FlyBase Gene Report: Dmel\eys

General Information

Symbol

Dmel\eys

Species

D. melanogaster

Name

eyes shut

Annotation Symbol

CG33955

Feature Type

protein_coding_gene

FlyBase ID

FBgn0031414

Gene Model Status

Current

Stock Availability

20 publicly available

Gene Summary

Essential for the formation of matrix-filled interrhabdomeral space: critical for the formation of epithelial lumina in the retina. Acts together with prominin (prom) and the cell adhesion molecule chaoptin (chp) to choreograph the partitioning of rhabdomeres into an open system. (UniProt, A0A1F4)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

spacemaker, spam, 21A6, mAb21A6, mAb 21A6

Key Links

Genomic Location

Cytogenetic map

22E1-22E1

Sequence location

2L:2,311,680..2,358,944 [+]

Recombination map

2-6

RefSeq locus

NT_033779 REGION:2311680..2358944

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables extracellular matrix structural constituent

inferred from mutant phenotype

(Cook et al., 2008)

enables protein binding

inferred from physical interaction with UniProtKB:O97148

(Ja et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables calcium ion binding

inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097

(InterPro Project Members, 2004-)

enables extracellular matrix structural constituent

inferred from biological aspect of ancestor with PANTHER:PTN008602128

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in cell morphogenesis

inferred from mutant phenotype

(Cook et al., 2008)

involved_in rhabdomere development

inferred from mutant phenotype

(Husain et al., 2006)

inferred from mutant phenotype

(Zelhof et al., 2006)

involved_in temperature compensation of the circadian clock

inferred from mutant phenotype

(Sehadova et al., 2009)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Zelhof et al., 2006)

located_in extracellular matrix

inferred from direct assay

(Cook et al., 2008, Husain et al., 2006)

located_in extracellular region

inferred from direct assay

(Zelhof et al., 2006)

located_in extracellular space

inferred from direct assay

(Husain et al., 2006)

located_in non-motile cilium

inferred from direct assay

(Lee et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN008602128

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the EYS family. (A0A1F4)

Protein Signatures (InterPro)

Summaries

Protein Function (UniProtKB)

(UniProt, A0A1F4)

Summary (Interactive Fly)

a proteoglycan secreted into the ommatidial apical matrix - critical for the formation of epithelial lumina in the fly retina - forms an extracellular shield that guards mechanosensory neurons from environmental insult

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\eys for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A1F4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 5.44

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

eys-RE

FBtr0344662

NM_001272995

7704

2176

eys-RF

FBtr0344663

NM_001032399

8481

2176

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

eys-PE

FBpp0311004

234.1

2176

5.18

FBpp0311005

234.1

2176

5.18

A0A1F4

NP_001027571

AAZ83988

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

2176 aa isoforms: eys-PE, eys-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eys using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eys_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.64

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic head sensory system

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

scolopale rod

(Blochlinger et al., 1991)

dendritic cap cell | restricted

(Blochlinger et al., 1991)

pupal stage

scolopidium

• extracellular space

(Park et al., 2013)

scolopidium | restricted

(Park et al., 2013)

adult stage

mechanosensory chaeta | distal

(Lee et al., 2010)

basiconic sensillum of antennal segment 3

• cilium | basal

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

coeloconic sensillum of antennal segment 3

• cilium | basal

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

trichoid sensillum of antennal segment 3

• cilium | basal

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

aristal sensillum

• cilium | basal

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

sensillum of sacculus

• cilium | basal

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

In scolopidia, eys is expressed In the the luminal space adjacent to the cilia dilation and the scolopidium base.

(Park et al., 2013)

eys protein is expressed in the base of the cilia in all sensilla of antenna segment 3. It is used as a marker for the cilia base.

(Grosjean et al., 2011)

Expression of eys is detected in the extracellular space surrounding the cilia of the mechanosensory bristles of the abdominal cuticle.

(Lee et al., 2010)

eys protein is localized to the extracellular dendritic cap surrounding the tip of sensory dendrites. Antibodies to eys label the scolopales of chordotonal organs, and a dot at the tip of each eo dendrite.

(Blochlinger et al., 1991)

Marker for

cilium

(Abuin et al., 2011, Grosjean et al., 2011, Benton et al., 2009)

scolopale rod

(Blochlinger et al., 1991)

Subcellular Localization

CV Term

Evidence

References

located_in cell surface

inferred from direct assay

(Zelhof et al., 2006)

located_in extracellular matrix

inferred from direct assay

(Cook et al., 2008, Husain et al., 2006)

located_in extracellular region

inferred from direct assay

(Zelhof et al., 2006)

located_in extracellular space

inferred from direct assay

(Husain et al., 2006)

located_in non-motile cilium

inferred from direct assay

(Lee et al., 2008)

Expression Deduced from Reporters

Reporter: Mi{PT-GFSTF.2}eys^{MI01874-GFSTF.2}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

Comment: inter-rhabdomere space

(Nagarkar-Jaiswal et al., 2015)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eys in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\eys

View exonic expression by tissue for Dmel\eys

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771890/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031414

