FlyBase Gene Report: Dmel\Arl1

General Information

Symbol

Dmel\Arl1

Species

D. melanogaster

Name

ADP ribosylation factor-like 1

Annotation Symbol

CG6025

Feature Type

protein_coding_gene

FlyBase ID

FBgn0000115

Gene Model Status

Current

Stock Availability

4 publicly available

Gene Summary

ADP ribosylation factor-like 1 (Arl1) encodes an Arf GTPase important for secretory granule maturation and for preventing early degradation of these granules. [Date last reviewed: 2023-01-26] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Arf72A, arl, Arflike at 72A, l(3)72Ae

Key Links

Genomic Location

Cytogenetic map

72C1-72C1

Sequence location

3L:15,983,135..15,984,362 [+]

Recombination map

3-43

RefSeq locus

NT_037436 REGION:15983135..15984362

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables GTP binding

inferred from direct assay

(Tamkun et al., 1991)

enables protein binding

inferred from physical interaction with FLYBASE:Sec71; FB:FBgn0028538

(Christis and Munro, 2012)

enables protein domain specific binding

inferred from physical interaction with FLYBASE:Golgin245; FB:FBgn0034854,FLYBASE:GCC88; FB:FBgn0037881,FLYBASE:GCC185; FB:FBgn0037979,FLYBASE:Golgin97; FB:FBgn0086757

(Sinka et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from biological aspect of ancestor with PANTHER:PTN000917851

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR005225, InterPro:IPR006689, InterPro:IPR024156

(InterPro Project Members, 2004-)

enables GTPase activity

inferred from electronic annotation with InterPro:IPR006689

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with UniProtKB:P40616

(Gene Ontology Curators, 2002-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in negative regulation of ER to Golgi vesicle-mediated transport

inferred from mutant phenotype

(Lee et al., 2011)

involved_in protein localization to Golgi apparatus

inferred from mutant phenotype

(Torres et al., 2014)

involved_in protein localization to Golgi membrane

inferred from direct assay

(Christis and Munro, 2012)

inferred from physical interaction with UniProtKB:Q9VJW1

(Christis and Munro, 2012)

involved_in secretory granule organization

inferred from mutant phenotype

(Torres et al., 2014)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in intracellular protein transport

inferred from biological aspect of ancestor with PANTHER:PTN000918181

(GO Reference Genome Project, 2011-)

involved_in neurotransmitter secretion

traceable author statement

(Lloyd et al., 2000)

involved_in synaptic vesicle endocytosis

traceable author statement

(Lloyd et al., 2000)

involved_in vesicle-mediated transport

inferred from biological aspect of ancestor with PANTHER:PTN000918181

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from genetic interaction with FLYBASE:ninaE; FB:FBgn0002940

(Lee et al., 2011)

is_active_in Golgi membrane

inferred from direct assay

(Lee et al., 2011)

located_in trans-Golgi network

inferred from direct assay

(Christis and Munro, 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000917851

(GO Reference Genome Project, 2011-)

is_active_in Golgi apparatus

inferred from biological aspect of ancestor with PANTHER:PTN000195580

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

ARF GTPASES

Protein Family (UniProt)

Belongs to the small GTPase superfamily. Arf family. (P25160)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

GTPase activity
RHEA 19669:

Summaries

Gene Snapshot

ADP ribosylation factor-like 1 (Arl1) encodes an Arf GTPase important for secretory granule maturation and for preventing early degradation of these granules. [Date last reviewed: 2023-01-26]

Gene Group (FlyBase)

ARF GTPASES -: The ADP-Ribosylation Factor (Arf) family are members of the Ras superfamily of small GTPases. Arfs are involved in the regulation of vesicular trafficking mediating processes such as cargo-sorting, vesicle assembly and membrane fusion. (Adapted from PMID:15731001).

Protein Function (UniProtKB)

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

(UniProt, P25160)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Arl1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P25160)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Arl1-RA

FBtr0075517

NM_079374

863

180

Additional Transcript Data and Comments

Reported size (kB)

1.05 (northern blot)

(Tamkun et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Arl1-PA

FBpp0075272

20.2

180

6.52

P25160

NP_524098

AAF49556

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

180 (aa); 20 (kD)

(Tamkun et al., 1991)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Arl1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Arl1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

1.82

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from genetic interaction with FLYBASE:ninaE; FB:FBgn0002940

(Lee et al., 2011)

is_active_in Golgi membrane

inferred from direct assay

(Lee et al., 2011)

located_in trans-Golgi network

inferred from direct assay

(Christis and Munro, 2012)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Arl1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Arl1

View exonic expression by tissue for Dmel\Arl1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39745/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000115

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000115

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000115

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6025

Flygut - An atlas of the Drosophila adult midgut

FBgn0000115

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Arl1

Transgenic constructs containing regulatory region of Arl1

Aberrations (Deficiencies and Duplications) ( 14 )

