FlyBase Gene Report: Dmel\Pcyt1

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\Pcyt1

General Information

Symbol

Dmel\Pcyt1

Species

D. melanogaster

Name

Phosphocholine cytidylyltransferase 1

Annotation Symbol

CG1049

Feature Type

protein_coding_gene

FlyBase ID

FBgn0041342

Gene Model Status

Stock Availability

20 publicly available

Enzyme Name (EC)

choline-phosphate cytidylyltransferase (2.7.7.15)

Gene Summary

Phosphocholine cytidylyltransferase 1 (Pcyt1) encodes a choline-phosphate cytidylyltransferase involved in the endosomal traffic of several protein including the products of Egfr and N. [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Cct1, CTP:phosphocholine cytidylyltransferase 1, Cct, Phosphocholine cytidylyltransferase

Key Links

Genomic Location

Cytogenetic map

Sequence location

3L:1,546,092..1,553,504 [+]

Recombination map

3-0.5

RefSeq locus

NT_037436 REGION:1546092..1553504

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables choline-phosphate cytidylyltransferase activity

inferred from direct assay

(Tilley et al., 2008)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables catalytic activity

inferred from electronic annotation with InterPro:IPR004821

(InterPro Project Members, 2004-)

enables choline-phosphate cytidylyltransferase activity

inferred from electronic annotation with InterPro:IPR045049

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000077494

(GO Reference Genome Project, 2011-)

enables phosphatidylcholine binding

inferred from biological aspect of ancestor with PANTHER:PTN000077494

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in determination of adult lifespan

inferred from mutant phenotype

(Landis et al., 2003)

involved_in endocytosis

inferred from mutant phenotype

(Weber et al., 2003)

involved_in establishment of ommatidial planar polarity

inferred from mutant phenotype

(Weber et al., 2003)

involved_in eye development

inferred from mutant phenotype

(Weber et al., 2003)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Weber et al., 2003)

involved_in oogenesis

inferred from mutant phenotype

(Gupta and Schupbach, 2003)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in CDP-choline pathway

inferred from electronic annotation with InterPro:IPR045049

(InterPro Project Members, 2004-)

involved_in phosphatidylcholine biosynthetic process

inferred by curator from GO:0004105

(Tilley et al., 2008)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Tilley et al., 2008)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

choline-phosphate cytidylyltransferase activity

phosphocholine + CTP + H(+) = CDP-choline + diphosphate (2.7.7.15)

RHEA 18997:

Summaries

Gene Snapshot

Phosphocholine cytidylyltransferase 1 (Pcyt1) encodes a choline-phosphate cytidylyltransferase involved in the endosomal traffic of several protein including the products of Egfr and N. [Date last reviewed: 2019-09-26]

Gene Group (FlyBase)

CYTIDYLYLTRANSFERASES -: Cytidylyltransferases catalyse the transfer of a cytidylyl group to an acceptor.

Gene Model and Products

Number of Transcripts

6

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Pcyt1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7K4C7)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0072738

2486

526

FBtr0072740

2407

526

FBtr0072741

2302

526

FBtr0072739

2529

526

FBtr0333396

2564

526

FBtr0345365

2754

526

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0072621

58.2

526

5.77

FBpp0072623

58.2

526

5.77

FBpp0072624

58.2

526

5.77

FBpp0072622

58.2

526

5.77

FBpp0305588

58.2

526

5.77

FBpp0311519

58.2

526

5.77

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

526 aa isoforms: Pcyt1-PA, Pcyt1-PB, Pcyt1-PC, Pcyt1-PD, Pcyt1-PE, Pcyt1-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q7K4C7

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pcyt1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.82

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

anterior midgut primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior midgut primordium

(Fisher et al., 2012)

salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)

salivary gland duct primordium

(Fisher et al., 2012)

embryonic stage 11 -- 15

salivary gland body primordium

(Fox et al., 2010)

embryonic epidermis

(Fox et al., 2010)

embryonic stage 13 -- 16

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Tilley et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Pcyt1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pcyt1

