FlyBase Gene Report: Dmel\Fatp1

General Information

Symbol

Dmel\Fatp1

Species

D. melanogaster

Name

Fatty acid transport protein 1

Annotation Symbol

CG46149

Feature Type

protein_coding_gene

FlyBase ID

FBgn0267828

Gene Model Status

Current

Stock Availability

15 publicly available

Enzyme Name (EC)

long-chain-fatty-acid--CoA ligase (6.2.1.3)

Gene Summary

Fatty acid transport protein 1 (Fatp1) encodes a transmembrane protein with acyl-CoA synthetase activity required for photoreceptor survival. It is involved in the cellular uptake of long-chain fatty acids with a role in the catabolism of fatty acids as well as synthesis of triglycerides. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Fatp, Fatty acid (long chain) transport protein, l(2)k10307, dFatp, fatty acid transport protein

Key Links

Genomic Location

Cytogenetic map

31F4-31F5

Sequence location

2L:10,510,672..10,517,218 [-]

Recombination map

2-43

RefSeq locus

NT_033779 REGION:10510672..10517218

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables long-chain fatty acid transmembrane transporter activity

inferred from biological aspect of ancestor with PANTHER:PTN001945407

(GO Reference Genome Project, 2011-)

enables long-chain fatty acid-CoA ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN001945407

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in triglyceride homeostasis

inferred from mutant phenotype

(Sujkowski et al., 2012)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in long-chain fatty acid import into cell

inferred from biological aspect of ancestor with PANTHER:PTN001945407

(GO Reference Genome Project, 2011-)

involved_in long-chain fatty acid metabolic process

inferred from biological aspect of ancestor with PANTHER:PTN001945407

(GO Reference Genome Project, 2011-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum membrane

inferred from biological aspect of ancestor with PANTHER:PTN001186241

(GO Reference Genome Project, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN001945407

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

SLC27 FAMILY OF FATTY ACID TRANSPORTERS

FATTY ACYL-COA SYNTHETASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

long-chain fatty acid-CoA ligase activity

a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate (6.2.1.3)

RHEA 15421: long-chain fatty acid transmembrane transporter activity
RHEA 39283:

Summaries

Gene Snapshot

Gene Group (FlyBase)

SLC27 FAMILY OF FATTY ACID TRANSPORTERS -: Solute carrier family 27 (SLC27) members are fatty acid transmembrane transporters. These proteins enhance the uptake of long-chain and very long chain fatty acids into the cells. (Adapted from FBrf0230430, PMID:26416577 and PMID:12856180).
FATTY ACYL-COA SYNTHETASES -: Fatty acyl-coenzyme A (CoA) synthetases catalyze the "activation" of fatty acids by their thioesterification to CoA. This is the initial reaction in fatty acid metabolism, allowing their participation in many fundamental anabolic and catabolic pathways. (Adapted from FBrf0237395.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Fatp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry E1JHE4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.54

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Stop-codon suppression (UGA) postulated; FlyBase analysis.

Gene model reviewed during 6.03

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Fatp1-RA

FBtr0347404

NM_079984

2744

626

Fatp1-RB

FBtr0347405

NM_164934

3401

626

Fatp1-RE

FBtr0347403

NM_001273425

2371

626

Fatp1-RF

FBtr0347406

NM_001169469

2744

746

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Fatp1-PA

FBpp0312554

70.2

626

9.15

FBpp0312555

70.2

626

9.15

FBpp0312553

70.2

626

9.15

FBpp0312556

84.4

746

9.63

E1JHE4

NP_001162940

ACZ94228

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

626 aa isoforms: Fatp1-PA, Fatp1-PB, Fatp1-PE

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Fatp1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fatp_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.03

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

organism

(Dourlen et al., 2012)

adult stage

retina

(Dourlen et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye photoreceptor cell

