FlyBase Gene Report: Dmel\asl

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\asl

General Information

Symbol

Dmel\asl

Species

D. melanogaster

Name

asterless

Annotation Symbol

CG2919

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261004

Gene Model Status

Stock Availability

9 publicly available

Gene Summary

asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

Cep152, mecD, sdu

Key Links

Genomic Location

Cytogenetic map

Sequence location

3R:5,603,236..5,606,543 [-]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5603236..5606543

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (15 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with FLYBASE:Sas-4; FB:FBgn0011020

(Gopalakrishnan et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to cytoskeletal protein-membrane anchor activity

inferred from biological aspect of ancestor with PANTHER:PTN008686725

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in asymmetric cell division

inferred from direct assay

(Januschke and Gonzalez, 2010)

involved_in centriole replication

inferred from mutant phenotype

(Blachon et al., 2008, Dobbelaere et al., 2008)

involved_in centrosome cycle

inferred from mutant phenotype

(Varmark et al., 2007, Bonaccorsi et al., 2000)

involved_in negative regulation of centriole elongation

inferred from mutant phenotype

(Galletta et al., 2016)

involved_in non-motile cilium assembly

inferred from mutant phenotype

(Blachon et al., 2008)

involved_in single fertilization

inferred from mutant phenotype

(Varmark et al., 2007)

involved_in sperm axoneme assembly

inferred from mutant phenotype

(Blachon et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in centrosome cycle

inferred from biological aspect of ancestor with PANTHER:PTN008686726

(GO Reference Genome Project, 2011-)

involved_in establishment of mitotic spindle localization

inferred from biological aspect of ancestor with PANTHER:PTN008686725

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

colocalizes_with centriole

inferred from direct assay

(Blachon et al., 2008)

located_in centriole

inferred from direct assay

(Stevens et al., 2010, Dobbelaere et al., 2008, Varmark et al., 2007)

located_in centrosome

inferred from direct assay

(Blachon et al., 2008)

located_in ciliary basal body

inferred from direct assay

(Alzyoud et al., 2021, Varmark et al., 2007)

located_in pericentriolar material

inferred from direct assay

(Gopalakrishnan et al., 2011, Blachon et al., 2008, Dobbelaere et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in microtubule organizing center

inferred from biological aspect of ancestor with PANTHER:PTN008686725

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

-

Summaries

Gene Snapshot

asterless (asl) encodes a component of the centriole that is required for centrosome function. It contributes to asymmetric cell division, sperm development and centriole replication and elongation. [Date last reviewed: 2019-03-07]

Summary (Interactive Fly)

coiled-coil protein - component of pancentriole and basal body - involved in stabilization/maintenance of pericentriolar material at the centrosome

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\asl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VNE4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0078743

3187

994

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0078392

116.6

994

5.90

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9VNE4

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\asl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

asl_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.89

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

adult midgut progenitor cell

(Schoenfelder et al., 2014)

salivary gland imaginal ring

(Schoenfelder et al., 2014)

oogenesis stage S5

(Schoenfelder et al., 2014)

oogenesis stage S6 -- S8

(Schoenfelder et al., 2014)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

colocalizes_with centriole

inferred from direct assay

(Blachon et al., 2008)

located_in centriole

inferred from direct assay

(Stevens et al., 2010, Dobbelaere et al., 2008, Varmark et al., 2007)

located_in centrosome

inferred from direct assay

(Blachon et al., 2008)

located_in ciliary basal body

inferred from direct assay

(Alzyoud et al., 2021, Varmark et al., 2007)

located_in pericentriolar material

inferred from direct assay

(Gopalakrishnan et al., 2011, Blachon et al., 2008, Dobbelaere et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\asl in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\asl

View exonic expression by tissue for Dmel\asl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261004

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259895

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261004

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2919

Flygut - An atlas of the Drosophila adult midgut

FBgn0261004

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 31 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of asl

Transgenic constructs containing regulatory region of asl

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

(Ryder, 2004.4.26)

