FB2020_06, released Dec 22, 2020

Gene: Dmel\larp

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General Information
Symbol
Dmel\larp
Species
D. melanogaster
Name
La related protein
Annotation Symbol
CG42551
Feature Type
protein_coding_gene
FlyBase ID
FBgn0261618
Gene Model Status
Current
Stock Availability
20 publicly available
Gene Snapshot
La related protein (larp) encodes a protein that associates and interacts with poly(A)-binding protein. It is required for multiple processes in male meiosis and syncytial embryo development. [Date last reviewed: 2019-02-28]
Other Summaries
Also Known As

l(3)S003108, l(3)S022529, meteor

Key Links
Genomic Location
Cytogenetic map
98C3-98C4
Sequence location
3R:28,318,162..28,336,440 [-]
Recombination map

3-95

RefSeq locus
NT_033777 REGION:28318162..28336440
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
involved_in male meiotic nuclear division
inferred from mutant phenotype
(Blagden et al., 2009, Ichihara et al., 2007)
involved_in mitochondrion inheritance
inferred from mutant phenotype
(Ichihara et al., 2007)
involved_in positive regulation of mitochondrial DNA replication
inferred from mutant phenotype
(Zhang et al., 2019)
involved_in positive regulation of mitochondrial translation
inferred from mutant phenotype
(Zhang et al., 2019)
involved_in spindle assembly involved in male meiosis
inferred from mutant phenotype
(Ichihara et al., 2007)
involved_in syncytial blastoderm mitotic cell cycle
inferred from mutant phenotype
(Blagden et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Blagden et al., 2009, Chauvet et al., 2000)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Clyne et al., 2003)
colocalizes_with mitochondrion
inferred from direct assay
(Ichihara et al., 2007)
located_in mitochondrion
inferred from direct assay
(Zhang et al., 2019, Zhang et al., 2016)
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
LA-RELATED PROTEINS -
La-related proteins (LARPs) containing two RNA-binding motifs: an LA motif and an RNA recognition motif. LARPs have been shown to be involved in the post-transcriptional regulation of gene expression. (Adapted from FBrf0238226 & PMID:25488812.)
Protein Function (UniProtKB)
RNA-binding protein required during male meiosis and development of the syncytial embryo. Binds poly-(A) tails of mRNAs and regulates their expression by regulating their stability or translation.
(UniProt, Q9VAW5)
Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\larp for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
gene
gene_with_edited_transcript
(Graveley et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
larp-RA
FBtr0089680
NM_080259
6745
965
larp-RB
FBtr0089682
NM_170366
6757
965
larp-RD
FBtr0301180
NM_170365
8064
1673
larp-RE
FBtr0301181
NM_001170286
6820
965
larp-RF
FBtr0306388
NM_001260417
7070
1409
larp-RG
FBtr0306389
NM_001260418
7915
1673
larp-RH
FBtr0306390
NM_001260419
7919
1673
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
larp-PA
FBpp0088622
106.2
965
9.12
NP_524998
AAF56783
larp-PB
FBpp0088624
106.2
965
9.12
NP_733245
AAN14139
larp-PD
FBpp0290398
178.1
1673
10.16
NP_733244
AAN14138
larp-PE
FBpp0290399
106.2
965
9.12
NP_001163757
ACZ95051
larp-PF
FBpp0297480
151.7
1409
10.09
NP_001247346
AFH06663
larp-PG
FBpp0297481
178.1
1673
10.16
NP_001247347
AFH06664
larp-PH
FBpp0297482
178.1
1673
10.16
NP_001247348
AFH06665
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

965 aa isoforms: larp-PA, larp-PB, larp-PE
1673 aa isoforms: larp-PD, larp-PG, larp-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Interacts with pAbp.

(UniProt, Q9VAW5)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\larp using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous | uniform
(Chauvet et al., 2000)
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 5
organism | striped

Comment: transient striped pattern

(Chauvet et al., 2000)
embryonic stage 8
anterior endoderm
(Chauvet et al., 2000)
posterior endoderm
(Chauvet et al., 2000)
mesoderm
(Chauvet et al., 2000)
embryonic stage 9 -- 12
posterior midgut primordium
(Chauvet et al., 2000)
trunk mesoderm
(Chauvet et al., 2000)
embryonic stage 11 -- 12
parasegment 2 of ectoderm
(Chauvet et al., 2000)
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
salivary gland body primordium

Comment: reported as salivary gland primordium

(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
tracheal primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
visceral muscle primordium
(Fisher et al., 2012)
embryonic stage 13
somatic muscle primordium
(Chauvet et al., 2000)
visceral muscle primordium
(Chauvet et al., 2000)
embryonic stage 16
embryonic/larval gut
(Chauvet et al., 2000)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
foregut primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
inclusive hindgut primordium
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
organism | faint | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 17
organism