• cytoplasm

(Dourlen et al., 2012)

secondary pigment cell

(Dourlen et al., 2012)

tertiary pigment cell

(Dourlen et al., 2012)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

organism

(Dourlen et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endomembrane system

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

Reporter: P{lacW}Fatp1^k10307

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval midgut

(Dourlen et al., 2012)

embryonic/larval proventriculus | posterior | restricted

(Dourlen et al., 2012)

adult stage

eye photoreceptor cell

(Dourlen et al., 2012)

secondary pigment cell

(Dourlen et al., 2012)

tertiary pigment cell

(Dourlen et al., 2012)

adult optic lobe | restricted

(Dourlen et al., 2012)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Fatp1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Fatp1

View exonic expression by tissue for Dmel\Fatp1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267828

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

26067068/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267828

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021953

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267828

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7400

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Fatp1

Transgenic constructs containing regulatory region of Fatp1

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(2L)BSC210

(Kahsai et al., 2016, Christensen and Cook, 2006.8.30)

Df(2L)BSC211

(Christensen and Cook, 2006.8.30)

Df(2L)BSC212

(Christensen and Cook, 2006.8.30)

Df(2L)Exel7048

(Kahsai et al., 2016, Ryder, 2004.4.26)

Df(2L)J2

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Gene not disrupted in

Df(2R)cn88b

(BDGP Project Members, 1994-1999)

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Fatp1^SK3

lethal (with Df(2L)BSC210)

Fatp1^k10307

lethal (with Df(2L)Exel7048)

Fatp1^k10307

lethal | recessive

lethal - all die during larval stage, with Scer\GAL4^sal.BO

Fatp1^GD1069

partially lethal - majority die, with Scer\GAL4^da.G32

Fatp1^GD1069

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Fatp1^GD1069

viable, with Scer\GAL4^Mef2.PR

Fatp1^GD1069

viable, with Scer\GAL4^pnr-MD237

Fatp1^GD1069

viable, with Scer\GAL4^tin.CΔ4

Fatp1^GD1069

Sterility

Allele

female sterile, with Scer\GAL4^Desat1.PB

female sterile, with Scer\GAL4^insc-Mz1407

Fatp1^GD1069

male fertile, with Scer\GAL4^insc-Mz1407

Fatp1^GD1069

Other Phenotypes

Allele

abnormal cold stress response | dominant | female limited

Fatp1^k10307

abnormal feeding behavior, with Scer\GAL4^Lsp2.PH

Fatp1^GD1069

abnormal feeding behavior | dominant

Fatp1^k10307

abnormal heat stress response | dominant | male limited

Fatp1^k10307

abnormal neurophysiology | adult stage | cell autonomous | somatic clone | conditional

Fatp1^k10307

abnormal oxidative stress response | dominant

Fatp1^k10307

abnormal starvation stress response | dominant

Fatp1^k10307

decreased fecundity | progressive, with Scer\GAL4^Desat1.PB

long lived, with Scer\GAL4^Lsp2.PH

Fatp1^GD1069

long lived, with Scer\GAL4^Mef2.PR

Fatp1^GD1069

long lived, with Scer\GAL4^Tub.PU

Fatp1^GD1069

long lived | dominant | female

Fatp1^k10307

long lived | RU486 conditional, with Scer\GAL4^Switch1.106

Fatp1^UAS.Tag:FLAG

short lived | :RU486 conditional | nutrition conditional, with Scer\GAL4^Switch1.106

Fatp1^HMC04206

Phenotype manifest in

Allele

adult heart, with Scer\GAL4^UAS.cHa, Scer\GAL4^tin.cBa

Fatp1^GD1069

adult oenocyte, with Scer\GAL4^insc-Mz1407

Fatp1^GD1069

embryonic/larval tracheal section | larval stage, with Scer\GAL4^sal.BO

Fatp1^GD1069

eye photoreceptor cell | adult stage | cell autonomous | somatic clone | conditional

