FB2026_02 , released June 18, 2026
Gene: Dmel\Cul5
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General Information
Symbol
Dmel\Cul5
Species
D. melanogaster
Name
Cullin 5
Annotation Symbol
CG1401
Feature Type
protein_coding_gene
FlyBase ID
FBgn0288875
Gene Model Status
Current
Stock Availability
8 publicly available
Gene Summary
Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

cul-5, shkl

Key Links
Genomic Location
Cytogenetic map
98F6-98F6
Sequence location
Recombination map
3-97
RefSeq locus
NT_033777 REGION:29059272..29062975
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables protein binding
inferred from physical interaction with UniProtKB:A1Z6E0
(Kugler et al., 2010)
enables ubiquitin ligase complex scaffold activity
inferred from physical interaction with FLYBASE:Roc2; FB:FBgn0044020
(Reynolds et al., 2008)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ubiquitin ligase complex scaffold activity
inferred from biological aspect of ancestor with PANTHER:PTN002631076
(GO Reference Genome Project, 2011-)
enables ubiquitin protein ligase binding
inferred from biological aspect of ancestor with PANTHER:PTN002631076
(GO Reference Genome Project, 2011-)
inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157
(InterPro Project Members, 2004-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in germ cell development
inferred from mutant phenotype
(Kugler et al., 2010)
involved_in germarium-derived egg chamber formation
inferred from mutant phenotype
(Kugler et al., 2010)
involved_in growth of a germarium-derived egg chamber
inferred from mutant phenotype
(Ayyub, 2011)
involved_in negative regulation of cell population proliferation
inferred from mutant phenotype
(Kugler et al., 2010)
involved_in negative regulation of receptor signaling pathway via JAK-STAT
inferred from mutant phenotype
(Stec et al., 2013)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Ayyub et al., 2005)
involved_in regulation of synaptic assembly at neuromuscular junction
inferred from mutant phenotype
(Ayyub, 2011)
involved_in sensory organ precursor cell fate determination
inferred from mutant phenotype
(Ayyub et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in protein ubiquitination
inferred by curator from GO:0031466
(Reynolds et al., 2008)
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000231993
(GO Reference Genome Project, 2011-)
involved_in ubiquitin-dependent protein catabolic process
inferred from electronic annotation with InterPro:IPR001373, InterPro:IPR016157
(InterPro Project Members, 2004-)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
part_of Cul5-RING ubiquitin ligase complex
inferred from direct assay
(Kugler et al., 2010, Reynolds et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
part_of Cul5-RING ubiquitin ligase complex
inferred from biological aspect of ancestor with PANTHER:PTN000939877
(GO Reference Genome Project, 2011-)
part_of cullin-RING ubiquitin ligase complex
inferred from electronic annotation with InterPro:IPR016157
(InterPro Project Members, 2004-)
part_of SCF ubiquitin ligase complex
inferred from biological aspect of ancestor with PANTHER:PTN000231993
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Cullin 5 (Cul5) is expressed in both neuronal and non-neuronal cells (such as in fusion sites of embryonic trachea). Reduction of the product of Cul5 in neuronal cells results in an increase in number of synaptic boutons in the larval neuromuscular junction. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CULLINS -
Cullins are an evolutionarily conserved, structurally-related gene family, with an N-terminal bearing cullin repeats followed by a cullin homology domain and a neddylation site. Cullins act as scaffolds to assemble multi-subunit Cullin-RING E3 ubiquitin ligase (CRL) complexes. A CRL complex is characterised by a cullin-RING-type E3 ubiquitin ligase interaction, which acts as the catalytic core and recruits the E2 ubiquitin-conjugating enzyme, and a cullin-adaptor protein-substrate recognition protein interaction which links the E3 ligase to its target for ubiquitination. (Adapted from FBrf0224296).
Pathway (FlyBase)
NEGATIVE REGULATORS OF JAK-STAT SIGNALING PATHWAY -
Negative regulators of JAK-STAT signaling down-regulate the pathway, attenuating transcriptional control by Stat92E.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cul5 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VAQ0)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cul5-RA
FBtr0085417
NM_143408
3325
852
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cul5-PA
FBpp0084786
96.9
852
8.54
Q9VAQ0
NP_651665
AAF56852
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cul5 using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.79

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13
embryonic epidermis | segmentally repeated
(Ayyub et al., 2005)
third instar larval stage
leg disc | restricted
(Ayyub et al., 2005)
anterior-posterior compartment boundary of the antennal disc
(Ayyub et al., 2005)
third instar larval stage -- prepupal stage
larval brain | restricted
(Ayyub et al., 2005)
Additional Descriptive Data

Cul5 transcript is localized to cells at the posterior segment margins in the embryonic epidermis.