Comment: 0-20 hr AEL

(Chauvet et al., 2000)
third instar larval stage
organism
(Chauvet et al., 2000)
adult stage | male
organism
(Chauvet et al., 2000)
adult stage | female
organism
(Chauvet et al., 2000)
embryonic stage -- adult stage
organism
(Ichihara et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous | uniform
(Chauvet et al., 2000)
embryonic stage 5
organism | striped

Comment: transient striped pattern

(Chauvet et al., 2000)
embryonic stage 8
anterior endoderm
(Chauvet et al., 2000)
posterior endoderm
(Chauvet et al., 2000)
mesoderm
(Chauvet et al., 2000)
embryonic stage 9 -- 12
anterior midgut primordium
(Chauvet et al., 2000)
posterior midgut primordium
(Chauvet et al., 2000)
trunk mesoderm
(Chauvet et al., 2000)
embryonic stage 11 -- 12
parasegment 2 of ectoderm
(Chauvet et al., 2000)
embryonic stage 13
somatic muscle primordium
(Chauvet et al., 2000)
visceral muscle primordium
(Chauvet et al., 2000)
embryonic stage 16
embryonic/larval gut
(Chauvet et al., 2000)
spermatogenesis
primary spermatocyte
(Ichihara et al., 2007)
oogenesis & adult stage | female
egg chamber
(Zhang et al., 2016)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
testis
(Ichihara et al., 2007)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Blagden et al., 2009, Chauvet et al., 2000)
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
inferred from direct assay
(Clyne et al., 2003)
colocalizes_with mitochondrion
inferred from direct assay
(Ichihara et al., 2007)
located_in mitochondrion
inferred from direct assay
(Zhang et al., 2019, Zhang et al., 2016)
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: P{PTT-GC}larpZCL2726
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis & adult stage | female
follicle cell
(Cooley et al., 2002.10-2003.5)
nurse cell
(Cooley et al., 2002.10-2003.5)
oocyte
(Cooley et al., 2002.10-2003.5)
Reporter: PBac{681.P.FSVS-1}larpCPTI002498
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
medulla
(Knowles-Barley, 2011.8.24)
lamina
(Knowles-Barley, 2011.8.24)
Reporter: PBac{754.P.FSVS-0}larpCPTI003267
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult gnathal ganglion
(Knowles-Barley, 2011.8.24)
adult brain cell body rind

Comment: adult brain cortex and outer neuropil regions

(Knowles-Barley, 2011.8.24)
Reporter: PBac{768.FSVS-0}larpCPTI003605
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain

Comment: low, punctate expression throughout adult brain

(Knowles-Barley, 2011.8.24)
Reporter: PBac{GAL4D,EYFP}larp43
Stage
Tissue/Position (including subcellular localization)
Reference
first instar larval stage
embryonic/larval posterior spiracle
(Horn et al., 2003)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\larp in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 39 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 19 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of larp
Transgenic constructs containing regulatory region of larp
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female sterile
female sterile (with larpmtr-null)
female sterile (with larpS003108)
female sterile (with larpS022529)
female sterile | recessive
male sterile
male sterile (with larp06487)
male sterile (with larpmtr-null)
male sterile (with larpS003108)
male sterile (with larpS022529)
male sterile | recessive
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
flight defective, with Scer\GAL4Mef2.PR
meiotic cell cycle defective
mitotic cell cycle defective
mitotic cell cycle defective (with larpmtr-null)
mitotic cell cycle defective (with larpS003108)
mitotic cell cycle defective (with larpS022529)
visible
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
centrosome
centrosome (with larpmtr-null)
centrosome (with larpS022529)
chaeta
chaeta | supernumerary, with Scer\GAL4pnr-MD237
condensed nuclear chromosome
egg | maternal effect, with Scer\GAL4nos.PU
embryo | embryonic stage 4 (with larpmtr-null)
embryo | embryonic stage 4 (with larpS003108)
embryo | embryonic stage 4 (with larpS022529)
eye
macrochaeta
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitochondrion
mitochondrion & spermatocyte
mitotic anaphase
Nebenkern
nucleus
onion stage spermatid
ovary
spermatocyte
spindle
spindle (with larpmtr-null)
spindle (with larpS003108)
spindle (with larpS022529)
testis
trichogen cell, with Scer\GAL4pnr-MD237
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (7)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LARP1B
11 of 15
Yes
Yes
Hsap\LARP1
10 of 15
No
Yes
Hsap\LARP6
2 of 15
No
No
Hsap\LARP4B
1 of 15
No
No
1  
Hsap\LARP4
1 of 15
No
No
1  
Hsap\LARP7
1 of 15
No
No
Hsap\SSB
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Larp1
10 of 15
Yes
Yes
Mmus\Larp1b
5 of 15
No
Yes
Mmus\Larp6
2 of 15
No
No
Mmus\Larp4b
1 of 15
No
No
Mmus\Larp4
1 of 15
No
No
Mmus\Ssb
1 of 15
No
No
Rattus norvegicus (Norway rat) (6)
Rnor\Larp1
6 of 13
Yes
Yes
Rnor\Larp1b
4 of 13
No
Yes
Rnor\Larp6
2 of 13
No
No
Rnor\RGD1565989
2 of 13
No
Yes
Rnor\Larp4b
1 of 13
No
No
Rnor\Ssb
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\larp1b
7 of 12
Yes
Yes
Xtro\larp1
6 of 12
No
Yes
Xtro\larp6-like.1
2 of 12
No
No
Xtro\larp6
2 of 12
No
No
Xtro\larp4b
1 of 12
No
No
Xtro\ssb
1 of 12
No
No
Danio rerio (Zebrafish) (7)
Drer\larp1b
8 of 15
Yes
Yes
Drer\larp1
8 of 15
Yes
Yes
Drer\larp6a
2 of 15
No
No
Drer\faxdc2
1 of 15
No
No
Drer\larp4b
1 of 15
No
No
Drer\larp6b
1 of 15
No
No
Drer\ssb
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (2)
Cele\larp-1
9 of 15
Yes
Yes
Cele\ssb-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\LARP1a
6 of 9
Yes
Yes
Atha\LARP1b
1 of 9
No
Yes
Atha\LARP1c
1 of 9
No
No
Atha\LARP6a
1 of 9
No
No
Atha\LARP6b
1 of 9
No
No
Atha\LARP6c
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\SLF1
5 of 15
Yes
Yes
Scer\SRO9
5 of 15
Yes
Yes
Scer\LHP1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC1527.03
4 of 12
Yes
Yes
Spom\sla1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901PK )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD18036
Drosophila sechellia
Dsec\GM16297
Drosophila erecta
Dere\GG12072
Drosophila yakuba
Dyak\GE10516
Drosophila ananassae
Dana\GF16129
Drosophila pseudoobscura pseudoobscura
Dpse\GA27083
Drosophila persimilis
Dper\GL23866
Drosophila willistoni
Dwil\GK22522
Drosophila virilis
Dvir\GJ24490
Drosophila mojavensis
Dmoj\GI24848
Drosophila grimshawi
Dgri\GH13999
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915026Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17023212
Glossina morsitans
Tsetse fly
Gmor\GMOY008236
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01240
Mayetiola destructor
Hessian fly
Mdes\Mdes000842
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009073
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004134
Anopheles darlingi
American malaria mosquito
Adar\ADAC005482
Anopheles gambiae
Malaria mosquito
Agam\AGAP005291
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001096
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01YX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA001644
Danaus plexippus
Monarch butterfly
Dple\DPOGS210658-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010791
Apis florea
Little honeybee
Aflo\2870017508
Apis mellifera
Western honey bee
Amel\GB46019
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24741
Bombus terrestris
Buff-tailed bumblebee
Bter\15214462
Linepithema humile
Argentine ant
Lhum\LH19956
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001332
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005411
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02439
Tribolium castaneum
Red flour beetle
Tcas\TC013624
Pediculus humanus
Human body louse
Phum\PHUM118530
Cimex lectularius
Bed bug
Clec\CLEC004882
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005438
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_10144
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01WG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR002960
Ixodes scapularis
Black-legged tick
Isca\ISCW002174
Stegodyphus mimosarum
African social velvet spider
Smim\KFM82277.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73112.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63044.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g06860
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_304229
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02X0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_017412gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Larp1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003088
Gallus gallus
Domestic chicken
Ggal\LARP1
Gallus gallus
Domestic chicken
Ggal\LARP1B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Achl
3 of 10
La
3 of 10
Larp4B
2 of 10
Larp7
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LARP1B; La ribonucleoprotein 1B
    11 of 15
        LARP1; La ribonucleoprotein 1, translational regulator
        10 of 15
        612059
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            larp - CG6701
            experimental knowledge based
            (Guruharsha et al., 2011)
            larp - CG7878
            experimental knowledge based
            (Guruharsha et al., 2011)
            larp - CycG
            two hybrid
            (Hu et al., 2017.6.13)
            larp - Dhx15
            experimental knowledge based
            (Guruharsha et al., 2011)
            larp - Dsor1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            larp - MED4
            two hybrid
            (Hu et al., 2017.6.13)
            larp - Myc
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - Pdk1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - Pi3K21B
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - Pi3K92E
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - Pink1
            enzymatic study, western blot
            (Zhang et al., 2019)
            larp - Pten
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - RasGAP1
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            larp - S6kII
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - Tsc1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - foxo
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - gig
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - nito
            experimental knowledge based
            (Guruharsha et al., 2011)
            larp - osk
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Hurd et al., 2016)
            larp - pAbp
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Blagden et al., 2009)
            larp - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            larp - spoon
            anti tag coimmunoprecipitation, western blot, peptide massfingerprinting
            (Zhang et al., 2016)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            larp
            enhanceable
            pAbp
            (Blagden et al., 2009)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            pAbp
            enhanceable
            larp
            (Blagden et al., 2009)
            spoon
            suppressible
            larp
            (Zhang et al., 2019)
            External Data
            Subunit Structure (UniProtKB)
            Interacts with pAbp.
            (UniProt, Q9VAW5 )
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3R
            Recombination map

