FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Notum
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General Information
Symbol
Dmel\Notum
Species
D. melanogaster
Name
Notum
Annotation Symbol
CG13076
Feature Type
protein_coding_gene
FlyBase ID
FBgn0044028
Gene Model Status
Current
Stock Availability
8 publicly available
Enzyme Name (EC)
Gene Summary
Notum (Notum) encodes an enzyme that cleaves glycophosphatidylinositol anchors. It acts via the product of dlp to influence the range and activity of secreted signaling proteins that interact with proteoglycans in the imaginal discs. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

wf, wingful, l(3)72CDf, l(3)72Da

Key Links
Genomic Location
Cytogenetic map
72C3-72D1
Sequence location
Recombination map
3-44
RefSeq locus
NT_037436 REGION:16023480..16032752
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
NOT enables deacetylase activity
inferred from direct assay
(Kreuger et al., 2004)
NOT enables glycerophospholipase activity
inferred from direct assay
(Kakugawa et al., 2015)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables hydrolase activity
inferred from electronic annotation with InterPro:IPR004963
(InterPro Project Members, 2004-)
enables palmitoleyl hydrolase activity
inferred from sequence or structural similarity with UniProtKB:Q6P988
(Gene Ontology Curators, 2002-)
enables protein-containing complex destabilizing activity
inferred from biological aspect of ancestor with PANTHER:PTN009047513
(GO Reference Genome Project, 2011-)
Biological Process (9 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in digestive tract morphogenesis
inferred from mutant phenotype
(Tian et al., 2019)
involved_in negative regulation of canonical Wnt signaling pathway
inferred from direct assay
(Kakugawa et al., 2015)
inferred from mutant phenotype
(Kakugawa et al., 2015, Gerlitz and Basler, 2002)
inferred from genetic interaction with FLYBASE:Sulf1; FB:FBgn0040271
(You et al., 2011)
inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930
(Han et al., 2005)
involved_in positive regulation of smoothened signaling pathway
inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930
(Ayers et al., 2012)
inferred from mutant phenotype
(Ayers et al., 2010)
involved_in regulation of compound eye pigmentation
inferred from mutant phenotype
(Lim and Tomlinson, 2006)
involved_in ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
involved_in wing disc development
inferred from mutant phenotype
(Gerlitz and Basler, 2002)
involved_in wing disc dorsal/ventral pattern formation
inferred from genetic interaction with FLYBASE:dally; FB:FBgn0263930
(Han et al., 2005)
involved_in wing disc pattern formation
inferred from mutant phenotype
(Ayers et al., 2012, Ayers et al., 2010)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in negative regulation of canonical Wnt signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN009047513
(GO Reference Genome Project, 2011-)
involved_in protein depalmitoleylation
inferred from sequence or structural similarity with UniProtKB:Q6P988
(Gene Ontology Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Kakugawa et al., 2015)
inferred from direct assay
(Gerlitz and Basler, 2002)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the pectinacetylesterase family. Notum subfamily. (Q9VUX3)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
palmitoleyl hydrolase activity
Summaries
Gene Snapshot
Notum (Notum) encodes an enzyme that cleaves glycophosphatidylinositol anchors. It acts via the product of dlp to influence the range and activity of secreted signaling proteins that interact with proteoglycans in the imaginal discs. [Date last reviewed: 2019-03-14]
Pathway (FlyBase)
POSITIVE REGULATORS OF HEDGEHOG SIGNALING PATHWAY -
Positive regulators of hedgehog signaling up-regulate the pathway, resulting in the activation of transcription of hh-responsive genes.
NEGATIVE REGULATORS OF WNT-TCF SIGNALING PATHWAY -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Gene Group (FlyBase)
UNCLASSIFIED CARBOXYLIC ESTER HYDROLASES -
This group comprises carboxylic ester hydrolases that do not classify under other groups in FlyBase.
Protein Function (UniProtKB)
Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors (PubMed:25731175). Also acts as a regulator of long-range activity of Hedgehog (hh), possibly by regulating the switch between low and high level hh pathway signaling (PubMed:20412775, PubMed:22872085).
(UniProt, Q9VUX3)
Summary (Interactive Fly)

alpha/ß-hydrolase - Wingless antagonist - acts to induce cleavage of the Dlp glypican at the level of its GPI anchor leading to shedding of Dlp - spatially regulated modification of Dlp by Notum employs the ligand binding activity of Dlp to promote or inhibit signaling in a context-dependent manner

Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Notum for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VUX3)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Notum-RA
FBtr0075435
NM_168643
3792
671
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Notum-PA
FBpp0075193
76.9
671
10.55
Q9VUX3
NP_730096
AAF49550
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Notum using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
ectoderm | segmentally repeated
(Halfon et al., 2011)
mesoderm | dorsal | restricted
(Halfon et al., 2011)
embryonic precursor of adult hindgut
(Halfon et al., 2011)
extended germ band stage
organism | segmentally repeated
(Giraldez et al., 2002)
embryonic stage 13
organism | segmentally repeated
(Gerlitz and Basler, 2002)
third instar larval stage
imaginal disc | restricted

Comment: pattern similar to that of wg

(Gerlitz and Basler, 2002)
dorsal-ventral compartment boundary of the wing disc
(Giraldez et al., 2002)
Additional Descriptive Data

Transcript is detected in a segmentally repeated pattern in germ band extended embryos in 2 rows of cells anterior to en expressing cells that likely correspond to wg expressing cells. The expression of Notum in the wing disc also appears to overlap the wg expression pattern.

(Giraldez et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular space
inferred from direct assay
(Kakugawa et al., 2015)
inferred from direct assay
(Gerlitz and Basler, 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Notum in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Notum
Transgenic constructs containing regulatory region of Notum
Aberrations (Deficiencies and Duplications) ( 14 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(3L)st-f13)
lethal | recessive
lethal - all die before end of pupal stage (with Df(3L)st-f13)
lethal - all die before end of pupal stage | recessive
lethal - all die during embryonic stage, with Scer\GAL4ptc-559.1
partially lethal (with Df(3L)st-f13)
partially lethal - majority die
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
viable (with NotumI6)
viable (with NotumKO)
Other Phenotypes
Allele
abnormal neuroanatomy
decreased size | adult stage, with Scer\GAL4C-765
decreased size | adult stage, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
decreased size | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
increased cell death | somatic clone
some die during embryonic stage, with Scer\GAL4ptc-559.1
some die during pupal stage (with Df(3L)st-f13)
some die during pupal stage | recessive
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Notum-S168
visible, with Scer\GAL4sd-S278
visible, with Scer\GAL4sd-SG29.1
visible, with Scer\GAL4wg-Gal4
visible | adult stage, with Scer\GAL4C-765
visible | adult stage, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
visible | cell non-autonomous | recessive | somatic clone
visible | recessive | somatic clone
Phenotype manifest in
Allele
abdominal sternite bristle | increased number (with Df(3L)st-f13)
adult thorax | dorsal | ectopic, with Scer\GAL4sd-SG29.1
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
denticle | ectopic, with Scer\GAL4αTub84B.PL
denticle row 1
dorsal row of wing sensilla, with Scer\GAL4ap-md544
dorsocentral bristle | increased number (with Df(3L)st-f13)
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4αTub84B.PL
embryonic/first instar larval cuticle | rescuable maternal effect
external sensory organ precursor cell | ectopic | somatic clone
eye
eye | somatic clone
leg, with Scer\GAL4wg-Gal4
mechanosensory chaeta | ectopic
mechanosensory ventral triple row bristle | ectopic | somatic clone
medial row of triple row of wing sensilla | ectopic
mesonotum, with Scer\GAL4dpp.blk1
mesonotum, with Scer\GAL4sd-S278
pigment cell | somatic clone
sensory mother cell | ectopic
sensory mother cell | ectopic | somatic clone
taste bristle | ectopic
ventral denticle belt
ventral denticle belt | rescuable maternal effect
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4C-765
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4Notum-S168
wing, with Scer\GAL4nub-AC-62, Scer\GAL80elav.PU
wing, with Scer\GAL4sd-S278
wing, with Scer\GAL4sd-SG29.1
wing blade dorsal compartment, with Scer\GAL4ap-md544
wing disc (with Df(3L)st-f13)
wing disc (with Notum3)
wing disc (with NotumI6)
wing disc | larval stage, with Hsap\RELAp65(AD)::pMag.Ubi, Scer\GAL4rn-G4DBD::nMagHigh1
wing margin
wing margin | posterior, with Scer\GAL4en-e16E
wing margin bristle, with Scer\GAL4Notum-S168
wing margin bristle | absent, with Scer\GAL4salm.PU
wing margin bristle | increased number (with Df(3L)st-f13)
wing margin bristle | increased number (with NotumI6)
wing margin bristle | increased number (with NotumKO)
wing margin bristle | posterior, with Scer\GAL4en-e16E
wing margin taste bristle | increased number
wing sensillum, with Scer\GAL4C-765
wing sensillum | cell non-autonomous | somatic clone | increased number
wing vein | ectopic, with Scer\GAL4C-765
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\NOTUM
11 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Notum
11 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Notum
10 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (2)
Xtro\notum
8 of 13
Yes
Yes
Xtro\LOC100493204
6 of 13
No
Yes
Danio rerio (Zebrafish) (3)
Drer\notum1a
12 of 14
Yes
Yes
Drer\notum2
12 of 14
Yes
Yes
Drer\notum1b
3 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (1)
Agam\AgaP_AGAP006073
11 of 12
Yes
Yes
Arabidopsis thaliana (thale-cress) (12)
Atha\AT4G19410
8 of 13
Yes
Yes
Atha\AT5G45280
8 of 13
Yes
Yes
Atha\AT3G09405
7 of 13
No
Yes
Atha\AT3G09410
7 of 13
No
Yes
Atha\AT4G19420
7 of 13
No
Yes
Atha\AT1G09550
6 of 13
No
Yes
Atha\AT1G57590
6 of 13
No
Yes
Atha\AT2G46930
6 of 13
No
Yes
Atha\AT3G05910
6 of 13
No
Yes
Atha\AT3G62060
6 of 13
No
Yes
Atha\AT5G23870
6 of 13
No
Yes
Atha\AT5G26670
6 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Notum. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NOTUM; notum, palmitoleoyl-protein carboxylesterase
    11 of 14
    609847
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        RNA-RNA
        Physical Interaction
        Assay
        References
        Notum - mir-315
        luminiscence technology, necessary binding region, fluorescence technology
        (Silver et al., 2007)
        protein-protein
        Physical Interaction
        Assay
        References
        Notum - wg
        pull down, western blot
        (McGough et al., 2020)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Notum
        suppressible
        amls
        (Reim et al., 2014)
        Notum
        suppressible
        dally
        (Kakugawa et al., 2015)
        Notum
        suppressible
        dlp
        (Kirkpatrick et al., 2004)
        Notum
        enhanceable
        dlp
        (Kreuger et al., 2004)
        Notum
        suppressible
        mir-315
        (Silver et al., 2007)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        dlp
        enhanceable
        Notum
        (Kreuger et al., 2004)
        mir-315
        suppressible
        Notum
        (Silver et al., 2007)
        Sulf1
        enhanceable
        Notum
        (You et al., 2011)
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyBase
        External Links
        External Data
        Linkouts
        KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-44
        Cytogenetic map
        72C3-72D1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        72C3-72D1
        Limits computationally determined from genome sequence between P{EP}Tfb2EP572 and P{lacW}thj5C8&P{PZ}Mbs03802
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        72D-72D
        (Gerlitz, 2002.2.12)
        Experimentally Determined Recombination Data
        Location