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7245

Flygut - An atlas of the Drosophila adult midgut

FBgn0031414

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 29 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 19 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of eys

Transgenic constructs containing regulatory region of eys

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)BSC37

(Husain et al., 2006)

Df(2L)Exel6007

(Ryder, 2004.4.26)

Df(2L)Exel7010

(Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Other Phenotypes

Allele

abnormal locomotor behavior | heat sensitive

eys²⁶⁴⁹

abnormal locomotor rhythm

abnormal locomotor rhythm, with Scer\GAL4^nan.PK

eys^NIG.15388R

abnormal neurophysiology | adult stage | heat sensitive

eys²⁶⁴⁹

flightless | heat sensitive

eys²⁶⁴⁹

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

eys^GD9004

uncoordinated | adult stage | heat sensitive

Phenotype manifest in

Allele

eye

eys¹

eye photoreceptor cell stalk

Johnston organ | heat sensitive

eys²⁶⁴⁹

mechanosensory neuron | adult stage | heat sensitive

eys²⁶⁴⁹

ocellar retinula cell, with Scer\GAL4^GMR.PF

eys^UAS.cZa

ocellar retinula cell, with Scer\GAL4^hs.PB

eys^UAS.cZa

ocellus rhabdomere, with Scer\GAL4^GMR.PF

eys^UAS.cZa

ommatidium

eys¹

ommatidium, with Scer\GAL4^GMR.PF

eys^UAS.cZa

photoreceptor neuron

photoreceptor neuron | chemical conditional

eys¹

photoreceptor neuron | conditional

eys¹

rhabdomere

rhabdomere, with Scer\GAL4^hs.PB

eys^UAS.cZa

rhabdomere | P-stage

eys¹

rhabdomere of eye photoreceptor cell

eys¹

scolopale rod | heat sensitive

eys²⁶⁴⁹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (41)

Hsap\EYS

8 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\SHBG

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (25)

Rnor\Notch2

2 of 14

Yes

Rnor\Svep1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Shbg

1 of 14

Yes

Rnor\Slit1

1 of 14

Rnor\Slit3

1 of 14

Rnor\Tenm3

1 of 14

Mus musculus (laboratory mouse) (26)

Mmus\Crb2

2 of 14

Yes

Mmus\Notch1

2 of 14

Yes

Mmus\Notch2

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (22)

Xtro\crb2

2 of 13

Yes

Xtro\LOC100490929

2 of 13

Yes

Xtro\notch1

2 of 13

Yes

Xtro\notch2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (45)

Drer\eys

6 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\shbg

1 of 14

Yes

Drer\si:ch211-186j3.6

1 of 14

Drer\si:ch211-246m6.5

1 of 14

Yes

Drer\si:dkey-22o22.2

1 of 14

Drer\si:dkey-237h12.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (25)

Cele\txt-5

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\F35D2.3

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\T01D3.1

1 of 14

Cele\T19D12.6

1 of 14

Cele\T25C12.3

1 of 14

Yes

Cele\ten-1

1 of 14

Cele\unc-52

1 of 14

Cele\Y38C1AA.9

1 of 14

Yes

Cele\Y46G5A.29

1 of 14

Yes

Cele\Y64G10A.7

1 of 14

Cele\Y70G10A.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (19)

Agam\AgaP_AGAP007900

2 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:eys. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

3 of 13

CadN2

1 of 13

CadN

1 of 13

crb

1 of 13

dpy

1 of 13

Nrx-1

1 of 13

sli

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

uif

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

retinitis pigmentosa 25

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

eys¹

model of retinal degeneration

CEA

(Gurudev et al., 2014)

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

EYS; EGF-like photoreceptor maintenance factor

model of retinitis pigmentosa 25

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

EYS; EGF-like photoreceptor maintenance factor

8 of 14

EYES SHUT HOMOLOG; EYS

RETINITIS PIGMENTOSA 25; RP25

retinitis pigmentosa 25

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Dmel gene

Ortholog showing functional complementation

Supporting References

eys

Hsap\EYS

(Nie et al., 2012)

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Nie et al., 2014)

suppressible

(Gurudev et al., 2014)

eys|prom

suppressible

crb

(Gurudev et al., 2014)

enhanceable

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

suppressible

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

enhanceable

(Nie et al., 2014)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

prom|chp

enhanceable

eys

(Zelhof et al., 2006)

rumi

enhanceable

eys

(Haltom et al., 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

533487

DroID - A comprehensive database of gene and protein interactions.

