FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\AdamTS-A
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General Information
Symbol
Dmel\AdamTS-A
Species
D. melanogaster
Name
ADAM metallopeptidase with thrombospondin type 1 motif A
Annotation Symbol
CG14869
Feature Type
protein_coding_gene
FlyBase ID
FBgn0286071
Gene Model Status
Current
Stock Availability
8 publicly available
Enzyme Name (EC)
Gene Summary
ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

l(3)89Aa

Key Links
Genomic Location
Cytogenetic map
88F5-88F6
Sequence location
Recombination map
3-57
RefSeq locus
NT_033777 REGION:15442246..15476193
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables metalloendopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001590, InterPro:IPR012314
(InterPro Project Members, 2004-)
enables metallopeptidase activity
inferred from electronic annotation with InterPro:IPR024079
(InterPro Project Members, 2004-)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR012314
(InterPro Project Members, 2004-)
Biological Process (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Ismat et al., 2013)
involved_in extracellular matrix organization
inferred from mutant phenotype
(Ismat et al., 2013)
involved_in germ cell migration
inferred from mutant phenotype
(Ismat et al., 2013)
involved_in larval salivary gland morphogenesis
inferred from mutant phenotype
(Ismat et al., 2013)
involved_in mesodermal cell migration
inferred from mutant phenotype
(Ismat et al., 2013)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in extracellular matrix organization
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR013273
(InterPro Project Members, 2004-)
involved_in proteolysis
inferred from electronic annotation with InterPro:IPR001590
(InterPro Project Members, 2004-)
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(GO Reference Genome Project, 2011-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular matrix
inferred from biological aspect of ancestor with PANTHER:PTN000347317
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
metalloendopeptidase activity
Summaries
Gene Snapshot
ADAM metallopeptidase with thrombospondin type 1 motif A (AdamTS-A) encodes a secreted matrix metalloprotease involved in cell migration. Loss of AdamTS-A in the salivary glands results in apical surface irregularities and cell elongation defects. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ADAM WITH THROMBOSPONDIN MOTIF -
A Disintegrin And Metalloprotease Thrombospondin motif (ADAMTS) belongs to the metzincin superfamily of metalloproteases. ADAMTS is related to ADAM proteins, sharing in part their domain organisation. However, ADAMTS includes proteins that contain a variable number of thrombospondin-like repeats instead of disintegrin and cysteine rich domains. ADAMTS proteases are included in MEROPS family M12, subfamily B. (Adapted from FBrf0214506).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\AdamTS-A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q8SXB0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
AdamTS-A-RB
FBtr0083160
NM_206496
6965
1688
AdamTS-A-RC
FBtr0334629
NM_001275675
6164
1585
AdamTS-A-RE
FBtr0339398
NM_169659
5932
1537
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
AdamTS-A-PB
FBpp0082614
189.9
1688
7.81
Q8SXB0
NP_996218
AAS65157
AdamTS-A-PC
FBpp0306691
179.3
1585
8.03
A0A0B4KHK4
NP_001262604
AGB95984
AdamTS-A-PE
FBpp0308490
173.6
1537
7.87
Q7KSH7
NP_732036
AAF55199
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\AdamTS-A using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.81

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 8
embryonic/larval hemocyte
(Ismat et al., 2013)
embryonic stage 11 -- 15
longitudinal trunk visceral muscle primordium
(Ismat et al., 2013)
embryonic stage 12 -- 16
embryonic/larval salivary gland

Comment: secretory cells

(Ismat et al., 2013)
embryonic stage 14
embryonic/larval visceral tracheal branch
(Ismat et al., 2013)
embryonic stage 16
embryonic/larval midgut longitudinal visceral muscle cell
(Ismat et al., 2013)
third instar larval stage
embryonic/larval salivary gland
(Skeath et al., 2017)
embryonic/larval fat body
(Skeath et al., 2017)
adult stage
perineurial glial cell
(Skeath et al., 2017)
subperineurial glial cell
(Skeath et al., 2017)
Additional Descriptive Data

Reporter expression is observed in all perineurial and subperineurial glial cells.