Inferred from location ( 5 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

asl^GD9853

lethal (with asl²)

asl³

lethal (with asl³)

asl²

lethal | recessive

asl²

asl^c01524

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

asl^GD9853

viable, with Scer\GAL4^pnr-MD237

asl^GD9853

viable, with Scer\GAL4^tin.CΔ4

asl^GD9853

viable (with asl¹)

viable (with asl²)

asl¹

viable (with asl³)

asl¹

Sterility

Allele

female sterile | recessive

asl¹

asl^c01524

asl¹

male sterile | recessive

asl¹

Other Phenotypes

Allele

abnormal cell polarity

asl³

abnormal cytokinesis | male | recessive

asl¹

abnormal locomotor behavior | adult stage, with Scer\GAL4^Mef2.PR

asl^GD9853

abnormal meiotic cell cycle

asl¹

abnormal meiotic cell cycle | recessive

asl¹

abnormal mitotic cell cycle | larval stage

abnormal mitotic cell cycle | larval stage (with asl²)

asl³

abnormal mitotic cell cycle | larval stage (with asl³)

asl²

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

asl^GD9853

uncoordinated | adult stage

asl^mecD

Phenotype manifest in

Allele

anaphase & condensed nuclear chromosome

asl²

anaphase & condensed nuclear chromosome (with asl²)

asl³

anaphase & condensed nuclear chromosome (with asl³)

asl²

aster & spermatocyte

asl^unspecified

axoneme | P-stage

asl^mecD

asl¹

centriole, with Scer\GAL4^{VP16.mat.αTub67C}

asl^UASp.GFP

centriole (with Df(3R)ED5177)

asl²

centriole | female | pharate adult stage

asl^mecD

centriole | larval stage

asl^mecD

centriole | progressive

asl^mecD

centriole | P-stage

asl^mecD

centriole | third instar larval stage (with Df(3R)ED5177)

asl^mecD

centrosome (with asl²)

asl³

centrosome (with asl³)

asl²

centrosome & spermatocyte

asl^unspecified

ciliary rootlet (with asl²)

asl³

ciliary rootlet (with asl³)

asl²

cilium & mechanosensory sensory organ

asl^mecD

female germline stem cell | pharate adult stage

asl^mecD

germline stem cell (with Df(3R)ED5177)

asl²

larval brain & ganglion mother cell

asl²

larval brain & ganglion mother cell (with asl²)

asl³

larval brain & ganglion mother cell (with asl³)

asl²

larval brain & ganglion mother cell & aster

asl²

larval brain & ganglion mother cell & aster (with asl²)

asl³

larval brain & ganglion mother cell & aster (with asl³)

asl²

larval brain & ganglion mother cell & centrosome

asl²

larval brain & ganglion mother cell & centrosome (with asl²)

asl³

larval brain & ganglion mother cell & centrosome (with asl³)

asl²

larval brain & neuroblast

asl²

larval brain & neuroblast (with asl²)

asl³

larval brain & neuroblast (with asl³)

asl²

larval brain & neuroblast & aster

larval brain & neuroblast & aster (with asl²)

asl³

larval brain & neuroblast & aster (with asl³)

asl²

larval brain & neuroblast & centrosome

larval brain & neuroblast & centrosome (with asl²)

asl³

larval brain & neuroblast & centrosome (with asl³)

asl²

larval brain & neuroblast & spindle

asl^unspecified

larval brain | larval stage, with Scer\GAL4^insc-Mz1407

asl^GD9853

asl^mecD

male germline stem cell | progressive

asl^mecD

male germline stem cell | third instar larval stage (with Df(3R)ED5177)

asl^mecD

asl¹

meiotic anaphase I & nuclear chromosome

asl^unspecified

meiotic anaphase I | male

asl¹

meiotic cell cycle & spermatocyte

asl^unspecified

meiotic cell cycle & spindle | male

asl^unspecified

meiotic metaphase I | male

asl¹

asl²

microtubule (with asl²)

