FlyBase Gene Report: Dmel\Lrp4

General Information

Symbol

Dmel\Lrp4

Species

D. melanogaster

Name

LDL receptor related protein 4

Annotation Symbol

CG8909

Feature Type

protein_coding_gene

FlyBase ID

FBgn0030706

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

LDL receptor related protein 4 (Lrp4) encodes a type I transmembrane protein that is enriched in presynaptic terminals and regulates synaptic organization in the olfactory circuit. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

14A1-14A1

Sequence location

X:15,910,870..15,921,013 [+]

Recombination map

1-52

RefSeq locus

NC_004354 REGION:15910870..15921013

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in presynaptic active zone organization

inferred from mutant phenotype

(Mosca et al., 2017)

inferred from mutant phenotype

(DePew et al., 2024)

involved_in synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(DePew et al., 2024)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Mosca et al., 2017)

located_in presynaptic periactive zone

inferred from direct assay

(DePew et al., 2024, Mosca et al., 2017)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002557696

(GO Reference Genome Project, 2011-)

located_in presynaptic membrane

inferred from experiment

(DePew et al., 2024, Mosca et al., 2017)

located_in synaptic membrane

inferred from sequence or structural similarity with UniProtKB:Q9QYP1

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the LDLR family. (Q9VXM0)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Functions presynaptically to promote the function and organization of active zones (PubMed:28606304, PubMed:38738619). Acts upstream of Srpk79D in presynaptic active zone organization; may be involved in presynaptic localization of Srpk79D (PubMed:28606304, PubMed:38738619). Required in excitatory neurons, but not in inhibitory neurons (PubMed:28606304). May be involved in presynaptic and postsynaptic cytoskeleton and membrane organization during active zone maturation at neuromuscular junctions (PubMed:38738619). Required in olfactory receptor neurons for normal olfactory attraction behavior (PubMed:28606304).

(UniProt, Q9VXM0)

Summary (Interactive Fly)

low-density lipoprotein receptor-related protein in the same family as Arrow, a Wingless co-receptor - coordinates synapse number and function in the brain - functions via the conserved kinase SRPK79D to ensure normal synapse number and behavior, occurs preferentially in excitatory neurons

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Lrp4 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VXM0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Lrp4-RB

FBtr0074125

NM_167474

7002

2009

Lrp4-RC

FBtr0301666

NM_001169298

7442

2008

Lrp4-RD

FBtr0340309

NM_001298378

7168

2008

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Lrp4-PB

FBpp0073931

225.9

2009

6.19

FBpp0290880

225.8

2008

6.19

FBpp0309270

225.8

2008

6.19

B5X533

NP_001285307

AHN59777

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2008 aa isoforms: Lrp4-PC, Lrp4-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with Srpk79D; involved in proper localization of Srpk79D in the presynapse.

(UniProt, Q9VXM0)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lrp4 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.77

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Arbeitman et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic central brain neuron

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

lateral cord neuron

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

(Arbeitman et al., 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain

(Mosca et al., 2017)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Lrp4 is enriched in the synaptic neuropil of the adult antennal lobe.

(Mosca et al., 2017)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in axon terminus

inferred from direct assay

(Mosca et al., 2017)

located_in presynaptic periactive zone

inferred from direct assay

(DePew et al., 2024, Mosca et al., 2017)

Expression Deduced from Reporters

Reporter: P{GMR90B08-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Mosca et al., 2017)

olfactory receptor neuron

(Mosca et al., 2017)

projection neuron

(Mosca et al., 2017)

glutamatergic neuron | subset

(Mosca et al., 2017)

cholinergic neuron | subset

(Mosca et al., 2017)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lrp4 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Lrp4

View exonic expression by tissue for Dmel\Lrp4

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030706

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32552/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030706