View exonic expression by tissue for Dmel\Pcyt1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0041342

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

117353/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041342

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041342

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041342

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1049

Flygut - An atlas of the Drosophila adult midgut

FBgn0041342

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pcyt1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 37 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pcyt1

Transgenic constructs containing regulatory region of Pcyt1

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

(Schupbach, 2000.3.4)

(Ryder, 2004.4.26)

Df(3L)Pcyt1²⁹⁹

(Gupta and Schupbach, 2003)

Gene not disrupted in

Df(3L)Pcyt1¹²⁴

(Gupta and Schupbach, 2003)

Gene partially disrupted in

Df(3L)Pcyt1⁹⁹

(Gupta and Schupbach, 2003)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of first instar larval stage

lethal - all die before end of larval stage (with Df(3L)Ar14-8)

Pcyt1^EP831

partially lethal

Pcyt1¹⁶⁹¹⁹

partially lethal - majority live

Pcyt1¹⁶⁹¹⁹

partially lethal - majority live (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

viable, with Scer\GAL4^Mef2.PR

Pcyt1^GD6991

viable, with Scer\GAL4^pnr-MD237

Pcyt1^GD6991

viable, with Scer\GAL4^tin.CΔ4

Pcyt1^GD6991

Sterility

Allele

Pcyt1¹⁶⁹¹⁹

female sterile (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

male semi-sterile

Pcyt1¹⁶⁹¹⁹

Other Phenotypes

Allele

abnormal developmental rate

Pcyt1¹⁶⁹¹⁹

abnormal developmental rate (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

abnormal planar polarity

Pcyt1¹⁶⁹¹⁹

abnormal planar polarity (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

abnormal planar polarity (with Pcyt1¹⁶⁹¹⁹)

Pcyt1^EP831

abnormal planar polarity (with Pcyt1^EP831)

Pcyt1¹⁶⁹¹⁹

abnormal planar polarity | somatic clone | third instar larval stage

long lived, with Tn10\tetR^rtTA.Act5C

Pcyt1^PdL8R128

some die during first instar larval stage

some die during third instar larval stage (with Df(3L)Ar14-8)

Pcyt1^EP831

Pcyt1^+t11.2

Phenotype manifest in

Allele

Pcyt1⁹⁹

clathrin-coated pit

Pcyt1²⁹⁹

Pcyt1²⁹⁹

crossvein | increased number, with Scer\GAL4^sd-SG29.1

Pcyt1^Ala.UAS

dorsal appendage | maternal effect

Pcyt1¹²⁴

egg | maternal effect

Pcyt1¹⁶⁹¹⁹

egg chamber | germline clone | somatic clone

Pcyt1^unspecified

egg operculum | maternal effect (with Pcyt1¹²⁴)

Pcyt1²⁹⁹

egg operculum | maternal effect (with Pcyt1²⁹⁹)

Pcyt1¹²⁴

eye photoreceptor cell

Pcyt1¹⁶⁹¹⁹

eye photoreceptor cell (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

eye photoreceptor cell (with Pcyt1¹⁶⁹¹⁹)

Pcyt1^EP831

eye photoreceptor cell (with Pcyt1^EP831)

Pcyt1¹⁶⁹¹⁹

Pcyt1¹⁶⁹¹⁹

female germline stem cell

Pcyt1⁹⁹

late endosome | larval stage

Pcyt1²⁹⁹

Pcyt1¹⁶⁹¹⁹

nurse cell spectrosome

Pcyt1⁹⁹

Pcyt1¹⁶⁹¹⁹

ommatidium (with Df(3L)Ar14-8)

Pcyt1¹⁶⁹¹⁹

ommatidium (with Pcyt1¹⁶⁹¹⁹)

Pcyt1^EP831

ommatidium (with Pcyt1^EP831)