Fatp1^k10307

eye photoreceptor cell | conditional, with Scer\GAL4^GMR.PU, Scer\GAL4^ey.PU

Fatp1^GD16442

eye photoreceptor cell | somatic clone

Fatp1^k10307

lipid droplet | adult stage, with Scer\GAL4^insc-Mz1407

Fatp1^GD1069

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (21)

Hsap\SLC27A1

12 of 14

Yes

Hsap\SLC27A4

12 of 14

Yes

Hsap\SLC27A2

7 of 14

Yes

Hsap\SLC27A3

6 of 14

Yes

Hsap\SLC27A6

6 of 14

Hsap\SLC27A5

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (17)

Rnor\Slc27a1

12 of 14

Yes

Rnor\Slc27a4

12 of 14

Yes

Rnor\Slc27a2

7 of 14

Yes

Rnor\Slc27a3

6 of 14

Yes

Rnor\Slc27a6

6 of 14

Yes

Rnor\Slc27a5

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (18)

Mmus\Slc27a1

12 of 14

Yes

Mmus\Slc27a4

12 of 14

Yes

Mmus\Slc27a2

6 of 14

Mmus\Slc27a3

6 of 14

Yes

Mmus\Slc27a6

6 of 14

Mmus\Slc27a5

5 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\slc27a3

6 of 13

Yes

Xtro\epgn

5 of 13

Yes

Xtro\slc27a4

5 of 13

Xtro\slc27a2

4 of 13

Yes

Xtro\slc27a6

4 of 13

Yes

Xtro\supt20hl1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (19)

Drer\slc27a1a

12 of 14

Yes

Drer\slc27a1b

12 of 14

Yes

Drer\slc27a4

12 of 14

Yes

Drer\slc27a2a

7 of 14

Yes

Drer\slc27a2b

7 of 14

Yes

Drer\zgc:158482

7 of 14

Yes

Drer\zgc:101540

6 of 14

Yes

Drer\slc27a6

5 of 14

Yes

Drer\LOC568883

4 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (17)

Cele\acs-20

11 of 14

Yes

Cele\acs-22

11 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP001763

10 of 12

Yes

5 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (28)

Atha\AAE11

2 of 13

Yes

Atha\AT1G20490

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\FAT1

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\SPCC1827.03c

1 of 12

Yes

Escherichia coli (enterobacterium) (3)

Ecol\caiC

2 of 11

Yes

Ecol\fadD

1 of 11

Ecol\fadK

1 of 11

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Fatp1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (22)

10 of 13

10 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

bgm

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

hll

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Fatp1^HMC03111

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Le et al., 2024)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SLC27A1; solute carrier family 27 member 1

12 of 14

600691

SLC27A4; solute carrier family 27 member 4

12 of 14

604194

ICHTHYOSIS PREMATURITY SYNDROME; IPS

SLC27A2; solute carrier family 27 member 2

7 of 14

603247

SLC27A3; solute carrier family 27 member 3

6 of 14

604193

SLC27A6; solute carrier family 27 member 6

6 of 14

604196

SLC27A5; solute carrier family 27 member 5

5 of 14

603314

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Fatp1 - CCT8

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - CG9752

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Chc

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Gfat2

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - GluProRS

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Idh3a

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Ipo9

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Kap-α3

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Kdsr

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - MRP

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Mpcp2

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Ost1

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Past1

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Pp2A-29B

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Rpn1

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - SERCA

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - ScsβA

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Sec61α

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Tapδ

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - Tecr

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - spidey

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - wal

experimental knowledge based

(Guruharsha et al., 2011)

Fatp1 - βCOP

experimental knowledge based

(Guruharsha et al., 2011)

RNA-protein

Physical Interaction

Assay

References

Fatp1 - egl

anti tag coimmunoprecipitation, full identification by DNA sequencing, quantitative reverse transcription pcr

(Goldman et al., 2021, Vazquez-Pianzola et al., 2017)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Fatp1

suppressible

Arr2

(Dourlen et al., 2012)