asl³

microtubule (with asl³)

asl²

microtubule basal body & mechanosensory sensory organ

asl^mecD

microtubule basal body & spermatid

asl^mecD

microtubule basal body & spermatocyte (with Df(3R)ED5177)

mitosis & nuclear chromosome

asl²

mitosis & nuclear chromosome (with asl²)

asl³

mitosis & nuclear chromosome (with asl³)

asl²

Nebenkern derivative

neuroblast & nucleus

asl²

neuroblast & nucleus (with asl²)

asl³

neuroblast & nucleus (with asl³)

asl²

nucleus | P-stage

asl^mecD

onion stage spermatid

asl¹

onion stage spermatid & nucleus

asl¹

asl¹

spermatid | P-stage

asl^mecD

spermatid axoneme

asl^mecD

asl¹

spermatocyte & aster

spermatocyte & aster (with asl¹)

spermatocyte & aster (with asl²)

spermatocyte & aster (with asl³)

spermatocyte & spindle

asl^unspecified

asl¹

spindle & spermatocyte

asl^unspecified

asl^mecD

wing disc | larval stage

asl^mecD

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

1 of 14

Yes

Yes

1 of 14

Yes

No

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

1 of 14

Yes

No

Mus musculus (laboratory mouse) (2)

1 of 14

Yes

Yes

1 of 14

Yes

No

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (2)

1 of 14

Yes

Yes

1 of 14

Yes

No

Caenorhabditis elegans (Nematode, roundworm) (2)

1 of 14

Yes

Yes

1 of 14

Yes

No

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP003526

9 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:asl. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

microcephaly, centrosome-SAC dysfunction

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

model of microcephaly

CEA with mad2^G6595

(Poulton et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

molecular sieving, peptide massfingerprinting, static light scattering, molecular weight, two hybrid, anti tag coimmunoprecipitation, western blot, anti tag western blot

(Boese et al., 2018, Galletta et al., 2016, Klebba et al., 2015)

experimental knowledge based

(Guruharsha et al., 2011)

two hybrid, cosedimentation, anti tag western blot

(Fu et al., 2016, Galletta et al., 2016)

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Galletta et al., 2016, Galletta et al., 2016)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Januschke et al., 2013)

(Galletta et al., 2016, Galletta et al., 2016)

cosedimentation in solution, western blot

(Gopalakrishnan et al., 2011)

(Galletta et al., 2016)

anti tag coimmunoprecipitation, anti tag western blot, cosedimentation through density gradient, western blot, two hybrid, anti bait coimmunoprecipitation, cosedimentation in solution

(Galletta et al., 2016, Richens et al., 2015, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)

cosedimentation through density gradient, comigration in sds page

(Ábrahám et al., 2023)

anti bait coimmunoprecipitation, anti tag western blot, two hybrid, western blot, anti tag coimmunoprecipitation, pull down, peptide massfingerprinting, autoradiography, cosedimentation through density gradient

(Galletta et al., 2016, Galletta et al., 2016, Klebba et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010, Dzhindzhev et al., 2010)

experimental knowledge based

(Guruharsha et al., 2011)

anti tag coimmunoprecipitation, anti tag western blot, two hybrid, pull down, autoradiography, cosedimentation

(Fu et al., 2016, Galletta et al., 2016)

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(McLamarrah et al., 2020, Galletta et al., 2016)

(Galletta et al., 2016)

experimental knowledge based

(Guruharsha et al., 2011)

anti bait coimmunoprecipitation, western blot, anti tag western blot, cosedimentation in solution, two hybrid, cosedimentation through density gradient

(Galletta et al., 2016, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)

two hybrid, anti bait coimmunoprecipitation, western blot

(Galletta et al., 2016, Galletta et al., 2016, Klebba et al., 2015, Conduit et al., 2014, Conduit et al., 2010)

(Galletta et al., 2016)

anti bait coimmunoprecipitation, anti tag western blot

(Gopalakrishnan et al., 2011)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Galletta et al., 2016)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Wakefield et al., 2001)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65888

DroID - A comprehensive database of gene and protein interactions.

