DGCR8
double-stranded RNA-binding protein - essential for the biogenesis of canonical miRNAs - required for imaginal disc growth
Please see the JBrowse view of Dmel\pasha for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.48
Gene model reviewed during 5.53
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pasha using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\pasha in JBrowse3-102
3-99.1
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
pasha is essential for the biogenesis of canonical miRNAs, but is dispensible for the processing and function of mirtron-derived regulatory RNAs.
pasha is required for normal projection neuron dendrite targeting and axon-terminal elaboration.
RNAi knockdown of pasha function in S2 cells results in an accumulation of pri-miRNAs and a reduction of pre-miRNAs and mature miRNAs.
Source for identity of: pasha CG1800