(Ayyub et al., 2005)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
larval central nervous system
(Ayyub, 2011)
embryonic stage 16
tracheal fusion cell of embryonic/larval tracheal dorsal trunk
(Ayyub, 2011)
larval stage
larval ventral nerve cord | restricted
(Ayyub, 2011)
third instar larval stage
eye disc posterior to the morphogenetic furrow
(Ayyub, 2011)
antennal disc | restricted
(Ayyub, 2011)
embryonic/larval neuromuscular junction
(Ayyub, 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism
(Ayyub, 2011)
Additional Descriptive Data

Cul5 protein is detected in the embryonic central nervous system and larval ventral nerve cord. In embryos, it is also detected at the fusion sites on the dorsal trunk. In third instar larva, it is detected in the photoreceptors of the eye disc, posterior to the morphogenetic furrow, in the third segment of the antenna disc, and in glutamatergic type I boutons at the neuromuscular junction.

(Ayyub, 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of Cul5-RING ubiquitin ligase complex
inferred from direct assay
(Kugler et al., 2010, Reynolds et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cul5 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 10 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cul5
Transgenic constructs containing regulatory region of Cul5
Aberrations (Deficiencies and Duplications) ( 2 )
Inferred from experimentation ( 2 )
Gene disrupted in
Df(3R)3450
(Ayyub, 2011, Ayyub et al., 2005)
Df(3R)Exel6211
(Ryder, 2004.4.26)
Inferred from location ( 4 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4hs.2sev
lethal - all die before end of larval stage, with Scer\GAL4arm.PS
lethal - all die before end of larval stage, with Scer\GAL4elav.PU
lethal - all die before end of larval stage | conditional, with Scer\GAL4hs.PB
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell cycle | embryonic stage (with Cul5GM130)
abnormal cell cycle | embryonic stage (with Cul5GM163)
abnormal cell number | adult stage
abnormal cell number | adult stage, with Scer\GAL4sca-P309
abnormal cell number | adult stage (with Cul5EY00051)
abnormal cell number | adult stage (with Cul5EY21463)
abnormal cell number | adult stage | recessive
abnormal neuroanatomy, with Scer\GAL4elav.PU
abnormal neuroanatomy (with Df(3R)3450)
abnormal size | adult stage, with Scer\GAL4Dll-981
abnormal size | adult stage, with Scer\GAL4GMR.PU
abnormal size | adult stage, with Scer\GAL4ptc-559.1
abnormal size | adult stage, with Scer\GAL4sd-SG29.1
increased cell number, with Scer\GAL4sca-P309
increased occurrence of cell division | third instar larval stage, with Scer\GAL4sd-SG29.1
neoplasia | adult stage | female
some die during larval stage, with Scer\GAL4arm.PS
some die during larval stage, with Scer\GAL4elav.PU
some die during larval stage | conditional, with Scer\GAL4hs.PB
visible, with Scer\GAL4Dll-981
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PU
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4sca-537.4
visible, with Scer\GAL4sca-P309
visible, with Scer\GAL4sd-SG29.1
visible, with Scer\GAL4wg.PM
visible (with Df(3R)3450)
Phenotype manifest in
Allele
adult thorax, with Scer\GAL4ptc-559.1
antenna, with Scer\GAL4ptc-559.1
antenna | increased number, with Scer\GAL4wg.PM
arista, with Scer\GAL4Dll-981
centrosome & cleavage nucleus | maternal effect (with Cul5GM45)
centrosome & cleavage nucleus | maternal effect (with Cul5GM163)
cleavage nucleus | maternal effect (with Cul5GM45)
cleavage nucleus | maternal effect (with Cul5GM163)
egg
egg chamber
egg chamber (with Cul5EY00051)
egg chamber (with Cul5EY21463)
embryo (with Cul5GM130)
embryo (with Cul5GM163)
embryo | maternal effect (with Cul5GM130)
embryo | maternal effect (with Cul5GM163)
external sensory organ precursor cell IIa, with Scer\GAL4sca-P309
external sensory organ precursor cell IIb | increased number, with Scer\GAL4sca-P309
