FlyBase Allele Report: Dmel\wg[UAS.cLa]

Embryos expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^ptc-559.1 lack cell mixing at the segment boundary during dorsal closure (in the abdominal segments of wild-type embryos at the end of dorsal closure, a mixer cell moves across the segment boundary from the anterior compartment to the posterior compartment and two cells from the ventral ectoderm intercalate into the leading edge, posterior to the mixer cell).

Embryos expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E show normal cell intercalation and mixer cell shifting at the segment boundary during dorsal closure.

(Gettings et al., 2010)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^Act5C.PI in the dorsal proximal cells of the prothoracic leg disc results in the formation of a blastema, a structure needed for imaginal disc regeneration, in 59% of cases.

(Wells et al., 2006)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E results in the loss of row 1 denticles, either completely or partially in all abdominal denticle belts.

(Desbordes et al., 2005)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^vg.PM does not result in cuticular transformation of the eye. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^Ubx.PdC in clones in the notum is not associated with histotype transformations or "mixed" tissues.

(Baena-Lopez and Garcia-Bellido, 2003)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^sim.PS in embryos results in the most ventral portions of the denticle belts secreting naked cuticle.

(Desbordes and Sanson, 2003)

wg^Scer\UAS.cLa; Scer\GAL4^dpp.blk1 third instar wing discs show expansion of the proximal wing pouch, hinge and notum regions. BrdU incorporation is increased in the proximal wing pouch, but decreased in the centre (distal region) of the wing pouch, compared to wild-type controls.

(Giraldez and Cohen, 2003)

Flies expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^cad-em459 show small duplications of the penis apparatus or the complete absence of terminalia.

(Gorfinkiel et al., 2003)

Cells in the wing disc expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^Act5C.PP cycle aberrantly, compared to internal control cells; the cells have cell cycle phasing characteristic of mature wing disc cells, rather than phasing appropriate for their chronological age. Cell size is normal.

(Johnston and Sanders, 2003)

Flies carrying wg^Scer\UAS.cLa expressed under the control of Scer\GAL4^dpp.blk1 which are grown at 35^oC until the early third instar and then downshifted to 18^oC show mutant wing hinge phenotypes; axillary sclerite 1, axillary sclerite 2 and the unnamed plate are missing and axillary sclerite 3 is sometimes duplicated. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^30A causes loss of the axillary pouch and expansion of the pleural sclerite in the ventral wing hinge.

(Buratovich and Wilder, 2001)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^twi.PG has no obvious effect on germ cell behaviour in the embryo.

(Deshpande et al., 2001)

When wg^Scer\UAS.cLa is driven by Scer\GAL4^en-e16E, mild denticle belt phenotype is seen: denticle row 1 is missing.

(Dubois et al., 2001)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^ey.PB results in near complete deletion of the eye.

(Kumar and Moses, 2001)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1 blocks furrow birth and reincarnation in the eye disc.

(Kumar and Moses, 2001)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^btl.PS results in an increase in the dorsal trunk of the tracheal system at the expense of the visceral branch. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^ptc-559.1 results in a naked cuticle phenotype.

(Llimargas and Lawrence, 2001)

wg^Scer\UAS.cLa driven by Scer\GAL4^ap-md544 causes an apparent duplication of the wing pouch.

(Nagel et al., 2001)

Somatic clones of wg^Scer\UAS.cLa expressing cells (driven by Scer\GAL4^Ubx.PdC) induce large outgrowths in the hinge and notum regions with wing histotype. In adult wings these clones are associated with the differentiation of wing margin structures but not with outgrowths.

(Baonza and Garcia-Bellido, 2000)

Early induced clones of wg overexpression produce notum to wing transformation.

(Baonza et al., 2000)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^da.G32 results in a uniform lawn of 4^o cells in the dorsal epidermis of the embryo (in wild-type embryos each parasegment contains 4 types of cells in the dorsal epidermis; the 1^o, 2^o and 3^o cells in the anterior half of the parasegment and the 4^o cells in the posterior half of the parasegment).

