GluCl, glc, DrosGluCl-α, DrosGluCl, DmGluClα
glutamate-gated chloride channel, component of the ON and OFF pathway in the optic lobe - together with Rdl serves as a co-receptor for the insecticides nodulisporic acid and ivermectin - open-channel conformation causes a continuous inflow of chloride ions and sustained membrane hyperpolarization - antenna lobe
Please see the JBrowse view of Dmel\GluClα for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.52
Annotated transcripts may not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
There is a sequence repeat which involves the alternative final exons of GluClalpha, CG6300, and CG11659. A section of the long GluClalpha 3' UTR is not part of the repeat.
Gene model reviewed during 5.47
Gene model reviewed during 5.56
Multiphase exon postulated: reading frame of first coding exon differs in alternative transcripts.
9.7, 9.0, 6.0, 4.4, 3.0 (northern blot)
None of the polypeptides share 100% sequence identity.
456 (aa)
Expression of GluClα RNA in Xenopus laevis oocytes gives rise to a homomeric chloride channel gated by glutamate and avermectin.
Pentamer (By similarity). Homomultimer.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\GluClα using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
GluClα is strongly expressed in all major ON pathway medulla neurons: Mi1, Tm3, Mi4, and Mi9. It is also expressed in OFF pathway neurons (Tm1, Tm2, Tm4, and Tm9), although weaker in Tm9. Single cell RNA-seq results extracted from FBrf0239558 and FBrf0239740.
JBrowse - Visual display of RNA-Seq signals
View Dmel\GluClα in JBrowse3-67
3-69.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
GluClα is a glutamate gated chloride channel that is dual gated by glutamate and avermectin, exhibits a rapidly desensitising glutamate response and lack of potentiation of the glutamate response by avermectin.
Source for merge of: GluClα BcDNA:HL07853
"GluClα" may be "ort".
Source for merge of GluClα BcDNA:HL07853 was a shared cDNA ( date:030728 ).