Fatp1

suppressible

ninaE

(Dourlen et al., 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

suppressible

(Liu et al., 2017)

External Data

Linkouts

MIST (protein-protein) - An integrated Molecular Interaction Database

26067068

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

gene_with_stop_codon_read_through

(FlyBase Genome Annotators, 2014)

nuclear_gene

protein_coding_gene

(FlyBase Genome Annotators, 2013)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-43

Cytogenetic map

31F4-31F5

Sequence location

2L:10,510,672..10,517,218 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

31F4-31F5

Limits computationally determined from genome sequence between P{lacW}l(2)k09116^k09116&P{lacW}Fatp^k10307 and P{PZ}dbf¹

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

31F4-31F5

(determined by in situ hybridisation)

(Spradling et al., 1999)

31F4-31F5

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-43

(FlyBase, 2016)

2-35.9

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (15)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

10988

y¹ w^67c23; P{lacW}Fatp1^k10307/CyO

79440

y¹ sc^* v¹ sev²¹; P{TOE.GS01376}attP40

86384

y¹ w^*; TI{CRIMIC.TG4.2}Fatp1^{CR01433-TG4.2}/SM6a

50709

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03111}attP2

55919

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04206}attP2

55273

y¹ sc^* v¹ sev²¹; P{TRiP.HMC03960}attP40

NIG-Fly

7400R-1

P{NIG.7400R}1

M2L-0138

y¹ w¹¹¹⁸; Fatp1^SK3 P{neoFRT}40A/CyO-Tb

M2L-0139

y¹ w¹¹¹⁸; Fatp1^SK4 P{neoFRT}40A/CyO-Tb

VDRC

v100124

P{KK104809}VIE-260B

v9406

w¹¹¹⁸; P{GD1069}v9406

v48719

w¹¹¹⁸ P{GD16442}v48719

More stocks available...

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (93)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

SD05207

Other clones

DPiM_SD05207

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0267828

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Dourlen et al., 2012)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG45083) in release 5.54 of the genome annotation.

(FlyBase Genome Annotators, 2013)

Source for new gene model annotation: CG45083 (release 5.54).

(Hayden and Bosco, 2008)

Relationship to Other Genes

Source for database merge of

Source for merge of: Fatp CG7400

(Misra, 2000.8.9)

Source for merge of: Fatp anon-WO0121795.74

(FlyBase, 1996-)

Source for merge of: Fatp CG45083

(FlyBase Genome Annotators, 2014)

Additional comments

Annotations CG7400 and CG45083 (which were previously annotated as two non-overlapping open reading frames of a dicistronic transcript) merged as CG46149 in release 6.03 of the genome annotation.

(FlyBase Genome Annotators, 2014)

FlyBase curator comment: the insertion in the "e00177" Exelixis line (PBac{RB}Lrr47^e00177) was originally assigned to the Fatp gene in FBrf0179797, resulting in the "Fatp^e00177" (FBal0160474) allele. However, FBrf0184340 shows that the insertion is actually within Lrr47.

(Bloomington Drosophila Stock Center, 2004.11.6)

Source for merge of Fatp anon-WO0121795.74 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Fatp1 Fatp

(FlyBase, 2017-)

Nomenclature comments

Featherstone, 2011 (FBrf0214274) identifies two SLC27/FATP genes: 'Fatp' (CG46149) and CG30194 (now called CG44252). Dourlen et al., 2015 (FBrf0230430) identify three D. melanogaster FATP genes: 'Fatp' (CG46149), CG30194 (i.e. CG44252) and CG3394. Orthology searches using human FATP genes confirm these three D. melanogaster hits. Therefore, re-named 'Fatp' as 'Fatp1', and CG44252 and CG3394 as 'Fatp2' and Fatp3', respectively.