(Buratovich et al., 2000)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^btl.PS results in a dorsal trunk which is thicker than wild type, while the visceral branches of the tracheal system are missing or very much reduced.

(Llimargas, 2000)

Embryos expressing wg^Scer\UAS.cLa under the control of both Scer\GAL4^how-24B and Scer\GAL4^twi.PG have grossly abnormal gut morphology.

(Yang et al., 2000)

When expression is driven by Scer\GAL4^dpp.blk1 almost the entire pleura is transformed to tergite and sternite identities. Clones induced in the pleura, driven by Scer\GAL4^αTub84B.PP, cause nonautonomous transformations to tergite or sternite.

(Kopp et al., 1999)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1 can result in duplication of the pouch in the wing disc.

(Nagaraj et al., 1999)

When expression is driven by Scer\GAL4^en-e16E row 1 of the denticle belt is lost. Expression of wg^Scer\UAS.cLa driven by Scer\GAL4^en-e16E in a wg^l-17 background generates an expanse of naked cuticle anterior to the Scer\GAL4^en-e16E driven wg source in each segment. Posteriorly, denticles of rows type 2-6 form.

(Sanson et al., 1999)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1 results in partial absence of male external genitalia and duplication of the thorn bristle row and long bristle in female external genitalia.

(Emerald and Roy, 1998)

The notum and hinge regions of the wing disc are enlarged in larvae expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^dpp.blk1. The eye discs are enlarged. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^A9 does not have a significant effect on cell proliferation in the wing pouch.

(Go et al., 1998)

Scer\GAL4^dpp.blk1-mediated expression partially blocks differentiation near the margins of the eye disc, differentiation is restricted to the median portion of the disc. Ectopic wg expression can generate a new dorsal-ventral axis in the eye disc.

(Heberlein et al., 1998)

Expands G2 arrest in the ZNC of the developing wing, extending dorsally and ventrally.

(Johnston and Edgar, 1998)

Scer\GAL4^C-765-mediated expression causes expansion of ventral leg structures (such as the sex comb), loss of dorsal leg structures leading to a curvature of the distal segments and transdetermination to wing. Ventral wing hinge structures, such as the pleural wing process, have replaced proximal-dorsal leg tissue. wg^Act5C.PS; Scer\GAL4^dpp.blk1/wg^Scer\UAS.cLa leg discs are three to five times the size of wild-type leg discs. Ventral wing hinge structures are found in the dorsal leg region. Small areas of wing tissue occur in proximal segments of the legs.

(Maves and Schubiger, 1998)

When expression is driven in the mesoderm by Scer\GAL4^how-24B, the midgut and epidermal phenotype of wg mutants is partially rescued.

(Yu et al., 1998)

Scer\GAL4^dpp.blk1 mediated expression causes duplication of the vaginal plates and reduced vulva. Males exhibit reduced claspers, lateral plates, lateral lobe and apodeme and abnormal anal plate.

(Sanchez et al., 1997)

Scer\GAL4^dpp.blk1 induced expression causes transdetermination in the adults; maxillary palp to antenna, antenna to maxillary palp, leg to wing and leg to haltere. Bifurcation and overgrowth of the antenna, but not the legs. Head and untransformed legs exhibit substantial loss of dorsal pattern elements. Wings exhibit pattern abnormalities.

(Johnston and Schubiger, 1996)

Expression driven by P{GawB}Bx^MS1096 causes high density of wing margin bristles in pharate adults and an increase in size of the dorsal hinge.

(Neumann and Cohen, 1996)

Supernumerary wing formation in the portion of the wing disc normally fated to give rise to the body wall. Adults with wing duplications can be recovered when larvae are raised at 18^oC.

(Ng et al., 1996)

Expression under the control of Scer\GAL4^e22c causes a naked phenotype.

