FlyBase Gene Report: Dmel\Gyc32E

General Information

Symbol

Dmel\Gyc32E

Species

D. melanogaster

Name

Guanylyl cyclase at 32E

Annotation Symbol

CG33114

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010197

Gene Model Status

Current

Stock Availability

13 publicly available

Enzyme Name (EC)

guanylate cyclase (4.6.1.2)

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

GC, Guanyl cyclase at 32E

Key Links

Genomic Location

Cytogenetic map

32D5-32D5

Sequence location

2L:11,138,759..11,149,101 [-]

Recombination map

2-44

RefSeq locus

NT_033779 REGION:11138759..11149101

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (6 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (6 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719

(InterPro Project Members, 2004-)

enables guanylate cyclase activity

non-traceable author statement

(Gigliotti et al., 1993)

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

enables peptide receptor activity

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

enables phosphorus-oxygen lyase activity

inferred from electronic annotation with InterPro:IPR018297

(InterPro Project Members, 2004-)

enables signaling receptor activity

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Gigliotti et al., 1993)

NOT enables protein kinase activity

inferred from key residues

(Anamika et al., 2009)

Biological Process (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in cGMP biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

involved_in cyclic nucleotide biosynthetic process

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

involved_in receptor guanylyl cyclase signaling pathway

non-traceable author statement

(Gigliotti et al., 1993)

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN000229249

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with FLYBASE:Gyc76C; FB:FBgn0266136

(Gene Ontology Curators, 2002-)

non-traceable author statement

(Gigliotti et al., 1993)

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES

Protein Family (UniProt)

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q07553)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

guanylate cyclase activity

GTP = 3',5'-cyclic GMP + diphosphate (4.6.1.2)

RHEA 13665:

Summaries

Gene Group (FlyBase)

RECEPTOR GUANYLATE CYCLASES -: Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gyc32E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q07553)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.52

Gene model reviewed during 5.40

Single-base exon is postulated.

Gene model reviewed during 5.57

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gyc32E-RB

FBtr0112856

NM_001103678

3844

1191

Gyc32E-RD

FBtr0343625

NM_176013

3760

1163

Gyc32E-RG

FBtr0346610

NM_001298905

3736

1155

Additional Transcript Data and Comments

Reported size (kB)

4.5 (northern blot)

(Gigliotti et al., 1993)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gyc32E-PB

FBpp0111769

134.3

1191

7.89

FBpp0310220

130.9

1163

7.77

FBpp0312190

129.9

1155

7.54

X2J5N3

NP_001285834

AHN54348

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gyc32E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gyc32E_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.39

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1

organism | ubiquitous

(Gigliotti et al., 1993)

oogenesis

germarium

(Gigliotti et al., 2000)

oogenesis stage S10

egg chamber

(Gigliotti et al., 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

(Gigliotti et al., 1993)

adult stage

adult head

(Gigliotti et al., 1993)

adult stage & oogenesis

germarium

(Gigliotti et al., 1993)

adult stage & oogenesis stage S10

nurse cell

(Gigliotti et al., 1993)

Additional Descriptive Data

Weak Gyc32E expression was observed in RNA from larvae and adult heads on northern blots. By in situ hybridization, transcripts are detected in ovaries in germarium regions 2 and 3. They disappear and then reappear at stage S10 in nurse cells. Gyc32E transcripts are uniform in very early embryos. Later they are confined to yolk and are not present in blastoderm cells. They reappear along the germ band of germ band elongated embryos.

(Gigliotti et al., 1993)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gyc32E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gyc32E

View exonic expression by tissue for Dmel\Gyc32E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010197

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34553/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010197

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010197

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010197

Flygut - An atlas of the Drosophila adult midgut

FBgn0010197

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gyc32E

Transgenic constructs containing regulatory region of Gyc32E

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2L)salm^FRT

(Spletter et al., 2015)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (56)

Hsap\NPR1

4 of 14

Yes

Hsap\NPR2

4 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (28)

Rnor\Gucy2g

5 of 14

Yes

Rnor\Npr1

4 of 14

Rnor\Npr2

4 of 14

Rnor\Gucy2c

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (29)

Mmus\Gucy2g

5 of 14

Yes

Mmus\Npr2

4 of 14

Mmus\Gucy2c

3 of 14

Yes

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (33)

Xtro\gucy2d

2 of 13

Yes

Xtro\npr1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101732477

1 of 13

Yes

Xtro\LOC101732945

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\npr3

1 of 13

Xtro\tesk2

1 of 13

Danio rerio (Zebrafish) (42)

Drer\gucy2g

5 of 14

Yes

Drer\si:dkey-37g12.1

5 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Drer\gucy2cb

2 of 14

Yes

Drer\gucy2d

2 of 14

Drer\LOC100333871

2 of 14

Yes

Drer\npr3

2 of 14

Drer\si:ch211-132f19.7

2 of 14

Drer\si:dkey-206f10.1

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (53)

Cele\gcy-12

10 of 14

Yes

Cele\gcy-9

5 of 14

Yes

Cele\gcy-15

5 of 14

Yes

Cele\gcy-21

5 of 14

Yes

Cele\gcy-2

4 of 14

Cele\gcy-4

4 of 14

Cele\gcy-8

4 of 14

Yes

Cele\gcy-11

4 of 14

Yes

Cele\gcy-17

4 of 14

Cele\gcy-18

4 of 14

Yes

Cele\gcy-20

4 of 14

Cele\gcy-22

4 of 14

Yes

Cele\gcy-23

4 of 14

Yes

Cele\gcy-28

4 of 14

Cele\daf-11

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Cele\gcy-29

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

Cele\acy-2

1 of 14

Cele\dlk-1

1 of 14

Cele\flr-4

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (34)