FBgn0261004

MIST (protein-protein) - An integrated Molecular Interaction Database

40682

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

3R

Recombination map

3-47.5

Cytogenetic map

Sequence location

3R:5,603,236..5,606,543 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B4-83B5

Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

3-

(Giansanti et al., 1991)

Left of (cM)

P{EP}Rga^EP3713

(Varmark et al., 2007)

Ki

(Bonaccorsi et al., 1998, Bonaccorsi et al., 1996)

cu

(Giansanti et al., 1991)

Right of (cM)

P{EP}kra^EP3591

(Varmark et al., 2007)

st

(Giansanti et al., 1991)

Notes

Mapped halfway between st and cu.

(Giansanti et al., 1991)

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

606342

w^* P{Ubi-YFP-asl.FL}1

10582

w¹¹¹⁸; PBac{PB}asl^c01524

38220

y¹ v¹; P{TRiP.GL00661}attP40

606344

w^*; asl³ e^s ca¹/TM6B, Tb¹

35039

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01453}attP2

606343

w^*; ru¹ hry¹ asl¹ e^s/TM6B, Tb¹

2919R-3

v25457

w¹¹¹⁸; P{GD9853}v25457

v342944

P{hsFLP}1, y1 w1118; P{HD_CFD02398}attP40/CyO-GFP

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH02902

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261004

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261004

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Tian et al., 2021, Fu et al., 2016, Franz et al., 2013, Januschke et al., 2013, Klebba et al., 2013, Roque et al., 2012, Conduit et al., 2010, Dzhindzhev et al., 2010, Stevens et al., 2009, Blachon et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-ThermoFischer : Centriolar proteins were tagged with GFP at either the N- or C- terminus and used to create stable S2 cell lines. S2 cell lines constitutively expressing the following constructs were created: asl-GFP, Sas-6-GFP, ana1-GFP, GFP-ana1, Cep135-GFP, ana3-GFP, Rcd4-GFP, ana2-GFP, GFP-asl.
(Tian et al., 2021)

Other Comments

asl protein is closely associated with the centriole wall, but is not part of the centriole structure.

(Blachon et al., 2008)

asl is required for centriole duplication.

(Blachon et al., 2008)

asl is involved in centriole duplication and is required for efficient recruitment of pericentriolar material.

(Dobbelaere et al., 2008)

Expression is enriched in embryonic gonads.

(Shigenobu et al., 2006)

Identification: in a genetic screen for mutants defective in mechanosensation.

(Avidor-Reiss et al., 2001)

Mutants have severe defects in mechanosensory transduction.

(Avidor-Reiss et al., 2001)

asl is required for aster formation during male meiosis.

(Bonaccorsi et al., 1998)

Mutants are male sterile with no spindle aster in primary spermatocytes.

Relationship to Other Genes

Source for database merge of

Source for merge of: asl CG2919

(Varmark et al., 2007)

Source for merge of: asl mecD

(Blachon et al., 2008)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

ASL

(Pimenta-Marques et al., 2024, Pimenta-Marques et al., 2016, Januschke et al., 2013, Enjolras et al., 2012)