(Lawrence et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

dpp^UAS.cSa/wg^UAS.cLa, Scer\GAL4^ap-md544 is an enhancer of hyperplasia phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

NOT Enhancer of

Statement

Reference

wg^UAS.cLa, Scer\GAL4^ap-md544 is a non-enhancer of hyperplasia phenotype of Egfr^UAS.cBa, Scer\GAL4^ap-md544

(Herranz et al., 2014)

Suppressor of

Statement

Reference

Scer\GAL4^bbg-C96/wg^UAS.cLa is a suppressor of visible phenotype of ct^K

(Krupp et al., 2005)

Scer\GAL4^A9/wg^UAS.cLa is a suppressor of abnormal size | larval stage phenotype of Scer\GAL4^A9, vg^UAS.cKa

(Go et al., 1998)

Other

Statement

Reference

Egfr^UAS.cBa, Scer\GAL4^ap-md544, dpp^UAS.cSa, wg^UAS.cLa has neoplasia phenotype

(Herranz et al., 2014)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has visible | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^vg.PM, vg^UAS.cZa, wg^UAS.cLa has visible phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^T155, dpp^UAS.cSa, wg^UAS.cLa has visible phenotype

(Kopp et al., 1999)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype, enhanceable by Scer\GAL4^en-e16E

(Dubois et al., 2001)

Suppressed by

Statement

Reference

Scer\GAL4^Act5C.PI, wg^UAS.cLa has prothoracic leg disc phenotype, suppressible by p53^5A-1-4

(Wells et al., 2006)

Scer\GAL4^Act5C.PI, wg^UAS.cLa has prothoracic leg disc phenotype, suppressible by Dronc^I29

(Wells et al., 2006)

Scer\GAL4^btl.PS, wg^UAS.cLa has larval tracheal system phenotype, suppressible | partially by Df(2L)32FP-5

(Llimargas, 2000)

NOT suppressed by

Statement

Reference

Scer\GAL4^btl.PS, wg^UAS.cLa has embryonic/larval visceral tracheal branch phenotype, non-suppressible by Df(2L)32FP-5

(Llimargas, 2000)

Suppressor of

Statement

Reference

Scer\GAL4^bbg-C96/wg^UAS.cLa is a suppressor of dorsal row of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

Scer\GAL4^bbg-C96/wg^UAS.cLa is a suppressor of ventral row of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

Scer\GAL4^bbg-C96/wg^UAS.cLa is a suppressor of wing blade phenotype of ct^K

(Krupp et al., 2005)

Scer\GAL4^bbg-C96/wg^UAS.cLa is a suppressor of wing margin bristle phenotype of ct^K

(Krupp et al., 2005)

wg^UAS.cLa/Scer\GAL4^dpp.blk1 is a suppressor of wing disc phenotype of Scer\GAL4^dpp.blk1, ey^UAS.cHa

(Niwa et al., 2004)

wg^UAS.cLa/Scer\GAL4^dpp.blk1 is a suppressor of leg disc phenotype of Scer\GAL4^dpp.blk1, ey^UAS.cHa

(Niwa et al., 2004)

wg^UAS.cLa, Scer\GAL4^arm.PS is a suppressor | partially of embryonic/first instar larval cuticle phenotype of Axn^UAS.GFP, Scer\GAL4^arm.PS

(Cliffe et al., 2003)

Scer\GAL4^en-e16E/wg^UAS.cLa is a suppressor of neuroblast NB7-3 phenotype of hh^AC

(Deshpande et al., 2001)

Scer\GAL4^A9/wg^UAS.cLa is a suppressor of wing disc | larval stage phenotype of Scer\GAL4^A9, vg^UAS.cKa

(Go et al., 1998)

Scer\GAL4^A9/wg^UAS.cLa is a suppressor of wing disc phenotype of Scer\GAL4^A9, vg^UAS.cKa

(Go et al., 1998)

wg^UAS.cLa/Scer\GAL4^h-1J3 is a suppressor of ventral denticle belt phenotype of smo³

(Quirk et al., 1997)

NOT Suppressor of

Statement

Reference

Scer\GAL4^bbg-C96/wg^UAS.cLa is a non-suppressor of medial row of triple row of wing sensilla phenotype of ct^K

(Krupp et al., 2005)

wg^UAS.cLa, Scer\GAL4^dpp.blk1 is a non-suppressor of eye disc morphogenetic furrow | ectopic phenotype of Raf^CA.UAS.cUa, Scer\GAL4^dpp.blk1