        3-44

        (FlyBase, 2016)

        3-38.2

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (8)
        Genomic Clones (25)
        cDNA Clones (34)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                DRSC - Results frm RNAi screens
                Antibody Information
                Laboratory Generated Antibodies
                 
                Commercially Available Antibodies
                 
                Cell Line Information
                Publicly Available Cell Lines
                 
                  Other Stable Cell Lines
                   
                  Other Comments

                  The 'l(3)72Da' (Notum) complementation group comprises 8 EMS-induced mutant alleles.

                  (Cooper and Kennison, 2011)

                  Notum cooperates with dlp to limit wg signalling.

                  (Kirkpatrick et al., 2004)

                  Co-expression of Notum and dlp in S2 cells leads to the cleavage of the GPI-anchor of dlp protein and relase of dlp protein into the culture medium

                  (Kreuger et al., 2004)

                  Notum antagonizes the wg signaling pathway, restricting the region of high-response to wg and helping to shape the activity gradient in different contexts throughout development.

                  (Giraldez and Cohen, 2001)

                  Homozygous mutants for Notum develop an excess of naked cuticle during embryogenesis. Mutant larvae have wing pouch duplications, resulting in a loss of notum specification.

                  (Giraldez and Cohen, 2001)

                  Identified during a mutagenesis of the 71F-72D region.

                  (Melendez et al., 1995)
                  Relationship to Other Genes
                  Source for database merge of

                  Source for merge of: Notum l(3)72Da

                  (Giraldez et al., 2002)

                  Source for merge of: Notum l(3)72CDf

                  (Basler, 2002.7.9)

                  Source for merge of: Notum CG13076

                  (FlyBase, 1996-)

                  Source for merge of: Notum anon-WO0118547.482 anon-WO03062410.10 anon-WO03062410.8

                  (FlyBase, 1996-)
                  Additional comments

                  "l(3)72Db" does not correspond to "Notum"; "l(3)72Db8" complements a "Notum" mutant.