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030706

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030706

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8909

Flygut - An atlas of the Drosophila adult midgut

FBgn0030706

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Lrp4

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Lrp4

Transgenic constructs containing regulatory region of Lrp4

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

Lrp4^GD14320

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

Lrp4^GD2637

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Lrp4^GD14320

viable, with Scer\GAL4^Mef2.PR

Lrp4^GD14320

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Lrp4^GD14320

viable | recessive

Lrp4^dalek

Other Phenotypes

Allele

abnormal cell number | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

abnormal neuroanatomy | adult stage

Lrp4^dalek

abnormal neuroanatomy | adult stage, with Scer\GAL4^Gad1.3.098

Lrp4^{UAS.Tag:HA,Tag:FLAG}

abnormal neuroanatomy | adult stage, with Scer\GAL4^Mz19

abnormal neuroanatomy | adult stage, with Scer\GAL4^peb-GAL4

abnormal smell perception | adult stage, with Scer\GAL4^peb-GAL4

decreased body size | adult stage

Lrp4^dalek

Phenotype manifest in

Allele

adult antennal lobe projection neuron

Lrp4^dalek

adult antennal lobe projection neuron, with Scer\GAL4^Mz19

adult antennal lobe projection neuron, with Scer\GAL4^Mz699

Lrp4^{UAS.Tag:HA,Tag:FLAG}

adult olfactory receptor neuron

Lrp4^dalek

adult olfactory receptor neuron, with Scer\GAL4^peb-GAL4

axon terminus | adult stage | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

cone cell | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

GABAergic neuron | adult stage, with Scer\GAL4^Gad1.3.098

Lrp4^{UAS.Tag:HA,Tag:FLAG}

larval brain | larval stage, with Scer\GAL4^insc-Mz1407

Lrp4^GD14320

outer medulla | adult stage | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

photoreceptor cell R7 | adult stage | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

pigment cell | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

presynaptic active zone | adult stage

Lrp4^dalek

presynaptic active zone | adult stage, with Scer\GAL4^Gad1.3.098

Lrp4^{UAS.Tag:HA,Tag:FLAG}

presynaptic active zone | adult stage, with Scer\GAL4^Mz19

presynaptic active zone | adult stage, with Scer\GAL4^Mz699

Lrp4^{UAS.Tag:HA,Tag:FLAG}

presynaptic active zone | adult stage, with Scer\GAL4^peb-GAL4

retina | somatic clone, with Scer\GAL4^GMR.long

Lrp4^{UAS.Tag:HA,Tag:FLAG}

synapse | adult stage

Lrp4^dalek

synapse | adult stage, with Scer\GAL4^Gad1.3.098

Lrp4^{UAS.Tag:HA,Tag:FLAG}

synapse | adult stage, with Scer\GAL4^Mz19

synapse | adult stage, with Scer\GAL4^Mz699

Lrp4^{UAS.Tag:HA,Tag:FLAG}

synapse | adult stage, with Scer\GAL4^peb-GAL4

T-bar | adult stage

Lrp4^dalek

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (58)

Hsap\LRP4

12 of 14

Yes

6 of 14

6 of 14

5 of 14

4 of 14

Yes

Hsap\EGF

3 of 14

Yes

Hsap\LRP1B

3 of 14

Hsap\LRP2

3 of 14

Hsap\LDLRAD3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (39)

Rnor\Lrp4

12 of 14

Yes

6 of 14

6 of 14

5 of 14

3 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Rnor\Vldlr

2 of 14

Rnor\C1r

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (47)

Mmus\Lrp4

11 of 14

Yes

6 of 14

6 of 14

5 of 14

3 of 14

Yes

Mmus\Lrp1b

3 of 14

Mmus\Lrp2

3 of 14

Mmus\Sorl1

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Pros1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (45)

Xtro\lrp4

8 of 13

Yes

4 of 13

2 of 13

2 of 13

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\vldlr

1 of 13

Xtro\vwf

1 of 13

Danio rerio (Zebrafish) (51)

Drer\lrp4

6 of 14

Yes

Drer\lrp5

6 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\egf

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\vldlr

2 of 14

Drer\cd248a

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100536757

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (31)

Cele\lrp-1

3 of 14

Yes

Cele\lrp-2

3 of 14

Yes

Cele\rme-2

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\clec-180

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (71)

Agam\AgaP_AGAP000037

12 of 12

Yes

3 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\PEP1

1 of 13

Yes

Scer\VTH1

1 of 13

Yes

Scer\VTH2

1 of 13

Yes

Scer\YNR065C

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\vps10

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Lrp4. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (49)

arr

5 of 13

LpR2

4 of 13

mgl

4 of 13

cue

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

Ndg

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

crb

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

MP1

1 of 13

Sfp53D

1 of 13

slow

1 of 13

snk

1 of 13

tpr

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 4 )