(Skeath et al., 2017)

AdamTS-A is expressed in cells that migrate as individuals, including hemocytes and in caudal visceral mesoderm. Expression is also observed in the secretory cells of the salivary gland, the visceral branch, and in longitudinal visceral muscle fibers.

(Ismat et al., 2013)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\AdamTS-A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of AdamTS-A
Transgenic constructs containing regulatory region of AdamTS-A
Aberrations (Deficiencies and Duplications) ( 19 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with AdamTS-AKO)
lethal (with AdamTS-Arnwy1)
lethal (with AdamTS-Arnwy2)
lethal (with Df(3R)88F5)
lethal | recessive
lethal - all die before end of larval stage (with Df(3R)88F5)
partially lethal - majority die (with Df(3R)88F5)
partially lethal - majority live
partially lethal - majority live (with AdamTS-Arnwy1)
partially lethal - majority live (with AdamTS-Arnwy2)
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell migration (with Df(3R)88F5)
abnormal developmental rate
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4Gli-rL82, Scer\GAL4NP6293
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy1)
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy2)
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
abnormal neuroanatomy | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
uncoordinated
uncoordinated (with AdamTS-Arnwy1)
uncoordinated (with AdamTS-Arnwy2)
Phenotype manifest in
Allele
embryonic/larval salivary gland (with Df(3R)88F5)
embryonic/larval visceral tracheal branch (with Df(3R)88F5)
germline cell | embryonic stage (with Df(3R)88F5)
larval brain | third instar larval stage
larval brain | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
larval brain | third instar larval stage, with Scer\GAL4Gli-rL82, Scer\GAL4NP6293
larval brain | third instar larval stage, with Scer\GAL4repo
larval brain | third instar larval stage (with AdamTS-Arnwy1)
larval brain | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
larval brain | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
larval brain | third instar larval stage (with AdamTS-Arnwy2)
larval brain | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
larval brain | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
larval ventral nerve cord | third instar larval stage, with AdamTS-Arnwy2/AdamTS-Arnwy1, Scer\GAL4repo
larval ventral nerve cord | third instar larval stage, with Scer\GAL4repo
larval ventral nerve cord | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.cIa, Scer\GAL4repo
larval ventral nerve cord | third instar larval stage (with AdamTS-Arnwy1), with AdamTS-AUAS.RB, Scer\GAL4repo
