FlyBase Gene Report: Dmel\svr

General Information

Symbol

Dmel\svr

Species

D. melanogaster

Name

silver

Annotation Symbol

CG4122

Feature Type

protein_coding_gene

FlyBase ID

FBgn0004648

Gene Model Status

Current

Stock Availability

30 publicly available

Enzyme Name (EC)

Gene Summary

Metallocarboxypeptidase that catalyzes the release of C-terminal arginine or lysine residues from peptides and proteins (PubMed:12393882, PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:31309630). Functionally important for processing a broad range of proteins including growth factors, peptide hormones (such as Akh) and neuropeptides (PubMed:16556608, PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Consequently, it is involved in a wide range of processes including viability, memory formation, locomotive activity, wing formation, and peptide-regulated behaviors such as starvation-induced hyperactivity, appetitive gustatory preference, and cold and ethanol sensitivity (PubMed:20386952, PubMed:20600119, PubMed:27430952, PubMed:31309630). Key enzyme in neuropeptide processing (PubMed:31309630). Involved in regulation of memory formation, possibly via the insulin pathway in neurosecretory cells (PubMed:27430952). (UniProt, P42787)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

EG:171D11.3 , CPD, slv

Key Links

Genomic Location

Cytogenetic map

1B5-1B7

Sequence location

X:496,446..509,072 [+]

Recombination map

1-0

RefSeq locus

NC_004354 REGION:496446..509072

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables carboxypeptidase activity

inferred from mutant phenotype

(Pauls et al., 2019, Sidyelyeva et al., 2010)

inferred from direct assay

(Sidyelyeva et al., 2006)

enables metallocarboxypeptidase activity

inferred from direct assay

(Tanco et al., 2010)

inferred from direct assay

(Sidyelyeva and Fricker, 2002)

enables zinc ion binding

inferred from direct assay

(Tanco et al., 2010)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables metallocarboxypeptidase activity

inferred from electronic annotation with InterPro:IPR000834

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000163973

(GO Reference Genome Project, 2011-)

enables zinc ion binding

inferred from electronic annotation with InterPro:IPR000834

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Sidyelyeva et al., 2006)

involved_in long-term memory

inferred from mutant phenotype

(Sidyelyeva et al., 2010)

involved_in neuropeptide processing

inferred from mutant phenotype

(Pauls et al., 2019)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in peptide metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000163973

(GO Reference Genome Project, 2011-)

involved_in protein processing

inferred from biological aspect of ancestor with PANTHER:PTN000163973

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from electronic annotation with InterPro:IPR000834

(InterPro Project Members, 2004-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Sidyelyeva et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000163973

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

M14 METALLOCARBOXYPEPTIDASES

Protein Family (UniProt)

Belongs to the peptidase M14 family. (P42787)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

carboxypeptidase activity
RHEA 28783: metallocarboxypeptidase activity

Summaries

Gene Group (FlyBase)

M14 METALLOCARBOXYPEPTIDASES -: M14 metallopeptidases belong to MEROPS family M14. They hydrolyse single, C-terminal amino acids from polypeptide chains and have a recognition site for the free C-terminal carboxyl group, which is a key determinant of specificity. Their functions are numerous and diverse, and include digestion of food and processing of bioactive peptides. (Adapted from FBrf0239469.)

Protein Function (UniProtKB)

(UniProt, P42787)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

svr: silver

Color of legs, wings, veins, and integument pale and silvery. Bristles and trident pattern on thorax dark. Tyrosinase formed in adult (Horowitz). Wings of all males and some females pointed. Viability fair. Larval mouth parts normal in color. RK2.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\svr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P42787)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

3MN8

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

svr-RB

FBtr0070081

NM_080293

5890

1406

svr-RD

FBtr0070084

NM_206599

5904

1404

svr-RE

FBtr0070085

NM_206598

3144

433

svr-RF

FBtr0070086

NM_206597

3130

435

svr-RG

FBtr0070087

NM_206596

5828

1439

svr-RH

FBtr0290016

NM_166846

5842

1437

svr-RI

FBtr0290017

NM_001144669

5267

1292

svr-RJ

FBtr0340146

NM_001297813

3092

433

svr-RL

FBtr0344737

NM_001297814

2851

435

svr-RM

FBtr0344738

NM_176679

5611

1406

svr-RN

FBtr0344739

NM_001297815

4986

1439

Additional Transcript Data and Comments

Reported size (kB)

6-7, 3.9, 3.3, 2.5, 1.5 (compiled cDNA)

