FlyBase Gene Report: Dmel\Gp150

General Information

Symbol

Dmel\Gp150

Species

D. melanogaster

Name

Gp150

Annotation Symbol

CG5820

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013272

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Gp150 (Gp150) encodes a transmembrane glycoprotein that regulates Notch signaling and is involved in eye development. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

58D3-58D3

Sequence location

2R:22,317,662..22,329,416 [+]

Recombination map

2-99

RefSeq locus

NT_033778 REGION:22317662..22329416

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in cell surface receptor protein tyrosine phosphatase signaling pathway

inferred from direct assay

(Tian and Zinn, 1994)

involved_in compound eye development

inferred from mutant phenotype

(Fetchko et al., 2002)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Tian and Zinn, 1994)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gp150 (Gp150) encodes a transmembrane glycoprotein that regulates Notch signaling and is involved in eye development. [Date last reviewed: 2019-03-07]

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gp150 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q8MLT4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.51

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gp150-RA

FBtr0071813

NM_166527

4216

1051

Gp150-RB

FBtr0071814

NM_166528

4255

1051

Gp150-RC

FBtr0071815

NM_166529

4360

1051

Gp150-RD

FBtr0071816

NM_057701

4190

1076

Gp150-RE

FBtr0342985

NM_001299784

4422

1044

Gp150-RF

FBtr0342986

NM_001299785

4124

1051

Additional Transcript Data and Comments

Reported size (kB)

4.5 (northern blot)

(Tian and Zinn, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Gp150-PA

FBpp0071726

118.2

1051

4.56

FBpp0071727

118.2

1051

4.56

FBpp0071728

118.2

1051

4.56

FBpp0071729

121.0

1076

4.62

FBpp0309749

117.4

1044

4.54

FBpp0309750

118.2

1051

4.56

Q24007

NP_001286714

AHN56509

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1051 aa isoforms: Gp150-PA, Gp150-PB, Gp150-PC, Gp150-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

1051 (aa); 150 (kD observed); 115 (kD predicted)

(Tian and Zinn, 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gp150 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.98

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

epithelial cell

• cytoplasm | apical

Comment: clustered apical distribution

(Lecuyer et al., 2007)

epithelium

• cytoplasm | apical

(Lecuyer et al., 2007)

neuroblast

Comment: asymetrically distributed

(Lecuyer et al., 2007)

ventral midline of embryo

(Wheeler et al., 2009)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal epidermis primordium

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

(Tian and Zinn, 1994)

organism | segmentally repeated

(Tian and Zinn, 1994)

embryonic stage 3 -- 12

(Tian and Zinn, 1994)

embryonic stage 10 -- 12

ventral midline of embryo

(Tian and Zinn, 1994)

Additional Descriptive Data

Gp150 transcripts are most abundant between 3 and 12 hours of embryogenesis. Gp150 transcripts are expressed in most or all cells of the embryo. Elevated levels are observed along the ventral midline and in segmentally repeated lateral patches in the epithelium. At stage 12, expression is observed in stripes located just posterior to the segmental grooves.

(Tian and Zinn, 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

eye disc

• late endosome

(Li et al., 2003)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Both sca and Gp150 protein were detected in late endosomes in eye discs. sca protein was frequently found in large particles in these endosomes.

(Li et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in plasma membrane

inferred from direct assay

(Tian and Zinn, 1994)

Expression Deduced from Reporters

Reporter: P{GawB}Gp150^52A

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval ventral nerve cord

(Cheng et al., 1998)

ventral midline of embryo

(Kester and Nambu, 2011)

embryonic stage 11 -- 15

ventral midline of embryo

(Melnattur et al., 2002)

embryonic stage 11 -- 17

larval VUM neuron

(Zhou et al., 1997)

medial cell body glial cell

(Zhou et al., 1997)

embryonic stage 15 -- 16

larval somatic muscle cell | ventral

(Melnattur et al., 2002)

larval somatic muscle cell | lateral

(Melnattur et al., 2002)

frontal sac

(Melnattur et al., 2002)

embryonic stage 16

midline glial cell

(Melnattur et al., 2002)