Pcyt1¹⁶⁹¹⁹

ommatidium | larval stage | somatic clone

oocyte | germline clone | somatic clone

Pcyt1^unspecified

oocyte | somatic clone

Pcyt1^unspecified

Pcyt1⁹⁹

photoreceptor cell R3 | larval stage | somatic clone

photoreceptor cell R4 | larval stage | somatic clone

rhabdomere | larval stage | somatic clone

Pcyt1¹⁷⁹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

13 of 14

Yes

Yes

2

12 of 14

No

Yes

2 of 14

No

No

3

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

13 of 14

Yes

Yes

12 of 14

No

Yes

2 of 14

No

No

Mus musculus (laboratory mouse) (3)

12 of 14

Yes

Yes

12 of 14

Yes

Yes

2 of 14

No

No

Xenopus tropicalis (Western clawed frog) (3)

10 of 13

Yes

Yes

6 of 13

No

Yes

1 of 13

No

No

Danio rerio (Zebrafish) (5)

12 of 14

Yes

Yes

12 of 14

Yes

Yes

11 of 14

No

Yes

11 of 14

No

Yes

2 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (5)

12 of 14

Yes

No

12 of 14

Yes

No

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP002263

9 of 12

Yes

Yes

Agam\AgaP_AGAP009264

2 of 12

No

No

Arabidopsis thaliana (thale-cress) (3)

10 of 13

Yes

Yes

10 of 13

Yes

Yes

2 of 13

No

No

Saccharomyces cerevisiae (Brewer's yeast) (2)

10 of 13

Yes

Yes

2 of 13

No

No

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPCC1827.02c

9 of 12

Yes

Yes

Spom\SPAC15E1.05c

2 of 12

No

No

Escherichia coli (enterobacterium) (1)

3 of 11

Yes

No

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Pcyt1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (2)

12 of 13

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

PCYT1A; phosphate cytidylyltransferase 1A, choline

model of spondylometaphyseal dysplasia with cone-rod dystrophy

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Pcyt1¹⁶⁹¹⁹

ameliorates congenital generalized lipodystrophy

modeled by Seipin^null

(Tian et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PCYT1A; phosphate cytidylyltransferase 1A, choline

13 of 14

spondylometaphyseal dysplasia with cone-rod dystrophy

PCYT1B; phosphate cytidylyltransferase 1B, choline

12 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pcyt1 - CG11980

experimental knowledge based

(Guruharsha et al., 2011)

Pcyt1 - CG13001

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Weber et al., 2003)

enhanceable

(Weber et al., 2003)

enhanceable

(Weber et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Weber et al., 2003)

enhanceable

(Weber et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

72882

DroID - A comprehensive database of gene and protein interactions.

FBgn0041342

MIST (genetic) - An integrated Molecular Interaction Database

117353

MIST (protein-protein) - An integrated Molecular Interaction Database

117353

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PC

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PC

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3L

Recombination map

3-0.5

Cytogenetic map

Sequence location

3L:1,546,092..1,553,504 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62A3-62A5

Limits computationally determined from genome sequence between P{EP}rho^EP3704&P{PZ}l(3)06226⁰⁶²²⁶ and P{PZ}dlt⁰⁴²⁷⁶

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-0.5

(FlyBase, 2016)

3-2.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

22123

w¹¹¹⁸; P{EPg}Pcyt1^HP35812

85365

w¹¹¹⁸; PBac{PB}Pcyt1^c03632

61286

y¹ v¹; P{TRiP.HMJ23118}attP40

36018

y¹ w^*; Mi{MIC}Pcyt1^MI02624

7319

w^*; P{lacW}Pcyt1¹⁶⁹¹⁹/TM6B, Tb⁺

109013

w^*; P{EP}Pcyt1^EP3379 / TM2

123308

w¹¹¹⁸; P{RS3}Pcyt1^CB-0748-3

125904

w¹¹¹⁸; P{RS5}Pcyt1^5-SZ-3125

1049R-1

P{NIG.1049R}1/SM6a, Duox^Cy

HMJ23118

y¹ v¹; P{TRiP.HMJ23118}attP40/CyO

v100575

P{KK108281}VIE-260B

v18628

w¹¹¹⁸; P{GD6991}v18628/TM3

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (122)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD46058

Other clones

DPiM_LD46058

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0041342

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0041342

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Grillet et al., 2016, Wilfling et al., 2013)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Cct1 mutants show increased endocytosis, leading to the internalization of N and Egfr receptors, resulting in decreased signalling of the pathways that these receptors are involved in.

