APC2, dAPC2, APC2/mr
APC2 subunit of the anaphase promoting complex - Cullin homology protein - regulates protein degradation and cell cycle - morula regulates variant cell cycles, because in addition to disrupting the archetypal cycle (G1-S-G2-M), morula mutations affect the rapid embryonic divisions as well as the endo cycle that produces polyploid cells
Please see the JBrowse view of Dmel\mr for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\mr in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
mr is required to maintain the absence of mitosis during the endo cycle, and is also necessary for dividing cells to exit mitosis.
mr is required for the maintenance of endomitosis in the nurse cells of the adult female ovary. Nurse cells of hypomorphic alleles revert to a mitotic-like state instead of going on to become highly polyploid.
Source for merge of: mr CG3060
Source for merge of mr CG3060 was sequence comparison ( date:021108 ).