FBgn0031414

MIST (genetic) - An integrated Molecular Interaction Database

3771890

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_edited_transcript

(Graveley et al., 2011)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-6

Cytogenetic map

22E1-22E1

Sequence location

2L:2,311,680..2,358,944 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

22E1-22E1

Limits computationally determined from genome sequence between P{lacW}s4989 and P{lacW}Rab5^k08232

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-6

(FlyBase, 2016)

2-4.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

12661

w¹¹¹⁸; P{GT1}eys^BG02208

31513

y¹ v¹; P{TRiP.JF01069}attP2

31514

y¹ v¹; P{TRiP.JF01070}attP2

33764

y¹ v¹; P{TRiP.JF02463}attP2

33766

y¹ v¹; P{TRiP.JF02708}attP2

NIG-Fly

15388R-3

P{NIG.15388R}3

15388R-4

P{NIG.15388R}4

JF02463

y¹ v¹; P{TRiP.JF02463}attP2

M2L-2407

y¹ w¹¹¹⁸; eys^SK3 P{neoFRT}40A/CyO-Tb

M2L-2408

y¹ w¹¹¹⁸; eys^SK6 P{neoFRT}40A/CyO-Tb

VDRC

v106942

P{KK105481}VIE-260B

v22541

w¹¹¹⁸; P{GD12181}v22541

More stocks available...

Genomic Clones (41)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (6)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

HL01481

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0031414

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

HL02385

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0031414

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

21A6

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The eys protein forms an extracellular shield that guards mechanosensory cells from environmental insult, protecting them from cellular deformation caused by heat-induced osmotic imbalance.

(Cook et al., 2008)

eys and prom define two independent steps in interrhabdomeral space formation.

(Husain et al., 2006)

eys function is critical for the formation of epithelial lumina in the fly retina.

(Husain et al., 2006)

eys is necessary to produce the open rhadbom system of Drosophila eyes.

(Zelhof et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG15388 CG15389 CG7245

(Miller et al., 2005)

Additional comments

Annotations CG15388, CG15389 and CG7245 merged as CG33955 (which corresponds to eys) in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (24)

Reported As

Symbol Synonym

21A6

(Egoz-Matia et al., 2011, Lee et al., 2008, Zelhof et al., 2003)

CG15388

(Yano et al., 2009, Zelhof, 2006, Miller et al., 2005)

CG15389

(Zelhof, 2006, Miller et al., 2005)

CG33955

(National Institute of Genetics Fly Stocks, 2022-, Neuert et al., 2017, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2008)

CG7245

(Ni et al., 2009, Husain et al., 2006, Mahr and Aberle, 2006, Zelhof, 2006, Laviolette et al., 2005, Miller et al., 2005, Wucherpfennig et al., 2003)

CT35437

(Hynes and Zhao, 2000)

EYS

(Mahato et al., 2018, Nie et al., 2012, Ma and Jarman, 2011, Cheng et al., 2010, Lee et al., 2010)

Eyes Shut

(Zhang et al., 2013)

Eys

(Nakamura et al., 2020, Raghuraman et al., 2020, Laffafian and Tepass, 2019, Satoh et al., 2015, Boekhoff-Falk and Eberl, 2014, Mendes Maia et al., 2014, Bharadwaj et al., 2013, Coelho et al., 2013)

MAb21A6

(Lee et al., 2008)

SPAM

(Park et al., 2015, Lee et al., 2010, Lee et al., 2008)

Spam

(Coelho et al., 2013, Park et al., 2013)

mAb 21A6

(Lee et al., 2010, Benton et al., 2009)

mAb21A6

(Zelhof et al., 2006, Blochlinger et al., 1991)

spacemaker

(Zelhof, 2006.6.15)

spam

(Ni et al., 2009, Sehadova et al., 2009, Cook et al., 2008, Osorio, 2007, Zelhof, 2006, Zelhof et al., 2006)

Name Synonyms

Eye shut

(Li et al., 2020)

Eyes Shut

(Coelho et al., 2013, Lee et al., 2008)

Eyes shut

(Li et al., 2020)

Eyeshut

(Ma and Jarman, 2011)

Spacemaker

(Coelho et al., 2013, Lee et al., 2008)

agrin-like

(Hynes and Zhao, 2000)

eyes shut

(Vieillard et al., 2015, Gurudev et al., 2014, Nie et al., 2012, Ni et al., 2009, Sehadova et al., 2009, Husain et al., 2008, Laurençon et al., 2007, Husain et al., 2006, Miller et al., 2005)

fibropellin

(Hynes and Zhao, 2000)

spacemaker

(Lee et al., 2010, Sehadova et al., 2009, Cook et al., 2008, Moses, 2006, Zelhof, 2006, Zelhof et al., 2006)

spam

(Zelhof, 2006.6.15)

Secondary FlyBase IDs

FBgn0053955
FBgn0031415
FBgn0031416

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3771890

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A1F4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

A0A1F4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9PBU9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A1F4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0031414

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3771890/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0031414

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0031414

FlyMine - An integrated database for Drosophila genomics

FBgn0031414

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33955

MARRVEL_MODEL - MARRVEL (model organism gene)

3771890

Linkouts

BioGRID - A database of protein and genetic interactions.

533487

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0031414

DroID - A comprehensive database of gene and protein interactions.

FBgn0031414

DRSC - Results frm RNAi screens

FBgn0031414

Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research

21A6

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

eys_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0031414

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0031414

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7245

Flygut - An atlas of the Drosophila adult midgut

FBgn0031414

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010461

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

3771890

References (108)

The following external sites may use different assemblies or annotations than FlyBase.

-0.64

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