(Kumar and Moses, 2001)

wg^UAS.cLa/Scer\GAL4^arm.PS is a non-suppressor of phenotype of lin^unspecified

(Hatini et al., 2000)

wg^UAS.cLa/Scer\GAL4^arm.PS is a non-suppressor of embryonic epidermis | dorsal phenotype of lin^unspecified

(Hatini et al., 2000)

Other

Statement

Reference

Notum³, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh⁵, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh⁵, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh^AC, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh^AC, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Notum³, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Notum^I6, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)Scf-R6/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)Scf-R6/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Notum^I6, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3L)VW3/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)VW3/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3L)XS543/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)XS543/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

+/Df(3L)brm11, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

+/Df(3L)brm11, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3L)fz2/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)fz2/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

+/Df(3L)hry-i22, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

+/Df(3L)hry-i22, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, brm², wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)rdgC-co2/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)rdgC-co2/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3L)th102/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3L)th102/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

+/Df(3R)Delta-BX12, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

+/Df(3R)Delta-BX12, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3R)hh/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3R)hh/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3R)l26c/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3R)l26c/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, brm², wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

+/Df(3R)ry615, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

+/Df(3R)ry615, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

+/Df(3R)ry75, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

+/Df(3R)ry75, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Df(3R)urd/+, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Df(3R)urd/+, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Notum³/Notum[+], Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Notum³/Notum[+], Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Notum[+]/Notum^I6, Scer\GAL4^en-e16E, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Notum[+]/Notum^I6, Scer\GAL4^en-e16E, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, brm[+]/brm², wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, brm[+]/brm², wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally[+]/dally¹⁰, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally[+]/dally¹⁰, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally^E385/dally[+], wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally^E385/dally[+], wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh[+]/hh⁵, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh[+]/hh⁵, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh[+]/hh^AC, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, hh[+]/hh^AC, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally¹⁰, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally¹⁰, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally^E385, wg^UAS.cLa has ventral denticle belt phenotype

(Desbordes et al., 2005)

Scer\GAL4^en-e16E, dally^E385, wg^UAS.cLa has embryonic/first instar larval cuticle phenotype

(Desbordes et al., 2005)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has wing | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has wing margin bristle | ectopic | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has mesonotum | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has wing hair | ectopic | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has wing hinge | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^Ubx.PdC, vg^UAS.cZa, wg^UAS.cLa has leg sensillum | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^vg.PM, vg^UAS.cZa, wg^UAS.cLa has eye phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^vg.PM, vg^UAS.cZa, wg^UAS.cLa has wing | ectopic | somatic clone phenotype

(Baena-Lopez and Garcia-Bellido, 2003)

Scer\GAL4^btl.PS, tkv⁸, wg^UAS.cLa has larval tracheal system phenotype

(Llimargas, 2000)

Scer\GAL4^btl.PS, tkv⁸, wg^UAS.cLa has embryonic/larval tracheal dorsal trunk phenotype

(Llimargas, 2000)

Scer\GAL4^T155, dpp^UAS.cSa, wg^UAS.cLa has abdominal tergite phenotype

(Kopp et al., 1999)

Scer\GAL4^T155, dpp^UAS.cSa, wg^UAS.cLa has pleurum phenotype

(Kopp et al., 1999)

Scer\GAL4^T155, dpp^UAS.cSa, wg^UAS.cLa has abdominal sternite phenotype

(Kopp et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either wg^Scer\UAS.cLa or dpp^Scer\UAS.cSa does not enhance the overproliferation seen in wing discs expressing Egfr^Scer\UAS.cBa under the control of Scer\GAL4^ap-md544. However, co-expression of wg^Scer\UAS.cLa and dpp^Scer\UAS.cSa with Egfr^Scer\UAS.cBa produces tumors consisting of epithelial and mesenchymal cell populations and showing loss of epithelial integrity.