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PU
germarium
haltere | heat sensitive, with Scer\GAL4sd-SG29.1
macrochaeta, with Scer\GAL4sca-537.4
macrochaeta, with Scer\GAL4sca-P309
macrochaeta (with Df(3R)3450)
microchaeta, with Scer\GAL4sca-537.4
NMJ bouton, with Scer\GAL4elav.PU
NMJ bouton, with Scer\GAL4pros.PMG
NMJ bouton (with Df(3R)3450)
NMJ bouton | larval stage | increased number, with Scer\GAL4elav.PU
NMJ bouton | larval stage | increased number (with Df(3R)3450)
nucleus | embryonic cycle 6 | maternal effect (with Cul5GM130)
nucleus | embryonic cycle 6 | maternal effect (with Cul5GM163)
nurse cell
nurse cell fusome
oocyte
polar follicle cell
primordial germ cell | germline clone | maternal effect
primordial germ cell | maternal effect
primordial germ cell | maternal effect (with Cul5GM45)
primordial germ cell | maternal effect (with Cul5GM163)
sensory organ cell | increased number, with Scer\GAL4sca-P309
tarsal segment, with Scer\GAL4Dll-981
thecogen cell | ectopic, with Scer\GAL4sca-537.4
trichogen cell, with Scer\GAL4sca-537.4
wing, with Scer\GAL4wg.PM
wing blade | heat sensitive, with Scer\GAL4sd-SG29.1
wing disc | third instar larval stage, with Scer\GAL4sd-SG29.1
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (8)
Hsap\CUL5
14 of 14
Yes
Yes
Hsap\CUL1
3 of 14
No
No
1  
Hsap\CUL2
3 of 14
No
No
1  
Hsap\CUL3
3 of 14
No
No
Hsap\CUL4A
3 of 14
No
No
Hsap\CUL4B
3 of 14
No
No
1  
Hsap\CACUL1
1 of 14
No
No
Hsap\CUL9
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Cul5
14 of 14
Yes
Yes
Rnor\Cul4b
4 of 14
No
No
Rnor\Cul1
3 of 14
No
No
Rnor\Cul2
3 of 14
No
No
Rnor\Cul4a
3 of 14
No
No
Rnor\Cul3
2 of 14
No
No
Rnor\Cacul1
1 of 14
No
No
Mus musculus (laboratory mouse) (7)
Mmus\Cul5
14 of 14
Yes
Yes
Mmus\Cul1
3 of 14
No
No
Mmus\Cul2
3 of 14
No
No
Mmus\Cul4a
3 of 14
No
No
Mmus\Cul4b
3 of 14
No
No
Mmus\Cul3
2 of 14
No
No
Mmus\Cacul1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\cul5
7 of 13
Yes
Yes
Xtro\cul1
2 of 13
No
No
Xtro\cul3
2 of 13
No
No
Xtro\cul4b
2 of 13
No
No
Xtro\cul2
1 of 13
No
No
Xtro\cul4a
1 of 13
No
No
Xtro\plat
1 of 13
No
Yes
Xtro\sez6l
1 of 13
No
No
Xtro\tnnt2
1 of 13
No
No
Danio rerio (Zebrafish) (10)
Drer\cul5b
14 of 14
Yes
Yes
Drer\cul5a
13 of 14
No
Yes
Drer\cul1a
3 of 14
No
No
Drer\cul3a
3 of 14
No
No
Drer\cul4b
3 of 14
No
No
Drer\cul1b
2 of 14
No
No
Drer\cul2
2 of 14
No
No
Drer\cul3b
2 of 14
No
No
Drer\cul4a
2 of 14
No
No
Drer\LOC108180715
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\cul-5
14 of 14
Yes
Yes
Cele\cul-1
3 of 14
No
No
Cele\cul-3
3 of 14
No
No
Cele\cul-4
3 of 14
No
No
Cele\cul-6
3 of 14
No
No
Cele\cul-2
2 of 14
No
No
Anopheles gambiae (African malaria mosquito) (6)
Agam\AgaP_AGAP002404
12 of 12
Yes
Yes
Agam\AgaP_AGAP003605
3 of 12
No
No
Agam\AgaP_AGAP007727
3 of 12
No
No
Agam\AgaP_AGAP008007
3 of 12
No
No
Agam\AgaP_AGAP008105
3 of 12
No
No
Agam\AgaP_AGAP005048
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\CUL4
4 of 13
Yes
No
Atha\AT1G43140
3 of 13
No
No
Atha\AT1G59790
3 of 13
No
No
Atha\AT1G59800
3 of 13
No
No
Atha\AT4G12100
3 of 13
No
Yes
Atha\CUL1
3 of 13
No
No
Atha\CUL2
3 of 13
No
No
Atha\CUL3
3 of 13
No
No
Atha\CUL3B
3 of 13
No
No
Atha\AT3G46910
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\CDC53
3 of 13
Yes
No
Scer\CUL3
2 of 13
No
No
Scer\RTT101
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\cul1
3 of 12
Yes
No
Spom\cul3
2 of 12
No
No
Spom\pcu4
2 of 12
No
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cul5. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (6)
Cul1
5 of 13
Cul2
5 of 13
Cul3
5 of 13
Cul4
5 of 13
Cul6
5 of 13
mr
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Cul5HMC03109
    exacerbates  Charcot-Marie-Tooth disease type 2
    modeled by Hsap\RAB40BY83X.UAS
    (Son et al., 2023)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CUL5; cullin 5
    14 of 14
    601741
        CUL1; cullin 1
        3 of 14
        603134
             