Agam\AgaP_AGAP008848

12 of 12

Yes

5 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (55)

Atha\GLR2

2 of 13

Yes

Atha\GLUR2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT1G78530

1 of 13

Atha\AT1G80640

1 of 13

Yes

Atha\AT2G16250

1 of 13

Yes

Atha\AT2G28940

1 of 13

Atha\AT2G43700

1 of 13

Yes

Atha\AT3G45420

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\AT5G03140

1 of 13

Yes

Atha\AT5G10530

1 of 13

Atha\AT5G24010

1 of 13

Atha\AT5G48940

1 of 13

Yes

Atha\AT5G63930

1 of 13

Yes

Atha\CIPK9

1 of 13

Atha\CR4

1 of 13

Yes

Atha\CRK3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\MAPKKK9

1 of 13

Atha\MRLK

1 of 13

Yes

Atha\NCRK

1 of 13

Yes

Atha\RK2

1 of 13

Yes

Atha\RK3

1 of 13

Yes

Atha\RKF1

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gyc32E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (42)

CG42637

9 of 13

Gyc76C

9 of 13

EHR

8 of 13

CG31183

7 of 13

CG3216

5 of 13

Gucy2d

4 of 13

Ac3

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Fak

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

mtt

1 of 13

Nmdar1

1 of 13

Phlpp

1 of 13

Pvr

1 of 13

sax

1 of 13

sev

1 of 13

tkv

1 of 13

wnd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

NPR2; natriuretic peptide receptor 2

model of acromesomelic dysplasia, Maroteaux type

IEA

(FlyBase, 2019-)

model of Miura type epiphyseal chondrodysplasia

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010197

MIST (protein-protein) - An integrated Molecular Interaction Database

34553

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Inactivation, recovery and regulation of the phototransduction cascade

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-44

Cytogenetic map

32D5-32D5

Sequence location

2L:11,138,759..11,149,101 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

32D5-32D5

Limits computationally determined from genome sequence between P{lacW}RfC38^k13807 and P{PZ}l(2)04008⁰⁴⁰⁰⁸&P{PZ}cmet⁰⁴⁴³¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-44

(FlyBase, 2016)

2-37.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (13)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

34120

y¹ w^*; Mi{MIC}Gyc32E^MI00914

40785

y¹ w^*; Mi{MIC}Gyc32E^MI05545

54528

y¹ w^*; Mi{MIC}Gyc32E^MI10319

14137

y¹ w^67c23; P{SUPor-P}Gyc32E^KG06014

65330

y¹ w^*; Mi{PT-GFSTF.0}Gyc32E^{MI05545-GFSTF.0}

81160

y¹ w^*; TI{CRIMIC.TG4.0}Gyc32E^{CR01046-TG4.0}

NIG-Fly

HMJ23918

y¹ v¹; P{TRiP.HMJ23918}attP40/CyO

M2L-2399

y¹ w¹¹¹⁸; Gyc32E^SK6 P{neoFRT}40A/CyO-Tb

M2L-2400

y¹ w¹¹¹⁸; Gyc32E^SK7 P{neoFRT}40A/CyO-Tb

VDRC

v330384

P{VSH330384}attP40

v108142

P{KK106110}VIE-260B

v342606

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD02450}attP40/CyO-GFP

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010197

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Preliminary experiments using a P element-borne copy of the wild type Gyc32E 12kb genomic region failed to rescue either abo¹ or l(2)gd1¹ phenotypes.

(Gigliotti et al., 1993)

Identified as the first transcription unit downstream of the blood insertion in abo¹.

(Gigliotti et al., 1993)

Relationship to Other Genes

Source for database merge of

Additional comments

Annotation CG6275 split into CG33114 (Gyc32E) and CG31867 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Source for identity of: Gyc32E CG6275

(Gong, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG33114

(National Institute of Genetics Fly Stocks, 2023-, National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.9.14, Vogel et al., 2013, Biswas et al., 2009, Keleman et al., 2009.8.5)

CG6275

(Ayoob et al., 2004, Morrison et al., 2000)

Cyg1

DMRGC

(Liu et al., 1995)

(Gigliotti et al., 2000, Malva et al., 1994, Gigliotti et al., 1993)

GYC 32E

(Morrison et al., 2000)

Gyc-r

Gyc32E

(Werner et al., 2024, Kanoh et al., 2021, Gene Disruption Project members, 2018-, Di Cara et al., 2015, Gene Disruption Project members, 2015-)

Name Synonyms

Guanyl cyclase at 32E

(Cho et al., 2005)

Guanylate cyclase receptor-type

Guanylyl cyclase at 32E

Secondary FlyBase IDs

FBgn0053114

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

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External Crossreferences and Linkouts ( 51 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34553

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q07553

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q07553

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q07553

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010197

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34553/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010197

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010197

FlyMine - An integrated database for Drosophila genomics

FBgn0010197

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33114

MARRVEL_MODEL - MARRVEL (model organism gene)

34553

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0010197

DRSC - Results frm RNAi screens

FBgn0010197

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gyc32E_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010197

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010197

Flygut - An atlas of the Drosophila adult midgut

FBgn0010197

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033927

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

34553

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Inactivation, recovery and regulation of the phototransduction cascade

References (54)

The following external sites may use different assemblies or annotations than FlyBase.

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