larval ventral nerve cord | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.cIa, Scer\GAL4repo
larval ventral nerve cord | third instar larval stage (with AdamTS-Arnwy2), with AdamTS-AUAS.RB, Scer\GAL4repo
longitudinal trunk visceral muscle primordium (with Df(3R)88F5)
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (60)
Hsap\ADAMTS9
12 of 14
Yes
Yes
Hsap\ADAMTS20
12 of 14
Yes
Yes
Hsap\ADAMTS1
6 of 14
No
Yes
1  
Hsap\ADAMTS4
6 of 14
No
Yes
Hsap\ADAMTS5
6 of 14
No
Yes
Hsap\ADAMTS8
6 of 14
No
Yes
Hsap\ADAMTS15
6 of 14
No
Yes
1  
Hsap\ADAMTS6
5 of 14
No
No
Hsap\ADAMTS7
4 of 14
No
No
Hsap\ADAMTS12
4 of 14
No
No
Hsap\ADAMTS16
4 of 14
No
No
Hsap\ADAMTS18
4 of 14
No
No
Hsap\ADAMTS2
3 of 14
No
Yes
Hsap\ADAMTS3
3 of 14
No
Yes
Hsap\ADAMTS10
3 of 14
No
No
Hsap\ADAMTS13
3 of 14
No
No
Hsap\ADAMTS14
3 of 14
No
Yes
Hsap\ADAMTS17
3 of 14
No
No
Hsap\ADAMTS19
3 of 14
No
No
Hsap\ADAMTSL1
2 of 14
No
No
Hsap\ADAMTSL2
2 of 14
No
Yes
Hsap\ADAMTSL3
2 of 14
No
No
Hsap\ADAMTSL4
2 of 14
No
No
Hsap\ADAMTSL5
2 of 14
No
No
Hsap\PAPLN
2 of 14
No
No
Hsap\THSD4
2 of 14
No
No
Hsap\THSD7A
2 of 14
No
Yes
Hsap\ADAM2
1 of 14
No
No
1  
Hsap\ADAM7
1 of 14
No
No
Hsap\ADAM8
1 of 14
No
No
Hsap\ADAM9
1 of 14
No
No
Hsap\ADAM10
1 of 14
No
No
Hsap\ADAM11
1 of 14
No
No
Hsap\ADAM12
1 of 14
No
No
Hsap\ADAM15
1 of 14
No
No
Hsap\ADAM17
1 of 14
No
No
Hsap\ADAM18
1 of 14
No
No
1  
Hsap\ADAM19
1 of 14
No
No
Hsap\ADAM20
1 of 14
No
No
Hsap\ADAM21
1 of 14
No
No
1  
Hsap\ADAM22
1 of 14
No
No
Hsap\ADAM23
1 of 14
No
No
Hsap\ADAM28
1 of 14
No
No
Hsap\ADAM29
1 of 14
No
No
Hsap\ADAM30
1 of 14
No
No
Hsap\ADAM32
1 of 14
No
No
1  
Hsap\ADAM33
1 of 14
No
No
Hsap\ADAMDEC1
1 of 14
No
No
Hsap\ADGRB1
1 of 14
No
No
Hsap\FLT1
1 of 14
No
No
Hsap\HMCN1
1 of 14
No
No
Hsap\HMCN2
1 of 14
No
No
Hsap\HSPG2
1 of 14
No
No
Hsap\SEMA5A
1 of 14
No
No
Hsap\SSPOP
1 of 14
No
No
Hsap\THBS1
1 of 14
No
No
Hsap\THBS2
1 of 14
No
No
Hsap\THSD7B
1 of 14
No
No
Hsap\WFIKKN1
1 of 14
No
No
Hsap\WFIKKN2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (31)
Rnor\Adamts9
12 of 14
Yes
Yes
Rnor\Adamts20
11 of 14
No
Yes
Rnor\Adamts1
7 of 14
No
Yes
Rnor\Adamts8
7 of 14
No
Yes
Rnor\Adamts15
7 of 14
No
Yes
Rnor\Adamts4
6 of 14
No
Yes
Rnor\Adamts5
5 of 14
No
Yes
Rnor\Adamts7
4 of 14
No
No
Rnor\Adamts12
4 of 14
No
No
Rnor\Adamts17
4 of 14
No
No
Rnor\Adamts18
4 of 14
No
No
Rnor\Adamts6
3 of 14
No
No
Rnor\Adamts10
3 of 14
No
No
Rnor\Adamts16
3 of 14
No
No
Rnor\Adamts19
3 of 14
No
Yes
Rnor\Adamts2
2 of 14
No
Yes
Rnor\Adamts3
2 of 14
No
Yes
Rnor\Adamts13
2 of 14
No
No
Rnor\Adamts14
2 of 14
No
Yes
Rnor\Adamtsl3
2 of 14
No
No
Rnor\Adamtsl4
2 of 14
No
No
Rnor\Adamtsl1
1 of 14
No
No
