

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3228

Flygut - An atlas of the Drosophila adult midgut

FBgn0001330

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 39 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of kz

Transgenic constructs containing regulatory region of kz

Aberrations (Deficiencies and Duplications) ( 46 )

Inferred from experimentation ( 46 )

Gene duplicated in

Dp(1;1)100

(Dobzhansky, 1932)

Dp(1;1)105

(Dobzhansky, 1932)

Dp(1;2;Y)w⁺

(Kramers et al., 1991, Kramers et al., 1983)

Dp(1;3)w^vco

(Perrimon et al., 1985)

(Dobzhansky, 1932)

(Dobzhansky, 1932)

(Dobzhansky, 1932)

(Perrimon et al., 1985)

Dp(1;Y)y²43T

(Alatortsev and Tolchkov, 1985)

Gene not duplicated in

Dp(1;1)112

(Dobzhansky, 1932)

Dp(1;2)51b

(Kramers et al., 1991)

(Schalet, 1986)

(Dobzhansky, 1932)

(Dobzhansky, 1932)

(Dobzhansky, 1932)

(Alatortsev and Tolchkov, 1985)

Gene disrupted in

Df(1)2F1-3A4

(Haenlin et al., 1985)

Df(1)64c18

(Alatortsev and Tolchkov, 1985, Perrimon et al., 1985, Perrimon et al., 1984, Gvozdev et al., 1977, Gvozdev et al., 1975)

Df(1)278.4B1

(Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)L271

(Haenlin et al., 1985, Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)Pgd-kz

(Kramers et al., 1991, Alatortsev and Tolchkov, 1985, Perrimon et al., 1985, Perrimon et al., 1984, Kramers et al., 1983, Gvozdev et al., 1977, Gvozdev et al., 1973)

Df(1)pn7a

(Alatortsev and Tolchkov, 1985, Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)TEM1

(Kramers et al., 1991, Alatortsev and Tolchkov, 1985)

Df(1)TEM304

(Kramers et al., 1991, Perrimon et al., 1985, Perrimon et al., 1984, Kramers et al., 1983, Gvozdev et al., 1975)

Df(1)TEM501

(Kramers et al., 1991, Kramers et al., 1983)

In(1)C99^Lw^m4R

(Perrimon et al., 1985)

T(1;3)pn¹²

(Alatortsev and Tolchkov, 1985)

Gene not disrupted in

Df(1)2F1-3A4

(Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)62g18

(Perrimon et al., 1984)

Df(1)dor2T

(Alatortsev and Tolchkov, 1985)

Df(1)JA52

(Perrimon et al., 1985)

Df(1)JC19

(Perrimon et al., 1984)

Df(1)JC105

(Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)l24

(Perrimon et al., 1985, Perrimon et al., 1984)

Df(1)N-8

(Kramers et al., 1991)

Df(1)N-54l9

(Kramers et al., 1991)

Df(1)N-264-105

(Kramers et al., 1991)

Df(1)Pgd35

(Perrimon et al., 1984)

Df(1)pn38

(Alatortsev and Tolchkov, 1985, Perrimon et al., 1985)

Df(1)Sp2F-3A

(Schalet, 1986)

Df(1)TEM1

(Gvozdev et al., 1977, Gvozdev et al., 1975)

Df(1)TEM7

(Kramers et al., 1991)

Df(1)TEM75

(Perrimon et al., 1984)

Df(1)TEM202

(Kramers et al., 1991)

Df(1)TEM304

(Alatortsev and Tolchkov, 1985, Gvozdev et al., 1977)

Df(1)TEM501

(Alatortsev and Tolchkov, 1985, Gvozdev et al., 1977, Gvozdev et al., 1975)

Df(1)w67k30

(Kramers et al., 1991)

Df(1)w258-48

(Kramers et al., 1991)

Df(1)w-rJ1

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)X12

(Perrimon et al., 1984)

In(1)pn⁴⁵

(Alatortsev and Tolchkov, 1985)

Inferred from location ( 27 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

cell lethal | germline clone

kz³¹

lethal

lethal, with Scer\GAL4^insc-Mz1407

kz^GD1473

lethal, with Scer\GAL4^Mef2.PR

kz^GD1473

lethal | recessive

lethal - all die before end of larval stage

kz²³

lethal - all die before end of larval stage | recessive

partially lethal - majority die | pharate adult stage P15(ii), with Scer\GAL4^pnr-MD237

kz^GD1473

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

kz^GD1473

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

kz^GD1473

viable, with Scer\GAL4^tin.CΔ4

kz^GD1473

Other Phenotypes

Allele

abnormal neuroanatomy | larval stage, with Scer\GAL4^insc-Mz1407

kz^GD1473

some die during larval stage

kz²³

some die during larval stage | recessive

visible, with Scer\GAL4^pnr-MD237

kz^GD1473

wild-type

Phenotype manifest in

Allele

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

kz^GD1473

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

kz^GD1473

mesonotum, with Scer\GAL4^pnr-MD237

kz^GD1473

trichogen cell, with Scer\GAL4^pnr-MD237

kz^GD1473

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\DHX37

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Dhx37

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (19)

