FlyBase Allele Report: Scer\GAL4[48Y]

General Information

Symbol

Scer\GAL4^48Y

Species

S. cerevisiae

Name

FlyBase ID

FBal0063393

Feature type

allele

Associated gene

Scer\GAL4

Associated Insertion(s)

P{GawB}48Y

Carried in Construct

Also Known As

48Y-Gal4, 48Y, 48YGal4, 48Y.Gal4

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Martin-Bermudo et al., 1997)

Progenitor genotype

Associated Insertion(s)

P{GawB}48Y

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{GawB}

enhancer trap

Encoded product / tool

GAL4

binary expression system - driver

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

endoderm

(Andrews et al., 2002)

embryonic stage 10 -- 13

anterior midgut primordium

(Martin-Bermudo et al., 1999)

posterior midgut primordium

(Martin-Bermudo et al., 1999)

embryonic stage 11

trunk visceral muscle primordium | faint

(Reim et al., 2012)

endoderm

(Reim et al., 2012)

embryonic stage 11 -- 13

epidermis | segmentally repeated

(Martin-Bermudo et al., 1997)

embryonic stage 11 -- 17

embryonic/larval midgut

(Martin-Bermudo et al., 1997)

Additional Information

Statement

Reference

Drives expression in the embryonic midgut.

(FlyBase Curators, 2017)

Marker for

anterior midgut primordium

(Martin-Bermudo et al., 1999)

posterior midgut primordium

(Martin-Bermudo et al., 1999)

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion | first instar larval stage, with Tsp2A^NIG.11415R

(Izumi et al., 2016)

abnormal cell adhesion | first instar larval stage, with Tsp2A^RNAi.UAS.1-2

(Izumi et al., 2016)

abnormal cell migration | embryonic stage | parental effect, with Hmgcr^UAS.cvDa

(Barton et al., 2024)

abnormal neuroanatomy, with comm^EP

(Kraut and Zinn, 2004)

abnormal neuroanatomy, with robo2^EP2582

(Kraut and Zinn, 2004)

abnormal neuroanatomy, with robo2^{Δcyto.UAS.Tag:MYC}

(Kraut and Zinn, 2004)

decreased rate of feeding behavior | adult stage, with tobi^UAS.cBa

(Williams et al., 2022)

increased rate of feeding behavior | adult stage, with tobi^HMJ02101

(Williams et al., 2022)

lethal - all die before end of first instar larval stage, with mesh^NIG.12074R

(Izumi et al., 2012)

lethal - all die during embryonic stage, with Hsap\EWSR1::Hsap\FLI1^1.UAS

(Mahnoor et al., 2024)

lethal - all die during embryonic stage, with Hsap\EWSR1::Hsap\FLI1^1+FStail.UAS

(Mahnoor et al., 2024)

lethal - all die during embryonic stage, with Hsap\EWSR1::Hsap\FLI1^1FS.UAS

(Mahnoor et al., 2024, Molnar et al., 2022)

lethal - all die during embryonic stage, with tsh^UAS.cGa

(Waltzer et al., 2001)

lethal - all die during larval stage, with Tsp2A^NIG.11415R

(Izumi et al., 2016)

lethal - all die during P-stage, with Hsap\EWSR1::Hsap\FLI1^bc.1.UAS

(Mahnoor et al., 2024)

some die during embryonic stage, with tsh^UAS.cGa

(Waltzer et al., 2001)

some die during first instar larval stage, with mesh^NIG.12074R

(Izumi et al., 2012)

viable, with Mnn1^UAS.cCa

(Cerrato et al., 2006)

viable, with Sec10^RNAi.UAS

(Andrews et al., 2002)

viable | female, with Tmem43^S333L.UAS

(Klinke et al., 2022)

viable | female, with Tmem43^WT.UAS

(Klinke et al., 2022)

wild-type, with Ilk^E359K.UAS

(Zervas et al., 2001)

wild-type, with Ilk^UAS.cZa

(Zervas et al., 2001)

Phenotype Manifest In

abdominal lateral pentascolopidial chordotonal organ lch5, with robo2^EP2582

(Kraut and Zinn, 2004)

abdominal lateral pentascolopidial chordotonal organ lch5, with robo2^{Δcyto.UAS.Tag:MYC}