Rnor\Adamtsl2
1 of 14
No
No
Rnor\Adamtsl5
1 of 14
No
No
Rnor\Hmcn1
1 of 14
No
No
Rnor\Papln
1 of 14
No
No
Rnor\Sspo
1 of 14
No
No
Rnor\Thsd7a
1 of 14
No
No
Rnor\Thsd7b
1 of 14
No
No
Rnor\Wfikkn1
1 of 14
No
No
Rnor\Wfikkn2
1 of 14
No
No
Mus musculus (laboratory mouse) (32)
Mmus\Adamts9
12 of 14
Yes
Yes
Mmus\Adamts20
12 of 14
Yes
Yes
Mmus\Adamts1
7 of 14
No
Yes
Mmus\Adamts15
7 of 14
No
Yes
Mmus\Adamts5
6 of 14
No
Yes
Mmus\Adamts8
6 of 14
No
Yes
Mmus\Adamts6
5 of 14
No
No
Mmus\Adamts4
4 of 14
No
Yes
Mmus\Adamts7
4 of 14
No
No
Mmus\Adamts10
4 of 14
No
No
Mmus\Adamts12
4 of 14
No
No
Mmus\Adamts16
4 of 14
No
No
Mmus\Adamts18
4 of 14
No
No
Mmus\Adamts2
3 of 14
No
Yes
Mmus\Adamts3
3 of 14
No
Yes
Mmus\Adamts13
3 of 14
No
No
Mmus\Adamts14
3 of 14
No
Yes
Mmus\Adamts17
3 of 14
No
No
Mmus\Adamts19
3 of 14
No
No
Mmus\Adamtsl1
2 of 14
No
No
Mmus\Adamtsl3
2 of 14
No
No
Mmus\Adamtsl4
2 of 14
No
No
Mmus\Papln
2 of 14
No
No
Mmus\Thsd4
2 of 14
No
No
Mmus\Adamtsl2
1 of 14
No
No
Mmus\Adamtsl5
1 of 14
No
No
Mmus\Adgrb1
1 of 14
No
No
Mmus\Hmcn1
1 of 14
No
No
Mmus\Hmcn2
1 of 14
No
No
Mmus\Sspo
1 of 14
No
No
Mmus\Thsd7b
1 of 14
No
Yes
Mmus\Wfikkn2
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (47)
Xtro\adamts9
7 of 13
Yes
Yes
Xtro\adamts20
7 of 13
Yes
Yes
Xtro\adamts6
4 of 13
No
No
Xtro\adamts15
4 of 13
No
Yes
Xtro\adamts1
3 of 13
No
Yes
Xtro\adamts3
3 of 13
No
Yes
Xtro\adamts5
3 of 13
No
Yes
Xtro\adamts8
3 of 13
No
Yes
Xtro\adamts16
3 of 13
No
Yes
Xtro\adamts4
2 of 13
No
No
Xtro\adamts10
2 of 13
No
No
Xtro\adamts13
2 of 13
No
No
Xtro\adamts14
2 of 13
No
Yes
Xtro\adamts17
2 of 13
No
No
Xtro\adamts18
2 of 13
No
Yes
Xtro\adamts19
2 of 13
No
No
Xtro\LOC100498221
2 of 13
No
Yes
Xtro\abo.2
1 of 13
No
Yes
Xtro\adam9
1 of 13
No
No
Xtro\adam11
1 of 13
No
No
Xtro\adam12
1 of 13
No
No
Xtro\adam28.1
1 of 13
No
No
Xtro\adam28.2
1 of 13
No
No
Xtro\adamts2
1 of 13
No
Yes
Xtro\adamts7
1 of 13
No
No
Xtro\adamts12
1 of 13
No
No
Xtro\adamtsl1
1 of 13
No
No
Xtro\adamtsl3
1 of 13
No
No
Xtro\adamtsl4
1 of 13
No
No
Xtro\adamtsl5
1 of 13
No
No
Xtro\camkmt
1 of 13
No
No
Xtro\dock9
1 of 13
No
No
Xtro\fgfr2
1 of 13
No
No
Xtro\hmcn1
1 of 13
No
No
Xtro\krt61
1 of 13
No
Yes
Xtro\LOC100493925
1 of 13
No
No
Xtro\med6
1 of 13
No
No
Xtro\rcn3
1 of 13
No
No
Xtro\sar1a
1 of 13
No
No
Xtro\sema5b
1 of 13
No
No
Xtro\tex10
1 of 13
No
No
Xtro\thsd4
1 of 13
No
No
Xtro\tmem170b
1 of 13
No
Yes
Xtro\traf7
1 of 13
No
Yes
Xtro\ubxn2a
1 of 13
No
No
Xtro\XB990656
1 of 13
No
No
Xtro\XB5838589
1 of 13
No
No
Danio rerio (Zebrafish) (39)
Drer\adamts9
11 of 14
Yes
Yes
Drer\adamts15a
7 of 14
No
Yes
Drer\LOC100001991
7 of 14
No
Yes
Drer\LOC100002059
7 of 14
No
Yes
Drer\adamts1
6 of 14
No
Yes