larval midline neuron

(Melnattur et al., 2002)

third instar larval stage

larval brain | restricted

Comment: cells of central brain

(Melnattur et al., 2002)

larval ventral nerve cord | restricted

Comment: cells along midline

(Melnattur et al., 2002)

leg disc | restricted

(Melnattur et al., 2002)

tibia | precursor

(Melnattur et al., 2002)

wing pouch

Comment: restricted from dorsal/ventral compartment boundary

(Melnattur et al., 2002)

wing hinge primordium

(Melnattur et al., 2002)

haltere disc | restricted

Comment: pattern is similar to that in the wing disc

(Melnattur et al., 2002)

eye-antennal disc | restricted | ventro-lateral

Comment: along ventro-lateral edge of disc

(Melnattur et al., 2002)

adult stage

adult brain | restricted

(Melnattur et al., 2002)

adult ventral nerve cord | restricted

(Melnattur et al., 2002)

adult fruitless aDT-h neuron

(Fan et al., 2013)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Gp150 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gp150

View exonic expression by tissue for Dmel\Gp150

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013272

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37549/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013272

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013272

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013272

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5820

Flygut - An atlas of the Drosophila adult midgut

FBgn0013272

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gp150

Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gp150

Transgenic constructs containing regulatory region of Gp150

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2R)02311

(Fetchko et al., 2002, Melnattur et al., 2002)

Df(2R)Liprin-γ^H1

(Astigarraga et al., 2010)

Df(2R)X58-7

(Melnattur et al., 2002)

Df(2R)X58-8

(Melnattur et al., 2002)

Df(2R)X58-12

(Kahsai et al., 2016, Melnattur et al., 2002)

Gene partially disrupted in

Df(2R)Liprin-γ^H1

(Astigarraga et al., 2010)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(2R)02311)

Gp150^52A

lethal (with Df(2R)X58-12)

Gp150^k11120b

lethal (with Gp150³)

Gp150^k11120b

lethal (with Gp150^k11120b)

Gp150³

lethal | pupal stage, with Scer\GAL4^pnr-MD237

Gp150^GD2506

lethal | recessive

Gp150^52A

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Gp150^GD10

lethal - all die during larval stage, with Scer\GAL4^Mef2.PR

partially lethal - majority die

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Gp150^GD14413

partially lethal - majority die (with Gp150²)

Gp150^52A

partially lethal - majority die (with Gp150³)

Gp150^52A

partially lethal - majority die (with Gp150^52A)

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Gp150^GD2506

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sterility

Allele

female sterile

Gp150^unspecified

female sterile (with Gp150²)

Gp150^52A

female sterile (with Gp150³)

Gp150^52A

female sterile (with Gp150^52A)

male semi-sterile

Gp150^unspecified

Other Phenotypes

Allele

abnormal behavior | recessive

Gp150^BG01043

abnormal body color, with Scer\GAL4^pnr-MD237

Gp150^GD14413

abnormal pain response | adult stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gp150^GD2506

some die during pupal stage, with Scer\GAL4^pnr-MD237

visible

visible, with Scer\GAL4^pnr-MD237

visible | recessive

Gp150^unspecified

Phenotype manifest in

Allele

anterior scutellar bristle (with Gp150³)

Gp150^k11120b

anterior scutellar bristle (with Gp150^k11120b)

Gp150³

chaeta | increased number, with Scer\GAL4^pnr-MD237

Gp150^GD14413

eye

eye (with Df(2R)02311)

Gp150³

eye (with Gp150³)

eye (with Gp150⁴)

Gp150³

eye (with Gp150^k11120b)

Gp150³

eye photoreceptor cell (with Gp150³)

Gp150⁴

eye photoreceptor cell (with Gp150⁴)

Gp150³

eye photoreceptor cell | somatic clone

Gp150³

eye photoreceptor cell | somatic clone (with Gp150^k11107b)

Gp150^k11120b

eye photoreceptor cell | somatic clone (with Gp150^k11120b)

Gp150^k11107b

macrochaeta (with Df(2R)Liprin-γ^H1)