(Kraut and Zinn, 2004)

adult midgut progenitor cell, with kay^Fbz.UAS

(Riese et al., 1997)

copper cell, with CrebB^Cbz.UAS

(Riese et al., 1997)

copper cell, with dve^A.UAS

(Nakagawa et al., 2011)

copper cell, with kay^Fbz.UAS

(Riese et al., 1997)

copper cell, with tsh^UAS.cGa

(Waltzer et al., 2001)

embryonic/larval midgut, with dve^{B.UAS.Tag:FLAG}

(Nakagawa et al., 2011)

embryonic/larval midgut, with FoxK^GD4313

(Casas-Tinto et al., 2008)

embryonic/larval midgut | embryonic stage, with Cdc42^N17.UAS

(Martin-Bermudo et al., 1999)

embryonic/larval midgut | embryonic stage, with Rac1^N17.UAS

(Martin-Bermudo et al., 1999)

embryonic/larval midgut | first instar larval stage, with Tsp2A^NIG.11415R

(Izumi et al., 2016)

embryonic/larval midgut | first instar larval stage, with Tsp2A^RNAi.UAS.1-2

(Izumi et al., 2016)

endoderm, with Egfr^DN.UAS

(Szuts et al., 1998)

gastric caecum primordium, with ci^{Zn:RD.UAS.Tag:MYC}

(Hosono et al., 2003)

germline cell, with wun2^EP2217

(Starz-Gaiano et al., 2001)

hub cell | first instar larval stage | increased number, with Delta^UAS.cJa

(Okegbe and DiNardo, 2011)

larva, with dve^{B.UAS.Tag:FLAG}

(Nakagawa et al., 2011)

lipid droplet | ectopic, with mdy^EY07280

(Tian et al., 2011)

lipid droplet | ectopic, with mino^EY00734

(Tian et al., 2011)

lipid droplet | ectopic, with Seipin^GD3208

(Tian et al., 2011)

maxillary palp, with parvin^UASp.mGFP6

(Chountala et al., 2012)

mesothoracic dorsal triscolopidial chordotonal organ dch3, with comm^EP

(Kraut and Zinn, 2004)

mesothoracic dorsal triscolopidial chordotonal organ dch3, with robo2^{Δcyto.UAS.Tag:MYC}

(Kraut and Zinn, 2004)

metathoracic dorsal triscolopidial chordotonal organ dch3, with comm^EP

(Kraut and Zinn, 2004)

metathoracic dorsal triscolopidial chordotonal organ dch3, with robo2^{Δcyto.UAS.Tag:MYC}

(Kraut and Zinn, 2004)

midgut, with dve^A.UAS

(Nakagawa et al., 2011)

midgut interstitial cell, with kay^Fbz.UAS

(Riese et al., 1997)

primordial germ cell | embryonic stage | parental effect, with Hmgcr^UAS.cvDa

(Barton et al., 2024)

salivary gland, with mdy^EY07280

(Tian et al., 2011)

salivary gland, with mino^EY00734

(Tian et al., 2011)

salivary gland, with Seipin^GD3208

(Tian et al., 2011)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hmgcr^UAS.cvDa, Scer\GAL4^48Y has abnormal cell migration | parental effect | embryonic stage phenotype, suppressible | partially by Met¹/gce^2.5k/Met²⁷/gce^MI02742

(Barton et al., 2024)

Suppressor of

Statement

Reference

if::mew^UAS.cMBb/Scer\GAL4^48Y is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

if::mew^UAS.cMBa/Scer\GAL4^48Y is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

Scer\GAL4^48Y/if^UAS.cMBa is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

if^m8.UAS/Scer\GAL4^48Y is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

Scer\GAL4^48Y/if^C.UAS is a suppressor of lethal phenotype of mew^M6

(Martin-Bermudo et al., 1997)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hmgcr^UAS.cvDa, Scer\GAL4^48Y has primordial germ cell | parental effect | embryonic stage phenotype, suppressible | partially by Met¹/gce^2.5k/Met²⁷/gce^MI02742

(Barton et al., 2024)