(Weber et al., 2003)

Mutations in Cct1 cause a variety of defects including mispositioning of the oocyte, packaging defects, and a shortening of the operculum.

(Gupta and Schupbach, 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Cct1 CG1049

(Gupta, 2002.3.21)

Additional comments

l(3)02104 may correspond to Cct1: the P{PZ}l(3)02104⁰²¹⁰⁴ insertion maps within the transcription unit.

(Gene Disruption Project members, 2015.10.8)

Nomenclature History

Source for database identify of

Source for identity of: Cct1 Cct

(Gupta, 2002.3.21)

Source for identity of: Pcyt1 Cct1

(FlyBase, 2009-)

Nomenclature comments

Renamed from 'Cct1' to 'Pcyt1' in order to reduce confusion with the CCT1/CG5374 gene, and to mirror the nomenclature in use for this enzyme in most other species.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CCT1

(Song et al., 2022, He et al., 2021, Chorlay et al., 2019, Haider et al., 2018, Kory et al., 2015, Krahmer et al., 2013, Wilfling et al., 2013, Weber et al., 2003, Weber et al., 2003)

CG1049

(Wang et al., 2019, Haider et al., 2018, Hosono et al., 2015, Hoffmann et al., 2013, Krahmer et al., 2013, Wilfling et al., 2013, Kühnlein, 2011, Keleman et al., 2009.8.5, Perkins et al., 2009, Boutros et al., 2002, Dobrosotskaya et al., 2002)

CT41283

(Ceriani et al., 2002)

Cct

(Gupta and Schupbach, 2000, Schupbach, 2000.3.4)

Cct1

(Yao et al., 2018, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Clandinin and Owens, 2016-, Wong et al., 2016, Carnes et al., 2015, Sanchez-Alvarez et al., 2015, Van Bortle et al., 2015, Lee et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Remolina et al., 2012, Remolina et al., 2012, Tian et al., 2011, Castorena et al., 2010, Fox et al., 2010, Guo et al., 2008, Tilley et al., 2008, Buszczak et al., 2007, Lai et al., 2007)

Pcyt1

(Bland, 2023, Martínez et al., 2020)

cct1

(Gupta and Schupbach, 2002)

pcyt1

(Zhao et al., 2024, Banerjee et al., 2021)

Name Synonyms

CTP-phosphocholine cytidylyltransferase

(Kory et al., 2015)

CTP:phosphocholine cytidylyltransferase

(Gupta and Schupbach, 2000)

CTP:phosphocholine cytidylyltransferase 1

(Carnes et al., 2015, Kühnlein, 2011, Gupta, 2002.3.21)

Phosphocholine cytidylyltransferase

(Dobrosotskaya et al., 2002, Dobrosotskaya et al., 2002)

Phosphocholine cytidylyltransferase 1

cytidylyltransferase 1

(Hoffmann et al., 2013)

Secondary FlyBase IDs

FBgn0035230

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 76 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

117353

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7K4C7

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7K4C7

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7K4C7

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0041342

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

117353/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0041342

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0041342

FlyMine - An integrated database for Drosophila genomics

FBgn0041342

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1049

MARRVEL_MODEL - MARRVEL (model organism gene)

117353

Linkouts

BioGRID - A database of protein and genetic interactions.

72882

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0041342

DroID - A comprehensive database of gene and protein interactions.

FBgn0041342

DRSC - Results frm RNAi screens

FBgn0041342

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0041342

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0041342

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1049

Flygut - An atlas of the Drosophila adult midgut

FBgn0041342

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0041342

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (genetic) - An integrated Molecular Interaction Database

117353

MIST (protein-protein) - An integrated Molecular Interaction Database

117353

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synthesis of PC

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Synthesis of PC

References (99)