            3-95

            Cytogenetic map
            98C3-98C4
            Sequence location
            3R:28,318,162..28,336,440 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            98C3-98C4
            Limits computationally determined from genome sequence between P{PZ}btzrL203 and P{PZ}l(3)0648706487
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            98C-98C
            (Chauvet, 2000.1.5)
            98C-98C
            (determined by in situ hybridisation)
            (Deak et al., 1997)
            Experimentally Determined Recombination Data
            Location

            3-95

            (FlyBase, 2016)

            3-93.4

            (Comeron et al., 2012)

            3-95.7

            (Ichihara et al., 2007)

            3-

            (Horn et al., 2003)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (20)
            Genomic Clones (26)
            cDNA Clones (87)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Blagden et al., 2009, Ichihara et al., 2007)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: larp meteor

            (Lada, 2005.9.6)
            Source for database merge of

            Source for merge of: larp CG14066

            (Bayraktaroglu, 2000.8.7)

            Source for merge of: larp CG14065

            (FlyBase Genome Annotators, 2009)

            Source for merge of: larp l(3)S003108 l(3)S022529

            (Blagden et al., 2009)

            Source for merge of: larp BcDNA:LD02611

            (FlyBase, 1996-)
            Additional comments

            Annotations CG14065 and CG14066 merged as CG42551 in release 5.15 of the genome annotation.

            (FlyBase Genome Annotators, 2009)

            Source for merge of larp BcDNA:LD02611 was a shared cDNA ( date:030728 ).

            (FlyBase, 1996-)
            Other Comments
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 67 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            FlyMine - An integrated database for Drosophila genomics
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Synonyms and Secondary IDs (18)
            Reported As
            Symbol Synonym
            0031/08
            (Deak et al., 1997)
            0225/29
            (Deak et al., 1997)
            BcDNA:LD02611
            CG14065
            (Ashwal-Fluss et al., 2014, Müller et al., 2010, Laviolette et al., 2005, FlyBase Curators, 2002-)
            CG14066
            (Keleman et al., 2009.8.5, Teleman et al., 2008, Ichihara et al., 2007, Quinones-Coello, 2007, Laviolette et al., 2005, Asha et al., 2003, Ponting et al., 2001)
            CG42551
            (Kolkhof et al., 2017, Hurd et al., 2016, Hosono et al., 2015, Ni et al., 2010.12.1, FlyBase Genome Annotators, 2009)
            Larp
            (He et al., 2019, Zhang et al., 2016, Sopko et al., 2015, Asha et al., 2003)
            dlarp
            (Chauvet et al., 2000)
            l(3)S003108
            (Blagden et al., 2009)
            l(3)S022529
            (Blagden et al., 2009)
            larp
            (Sapiro et al., 2020, Foley et al., 2019, Sinha et al., 2019, Zhang et al., 2019, Lee et al., 2018, Hsu and Drummond-Barbosa, 2017, Hu et al., 2017.6.13, Lee et al., 2016, Gene Disruption Project members, 2015-, Van Bortle et al., 2015, Kwon et al., 2013, Friedman et al., 2011, Mudiganti et al., 2010, Blagden et al., 2009, Wagner et al., 2009, Buszczak et al., 2007, Ichihara et al., 2007, Quinones-Coello, 2007, Laviolette et al., 2005)
            larp1
            (Singh et al., 2011)
            Name Synonyms
            CG14065
            Drosophila La related protein
            (Chauvet et al., 2000)
            La related protein
            (Lada, 2005.9.6, Chauvet, 2000.1.5)
            La-related protein
            (Zhang et al., 2016, Ye et al., 2010, Blagden et al., 2009)
            lethal (3) S003108
            lethal (3) S022529
            meteor
            (Ichihara et al., 2007, Blagden et al., 2005)
            Secondary FlyBase IDs
            • FBgn0260724
            • FBgn0040108
            • FBgn0039579
            • FBgn0039578
            • FBgn0047231
            • FBgn0061128
            • FBgn0061057
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (85)