Inferred from experimentation ( 14 )

Gene not disrupted in

Df(3L)A5

(Melendez et al., 1995)

Df(3L)BK10

(Melendez et al., 1995)

Df(3L)Brd6

(Melendez et al., 1995)

Df(3L)Brd20

(Melendez et al., 1995)

Df(3L)st-f13

(Melendez et al., 1995, Brizuela et al., 1994)

Df(3L)th102

(Tamkun et al., 1991)

Df(3L)th117

(Melendez et al., 1995)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal (with Df(3L)brm11)

Arl1^L2

lethal (with Df(3L)th102)

Arl1³

lethal | recessive

lethal - all die during embryonic stage | recessive

Arl1¹

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Arl1^GD6768

viable, with Scer\GAL4^Mef2.PR

Arl1^GD6768

viable, with Scer\GAL4^pnr-MD237

Arl1^GD6768

viable (with Df(3L)th102)

Arl1^EY03856

Sterility

Allele

fertile (with Df(3L)th102)

Arl1^EY03856

Other Phenotypes

Allele

abnormal size, with Scer\GAL4^en-e16E

abnormal size, with Scer\GAL4^sd.PU

increased cell death, with Scer\GAL4^en-e16E

increased cell death | somatic clone

Arl1¹

some die during embryonic stage | recessive

Arl1¹

some die during pupal stage

some die during third instar larval stage

wild-type

Phenotype manifest in

Allele

centrosome

Arl1¹

centrosome | embryonic stage 4

Arl1¹

embryo | embryonic stage 4

Arl1¹

embryonic/larval salivary gland, with Scer\GAL4^fkh.PU

embryonic/larval salivary gland (with Arl1¹)

Arl1²

embryonic/larval salivary gland (with Arl1²)

Arl1¹

embryonic/larval salivary gland (with Df(3L)brm11)

Arl1²

Golgi apparatus | somatic clone | increased number

Arl1¹

nucleus

Arl1¹

nucleus | embryonic stage 4

Arl1¹

rough endoplasmic reticulum membrane | somatic clone

Arl1¹

secretory granule, with Scer\GAL4^fkh.PU

secretory granule (with Arl1¹)

Arl1²

secretory granule (with Arl1²)

Arl1¹

secretory granule (with Df(3L)brm11)

Arl1²

spindle

Arl1¹

wing, with Scer\GAL4^en-e16E

wing, with Scer\GAL4^sd.PU

wing vein | increased number, with Scer\GAL4^sd.PU

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\ARL1

14 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (29)

Rnor\Arl1

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (31)

Mmus\Arl1

14 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (31)

Xtro\arl1

11 of 13

Yes

Xtro\arf5

3 of 13

Xtro\arf6

2 of 13

Xtro\arf11l.2

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\arl11l.1

1 of 13

Yes

Xtro\arl13a

1 of 13

Yes

Xtro\arl13b

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (45)

Drer\arl1

13 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Drer\si:ch1073-165f9.2

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\arl-1

14 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Cele\R186.3

1 of 14

Cele\sar-1

1 of 14

Anopheles gambiae (African malaria mosquito) (13)

Agam\AgaP_AGAP011730

12 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (26)

Atha\ARF3

9 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (7)

Scer\ARL1

13 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\arf1

2 of 12

Yes

Spom\arf6

2 of 12

Yes

Spom\alp41

1 of 12

Spom\sar1

1 of 12

Spom\srp102

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Arl1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

dnd

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Arl1^GD6768

ameliorates retinal degeneration

modeled by ninaE^D1

(Lee et al., 2011)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARL1; ARF like GTPase 1

14 of 14

603425

ARF3; ARF GTPase 3

3 of 14

103190

ARL6; ARF like GTPase 6

3 of 14

608845

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Arl1 - Arfip

anti tag coimmunoprecipitation, anti tag western blot

(Chang et al., 2015)

Arl1 - GCC185

two hybrid

(Torres et al., 2014, Sinka et al., 2008)

Arl1 - GCC88

two hybrid, pull down, western blot, peptide massfingerprinting

(Christis and Munro, 2012, Sinka et al., 2008)

Arl1 - Golgin245

pull down, peptide massfingerprinting, two hybrid, western blot

(Christis and Munro, 2012, Sinka et al., 2008)

Arl1 - Golgin97

pull down, western blot, two hybrid

(Sinka et al., 2008)

Arl1 - Sec71

pull down, molecular weight estimation by staining, peptide massfingerprinting, anti tag western blot

(Christis and Munro, 2012)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Arl1

(Müller et al., 2005)

ninaE

suppressible

Arl1

(Lee et al., 2011)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65056

DroID - A comprehensive database of gene and protein interactions.

