FlyBase Gene Report: Dmel\lmgA

General Information

Symbol

Dmel\lmgA

Species

D. melanogaster

Name

lemming A

Annotation Symbol

CG34440

Feature Type

protein_coding_gene

FlyBase ID

FBgn0250903

Gene Model Status

Current

Stock Availability

6 publicly available

Enzyme Name (EC)

Gene Summary

lemming A (lmgA) encodes the RING-finger containing Apc11 subunit of the APC/C ubiquitin ligase (E3). Together with the cullin subunit encoded by mr, it forms the minimal ubiquitin ligase module of the APC/C. [Date last reviewed: 2019-02-28] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

lmg, l(2)03424, lemming, APC11

Key Links

Genomic Location

Cytogenetic map

29D4-29D5

Sequence location

2L:8,524,999..8,528,618 [-]

Recombination map

2-33

RefSeq locus

NT_033779 REGION:8524999..8528618

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables ubiquitin protein ligase activity

inferred from direct assay

(Nagy et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables cullin family protein binding

inferred from electronic annotation with InterPro:IPR024991

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

enables ubiquitin protein ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR024991

(InterPro Project Members, 2004-)

enables zinc ion binding

inferred from sequence model

(Ying et al., 2011)

inferred from electronic annotation with InterPro:IPR024991

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from direct assay

(Nagy et al., 2012)

involved_in positive regulation of mitotic metaphase/anaphase transition

inferred from mutant phenotype

(Nagy et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in anaphase-promoting complex-dependent catabolic process

inferred from electronic annotation with InterPro:IPR024991

(InterPro Project Members, 2004-)

involved_in positive regulation of mitotic metaphase/anaphase transition

inferred from biological aspect of ancestor with PANTHER:PTN000129916

(GO Reference Genome Project, 2011-)

involved_in protein ubiquitination

inferred from sequence or structural similarity with UniProtKB:Q9NYG5

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

involved_in ubiquitin-dependent protein catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from direct assay

(Nagy et al., 2012)

part_of ubiquitin ligase complex

inferred from direct assay

(Nagy et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from electronic annotation with InterPro:IPR024991

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000129916

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000129805

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES

ANAPHASE-PROMOTING COMPLEX

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

ubiquitin protein ligase activity

Summaries

Gene Snapshot

Gene Group (FlyBase)

UNCLASSIFIED RING DOMAIN UBIQUITIN LIGASES -: This group comprises RING domain ubiquitin ligases that do not classify under other groups in FlyBase.
ANAPHASE-PROMOTING COMPLEX -: Anaphase-promoting complex/cyclosome (APC/C) is a multisubunit E3 ubiquitin ligase. Active during mitosis and G1 phases of the cell cycle, it mediates the degradation of cyclins and other key cell cycle regulators triggering the metaphase to anaphase transition and the exit from mitosis. (Adapted from PMID:12208841).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\lmgA for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KA43)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.48

Gene model reviewed during 5.46

Gene model reviewed during 5.54

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0079695

2953

FBtr0112743

2014

FBtr0333419

3507

FBtr0336885

510

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

lmgA-PA

FBpp0079303

9.9

7.89

FBpp0111655

9.9

7.89

FBpp0305611

9.9

7.89

FBpp0307833

9.9

7.89

Q7KA43

NP_001260262

AGB92798

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

85 aa isoforms: lmgA-PA, lmgA-PB, lmgA-PC, lmgA-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KA43

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lmgA using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lmgA_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.26

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 13 -- 16

organism | ubiquitous

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage -- embryonic stage

organism

(Nagy et al., 2012)

Additional Descriptive Data

lmgA transcripts are seen at all stages of development tested with the highest levels in late pupae and persisting into adults. Levels of mono- and dicistronic lmg transcripts are very similar.

(Nagy et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of anaphase-promoting complex

inferred from direct assay

(Nagy et al., 2012)

part_of ubiquitin ligase complex

inferred from direct assay

(Nagy et al., 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\lmgA in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\lmgA

View exonic expression by tissue for Dmel\lmgA

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250903

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740853/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250903

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250903

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 8 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of lmgA

Transgenic constructs containing regulatory region of lmgA

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene duplicated in

Df(2L)lmg¹³⁸

(Nagy et al., 2012)

Gene disrupted in

Df(2L)BSC215

(Christensen and Cook, 2006.8.30)

Df(2L)lmg^J023

(Nagy et al., 2012)

Df(2L)N22-5

(BDGP Project Members, 1994-1999)