(Herranz et al., 2014)

While 59% of Scer\GAL4^Act5C.PI>wg^Scer\UAS.cLa prothoracic leg discs form a blastema, only 22% of Scer\GAL4^Act5C.PI>wg^Scer\UAS.cLa, p53^5A-1-4 legs and 15% of Scer\GAL4^Act5C.PI>wg^Scer\UAS.cLa, Nc^I29 legs form a blastema.

(Wells et al., 2006)

In embryos expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E in a hh^AC/hh^AC background, naked cuticle is made over four to five cell diameters posterior as well as anterior to the en-expression domain. In these embryos, instead of denticle belts, a thin stripe of denticles similar to row 6 denticles are formed. In embryos expressing wg^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E in a hh^AC/+ background, an intermediate phenotype is seen, with small regions of naked cuticle ("gaps") being found within denticle belts, often replacing denticle rows 2-5.

(Desbordes et al., 2005)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^C96 suppresses the loss of wing blade tissue, including the slender recurved chemosensory wing margin bristles, seen in ct^K, ct^2s or ct⁶ flies, but does not rescue the loss of the stout mechanosensory wing margin bristles.

(Krupp et al., 2005)

Coexpression of wg^Scer\UAS.cLa with ey^Scer\UAS.cHa, under control of Scer\GAL4^dpp.blk1, completely blocks ectopic eye formation (using antibodies against elav to visualize eye differentiation) in leg and wing discs.

(Niwa et al., 2004)

Co-expression of vg^Scer\UAS.cZa and wg^Scer\UAS.cLa under the control of Scer\GAL4^vg.PM causes the transformation of the eye into wing blade, resulting in outgrowths with histotypical characteristics typical of wing blade. Co-expression of vg^Scer\UAS.cZa and wg^Scer\UAS.cLa under the control of Scer\GAL4^Ubx.PdC in clones in the wing imaginal disc leads to the formation of tubular and perpendicular outgrowths from the wing blade. The size of the outgrowths is larger than in clones expressing vg^Scer\UAS.cZa under the control of Scer\GAL4^Ubx.PdC and is dependent on the distance from the wing margin. All the cells of the wg-vg expressing clones are differentiated into wing margin sensory elements, whereas non-autonomous territories of the outgrowth are differentiated into wing blade trichomes. Co-expression of vg^Scer\UAS.cZa and wg^Scer\UAS.cLa under the control of Scer\GAL4^Ubx.PdC in clones in the wing hinge or notum cause transformation phenotypes; the cells autonomously differentiate into wing margin and non-autonomously differentiate into wing blade trichomes. Co-expression of vg^Scer\UAS.cZa and wg^Scer\UAS.cLa under the control of Scer\GAL4^Ubx.PdC in clones in the leg results in a "mixed" phenotype with leg chaetae mixed with wing blade trichomes in a "salt and pepper" distribution. Co-expression of vg^Scer\UAS.cZa and wg^Scer\UAS.cLa under the control of Scer\GAL4^Ubx.PdC in clones in the eye results in the cells autonomously differentiating into sensory elements of the wing margin.

(Baena-Lopez and Garcia-Bellido, 2003)

The overexpression of wg^Scer\UAS.cLa in a Axn^{Scer\UAS.T:Avic\GFP}, Scer\GAL4^arm.PS mutant leads to some restoration of naked cuticle.

(Cliffe et al., 2003)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^en-e16E in hh^AC embryos rescues the formation of neuroblast NB 7-3 95% of hemisegments.

(Deshpande et al., 2001)

The addition of either dor⁸ or Chc¹ to wg^Scer\UAS.cLa,Scer\GAL4^en-e16E animals leads to an enhancement of the denticle belt phenotype leading to large amounts of excess naked cuticle.

(Dubois et al., 2001)

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^wg.PM in a wg^l-17 Wnt2^unspecified double mutant background rescues some dorsal trunk in the trachea. However when wg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^btl.PS there is strong rescue, and more dorsal trunk is made.

(Llimargas and Lawrence, 2001)

The dorsal patterning defects in lin^unspecified embryos are not rescued by the expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^arm.PS.