FBgn0000115

MIST (protein-protein) - An integrated Molecular Interaction Database

39745

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Retrograde transport at the Trans-Golgi-Network

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-43

Cytogenetic map

72C1-72C1

Sequence location

3L:15,983,135..15,984,362 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

72C1-72C1

Limits computationally determined from genome sequence between P{EP}Tfb2^EP572 and P{lacW}th^j5C8&P{PZ}Mbs⁰³⁸⁰²

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

72A-72B

(determined by in situ hybridisation)

(Tamkun et al., 1991)

Experimentally Determined Recombination Data

Location

3-43

(FlyBase, 2016)

3-38.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (4)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

27052

y¹ v¹; P{TRiP.JF02378}attP2/TM3, Sb¹

4107

w¹¹¹⁸; Arl1^N6 P{white-un4}71F/TM3, Sb¹

17328

y¹ w^67c23; P{EPgy2}Arl1^EY03856/TM3, Sb¹ Ser¹

VDRC

v17826

w¹¹¹⁸; P{GD6768}v17826

Genomic Clones (7)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (62)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GM20805

Other clones

DPiM_GM20805

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0000115

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0000115

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Torres et al., 2014, Tamkun et al., 1991)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The 'l(3)72Ae' (Arf72A) complementation group comprises 3 EMS-induced mutant alleles.

(Cooper and Kennison, 2011)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.

(Kliman and Eyre-Walker, 1998)

Encodes a small GTP-binding protein of the ADP-ribosymation factor family.

(Tamkun et al., 1991)

Relationship to Other Genes

Source for database merge of

Source for merge of: Arf72A BcDNA:GM20805

(FlyBase, 1996-)

Additional comments

Source for merge of Arf72A BcDNA:GM20805 was a shared cDNA ( date:030728 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Arl1 Arf72A

(FlyBase, 2009-)

Nomenclature comments

Renamed 'Arf72A' to 'Arl1' to reflect symbol used in original paper (FBrf0054967), the orthology to H. sapiens ARL1, and popular use in the Drosophila literature.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

72CDd

(Melendez et al., 1995)

ARL1

(Dorer et al., 2006)

ARL1_DROME

(Storm and Sonnhammer, 2003)

Arf

(Maroni, 1994)

Arf72A

(Zeledon et al., 2019, Schopf and Huber, 2017, Kwon et al., 2013, Zhang et al., 2013, Armbruster and Luschnig, 2012, Cooper and Kennison, 2011, Kametaka et al., 2010, Costello et al., 2009, Beller et al., 2008, Guo et al., 2008, Sinka et al., 2008, Eisman et al., 2006, Saleh et al., 2006)

Arl1

(Wang et al., 2017, Fári et al., 2016, Chang et al., 2015, Christis and Munro, 2012, Kametaka et al., 2010, Wang et al., 2010, Sinka et al., 2008, Pasqualato et al., 2002, Kahn, 1995)

BcDNA:GM20805

CG 6025

(Dorer et al., 2006)

CG6025

(Hosono et al., 2015, McEachern et al., 2014, Christis and Munro, 2012, Cammarato et al., 2011, Li et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009.3.31, Sinka et al., 2008, Saleh et al., 2006, Colicelli, 2004, Verstreken and Bellen, 2000.9.4)

P25160

(Rojas et al., 2012)

arf72A

(Lee et al., 2011)

arf^72A

(Desbordes et al., 2005)

arl

(Armstrong et al., 2005, Melendez et al., 1995, Brizuela et al., 1994, Clark et al., 1993, Tamkun et al., 1991)

arl1

(Torres et al., 2014)

dARL1p

(Kahn et al., 1992)

dArl1

(Sinka et al., 2007)

l(3)72Ae

(Cooper and Kennison, 2011, Brizuela et al., 1994)

l(3)72CDd

(Bloomington Drosophila Stock Center, 1997.12.5)

Name Synonyms

ADP ribosylation factor-like 1

Arf-like 1

(Sinka et al., 2008)

Arf72A

(Kong et al., 2010)

Arflike at 72A

(McEachern et al., 2014, Cammarato et al., 2011)

Secondary FlyBase IDs

FBgn0064936
FBgn0016902

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39745

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P25160

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P25160

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P25160

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39745/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0000115

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0000115

FlyMine - An integrated database for Drosophila genomics

FBgn0000115

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6025

MARRVEL_MODEL - MARRVEL (model organism gene)

39745

Linkouts

BioGRID - A database of protein and genetic interactions.

65056

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0000115

DroID - A comprehensive database of gene and protein interactions.

FBgn0000115

DRSC - Results frm RNAi screens

FBgn0000115

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Arl1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0000115

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0000115

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6025

Flygut - An atlas of the Drosophila adult midgut

FBgn0000115

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0000115

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008443

MIST (protein-protein) - An integrated Molecular Interaction Database

39745

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Retrograde transport at the Trans-Golgi-Network

References (81)

The following external sites may use different assemblies or annotations than FlyBase.

1.82

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