Asl

(Bonente et al., 2025, Hu et al., 2025, Wong et al., 2025, Frappaolo et al., 2022, Hannaford et al., 2022, Alvarez-Rodrigo et al., 2021, Braun et al., 2021, Gillard et al., 2021, Nabais et al., 2021, Shoda et al., 2021, Szikora et al., 2021, Tian et al., 2021, Wainman, 2021, Debec et al., 2020, Dobbelaere et al., 2020, Gallaud et al., 2020, McLamarrah et al., 2020, Panda et al., 2020, Pavlova et al., 2019, Boese et al., 2018, Ramani et al., 2018, Tillery et al., 2018, Lattao et al., 2017, Carvajal-Gonzalez et al., 2016, Khire et al., 2016, Meghini et al., 2016, Nashchekin et al., 2016, Novak et al., 2016, Fu et al., 2015, Homem et al., 2015, Lopes et al., 2015, Richens et al., 2015, Rodrigues et al., 2015, Dzhindzhev et al., 2014, Hayashi et al., 2014, Mendes Maia et al., 2014, Zheng et al., 2014, Brownlee and Rogers, 2013, Couturier et al., 2013, Jauffred et al., 2013, Lerit and Rusan, 2013, Miyauchi et al., 2013, Gopalakrishnan et al., 2012, Reschen et al., 2012, Roque et al., 2012, Sabino et al., 2011, Conduit et al., 2010, Stevens et al., 2010, Stevens et al., 2010, Mottier-Pavie and Megraw, 2009, Rebollo et al., 2009, Stevens et al., 2009, Dix and Raff, 2007, Dix and Raff, 2007, Rebollo et al., 2007)

CG2919

(Japanese National Institute of Genetics, 2012.5.21, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Blachon et al., 2008, Dobbelaere et al., 2008, Rebollo et al., 2007, Varmark et al., 2007, Shigenobu et al., 2006)

Cep152

(Marthiens and Basto, 2020, Saurya et al., 2016)

DmAsl

(Shimanovskaya et al., 2014)

MecD

(Jana et al., 2016)

asl

(Mengistu, 2025, Matsuura et al., 2024, Szlanka et al., 2024, Bedont et al., 2023, Loh et al., 2023, Nieken et al., 2023, Aydogan et al., 2022, Cunningham et al., 2022, Sunchu et al., 2022, Villa-Fombuena et al., 2021, Aydogan et al., 2020, Chen and Yamashita, 2020, Gartenmann et al., 2020, Zheng et al., 2020, Blake-Hedges and Megraw, 2019, Endow et al., 2019, Aydogan et al., 2018, Garrido-Jimenez et al., 2018, Naveed et al., 2018, Riparbelli et al., 2018, Poulton et al., 2017, Galletta et al., 2016, Novak et al., 2016, Saurya et al., 2016, Baumbach et al., 2015, Chen et al., 2015, Conduit et al., 2015, Khire et al., 2015, Venkei and Yamashita, 2015, Gallaud et al., 2014, Novak et al., 2014, Poulton et al., 2014, Schoenfelder et al., 2014, Franz et al., 2013, Kitazawa et al., 2012, Gopalakrishnan et al., 2011, Januschke et al., 2011, Wang et al., 2011, Brodu et al., 2010, Dzhindzhev et al., 2010, Januschke and Gonzalez, 2010, Stevens et al., 2010, Blachon et al., 2009, Blachon et al., 2008, Castellanos et al., 2008, Dobbelaere et al., 2008, Giansanti et al., 2008, Bonaccorsi et al., 2007, Rusan and Peifer, 2007, Varmark et al., 2007)

mecD

(Blachon et al., 2008)

sdu

(Giansanti et al., 1991)

Name Synonyms

CG2919

asterless

(Rodrigues et al., 2015, Gatti et al., 2012, Giansanti et al., 2012, Blachon et al., 2008, Varmark et al., 2007)

mechanosensory D

(Avidor-Reiss et al., 2001)

mechanosensory mutant D

(Blachon et al., 2008)

star dust

Secondary FlyBase IDs

FBgn0259895
FBgn0004916
FBgn0004830
FBgn0037348
FBgn0043878

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40682

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VNE4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VNE4

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VNE4

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40682/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261004

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261004

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG2919

MARRVEL_MODEL - MARRVEL (model organism gene)

40682

Linkouts

BioGRID - A database of protein and genetic interactions.

65888

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261004

DroID - A comprehensive database of gene and protein interactions.

FBgn0261004

DRSC - Results frm RNAi screens

FBgn0261004

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

asl_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0259895

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261004

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2919

Flygut - An atlas of the Drosophila adult midgut

FBgn0261004

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

40682

References (197)