Df(2L)N22-14

(BDGP Project Members, 1994-1999)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lmgA⁰³⁴²⁴

lethal - all die before end of prepupal stage

lmgA^EY11317

lethal - all die before end of P-stage

lmgA⁰³⁴²⁴

viable

lmgA^d09381

Sterility

Allele

fertile

lmgA^d09381

Other Phenotypes

Allele

abnormal mitotic cell cycle | third instar larval stage

abnormal neuroanatomy | larval stage, with Scer\GAL4^elav-C155

lmgA^EP2077

abnormal neuroanatomy | somatic clone

lmgA⁰³⁴²⁴

decreased occurrence of cell division | somatic clone

lmgA⁰³⁴²⁴

increased cell death | third instar larval stage

increased occurrence of cell division | third instar larval stage

some die during pharate adult stage

lmgA⁰³⁴²⁴

some die during prepupal stage | recessive

lmgA^EY11317

Phenotype manifest in

Allele

anterior fascicle & synapse, with Scer\GAL4^elav-C155

lmgA^EP2077

eye

lmgA⁰³⁴²⁴

histoblast

lmgA⁰³⁴²⁴

larval brain | third instar larval stage

larval intersegmental nerve, with Scer\GAL4^elav-C155

lmgA^EP2077

neuroblast | somatic clone

lmgA⁰³⁴²⁴

wing disc | third instar larval stage

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (16)

Hsap\ANAPC11

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\RLIM

1 of 14

Hsap\RNF24

1 of 14

Yes

Hsap\RNF38

1 of 14

Hsap\RNF44

1 of 14

Hsap\RNF122

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (12)

Rnor\Anapc11

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Rnf139

1 of 14

Mus musculus (laboratory mouse) (12)

Mmus\Anapc11

13 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rlim

1 of 14

Mmus\Rnf24

1 of 14

Yes

Mmus\Rnf38

1 of 14

Mmus\Rnf122

1 of 14

Yes

Mmus\Rnf139

1 of 14

Xenopus tropicalis (Western clawed frog) (9)

Xtro\anapc11

6 of 13

Yes

Xtro\ltn1

1 of 13

Xtro\map3k1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (14)

Drer\anapc11

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Drer\rlim

1 of 14

Drer\rnf6

1 of 14

Drer\rnf24

1 of 14

Yes

Drer\rnf38

1 of 14

Drer\rnf44

1 of 14

Drer\rnf122

1 of 14

Yes

Drer\rnf139

1 of 14

Drer\rnf165b

1 of 14

Drer\ttc3

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\apc-11

12 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\plr-1

1 of 14

Cele\sel-11

1 of 14

Cele\T22B2.1

1 of 14

Yes

Cele\toe-4

1 of 14

Cele\Y54E10A.11

1 of 14

Cele\ZK637.14

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP008196

6 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP002028

1 of 12

Agam\AgaP_AGAP003561

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013357

1 of 12

Arabidopsis thaliana (thale-cress) (95)

Atha\APC11

12 of 13

Yes

Atha\AT5G26640

4 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G60360

1 of 13

Atha\AT1G68070

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT3G48030

1 of 13

Atha\AT3G54780

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G60710

1 of 13

Yes

Atha\AT5G67120

1 of 13

Atha\ATL1F

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RDUF1

1 of 13

Atha\RDUF2

1 of 13

Atha\RHA1A

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\RIN2

1 of 13

Atha\RIN3

1 of 13

Atha\RING1

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\APC11

12 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\apc11

12 of 12

Yes

Spom\rbx1

2 of 12

Spom\SPBC21D10.09c

1 of 12

Spom\SPBP4H10.07

1 of 12

Yes

Spom\SPCC4G3.12c

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:lmgA. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (6)

4 of 13

4 of 13

4 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ANAPC11; anaphase promoting complex subunit 11

13 of 14

614534

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

lmgA - Cdc23

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

lmgA - Cdk1

anti bait coimmunoprecipitation, western blot

(Mohd-Sarip et al., 2012)

lmgA - CycB

anti bait coimmunoprecipitation, western blot, enzymatic study

(Mohd-Sarip et al., 2012)

lmgA - Psc

pull down, autoradiography, anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry

(Mohd-Sarip et al., 2012)

lmgA - mr

two hybrid, anti bait coimmunoprecipitation, western blot, protein three hybrid

(Hu et al., 2017.6.13, Mohd-Sarip et al., 2012, Nagy et al., 2012)

lmgA - vih

protein three hybrid

(Nagy et al., 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

shtd

suppressible

lmgA

(Tanaka-Matakatsu et al., 2007)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0250903

MIST (genetic) - An integrated Molecular Interaction Database

5740853

MIST (protein-protein) - An integrated Molecular Interaction Database

5740853

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_dicistronic_mRNA

(FlyBase Genome Annotators, 2007)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-33

Cytogenetic map

29D4-29D5

Sequence location

2L:8,524,999..8,528,618 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29D4-29D5

