Reference Report

Reference
Citation	Miguel-Aliaga, I., Allan, D.W., Thor, S. (2004). Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. Development 131(23): 5837--5848. (Export to RIS)
FlyBase ID	FBrf0180178
Publication Type	Research paper
PubMed ID	15525669
PubMed Abstract	In the Drosophila nerve cord, a subset of neurons expresses the neuropeptide FMRFamide related (Fmrf). Fmrf expression is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal. However, this previously identified code does not fully explain the regulation of Fmrf. We have found that the Dachshund (Dac) and Eyes Absent (Eya) transcription co-factors participate in this combinatorial code. Previous studies have revealed an intimate link between Dac and Eya during eye development. Here, by analyzing their function in neurons with multiple phenotypic markers, we demonstrate that they play independent roles in neuronal specification, even within single cells. dac is required for high-level Fmrf expression, and acts potently together with apterous and BMP signaling to trigger Fmrf expression ectopically, even in motoneurons. By contrast, eya regulates Fmrf expression by controlling both axon pathfinding and BMP signaling, but cannot trigger Fmrf ectopically. Thus, we show that dac and eya perform entirely different functions in a single cell type to ultimately regulate a single phenotypic outcome.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2L)dac-4 Df(2L)eya¹⁰ Df(3R)Dl-KX23
Alleles (27)
	ap^md544 ap^P44 ap^Scer\UAS.cOa Avic\GFP^{EGFP.nls.Scer\UAS.T:Hsap\MYC} Avic\GFP^{Scer\UAS.T:Mmmm\c-Ha-Ras,T:Hsap\MYC} dac³ dac^P dac^Scer\UAS.cSa Ecol\lacZ^{ap.C.T:Btau\MAPT} Ecol\lacZ^Fmrf.WF3 Ecol\lacZ^so-7 eya^cli-IID eya^Scer\UAS.cBb gbb^Scer\UAS.cSb sax^{Q263D.Scer\UAS.T:Ivir\HA1} Scer\GAL4^ap-md544 Scer\GAL4^dac-p7d23 Scer\GAL4^dimm-929 Scer\GAL4^elav.PLu Scer\GAL4^elav-C155 Scer\GAL4^exex-Gal4 Scer\GAL4^repo sqz^ie sqz^Scer\UAS.cAa tkv^{DE-Q199D.Scer\UAS.T:Ivir\HA1} wit^A12 wit^B11
Constructs (12)
	P{apC-tau-lacZ} P{GAL4-elav.L} P{UAS-ap.O} P{UAS-dac.S} P{UAS-EGFP.F.MYC} P{UAS-eya.B.II} P{UAS-nls-myc-EGFP} P{UAS-sax.Q263D.T:HA1} P{UAS-sqz.A} P{UAS-Tgfβ-60A.S2} P{UAS-tkv^DE-Q199D} P{WF3}
Genes (21)
	ap Avic\GFP dac dimm Ecol\lacZ eya Fmrf gbb Glt Mad repo sax Scer\GAL4 so sqz T:Btau\MAPT T:Hsap\MYC T:Ivir\HA1 T:Mmmm\c-Ha-Ras tkv wit
Insertions (7)
	P{A92}so⁷ P{GAL4}repo P{GawB}ap^md544 P{GawB}dac^p7d23 P{GawB}dimm⁹²⁹ P{GawB}elav^C155 P{GawB}exex^Gal4