(Hatini et al., 2000)

The tracheal system defects caused by expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^btl.PS is largely suppressed by Df(2L)32FP-5, although the visceral branches remain partially reduced. When wg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^btl.PS in a tkv⁸ background a huge dorsal trunk is formed and no other tracheal branches are usually formed.

(Llimargas, 2000)

When dpp^Scer\UAS.cSa and wg^Scer\UAS.cLa are coexpressed via Scer\GAL4^T155 in pupae, abdominal pattern is restored to wild type, indicating that pleural and tergite/sternite fates are specified by the balance between competing wg and dpp activities.

(Kopp et al., 1999)

Significantly suppresses the reduction in the dorsal side of the wing pouch seen in larvae expressing vg^Scer\UAS.cKa under the control of Scer\GAL4^A9.

(Go et al., 1998)

Scer\GAL4^h-1J3-mediated expression in smo³ mutants at 18^oC suppresses the smo denticle belt phenotype.

(Quirk et al., 1997)

Although Scer\GAL4^arm.PS mediated expression of wg^Scer\UAS.cLa in wg^l-17 Df(2R)en^E embryos does not rescue segmentation, the embryos do lengthen a little but no Keilin's organs form. Instead of a lawn of denticles the ventral abdomen now makes naked cuticle. The T1 denticles resemble those normally found in the beard, although the beard is not small and localised. Scer\GAL4^arm.PS mediated expression of both wg^Scer\UAS.cLa and en^Scer\UAS.cGa in wg^l-17 Df(2R)en^E embryos causes a small beardless, near-spherical and unsegmented embryo with extruded organs (believed to be foregut and hindgut), i.e. less phenotypic rescue than for Scer\GAL4^arm.PS mediated expression of wg^Scer\UAS.cLa alone. Scer\GAL4^arm.PS mediated expression of both wg^Scer\UAS.cLa and hh^Scer\UAS.cIa in wg^l-17 Df(2R)en^E embryos causes naked cuticle to form in the place of the T1 beard. Scer\GAL4^prd.RG1 mediated expression of wg^Scer\UAS.cLa in wg^l-17 Df(2R)en^E embryos causes a lengthening of the whole embryo and instead of a lawn of denticles alternate stripes of naked and denticulate cuticle appear. Two types of denticle form in each band, small ones on the outside and larger ones inward. Individual denticles tend to point towards the nearest naked domain.

(Lawrence et al., 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Partially rescues

wg^UAS.cLa/Scer\GAL4^cad-em459 partially rescues wg^Sp-1/wg^l-16

(Gorfinkiel et al., 2003)

Scer\GAL4^en-e16E/wg^UAS.cLa partially rescues wg^l-17

(Sanson et al., 1999)

wg^UAS.cLa/Scer\GAL4^vg.PM partially rescues wg^spd-fg/wg^spd-hL2

(Neumann and Cohen, 1996)

Comments

Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^cad-em459 in wg^l-16/wg^Sp-1 females sometimes results in recovery of the vaginal plates and tergite eight, but not the vulva. The analia are much reduced in some cases and some females have no genital and anal structures. Expression of wg^Scer\UAS.cLa under the control of Scer\GAL4^cad-em459 in wg^l-16/wg^Sp-1 males results in recovery of genital structures such as the claspers and penis apparatus, although the penis apparatus is sometimes still reduced. Analia are almost normal or reduced.

(Gorfinkiel et al., 2003)

Expression of wg^Scer\UAS.cLa driven by Scer\GAL4^en-e16E in a wg^l-17 background rescues many rows of the denticle belts, except row 1.

(Sanson et al., 1999)

wg^spd-fg/wg^spd-hL2 transheterozygous wing phenotype can be partially rescued by Scer\GAL4^vg.PM induced expression of wg^Scer\UAS.cLa, rescue of the anterior wing margin and the posterior wing blade between vein 5 and the posterior margin.

(Neumann and Cohen, 1996)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

wg^Scer\UAS.cLa

wg^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lawrence

(Lawrence et al., 1995)

Secondary FlyBase IDs

References (75)

Report Sections

Open Close