Limits computationally determined from genome sequence between P{lacW}l(2)k03706^k03706&P{lacW}Acer^k07704 and P{PZ}lmg⁰³⁴²⁴

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

29D4-29D5

(determined by in situ hybridisation)

(Spradling et al., 1999)

29D4-29D5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-33

(FlyBase, 2016)

2-28.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

40857

y¹ v¹; P{TRiP.HMS02024}attP40/CyO

11330

P{PZ}lmgA⁰³⁴²⁴ lmgB⁰³⁴²⁴ cn¹/CyO; ry⁵⁰⁶

21361

y¹ w^67c23; P{EPgy2}lmgA^EY11317 lmgB^EY11317/CyO

35936

y¹ w^*; Mi{MIC}Acer^MI01059 lmgA^MI01059 lmgB^MI01059

FlyORF

F002722

M{UAS-lmgA.ORF.3xHA.GW}ZH-86Fb

NIG-Fly

2LG-0313

y² VhaAC39-1^cho-1 v¹; P{U6-lmgA.NIG.sgRNA}attP40/CyO

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (418)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

AT07979

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0250903

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0250903

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Mutations in lmg lead to abnormal mitoses and apoptosis in imaginal cells.

(Shirras, 2000.1.5)

Relationship to Other Genes

Source for database merge of

Source for merge of: lmg CG18042

(FlyBase, 1996-)

Additional comments

The "lemming" locus gives rise to a dicistronic transcript. The two open reading frames (ORFs) are lmgA (upstream ORF) and lmgB (downstream ORF). The lethal, morphological and mitotic phenotypes of the Df(2L)lmg¹³⁸ deletion (which affects both open reading frames) are rescued by expression of the lmgA ORF alone and the lmgB ORF does not appear to be efficiently translated in S2 cells.

(Nagy et al., 2012)

One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by lmg (CG34440) and CG34441 (CG34441).

(FlyBase Genome Annotators, 2007)

Source for merge of lmg CG18042 was sequence comparison ( date:000423 ).

(FlyBase Genome Annotators, 2007, FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: lmgA lmg

(Nagy et al., 2012)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

APC11

(Neuert et al., 2017, Buttitta et al., 2010, Silies and Klämbt, 2010)

APC11/lmg

(Weber and Mlodzik, 2017)

Apc11

(Tanaka-Matakatsu et al., 2007)

CG18042

(Schertel et al., 2013, Hayden and Bosco, 2008, Bocca et al., 2001, Kraut et al., 2001, Kraut et al., 2001)

CG34440

(National Institute of Genetics Fly Stocks, 2022-, Ying et al., 2011, FlyBase Genome Annotators, 2007)

Dromel_CG18042_FBtr0079695_lmg_uORF

(Hayden and Bosco, 2008)

Img

(Ying et al., 2011)

LMG

(Mohd-Sarip et al., 2012)

ORF1

(Nagy et al., 2012)

l(2)03424

(Spradling et al., 1999, Taylor and Shirras, 1997, BDGP Project Members, 1994-1999)

lmg

(Drechsler et al., 2018, Neuert et al., 2017, Ashwal-Fluss et al., 2014, Schertel et al., 2013, Nagy et al., 2012, Du et al., 2011, Buttitta et al., 2010, Silies and Klämbt, 2010, Hayden and Bosco, 2008, Hueber et al., 2007, Tanaka-Matakatsu et al., 2007, Christensen and Cook, 2006.8.30, Burgler and Macdonald, 2005)

lmgA

(National Institute of Genetics Fly Stocks, 2022-, Hu et al., 2017.6.13, Nagy et al., 2012)

Name Synonyms

Lemming

(Mohd-Sarip et al., 2012, Hayden and Bosco, 2008, Acquaviva and Pines, 2006)

lemming

(Silies and Klämbt, 2010, Kraut et al., 2001, Kraut et al., 2001)

lemming A

Secondary FlyBase IDs

FBgn0029004
FBgn0010539
FBgn0032056
FBgn0085469
FBan0018042

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 60 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

5740853

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KA43

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q7KA43

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KA43

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0250903

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

5740853/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0250903

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0250903

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34440

MARRVEL_MODEL - MARRVEL (model organism gene)

5740853

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0250903

DroID - A comprehensive database of gene and protein interactions.

FBgn0250903

DRSC - Results frm RNAi screens

FBgn0250903

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

lmgA_1

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0250903

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0250903

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007457

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Ubiquitin mediated proteolysis

MIST (genetic) - An integrated Molecular Interaction Database

5740853

MIST (protein-protein) - An integrated Molecular Interaction Database

5740853

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (56)

The following external sites may use different assemblies or annotations than FlyBase.

-0.26

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