FlyBase Gene Report: Dmel\schlank

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: Dmel\schlank

General Information

Symbol

Dmel\schlank

Species

D. melanogaster

Name

schlank

Annotation Symbol

CG3576

Feature Type

protein_coding_gene

FlyBase ID

FBgn0040918

Gene Model Status

Stock Availability

19 publicly available

Enzyme Name (EC)

sphingosine N-acyltransferase (2.3.1.24)

Gene Summary

schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Lag1, l(1)G0061, Longevity assurance gene 1, l(1)G0365, l(1)G0489

Key Links

Genomic Location

Cytogenetic map

Sequence location

X:6,257,668..6,267,228 [-]

Recombination map

1-16

RefSeq locus

NC_004354 REGION:6257668..6267228

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables sphingosine N-acyltransferase activity

inferred from direct assay

(Bauer et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR001356

(InterPro Project Members, 2004-)

enables sphingosine N-acyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000285423

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with MGI:MGI:1919199, MGI:MGI:2442564

(Bauer et al., 2009)

inferred from electronic annotation with InterPro:IPR016439

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in ceramide biosynthetic process

inferred from mutant phenotype

(Bauer et al., 2009)

involved_in negative regulation of lipid catabolic process

inferred from mutant phenotype

(Bauer et al., 2009)

involved_in positive regulation of lipid biosynthetic process

inferred from mutant phenotype

(Bauer et al., 2009)

involved_in SREBP signaling pathway

inferred from mutant phenotype

(Bauer et al., 2009)

involved_in triglyceride metabolic process

inferred from mutant phenotype

(Bauer et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in ceramide biosynthetic process

inferred from electronic annotation with InterPro:IPR016439

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000285423

(GO Reference Genome Project, 2011-)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Voelzmann et al., 2016)

located_in nuclear inner membrane

inferred from direct assay

(Voelzmann et al., 2016)

located_in nucleus

inferred from direct assay

(Voelzmann et al., 2016)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in endoplasmic reticulum

inferred from biological aspect of ancestor with PANTHER:PTN000285423

(GO Reference Genome Project, 2011-)

located_in membrane

inferred from sequence model

(Bauer et al., 2009)

inferred from electronic annotation with InterPro:IPR006634

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

UNCLASSIFIED NON-AMINOACYL ACYLTRANSFERASES

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

sphingosine N-acyltransferase activity

a fatty acyl-CoA + sphing-4-enine = an N-acylsphing-4-enine + CoA + H(+) (2.3.1.24)

RHEA 23768:

Summaries

Gene Snapshot

schlank (schlank) encodes a member of the Ceramide Synthases family involved in sphingolipid metabolism. It is essential for ceramide synthesis and modulates triacylglycerol levels and transcriptional expression of body fat metabolism regulators. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

UNCLASSIFIED NON-AMINOACYL ACYLTRANSFERASES -: This group comprises non-aminoacyl acyltransferases that do not classify under other groups in FlyBase.

Gene Model and Products

Number of Transcripts

2

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\schlank for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W423)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0070937

2201

400

FBtr0070938

2487

400

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0070898

46.4

400

9.80

FBpp0070899

46.4

400

9.80

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

400 aa isoforms: schlank-PA, schlank-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Q9W423

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\schlank using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.50

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4

(Bauer et al., 2009)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

embryonic stage 12 -- 15

embryonic epidermis | segmentally repeated

(Voelzmann and Bauer, 2011)

larval ventral nerve cord

(Voelzmann and Bauer, 2011)

embryonic brain | segmentally repeated

(Voelzmann and Bauer, 2011)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic proventriculus

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

embryonic/larval posterior spiracle

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 14 -- 15

larval peripheral nervous system

(Voelzmann and Bauer, 2011)

external sensory organ

(Voelzmann and Bauer, 2011)

embryonic/larval posterior spiracle

(Voelzmann and Bauer, 2011)

embryonic/larval gut

(Voelzmann and Bauer, 2011)

embryonic/larval foregut

(Voelzmann and Bauer, 2011)

embryonic/larval hindgut

(Voelzmann and Bauer, 2011)

embryonic/larval anterior midgut

(Voelzmann and Bauer, 2011)

embryonic/larval posterior midgut

(Voelzmann and Bauer, 2011)

embryonic stage 15

embryonic large intestine

(Voelzmann and Bauer, 2011)

(Bauer et al., 2009)

Additional Descriptive Data

schlank is ubiquitously expressed in embryos from early embryonic stages onward. Strong upregulation occurs in specific cells and organs. schlank is strongly expressed in a segmentally repeated pattern in the epidermis, in the ventral nerve cord, and in the developing brain. It is also found in the ectodermal foregut and hindgut, the endodermal anterior and posterior midgut, and in the posterior spiracles. It is also observed in sensory organs.