            CUL2; cullin 2
            3 of 14
            603135
                 
                CUL3; cullin 3
                3 of 14
                603136
                CUL4A; cullin 4A
                3 of 14
                603137
                    CUL4B; cullin 4B
                    3 of 14
                    300304
                     
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    Summary of Genetic Interactions
                    Interaction Browsers
                    View in FlyBase Interactions Browser   View in MIST tool (external link)
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Cul5
                    suppressible
                    Cul2
                    (Ayyub, 2011)
                    Cul5
                    suppressible
                    Cul3
                    (Ayyub et al., 2005)
                    Cul5
                    suppressible
                    grp|lok
                    (Deneke et al., 2019)
                    Cul5
                    suppressible
                    Src64B
                    (Hayden et al., 2022)
                    Cul5
                    suppressible
                    wg
                    (Ayyub et al., 2005)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    baz
                    enhanceable
                    Cul5
                    (Shao et al., 2010)
                    pnr
                    enhanceable
                    Cul5
                    (Pena-Rangel et al., 2002)
                    External Data
                    Linkouts
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    External Data
                    Linkouts
                    KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-97
                    Cytogenetic map
                    98F6-98F6
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    98F6-98F6
                    Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    Experimentally Determined Recombination Data
                    Location

                    3-97

                    (FlyBase, 2016)

                    3-94.6

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (8)
                    Genomic Clones (16)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (40)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Ayyub, 2011, Reynolds et al., 2008)
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          S2 cells are treated with dsRNA made from templates generated with primers directed against this gene to assess effect on degradation of dup and geminin genes.

                          (Higa et al., 2003)

                          The synchronous mitotic divisions and nuclear migration of the early embryo are affected in mutants leading to a reduction in germ cell number.

                          (Pusateri et al., 2003)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: shkl Cul5

                          (Hayden et al., 2022)
                          Additional comments
                          Nomenclature History
                          Source for database identify of

                          Source for identity of: cul-5 CG1401

                          (Ou et al., 2003)

                          Source for identity of: Cul5 cul-5

                          (FlyBase, 2009-)
                          Nomenclature comments

                          Renamed to be consistent with FlyBase nomenclature rules.

                          (FlyBase, 2009-)
                          Etymology
                          Synonyms and Secondary IDs (14)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 34 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          References (71)