Drer\adamts5
5 of 14
No
Yes
Drer\adamts12
5 of 14
No
No
Drer\LOC568792
5 of 14
No
Yes
Drer\adamts8a
4 of 14
No
Yes
Drer\adamts10
4 of 14
No
No
Drer\adamts18
4 of 14
No
No
Drer\adamts3
3 of 14
No
Yes
Drer\adamts6
3 of 14
No
No
Drer\adamts7
3 of 14
No
No
Drer\adamts17
3 of 14
No
No
Drer\adamts2a
2 of 14
No
Yes
Drer\adamts13
2 of 14
No
No
Drer\adamtsl3
2 of 14
No
No
Drer\adamtsl4
2 of 14
No
No
Drer\adamtsl7
2 of 14
No
No
Drer\LOC101886422
2 of 14
No
Yes
Drer\paplna
2 of 14
No
No
Drer\adamts2b
1 of 14
No
No
Drer\adamtsl2
1 of 14
No
Yes
Drer\adamtsl5
1 of 14
No
No
Drer\adgrb1a
1 of 14
No
No
Drer\col28a1a
1 of 14
No
No
Drer\hmcn1
1 of 14
No
No
Drer\hmcn2
1 of 14
No
No
Drer\LOC101885599
1 of 14
No
Yes
Drer\LOC101886654
1 of 14
No
Yes
Drer\obsl1b
1 of 14
No
No
Drer\paplnb
1 of 14
No
No
Drer\si:ch211-267e7.3
1 of 14
No
No
Drer\si:dkeyp-73b11.8
1 of 14
No
No
Drer\thsd7aa
1 of 14
No
Yes
Drer\wfikkn2a
1 of 14
No
No
Drer\wfikkn2b
1 of 14
No
No
Drer\wu:fb59d01
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (14)
Cele\gon-1
12 of 14
Yes
Yes
Cele\adt-1
2 of 14
No
No
Cele\adt-3
2 of 14
No
No
Cele\mig-17
2 of 14
No
No
Cele\T21B6.3
2 of 14
No
Yes
Cele\adm-2
1 of 14
No
No
Cele\adm-4
1 of 14
No
No
Cele\adt-2
1 of 14
No
No
Cele\F27D9.7
1 of 14
No
No
Cele\him-4
1 of 14
No
No
Cele\madd-4
1 of 14
No
No
Cele\mig-6
1 of 14
No
No
Cele\sup-17
1 of 14
No
No
Cele\unc-71
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (16)
Agam\AgaP_AGAP004201
12 of 12
Yes
Yes
Agam\AgaP_AGAP001113
3 of 12
No
No
Agam\AgaP_AGAP001662
2 of 12
No
No
Agam\AgaP_AGAP004961
2 of 12
No
No
Agam\AgaP_AGAP007792
2 of 12
No
No
Agam\AgaP_AGAP010001
2 of 12
No
Yes
Agam\AgaP_AGAP010003
2 of 12
No
No
Agam\AgaP_AGAP011737
2 of 12
No
No
Agam\AgaP_AGAP000974
1 of 12
No
No
Agam\AgaP_AGAP002268
1 of 12
No
No
Agam\AgaP_AGAP002381
1 of 12
No
No
Agam\AgaP_AGAP003070
1 of 12
No
No
Agam\AgaP_AGAP003496
1 of 12
No
No
Agam\AgaP_AGAP003498
1 of 12
No
No
Agam\AgaP_AGAP008790
1 of 12
No
No
Agam\AgaP_AGAP013468
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (0)
Saccharomyces cerevisiae (Brewer's yeast) (0)
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:AdamTS-A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (12)
AdamTS-B
6 of 13
Ppn
4 of 13
nolo
3 of 13
sona
3 of 13
stl
3 of 13
loh
2 of 13
CG31609
1 of 13
Kul
1 of 13
kuz
1 of 13
Meltrin
1 of 13
mmd
1 of 13
Tace
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif 9
    12 of 14
    605421
        ADAMTS20; ADAM metallopeptidase with thrombospondin type 1 motif 20
        12 of 14
        611681
            ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif 1
            6 of 14
            605174
                 
                ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif 4
                6 of 14
                603876
                    ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif 5
                    6 of 14
                    605007
                        ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif 8
                        6 of 14
                        605175
                            ADAMTS15; ADAM metallopeptidase with thrombospondin type 1 motif 15
                            6 of 14
                            607509
                               
                              ADAMTS6; ADAM metallopeptidase with thrombospondin type 1 motif 6
                              5 of 14
                              605008
                                  ADAMTS7; ADAM metallopeptidase with thrombospondin type 1 motif 7
                                  4 of 14
                                  605009
                                      ADAMTS12; ADAM metallopeptidase with thrombospondin type 1 motif 12
                                      4 of 14
                                      606184
                                          ADAMTS16; ADAM metallopeptidase with thrombospondin type 1 motif 16
                                          4 of 14
                                          607510
                                              ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif 18
                                              4 of 14
                                              607512
                                                ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif 2
                                                3 of 14
                                                604539
                                                ADAMTS3; ADAM metallopeptidase with thrombospondin type 1 motif 3
                                                3 of 14
                                                605011
                                                  ADAMTS10; ADAM metallopeptidase with thrombospondin type 1 motif 10
                                                  3 of 14
                                                  608990
                                                  ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif 13
                                                  3 of 14
                                                  604134
                                                  ADAMTS14; ADAM metallopeptidase with thrombospondin type 1 motif 14
                                                  3 of 14
                                                  607506
                                                      ADAMTS17; ADAM metallopeptidase with thrombospondin type 1 motif 17
                                                      3 of 14
                                                      607511
                                                      ADAMTS19; ADAM metallopeptidase with thrombospondin type 1 motif 19
                                                      3 of 14
                                                      607513
                                                        Functional Complementation Data
                                                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                        Interactions
                                                        Summary of Physical Interactions
                                                        Interaction Browsers
                                                        Summary of Genetic Interactions
                                                        Interaction Browsers
                                                        View in FlyBase Interactions Browser   View in MIST tool (external link)
                                                        Please look at the allele data for full details of the genetic interactions
                                                        Starting gene(s)
                                                        Interaction type
                                                        Interacting gene(s)
                                                        Reference
                                                        AdamTS-A
                                                        suppressible
                                                        Cad99C
                                                        (Ismat et al., 2013)
                                                        AdamTS-A
                                                        suppressible
                                                        LanA
                                                        (Skeath et al., 2017)
                                                        AdamTS-A
                                                        suppressible
                                                        mys
                                                        (Skeath et al., 2017)
                                                        AdamTS-A
                                                        suppressible
                                                        trol
                                                        (Skeath et al., 2017)
                                                        AdamTS-A
                                                        suppressible
                                                        vkg
                                                        (Skeath et al., 2017)
                                                        Starting gene(s)
                                                        Interaction type
                                                        Interacting gene(s)
                                                        Reference
                                                        External Data
                                                        Linkouts
                                                        Pathways
                                                        Signaling Pathways (FlyBase)
                                                        Metabolic Pathways
                                                        FlyBase
                                                        External Links
                                                        External Data
                                                        Linkouts
                                                        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                        Class of Gene
                                                        Genomic Location and Detailed Mapping Data
                                                        Chromosome (arm)
                                                        3R
                                                        Recombination map
                                                        3-57
                                                        Cytogenetic map
                                                        88F5-88F6
                                                        Sequence location
                                                        FlyBase Computed Cytological Location
                                                        Cytogenetic map
                                                        Evidence for location
                                                        88F5-88F6
                                                        Limits computationally determined from genome sequence between P{lacW}MRG15j6A3 and P{PZ}l(3)0653606536
                                                        Experimentally Determined Cytological Location
                                                        Cytogenetic map
                                                        Notes
                                                        References
                                                        Experimentally Determined Recombination Data
                                                        Location