(Voelzmann and Bauer, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4

(Bauer et al., 2009)

embryonic stage 12 -- 15

embryonic epidermis | segmentally repeated

(Voelzmann and Bauer, 2011)

larval ventral nerve cord

(Voelzmann and Bauer, 2011)

embryonic brain | segmentally repeated

(Voelzmann and Bauer, 2011)

embryonic stage 13 -- 15

(Voelzmann and Bauer, 2011)

CNS surface glial cell

(Voelzmann and Bauer, 2011)

larval channel glial cell

(Voelzmann and Bauer, 2011)

embryonic stage 13 -- 17

larval glial cell

(Voelzmann and Bauer, 2011)

embryonic stage 14 -- 15

larval peripheral nervous system

(Voelzmann and Bauer, 2011)

external sensory organ

(Voelzmann and Bauer, 2011)

embryonic/larval posterior spiracle

(Voelzmann and Bauer, 2011)

embryonic/larval gut

(Voelzmann and Bauer, 2011)

embryonic/larval foregut

(Voelzmann and Bauer, 2011)

embryonic/larval hindgut

(Voelzmann and Bauer, 2011)

embryonic/larval anterior midgut

(Voelzmann and Bauer, 2011)

embryonic/larval posterior midgut

(Voelzmann and Bauer, 2011)

embryonic stage 15

embryonic large intestine

(Voelzmann and Bauer, 2011)

embryonic/larval fat body

(Voelzmann et al., 2016)

third instar larval stage

embryonic/larval fat body

(Bauer et al., 2009)

(Bauer et al., 2009)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

day 5 of adulthood | male -- day 7 of adulthood | male

(Wasbrough et al., 2010)

Additional Descriptive Data

schlank is ubiquitously expressed in embryos from early embryonic stages onward. Strong upregulation occurs in specific cells and organs. schlank is strongly expressed in a segmentally repeated pattern in the epidermis, in the ventral nerve cord, and in the developing brain. It is also found in the ectodermal foregut and hindgut, the endodermal anterior and posterior midgut, and in the posterior spiracles. It is also observed in sensory organs. A close look at the gastrointestinal tract shows that schlank is strongly expressed at the ectodermal foregut/endodermal midgut boundary at the site of the ball-like evagination. In the hindgut, it is strongly expressed in the large intestine in a single cell layer and especially at the border between the large intestine and the rectum as well as the border between large and small intestine. The rectum and small intestine show only basal expression. schlank is also strongly enriched in the central nervous system, especially in the majority of glial cells from stage 13 on but not before. It is enriched in surgace glia, channel glia, and peripheral glia. schlank is also enriched in the nearly all neurons of the ventral and lateral sensory group, including ventral and lateral external sensory neurons (v'es, les), ventral and lateral dendritic arborisation neurons (vda, lda), ventral' tracheal dendritic neurons (v'td), and lateral chordotonal neurons (lch). It is also enriched in the majority of sensory organs in the head region, including dorsal organ, Bolwig's organ and labral sensory complex.

(Voelzmann and Bauer, 2011)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in endoplasmic reticulum

inferred from direct assay

(Voelzmann et al., 2016)

located_in nuclear inner membrane

inferred from direct assay

(Voelzmann et al., 2016)

located_in nucleus

inferred from direct assay

(Voelzmann et al., 2016)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\schlank in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\schlank

View exonic expression by tissue for Dmel\schlank

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040918

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50392/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040918

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040918

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040918

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3576

Flygut - An atlas of the Drosophila adult midgut

FBgn0040918

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 21 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 16 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of schlank

Transgenic constructs containing regulatory region of schlank

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

(Christensen et al., 2008.10.20)

(Ryder, 2004.4.26)

Inferred from location ( 22 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

schlank^G0061

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of larval stage, with Scer\GAL4^αTub84B.PL

schlank^GD15550

lethal - all die before end of P-stage

schlank^G0061

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

schlank^GD4653

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

Sterility

Allele

female sterile germline-dependent | germline clone

schlank^G0349

Other Phenotypes

Allele

abnormal developmental rate | larval stage

abnormal developmental rate | larval stage, with Scer\GAL4^da.G32

schlank^RNAi.UAS

abnormal neuroanatomy | larval stage (with schlank^G0061)

schlank^G0489

abnormal neuroanatomy | larval stage (with schlank^G0489)

schlank^G0061

abnormal starvation stress response | RU486 conditional, with Scer\GAL4^{Act5C.Switch.PR}

schlank^JF02502

abnormal starvation stress response | RU486 conditional, with Scer\GAL4^da.Switch.PT

schlank^JF02502

decreased body size | larval stage

decreased body size | larval stage, with Scer\GAL4^da.G32

schlank^RNAi.UAS

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP0001

schlank^GD15550

flightless, with Scer\GAL4^Mef2.PR

schlank^GD15550

short lived, with Scer\GAL4^{Act5C.Switch.PR}

schlank^JF02502

short lived, with Scer\GAL4^Mef2.PR

schlank^GD15550

some die during larval stage

some die during pharate adult stage

schlank^G0061

visible, with Scer\GAL4^Bx-MS1096

schlank^KK108152

visible, with Scer\GAL4^pnr-MD237

visible | male limited, with Scer\GAL4^Bx-MS1096

schlank^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

adult midgut | conditional, with Scer\GAL4^NP0001

schlank^GD15550

embryonic/larval neuromuscular junction (with schlank^G0061)

