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Citation
Watanabe, K., Chiu, H., Pfeiffer, B.D., Wong, A.M., Hoopfer, E.D., Rubin, G.M., Anderson, D.J. (2017). A Circuit Node that Integrates Convergent Input from Neuromodulatory and Social Behavior-Promoting Neurons to Control Aggression in Drosophila.  Neuron 95(5): 1112--1128.e7.
FlyBase ID
FBrf0236528
Publication Type
Research paper
Abstract

Diffuse neuromodulatory systems such as norepinephrine (NE) control brain-wide states such as arousal, but whether they control complex social behaviors more specifically is not clear. Octopamine (OA), the insect homolog of NE, is known to promote both arousal and aggression. We have performed a systematic, unbiased screen to identify OA receptor-expressing neurons (OARNs) that control aggression in Drosophila. Our results uncover a tiny population of male-specific aSP2 neurons that mediate a specific influence of OA on aggression, independent of any effect on arousal. Unexpectedly, these neurons receive convergent input from OA neurons and P1 neurons, a population of FruM(+) neurons that promotes male courtship behavior. Behavioral epistasis experiments suggest that aSP2 neurons may constitute an integration node at which OAergic neuromodulation can bias the output of P1 neurons to favor aggression over inter-male courtship. These results have potential implications for thinking about the role of related neuromodulatory systems in mammals.

PubMed ID
PubMed Central ID
PMC5588916 (PMC) (EuropePMC)
Related Publication(s)
Note

To Fight or Not to Fight.
Pereira and Murthy, 2017, Neuron 95(5): 986--988 [FBrf0236606]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (49)
    Genes (18)
    Natural transposons (2)
    Insertions (24)
    Experimental Tools (14)
    Transgenic Constructs (41)