(Settle et al., 1995)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

svr-PB

FBpp0070080

158.8

1406

6.74

FBpp0089123

158.5

1404

6.42

NP_996322

AAS65237

svr-PE

FBpp0089124

48.3

433

4.96

FBpp0089125

48.6

435

6.27

FBpp0089126

162.7

1439

6.31

FBpp0288455

162.4

1437

5.97

NP_726675

AAF45515

svr-PI

FBpp0288456

146.3

1292

6.27

NP_001138141

ACL82874

svr-PJ

FBpp0309132

48.3

433

4.96

FBpp0311069

48.6

435

6.27

FBpp0311070

158.8

1406

6.74

FBpp0311071

162.7

1439

6.31

X2J9Z1

NP_001284744

AHN59215

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1406 aa isoforms: svr-PB, svr-PM

435 aa isoforms: svr-PF, svr-PL

433 aa isoforms: svr-PE, svr-PJ

1439 aa isoforms: svr-PG, svr-PN

Additional Polypeptide Data and Comments

Reported size (kDa)

1119 (aa); 126.5 (kD predicted)

(Settle et al., 1995)

Comments

External Data

Domain

There are 3 carboxypeptidase-like domains (PubMed:12393882, PubMed:20386952). Only the first two domains seem to have catalytic activity (PubMed:12393882, PubMed:16556608, PubMed:20386952). However, in svr proteins there are two alternative carboxypeptidase-like 1 domains (CP-1), a catalytically inactive 1A form (in isoforms 3, 4 and 6) and an active 1B form (in isoforms 1, 5, and 7) (PubMed:12393882). All 3 carboxypeptidase-like domains (active CP-1, CP-2 and CP-3) appear to necessary for maintaining full viability (PubMed:20386952). The active CP-1 and CP-2 domains display redundant functions in terms of processing peptides involved in viability, and in behaviors like cold and ethanol sensitivity, as well as long-term memory (PubMed:20386952). However, the active CP-1 domain appears to preferentially remove C-terminal Arg residues while CP-2 preferentially removes C-terminal Lys residues (PubMed:20386952). The active CP-1 is sufficient for survival (PubMed:16556608). The CP-3 domain appears to be important for development from embryo to adult (PubMed:20386952).

The C-terminus in isoforms 4, 5 and 6 may be required for the retrograde transport of these proteins from the cell membrane to the trans-Golgi network.

(UniProt, P42787)

Crossreferences

InterPro - A database of protein families, domains and functional sites

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M14.011

PDB - An information portal to biological macromolecular structures

3MN8

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\svr using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

svr_1
svr_2

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.64

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Settle et al., 1995)

Additional Descriptive Data

svr transcripts are detected in Northern blots of embryonic RNA.

(Settle et al., 1995)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

located_in extracellular region

inferred from high throughput direct assay

(Karlsson et al., 2004)

located_in perinuclear region of cytoplasm

inferred from direct assay

(Sidyelyeva et al., 2010)

Expression Deduced from Reporters

Reporter: P{GawB}svr¹⁰²¹

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult mushroom body

(Lu et al., 2016)

adult neurosecretory cell of pars intercerebralis

(Lu et al., 2016)

Reporter: P{GawB}svr^PG33

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 17

embryonic/larval plasmatocyte

(Waltzer et al., 2003)

larval stage

Kenyon cell

(Pauls et al., 2019)

neuron | subset of larval central nervous system

(Pauls et al., 2019)

embryonic/larval corpus cardiacum

(Pauls et al., 2019)

ring gland

(Pauls et al., 2019)

adult stage

neuron | subset of adult central nervous system

(Pauls et al., 2019)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\svr in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\svr

View exonic expression by tissue for Dmel\svr

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

30998/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004648

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004648

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004648

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4122

Flygut - An atlas of the Drosophila adult midgut

FBgn0004648

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 67 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of svr

Transgenic constructs containing regulatory region of svr

Aberrations (Deficiencies and Duplications) ( 45 )

Inferred from experimentation ( 45 )

Gene duplicated in

Gene not disrupted in

Gene not duplicated in

Dp(1;3)sta

(Kramers et al., 1991)

Gene disrupted in

(Ryder, 2004.4.26)

(Green, 1982)

(Park and Yamamoto, 1993, Kramers et al., 1991, Kramers et al., 1983, Sutton, 1943, California Institute of Technology, 1940)

Df(1)y74k24.1

(Kramers et al., 1991, Kramers et al., 1983)

Df(1)y^-(1)

(Settle et al., 1995)

Df(1)y^-(2)

(Settle et al., 1995)