Gp150^k11120b

mesonotum, with Scer\GAL4^pnr-MD237

mesothoracic tergum & microchaeta

Gp150^k11107b

ocellar bristle

Gp150^k11107b

ommatidium

ommatidium (with Df(2R)02311)

Gp150³

ommatidium (with Gp150³)

ommatidium (with Gp150⁴)

Gp150³

ommatidium (with Gp150^k11120b)

ommatidium (with Gp150^P8)

Gp150^k11120b

ommatidium | somatic clone

Gp150³

ommatidium | somatic clone (with Gp150^k11107b)

Gp150^k11120b

ommatidium | somatic clone (with Gp150^k11120b)

Gp150^k11107b

photoreceptor cell R1 (with Gp150³)

Gp150^k11120b

photoreceptor cell R1 (with Gp150^k11120b)

Gp150³

photoreceptor cell R6 (with Gp150³)

Gp150^k11120b

photoreceptor cell R6 (with Gp150^k11120b)

Gp150³

photoreceptor cell R8 (with Gp150³)

Gp150^k11120b

photoreceptor cell R8 (with Gp150^k11120b)

Gp150³

photoreceptor cell R8 | cell autonomous | somatic clone

Gp150^k11120b

sarcomere, with Scer\GAL4^Mef2.PR

trichogen cell, with Scer\GAL4^pnr-MD237

Gp150^GD14413

wing margin, with Scer\GAL4^dpp.blk1

Gp150^UAS.cLa

wing margin bristle

wing margin bristle | ectopic

wing vein L3 | ectopic

Z disc, with Scer\GAL4^Mef2.PR

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (76)

Hsap\TSKU

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\FLRT2

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Lrrc15

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Lrig3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (57)

Xtro\nrros

2 of 13

Yes

Xtro\cetn3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\lrrc32.1

1 of 13

Xtro\lrrc32.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\slitrk3

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (26)

Drer\si:dkey-182i3.11

2 of 14

Yes

Drer\tlr22

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\dma-1

2 of 14

Yes

Cele\egg-6

2 of 14

Yes

Cele\lron-1

2 of 14

Yes

Cele\lron-5

2 of 14

Yes

Cele\lron-11

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (66)

Agam\AgaP_AGAP006645

6 of 12

Yes

Agam\AgaP_AGAP004832

2 of 12

Yes

Agam\AgaP_AGAP007059

2 of 12

Yes

Agam\AgaP_AGAP007061

2 of 12

Yes

Agam\APL1A

2 of 12

Yes

Agam\APL1B

2 of 12

Yes

Agam\APL1C

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP005693

1 of 12

Agam\AgaP_AGAP006183

1 of 12

Agam\AgaP_AGAP006348

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (22)

Atha\ARABIDILLO-2

1 of 13

Yes

Atha\AT2G48160

1 of 13

Yes

Atha\AT3G15410

1 of 13

Yes

Atha\AT3G63070

1 of 13

Yes

Atha\AT4G05497

1 of 13

Yes

Atha\AT4G15475

1 of 13

Yes

Atha\AT5G08230

1 of 13

Yes

Atha\AT5G10020

1 of 13

Yes

Atha\AT5G23340

1 of 13

Yes

Atha\AT5G27920

1 of 13

Yes

Atha\BAM3

1 of 13

Yes

Atha\BRI1

1 of 13

Yes

Atha\BRL3

1 of 13

Yes

Atha\ERL1

1 of 13

Yes

Atha\FLS2

1 of 13

Yes

Atha\GSO1

1 of 13

Yes

Atha\GSO2

1 of 13

Yes

Atha\HUA2

1 of 13

Yes

Atha\PEPR1

1 of 13

Yes

Atha\PIRL6

1 of 13

Yes

Atha\SKP2B

1 of 13

Yes

Atha\SLOMO

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Gp150. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (52)

2mit

2 of 13

18w

2 of 13

atk

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

chp

1 of 13

Con

1 of 13

Fbxl7

1 of 13

Fili

1 of 13

haf

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

lbk

1 of 13

Lrch

1 of 13

Lrt

1 of 13

MstProx

1 of 13

Phlpp

1 of 13

rdo

1 of 13

sli

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

trn

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Gp150 - Pten

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Gp150 - Ptp10D

enzymatic study, phosphatase assay, autoradiography, pull down, edman degradation

(Madan and Gopal, 2011, Tian and Zinn, 1994)

Gp150 - S6kII

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Gp150

enhanceable

Delta

(Fetchko et al., 2002)

Gp150

enhanceable

(Fetchko et al., 2002)

Gp150

enhanceable

sca

(Li et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Li et al., 2003)

suppressible

(Li et al., 2003)

enhanceable

(Li et al., 2003)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63166

DroID - A comprehensive database of gene and protein interactions.