                  (Giraldez, 2002.9.13)

                  Source for merge of Notum CG13076 was sequence comparison ( date:020425 ).

                  (FlyBase, 1996-)

                  Source for merge of Notum anon-WO0118547.482 anon-WO03062410.10 anon-WO03062410.8 was sequence comparison ( date:051113 ).

                  (FlyBase, 1996-)
                  Nomenclature History
                  Source for database identify of
                  Nomenclature comments
                  Etymology

                  The gene is named "wingful" after the mutant phenotype; mutant larval wing discs are enlarged with an extended wing blade region.

                  (Gerlitz and Basler, 2002)

                  The gene is named "Notum" on the basis of its mutant phenotypes in the adult.

                  (Giraldez et al., 2002)
                  Synonyms and Secondary IDs (18)
                  Reported As
                  Symbol Synonym
                  CG13076
                  (Hadar et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Häcker et al., 2005, Bolshakov et al., 2002)
                  Not
                  (Desbordes et al., 2005)
                  Notum
                  (Sun et al., 2024, Voutyraki et al., 2023, Magny et al., 2021, Slaidina et al., 2021, McGough et al., 2020, Rushton et al., 2020, Kopke et al., 2017, Clandinin and Owens, 2016-, Lee et al., 2016, Norman et al., 2016, Yamazaki et al., 2016, Bivik et al., 2015, Ashwal-Fluss et al., 2014, Ayers et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Raftery and Umulis, 2012, Cherbas et al., 2011, Cooper and Kennison, 2011, Gafuik and Steller, 2011, You et al., 2011, Ayers et al., 2010, Bennett et al., 2010, Hartmann et al., 2009, Gallet et al., 2008, Kennell et al., 2008, Liu et al., 2008, Parker et al., 2008, Lai et al., 2007, Li et al., 2007, Lim and Tomlinson, 2006, Kreuger et al., 2004)
                  Nt
                  (Vincent et al., 2011)
                  Wf
                  (Mbodj et al., 2013)
                  anon-WO0118547.482
                  anon-WO03062410.10
                  anon-WO03062410.8
                  l(3)72CDf
                  (Cooper and Kennison, 2011, Bloomington Drosophila Stock Center, 1997.12.5, Melendez et al., 1995)
                  l(3)72Da
                  (Cooper and Kennison, 2011)
                  notum
                  (Tian et al., 2019, Akai et al., 2018, Tian et al., 2017, Kakugawa et al., 2015, Hadar et al., 2012, Halfon et al., 2011, Slattery et al., 2011, Vincent et al., 2011, You et al., 2011, Chang et al., 2008, Häcker et al., 2005)
                  ntm
                  (Zhu, 2011)
                  wf
                  (Zhang et al., 2019, Jenny and Basler, 2016, Zhang et al., 2016, Schertel et al., 2013, Vincent et al., 2011, Song et al., 2010, Chang et al., 2008, Parker et al., 2007, Basler, 2002.7.9, Gerlitz, 2002.2.12, Gerlitz and Basler, 2002)
                  Name Synonyms
                  Notum
                  (Alvarez-Rodrigo et al., 2023, Shilo, 2016, Mohan et al., 2010, Song et al., 2010, Chang et al., 2008, Rafel and Milán, 2008, Silver et al., 2007, Giraldez and Cohen, 2001)
                  Wingful
                  (Silver et al., 2007)
                  lethal(3)72CDf
                  (Melendez et al., 1995)
                  lethal(3)72Da
                  notum
                  (Piddini and Vincent, 2009, Blauwkamp et al., 2008, Silver et al., 2007, Torroja et al., 2005)
                  wingful
                  (Zhang et al., 2019, Reim et al., 2014, Schertel et al., 2013, Vincent et al., 2011, Song et al., 2010, Chang et al., 2008, Lim and Tomlinson, 2006, Torroja et al., 2005, Gerlitz, 2002.2.12, Gerlitz and Basler, 2002)
                  wingful/notum
                  (Parker et al., 2007)
                  Secondary FlyBase IDs
                  • FBgn0005534
                  • FBgn0016904
                  • FBgn0036559
                  • FBgn0061961
                  • FBgn0067795
                  • FBgn0067796
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  Study result (0)
                  Result
                  Result Type
                  Title
                  External Crossreferences and Linkouts ( 40 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  Other crossreferences
                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                  FlyMine - An integrated database for Drosophila genomics
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL - MARRVEL (model organism gene)
                  PDB - An information portal to biological macromolecular structures
                  Linkouts
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  Flygut - An atlas of the Drosophila adult midgut
                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                  MIST (genetic) - An integrated Molecular Interaction Database
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  References (123)