Inferred from location ( 15 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

lethal - all die before end of larval stage

svr⁸

lethal - all die before end of larval stage | recessive

partially lethal

partially lethal - majority die | recessive

svr^dwp

viable

viable | recessive

svr^Poi

Sterility

Allele

fertile

svr^dwp

semi-sterile

svr^cc-y

Other Phenotypes

Allele

abnormal body color

abnormal body color | recessive

svr¹

abnormal cold stress response | recessive

abnormal memory | recessive

electrophoretic variant

some die during larval stage

svr⁸

some die during larval stage | recessive

visible

visible (with svr¹)

svr^PG33

visible (with svr^PG33)

visible (with svr^poi)

svr^PG33

visible | recessive

Phenotype manifest in

Allele

anterior crossvein

microchaeta

svr^poi-dish

posterior crossvein

wing

wing blade

wing blade (with svr¹)

svr^PG33

wing blade (with svr^PG33)

wing blade (with svr^poi)

svr^PG33

wing vein (with svr¹)

svr^PG33

wing vein (with svr^PG33)

wing vein (with svr^poi)

svr^PG33

wing vein L1

svr^poi

wing vein L2

svr^poi

wing vein L3

wing vein L4

wing vein L5

svr¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\CPD

13 of 14

Yes

Hsap\AEBP1

5 of 14

Yes

Hsap\CPE

5 of 14

Yes

Hsap\CPN1

5 of 14

Yes

Hsap\CPXM1

5 of 14

Yes

Hsap\CPXM2

5 of 14

Yes

Hsap\CPZ

5 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

Rnor\Cpd

13 of 14

Yes

Rnor\Aebp1

5 of 14

Yes

Rnor\Cpn1

5 of 14

Yes

Rnor\Cpxm1

5 of 14

Yes

Rnor\Cpz

5 of 14

Yes

Rnor\Cpe

4 of 14

Yes

Rnor\Cpxm2

4 of 14

Yes

Rnor\Cpm

3 of 14

Rnor\Cpa4

1 of 14

Mus musculus (laboratory mouse) (12)

Mmus\Cpd

13 of 14

Yes

Mmus\Aebp1

5 of 14

Yes

Mmus\Cpe

5 of 14

Yes

Mmus\Cpn1

5 of 14

Yes

Mmus\Cpxm2

5 of 14

Yes

Mmus\Cpz

5 of 14

Yes

Mmus\Cpxm1

4 of 14

Yes

3 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\cpd

6 of 13

Yes

Xtro\cpe

4 of 13

Yes

Xtro\cpz

4 of 13

Xtro\lman1

3 of 13

Xtro\aebp1

2 of 13

Yes

Xtro\cpm

2 of 13

Xtro\cpxm1

2 of 13

Yes

Xtro\cpxm2

2 of 13

Yes

Xtro\agbl3

1 of 13

Xtro\aurkaip1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC100489361

1 of 13

Xtro\LOC105947369

1 of 13

Danio rerio (Zebrafish) (14)

Drer\cpda

13 of 14

Yes

Drer\cpdb

11 of 14

Yes

Drer\aebp1a

5 of 14

Yes

Drer\aebp1b

5 of 14

Yes

Drer\cpe

5 of 14

Yes

Drer\cpn1

5 of 14

Yes

Drer\cpxm1a

5 of 14

Yes

Drer\cpz

4 of 14

Yes

Drer\cpm

3 of 14

Drer\cpxm1b

3 of 14

Yes

Drer\cpa6

1 of 14

Drer\cpb2

1 of 14

Drer\cpxm2

1 of 14

Yes

Drer\ddr2l

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\cpd-1

9 of 14

Yes

Cele\cpd-2

9 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (22)

Agam\AgaP_AGAP002414

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (1)

Atha\SOL1

8 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\ECM14

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:svr. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

7 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Ddr

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

AEBP1; AE binding protein 1

model of Ehlers-Danlos syndrome classic-like 2

IEA

(FlyBase, 2019-)

CPN1; carboxypeptidase N subunit 1

model of carboxypeptidase N deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 3 )

Allele

Disease

Interaction

References

svr^EP356

ameliorates Huntington's disease

modeled by Hsap\HTT^Q93.ex1.UAS

(Cao et al., 2008)

ameliorates tauopathy

modeled by Hsap\MAPT^UAS.cWa

(Cao et al., 2008)

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

svr^KG02090

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

svr¹²⁶

exacerbates Alzheimer's disease

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Cao et al., 2008)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CPD; carboxypeptidase D