FBgn0013272

MIST (genetic) - An integrated Molecular Interaction Database

37549

MIST (protein-protein) - An integrated Molecular Interaction Database

37549

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Rodriguez et al., 2012)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-99

Cytogenetic map

58D3-58D3

Sequence location

2R:22,317,662..22,329,416 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

58D3-58D3

Limits computationally determined from genome sequence between P{PZ}ari-2⁰⁷⁷⁶⁸ and P{lacW}l(2)k09801^k09801

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

58D1-58D3

(Zinn, 1994.9.28)

58D1-58D8

(Nakamura, 1996.8.8)

Experimentally Determined Recombination Data

Location

2-99

(FlyBase, 2016)

2-104.1

(Comeron et al., 2012)

(Zhou et al., 1997, Nakamura, 1996.8.8, Zinn, 1994.9.28)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Genomic Clones (22)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (558)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

RT10449

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0013272

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013272

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Endosomal sca and Gp150 may promote N activation in response to Dl, by regulating acquisition of insensitivity to Dl in a subset of cells.

(Li et al., 2003)

Gp150 is required for early ommatidial development and may function in intracellular vesicles to modulate Dl-N signalling for cell fate control and tissue morphogenesis.

(Fetchko et al., 2002)

Ptp10D and Gp150 form stable complexes in culture cells and in wild type larval tissue. Ptp10D cytoplasmic domain is sufficient to confer binding to Gp150. Results support the hypothesis that Ptp10D regulates Gp150 signaling in vivo.

(Fashena and Zinn, 1997)

Transmembrane Gp150 glycoprotein selectively interacts with the active site of the catalytic domain of Ptp10D (interaction is blocked by mutation of the active site or by the inhibitor vanadate). Ptp10D may function in vivo to regulate phosphorylation of Gp150 thereby controlling interactions with downstream effectors.

(Tian and Zinn, 1994)

Relationship to Other Genes

Source for database merge of

Source for merge of: Gp150 anon- EST:fe2A1

(Bayraktaroglu, 2000.11.2)

Source for merge of: Gp150 l(2)52A

(Melnattur et al., 2002)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Gp150 CG5820

(Milshina, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG5820

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Christis and Munro, 2012, Yano et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Molnar et al., 2006)

CT18251

(Hynes and Zhao, 2000)

GP150

(Fischer et al., 2024, Madan and Gopal, 2011, Nakahara and Carthew, 2004)

anon-EST:fe2A1

l(2)52A

p150

Name Synonyms

Gp150

anon-fast-evolving-2A1

glycoprotein 150

(Tian and Zinn, 1994)

Secondary FlyBase IDs

FBgn0022992
FBgn0025238
FBgn0027193

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 66 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37549

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q8MLT4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q8MLT4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0013272

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37549/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013272

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013272

FlyMine - An integrated database for Drosophila genomics

FBgn0013272

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG5820

MARRVEL_MODEL - MARRVEL (model organism gene)

37549

Linkouts

BioGRID - A database of protein and genetic interactions.

63166

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0013272

DroID - A comprehensive database of gene and protein interactions.

FBgn0013272

DRSC - Results frm RNAi screens

FBgn0013272

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0013272

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013272

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG5820

Flygut - An atlas of the Drosophila adult midgut

FBgn0013272

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0013272

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC001743

MIST (genetic) - An integrated Molecular Interaction Database

37549

MIST (protein-protein) - An integrated Molecular Interaction Database

37549

References (105)

The following external sites may use different assemblies or annotations than FlyBase.

-0.98

Report Sections