Human Ortholog

Disease

Evidence

References

LRP4; LDL receptor related protein 4

model of congenital myasthenic syndrome 17

IEA

(FlyBase, 2019-)

model of Cenani-Lenz syndactyly syndrome

IEA

(FlyBase, 2019-)

model of sclerosteosis 2

IEA

(FlyBase, 2019-)

EGF; epidermal growth factor

model of renal hypomagnesemia 4

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

LRP4; LDL receptor related protein 4

12 of 14

604270

LRP5; LDL receptor related protein 5

6 of 14

603506

LRP6; LDL receptor related protein 6

6 of 14

603507

coronary artery disease

LRP1; LDL receptor related protein 1

5 of 14

107770

keratosis pilaris atrophicans

SORL1; sortilin related receptor 1

4 of 14

602005

EGF; epidermal growth factor

3 of 14

131530

HYPOMAGNESEMIA 4, RENAL; HOMG4

renal hypomagnesemia 4

LRP1B; LDL receptor related protein 1B

3 of 14

608766

LRP2; LDL receptor related protein 2

3 of 14

600073

DONNAI-BARROW SYNDROME; DBS

Donnai-Barrow syndrome

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Lrp4 - Srpk79D

proximity ligation assay, fluorescence microscopy

(Mosca et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Lrp4

suppressible

GABA-B-R2

(Mosca et al., 2017)

Lrp4

enhanceable

loaf

(Douthit et al., 2021)

Lrp4

suppressible

loaf

(Douthit et al., 2021)

Lrp4

suppressible

Srpk79D

(Mosca et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

fzr

suppressible

Lrp4

(Neuert et al., 2017)

External Data

Subunit Structure (UniProtKB)

Interacts with Srpk79D; involved in proper localization of Srpk79D in the presynapse.

(UniProt, Q9VXM0 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58899

DroID - A comprehensive database of gene and protein interactions.

FBgn0030706

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-52

Cytogenetic map

14A1-14A1

Sequence location

X:15,910,870..15,921,013 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

14A1-14A1

Limits computationally determined from genome sequence between P{EP}Gβ13F^EP1071 and P{EP}EP1458&P{EP}EP1522

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-52

(FlyBase, 2016)

1-52.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

601909

w¹¹¹⁸; P{R54F08-p65.AD}attP40

72096

w¹¹¹⁸; P{VT062498-p65.AD}attP40

73143

w¹¹¹⁸; P{VT062501-p65.AD}attP40

72778

w¹¹¹⁸; P{VT062498-GAL4.DBD}attP2

73937

w¹¹¹⁸; P{VT062501-GAL4.DBD}attP2

Korea

12276

P{VT062501-GAL4}attP2

12815

P{VT062498-GAL4}attP2

10703

8909R-1

8909R-2

v108629

v29900

w¹¹¹⁸; P{GD14320}v29900

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (22)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH14506

Other clones

IP21864

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0030706

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0030706

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Mosca et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Lrp4 CG8909

(Mosca et al., 2017)

Nomenclature comments

Etymology

Named 'Lrp4' after the mammalian homologue.

(Mosca et al., 2017)

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

CG8909

(Mosca et al., 2017, Neuert et al., 2017, Transgenic RNAi Project members, 2017-, Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Soukup et al., 2009, Ni et al., 2008, Legube et al., 2006)

CT25574

(Hynes and Zhao, 2000)

Dm CG8909

(Konikoff et al., 2010)

LRP4

(Mosca et al., 2017)

Lrp4

(Douthit et al., 2021, Rosenthal and Yuan, 2021, Uçkun et al., 2021, Kurmangaliyev et al., 2020, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-)

lrp4

(DePew and Mosca, 2021, Mosca et al., 2017)

Name Synonyms

LDL receptor related protein 4

yolkless-like

(Hynes and Zhao, 2000)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 48 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32552

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VXM0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VXM0

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VXM0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0030706

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32552/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0030706

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0030706

FlyMine - An integrated database for Drosophila genomics

FBgn0030706

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8909

MARRVEL_MODEL - MARRVEL (model organism gene)

32552

Linkouts

BioGRID - A database of protein and genetic interactions.

58899

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0030706

DroID - A comprehensive database of gene and protein interactions.

FBgn0030706

DRSC - Results frm RNAi screens

FBgn0030706

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0030706

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0030706

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8909

Flygut - An atlas of the Drosophila adult midgut

FBgn0030706

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007146

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (48)

The following external sites may use different assemblies or annotations than FlyBase.

-0.77

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