13 of 14

603102

AEBP1; AE binding protein 1

5 of 14

602981

EHLERS-DANLOS SYNDROME, CLASSIC-LIKE, 2; EDSCLL2

Ehlers-Danlos syndrome classic-like 2

CPE; carboxypeptidase E

5 of 14

114855

BDV SYNDROME; BDVS

CPN1; carboxypeptidase N subunit 1

5 of 14

603103

CARBOXYPEPTIDASE N DEFICIENCY; CPND

carboxypeptidase N deficiency

CPXM1; carboxypeptidase X, M14 family member 1

5 of 14

609555

CPXM2; carboxypeptidase X, M14 family member 2

5 of 14

617348

CPZ; carboxypeptidase Z

5 of 14

603105

CPM; carboxypeptidase M

3 of 14

114860

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

svr

enhanceable

svr

suppressible

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

pnr

suppressible

svr

(Pena-Rangel et al., 2002)

suppressible

suppressible

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57568

DroID - A comprehensive database of gene and protein interactions.

FBgn0004648

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Golgi Associated Vesicle Biogenesis

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0

Cytogenetic map

1B5-1B7

Sequence location

X:496,446..509,072 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1B5-1B7

Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0

(FlyBase, 2016)

1-0.0

(Comeron et al., 2012, Goldschmidt, 1944)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (30)

Aberrations including deletions of this gene Aberrations including duplications of this gene

124

126

127

31407

w¹¹¹⁸; P{UAS-svr.2-3-t2}3

11167

11419

101191

105747

101192

105748

4122R-2

v330524

More stocks available...

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (181)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0004648

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0004648

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

svr has been cloned and sequenced.

(Bernasconi, 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: svr CG18503

(Ashburner, 2000.5.29)

Source for merge of: svr CpepE

(FlyBase, 1996-)

Additional comments

Source for merge of svr CpepE was sequence comparison ( date:000117 ).

(FlyBase, 1996-)

may be allelic to pld: pallid

Nomenclature History

Source for database identify of

Source for identity of: svr CG4122

(Nusskern, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (25)

Reported As

Symbol Synonym

CG18503

(Ashburner, 2000.5.29, Benos, 2000.12.13)

CG32818

CG4122

(Bourquard et al., 2023, Meadows, 2018.4.4, Aradska et al., 2015, Ni et al., 2010.12.1, Larschan et al., 2007, Larschan et al., 2007, Karlsson et al., 2004, Bourbon et al., 2002, Benos, 2000.12.13)

(Bernasconi, 1994)

CPD

(Tanco et al., 2010, Sidyelyeva and Fricker, 2002)

CpepE

CypD

(Cao et al., 2008)

EG:171D11.3

(Benos et al., 2001, Benos, 2000.12.13)

EP(X)0356

(Pena-Rangel et al., 2002)

dwp

l(1)1Bd

poi

slv

(Dobzhansky, 1932)

Name Synonyms

Carboxypeptidase D

(Sidyelyeva et al., 2006)

Carboxypeptidase E

DmSilver

(Pillmann et al., 2011)

Silver

(Pillmann et al., 2011)

carboxypeptidase

(Bernasconi, 1993.12.1)

carboxypeptidase D

(Sidyelyeva and Fricker, 2002)

chlorotic

dwarp

pointed

silver

(Carnes et al., 2015, Winbush et al., 2012, Sidyelyeva et al., 2010, Tanco et al., 2010, Cao et al., 2008, Wright, 1987)

Secondary FlyBase IDs

FBgn0000268
FBgn0000521
FBgn0003652
FBgn0012063
FBgn0029527
FBgn0052818

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 107 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

30998

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P42787

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P42787

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P42787

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

30998/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0004648

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0004648

FlyMine - An integrated database for Drosophila genomics

FBgn0004648

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG4122

MARRVEL_MODEL - MARRVEL (model organism gene)

30998

MEROPS - An information resource for peptidases (also termed proteases, proteinases and proteolytic enzymes) and the proteins that inhibit them.

M14.011

PDB - An information portal to biological macromolecular structures

3MN8

Linkouts

BioGRID - A database of protein and genetic interactions.

57568

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0004648

DroID - A comprehensive database of gene and protein interactions.

FBgn0004648

DRSC - Results frm RNAi screens

FBgn0004648

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

svr_1
svr_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0004648

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0004648

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4122

Flygut - An atlas of the Drosophila adult midgut

FBgn0004648

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0004648

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015532

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Golgi Associated Vesicle Biogenesis

References (114)

The following external sites may use different assemblies or annotations than FlyBase.

-1.64

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