                                                        3-57

                                                        (FlyBase, 2016)

                                                        3-56.8

                                                        (Comeron et al., 2012)

                                                        3-[58]

                                                        Left of (cM)
                                                        Right of (cM)
                                                        Notes
                                                        Stocks and Reagents
                                                        Stocks (8)
                                                        Genomic Clones (25)
                                                        cDNA Clones (26)
                                                         

                                                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                        cDNA clones, fully sequenced
                                                        BDGP DGC clones
                                                        Other clones
                                                          Drosophila Genomics Resource Center cDNA clones

                                                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                            cDNA Clones, End Sequenced (ESTs)
                                                            BDGP DGC clones
                                                            Other clones
                                                            RNAi and Array Information
                                                            Linkouts
                                                            Antibody Information
                                                            Laboratory Generated Antibodies
                                                             

                                                            polyclonal

                                                            (Ismat et al., 2013)
                                                            Commercially Available Antibodies
                                                             
                                                            Cell Line Information
                                                            Publicly Available Cell Lines
                                                             
                                                              Other Stable Cell Lines
                                                               
                                                                Other Comments

                                                                AdamTS-A is required for collective cell migration, including of the caudal visceral mesoderm, the visceral branch of the trachea, germ cells and the secretory portion of the salivary gland.

                                                                (Ismat et al., 2013)
                                                                Relationship to Other Genes
                                                                Source for database merge of

                                                                Source for merge of: CG14869 CG6107

                                                                (FlyBase Genome Annotators, 2002-2003)

                                                                Source for merge of: AdamTS-A l(3)89Aa

                                                                (Ismat et al., 2013)
                                                                Additional comments

                                                                The lethal allele identified as being carried on TM3 balancer chromosomes in FBrf0057262 (l(3)89Aa[1]) is an allele of AdamTS-A.

                                                                (Ismat et al., 2013)

                                                                Annotations CG6107 and CG14869 merged as CG14869 in release 3 of the genome annotation.

                                                                (FlyBase Genome Annotators, 2002-2003)
                                                                Nomenclature History
                                                                Source for database identify of

                                                                Source for identity of: AdamTS-A CG14869

                                                                (Ismat et al., 2013)
                                                                Nomenclature comments
                                                                Etymology
                                                                Synonyms and Secondary IDs (10)
                                                                Datasets (0)
                                                                Study focus (0)
                                                                Experimental Role
                                                                Project
                                                                Project Type
                                                                Title
                                                                Study result (0)
                                                                Result
                                                                Result Type
                                                                Title
                                                                External Crossreferences and Linkouts ( 41 )
                                                                Sequence Crossreferences
                                                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                                UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                                Other crossreferences
                                                                AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                                DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                                EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                                FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                                InterPro - A database of protein families, domains and functional sites
                                                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                                                MARRVEL_MODEL - MARRVEL (model organism gene)
                                                                Linkouts
                                                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                                References (67)