Mmus\Dhx37

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (21)

Xtro\dhx37

10 of 13

Yes

Xtro\gnl3l

9 of 13

Yes

Xtro\dhx33

2 of 13

Xtro\dhx38

2 of 13

Xtro\XB5817455

2 of 13

Yes

Xtro\ankh

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\ythdc2

1 of 13

Danio rerio (Zebrafish) (21)

Drer\dhx37

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tdrd9

1 of 14

Drer\ythdc2

1 of 14

Drer\zcchc17

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\rha-2

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (14)

Agam\AgaP_AGAP002687

11 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (23)

Atha\FAS4

13 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

Atha\AT5G10370

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\ECM16

11 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Schizosaccharomyces pombe (Fission yeast) (9)

Spom\SPAPB1A10.06c

10 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Escherichia coli (enterobacterium) (2)

Ecol\hrpA

3 of 11

Yes

Ecol\hrpB

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:kz. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

ath

5 of 13

CG3225

5 of 13

Dhx15

5 of 13

l(2)37Cb

5 of 13

pea

5 of 13

Prp16

5 of 13

CG1582

4 of 13

CG8915

4 of 13

mle

4 of 13

4 of 13

4 of 13

3 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DHX37; DEAH-box helicase 37

14 of 14

617362

DHX8; DEAH-box helicase 8

3 of 14

600396

DHX15; DEAH-box helicase 15

3 of 14

603403

DHX16; DEAH-box helicase 16

3 of 14

603405

NEUROMUSCULAR OCULOAUDITORY SYNDROME; NMOAS

DHX32; DEAH-box helicase 32 (putative)

3 of 14

607960

DHX33; DEAH-box helicase 33

3 of 14

614405

DHX35; DEAH-box helicase 35

3 of 14

DHX38; DEAH-box helicase 38

3 of 14

605584

RETINITIS PIGMENTOSA 84; RP84

retinitis pigmentosa 84

DHX40; DEAH-box helicase 40

3 of 14

607570

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

kz - CG12301

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ubx

enhanceable

(Burnette et al., 1999)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57743

DroID - A comprehensive database of gene and protein interactions.

FBgn0001330

MIST (protein-protein) - An integrated Molecular Interaction Database

31205

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Major pathway of rRNA processing in the nucleolus and cytosol

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.9

Cytogenetic map

2F1-2F1

Sequence location

X:2,237,858..2,242,035 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2F1-2F1

Limits computationally determined from genome sequence between P{EP}EP1460&P{EP}CG2924^EP1596 and P{EP}EP1606

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0.9

(FlyBase, 2016)

1-0.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

kz¹

65953

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06228}attP2

Kyoto

105703

kz¹

3228R-1

v104253

v37078

w¹¹¹⁸; P{GD1473}v37078/TM3

v318161

PBac{fTRG00582.sfGFP-TVPTBF}VK00033

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE43077

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001330

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001330

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

kz has been cloned and sequenced.

(Tirronen and Roos, 1992)

A saturation analysis of the 2D3--2F5 region detected the kz complementation group.

(Alatortsev and Tolchkov, 1985)

Germ line clonal analysis indicates that kz is germ line lethal.

(Perrimon et al., 1984)

In the viable allele kz¹, bristle are shorter and finer, like a slight Minute (Stern, 1930; Stern, 1934). Postscutellars often absent. Mutant hatches somewhat late. Viability fair; both sexes fertile. Recessive lethal alleles are slow to develop. First or second instar larvae stop developing; larvae may survive up to one week in arrested state (Perrimon, Engstrom and Mahowald, 1984). All lethal alleles are cell lethal in germ-line clones. kz¹ females, heterozygous for a deficiency for the locus or for a lethal allele, emerge occasionally, but only after a delay of several days (Perrimon, Engstrom and Mahowald, 1984).

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: kz CG3228

(Deng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG3228

(Çiçek et al., 2016, Hosono et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, Benos, 2000.12.13)

EG:30B8.2

(Benos et al., 2001, Benos, 2000.12.13)

(Gvozdev et al., 1975)

(Alatortsev and Tolchkov, 1985)

(Sarov et al., 2016, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Neumüller et al., 2011, Buszczak et al., 2007)

l(1)2Eb

l(1)N4

l67

(Kramers et al., 1991, Kramers et al., 1983)

Name Synonyms

kurz

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 52 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31205

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O46072

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O46072

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O46072

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31205/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001330

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001330

FlyMine - An integrated database for Drosophila genomics

FBgn0001330

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3228

MARRVEL_MODEL - MARRVEL (model organism gene)

31205

Linkouts

BioGRID - A database of protein and genetic interactions.

57743

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001330

DroID - A comprehensive database of gene and protein interactions.

FBgn0001330

DRSC - Results frm RNAi screens

FBgn0001330

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

kz_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001330

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001330

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3228

Flygut - An atlas of the Drosophila adult midgut

FBgn0001330

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0001330

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015731

MIST (protein-protein) - An integrated Molecular Interaction Database

31205

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Major pathway of rRNA processing in the nucleolus and cytosol

References (65)

The following external sites may use different assemblies or annotations than FlyBase.

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