(FlyBase, 2017-)

Etymology

Synonyms and Secondary IDs (20)

Reported As

Symbol Synonym

CG45083

(FlyBase Genome Annotators, 2013)

CG46149

(Kondo et al., 2017, FlyBase Genome Annotators, 2014)

CG7400

(Wu et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Wang et al., 2019, Vazquez-Pianzola et al., 2017, Baron et al., 2016, Chiang et al., 2016, Çiçek et al., 2016, Hosono et al., 2015, Krahmer et al., 2013, Faust et al., 2012, Cammarato et al., 2011, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Hayden and Bosco, 2008, Watkins et al., 2007, Hollien and Weissman, 2006, Hollien and Weissman, 2006, Oba et al., 2005, Oba et al., 2004)

Dromel_CG7400_FBtr0080133_fatp_mORF

(Hayden and Bosco, 2008)

Dromel_CG7400_FBtr0080133_fatp_uORF

(Hayden and Bosco, 2008)

FATP

(Pandey et al., 2021, Olarte et al., 2020, Toprak et al., 2020, Kory et al., 2015)

FATP1

(Le et al., 2024)

Fatp

(National Institute of Genetics Fly Stocks, 2022-, Yan et al., 2019, Anderson-Baron and Simmonds, 2018, Liu et al., 2017, Transgenic RNAi Project members, 2017-, Vazquez-Pianzola et al., 2017, Chiang et al., 2016, Sieber and Spradling, 2015, Van Bortle et al., 2015, FlyBase Genome Annotators, 2014, Luck et al., 2014, FlyBase Genome Annotators, 2013, Krahmer et al., 2013, Kwon et al., 2013, Faust et al., 2012, Izutsu et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Featherstone, 2011, Friedman et al., 2011, Levis et al., 2011.12.16, Napoletano et al., 2011, Reis et al., 2010, Jiang et al., 2009, Tan et al., 2009, Hayden and Bosco, 2008, Liu and Lehmann, 2008, Watkins et al., 2007, Christensen and Cook, 2006.8.30, Christensen and Cook, 2006.8.30, Christensen and Cook, 2006.8.30, Hollien and Weissman, 2006, Speder et al., 2006, Nelson et al., 2005, Yang et al., 2004)

Fatp1

(Fanara et al., 2023, Ceder and Fredriksson, 2022, Li et al., 2022, Pridie et al., 2020, Gene Disruption Project members, 2018-)

SLC27A1/4

(Baron et al., 2016)

SLC27A4

(Anderson-Baron and Simmonds, 2018)

anon-WO0121795.74

dFATP

(Kondo et al., 2017, Zhao et al., 2012)

dFatp

(Ding et al., 2022, Girard et al., 2021, Sujkowski et al., 2012)

fatp

(Huang and Ryoo, 2021, Dourlen et al., 2015, Coelho et al., 2013, Dourlen et al., 2012, Gambis et al., 2011, Palanker et al., 2009)

l(2)k10307

(Mesilaty-Gross et al., 1999, BDGP Project Members, 1994-1999)

Name Synonyms

Fatty acid (long chain) transport protein

(Anderson-Baron and Simmonds, 2018, Cammarato et al., 2011, Watkins et al., 2007, Nelson et al., 2005, Spradling et al., 1999)

Fatty acid transport protein

(Hayden and Bosco, 2008)

Fatty acid transport protein 1

fatty acid transport protein

(Kory et al., 2015, Coelho et al., 2013)

Secondary FlyBase IDs

FBgn0021953
FBgn0032263
FBgn0061183
FBgn0266458

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 63 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

26067068

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

E1JHE4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

E1JHE4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0267828

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

26067068/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0267828

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0267828

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG46149

MARRVEL_MODEL - MARRVEL (model organism gene)

26067068

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0267828

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fatp_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0021953

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0267828

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7400

MIST (protein-protein) - An integrated Molecular Interaction Database

26067068

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (122)

The following external sites may use different assemblies or annotations than FlyBase.

-1.03

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