Enhancer of

Statement

Reference

mdy^EY07280/Scer\GAL4^48Y is an enhancer of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

mdy^EY07280/Scer\GAL4^48Y is an enhancer of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

mino^EY00734/Scer\GAL4^48Y is an enhancer of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

mino^EY00734/Scer\GAL4^48Y is an enhancer of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Suppressor of

Statement

Reference

Lpin^GD14004/Scer\GAL4^48Y is a suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Cds^EY08412/Scer\GAL4^48Y is a suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

Cds^EY08412/Scer\GAL4^48Y is a suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Lpin^GD14004/Scer\GAL4^48Y is a suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

bsk^DN.UAS/Scer\GAL4^48Y is a suppressor | partially of embryonic/larval anterior midgut phenotype of puc^GS16811

(Taniguchi et al., 2007)

if::mew^UAS.cMBb/Scer\GAL4^48Y is a suppressor of phenotype of mew^M6

(Martin-Bermudo et al., 1997)

NOT Suppressor of

Statement

Reference

Agpat2^GD3463/Scer\GAL4^48Y is a non-suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

Agpat2^GD3463/Scer\GAL4^48Y is a non-suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Agpat1^GD3545/Scer\GAL4^48Y is a non-suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

Agpat1^GD3545/Scer\GAL4^48Y is a non-suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Agpat2^GD3463, Agpat1^GD3545, Scer\GAL4^48Y is a non-suppressor of salivary gland phenotype of Seipin^null

(Tian et al., 2011)

Agpat2^GD3463, Agpat1^GD3545, Scer\GAL4^48Y is a non-suppressor of lipid droplet | ectopic phenotype of Seipin^null

(Tian et al., 2011)

Itgbn^EP2235/Scer\GAL4^48Y is a non-suppressor of anterior midgut primordium | maternal effect phenotype of mys¹¹

(Devenport and Brown, 2004)

Itgbn^EP2235/Scer\GAL4^48Y is a non-suppressor of salivary gland common duct primordium | maternal effect phenotype of mys¹¹

(Devenport and Brown, 2004)

Scer\GAL4^48Y/if^UAS.cMBa is a non-suppressor of embryonic/larval midgut | embryonic stage phenotype of mew^M6

(Martin-Bermudo et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

drn^UAS.cLa/Scer\GAL4^48Y rescues drn¹

(Lai et al., 2023)

mesh^UAS.cIa/Scer\GAL4^48Y rescues mesh^f04955

(Izumi et al., 2012)

mew^UAS.cMBa/Scer\GAL4^48Y rescues mew^M6

(Martin-Bermudo et al., 1999)

mew^UAS.cMBa/Scer\GAL4^48Y rescues mew^M6

(Martin-Bermudo et al., 1997)

mew^UAS.cMBb/Scer\GAL4^48Y rescues mew^M6

(Martin-Bermudo et al., 1997)

Partially rescues

Scer\GAL4^48Y/pyr^UAS.cKa partially rescues Df(2R)BSC259/Df(2R)BSC25

(Reim et al., 2012)

ths^UAS.cSa/Scer\GAL4^48Y partially rescues Df(2R)BSC259/Df(2R)BSC25

(Reim et al., 2012)

zip^UAS.mGFP6/Scer\GAL4^48Y partially rescues zip³

(Okumura et al., 2010)

puc^UAS.cMa/Scer\GAL4^48Y partially rescues puc^GS16811

(Taniguchi et al., 2007)

mys^din.UAS/Scer\GAL4^48Y partially rescues mys¹¹

(Martin-Bermudo et al., 1999)

Fails to rescue

hth^UAS.cPa/Scer\GAL4^48Y fails to rescue hth^64-1

(Zohar-Stoopel et al., 2014)

shg^UAS.sgGFP/Scer\GAL4^48Y fails to rescue shg^R758

(Taniguchi et al., 2011)

Npc1a^UAS.EYFP/Scer\GAL4^48Y fails to rescue Npc1a¹

(Huang et al., 2005)

Npc1a^UAS.EYFP/Scer\GAL4^48Y fails to rescue Npc1a²

(Huang et al., 2005)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

4935

107953

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

48Y

(Martin-Bermudo et al., 1997)

GAL4^48Y

Scer\GAL4^48Y

Name Synonyms

Secondary FlyBase IDs

References (59)

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