schlank^G0489

embryonic/larval neuromuscular junction (with schlank^G0489)

schlank^G0061

endosome, with Scer\GAL4^phtm.PO

schlank^KK108152

prothoracic gland | third instar larval stage, with Scer\GAL4^phtm.PO

schlank^KK108152

terminal bouton | larval stage (with schlank^G0061)

schlank^G0489

terminal bouton | larval stage (with schlank^G0489)

schlank^G0061

trichogen cell, with Scer\GAL4^pnr-MD237

wing, with Scer\GAL4^Bx-MS1096

schlank^KK108152

wing | male limited, with Scer\GAL4^Bx-MS1096

schlank^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

13 of 14

Yes

Yes

12 of 14

No

Yes

1

10 of 14

No

Yes

1

9 of 14

No

Yes

8 of 14

No

Yes

1

1 of 14

No

Yes

1 of 14

No

No

1

1 of 14

No

No

1 of 14

No

No

1

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (9)

12 of 14

Yes

Yes

12 of 14

Yes

Yes

9 of 14

No

Yes

9 of 14

No

Yes

8 of 14

No

Yes

1 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Mus musculus (laboratory mouse) (9)

13 of 14

Yes

Yes

11 of 14

No

Yes

10 of 14

No

Yes

9 of 14

No

Yes

4

8 of 14

No

Yes

2 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

1 of 14

No

No

Xenopus tropicalis (Western clawed frog) (7)

9 of 13

Yes

Yes

8 of 13

No

Yes

6 of 13

No

Yes

5 of 13

No

Yes

4 of 13

No

Yes

2 of 13

No

Yes

1 of 13

No

No

Danio rerio (Zebrafish) (12)

13 of 14

Yes

Yes

12 of 14

No

Yes

9 of 14

No

Yes

9 of 14

No

Yes

8 of 14

No

Yes

8 of 14

No

Yes

8 of 14

No

Yes

8 of 14

No

Yes

3 of 14

No

Yes

1 of 14

No

No

1 of 14

No

No

Drer\zgc:113278

1 of 14

No

No

Caenorhabditis elegans (Nematode, roundworm) (4)

13 of 14

Yes

Yes

12 of 14

No

Yes

3 of 14

No

Yes

1 of 14

No

No

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP001761

12 of 12

Yes

Yes

Agam\AgaP_AGAP010386

1 of 12

No

No

Arabidopsis thaliana (thale-cress) (4)

12 of 13

Yes

Yes

11 of 13

No

Yes

11 of 13

No

Yes

11 of 13

No

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

9 of 13

Yes

Yes

9 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

10 of 12

Yes

Yes

8 of 12

No

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:schlank. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CERS3; ceramide synthase 3

model of autosomal recessive congenital ichthyosis 9

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

exacerbates neuronal ceroid lipofuscinosis

modeled by cathD¹

(Kuronen et al., 2009)

schlank^JF02502

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Kong et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CERS5; ceramide synthase 5

13 of 14

CERS6; ceramide synthase 6

12 of 14

CERAMIDE SYNTHASE 6; CERS6

CERS2; ceramide synthase 2

10 of 14

CERAMIDE SYNTHASE 2; CERS2

CERS4; ceramide synthase 4

9 of 14

CERS3; ceramide synthase 3

8 of 14

CERAMIDE SYNTHASE 3; CERS3

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 9; ARCI9

autosomal recessive congenital ichthyosis 9

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

schlank - Blos1

two hybrid array

(Shokri et al., 2019)

schlank - CG31955

two hybrid array

(Shokri et al., 2019)

schlank - HDAC1

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, western blot

(Yuan et al., 2024)

two hybrid array

(Shokri et al., 2019)

schlank - Sox21b

two hybrid array

(Shokri et al., 2019)

schlank - Su(z)12

anti tag coimmunoprecipitation, anti tag western blot

(Yuan et al., 2024)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

schlank - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Kuronen et al., 2009)

suppressible

(Ida et al., 2009)

suppressible

(Jung et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

72669

DroID - A comprehensive database of gene and protein interactions.

FBgn0040918

MIST (protein-protein) - An integrated Molecular Interaction Database

50392

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Sphingolipid de novo biosynthesis

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Sphingolipid de novo biosynthesis

Class of Gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

X

Recombination map

1-16

Cytogenetic map

Sequence location

X:6,257,668..6,267,228 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5E3-5E4

Limits computationally determined from genome sequence between P{EP}EP1457^EP1457&P{EP}CG5928^EP1083 and P{EP}EP1311&P{EP}EP1384

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

5E1-5E2

(determined by in situ hybridisation)

(Peter et al., 2002, Schäfer et al., 1999.6.15, Schäfer et al., 1999.8.12)

5E-5E

(determined by in situ hybridisation)

(Schäfer et al., 1999.12.2)

9E3-9E4

(determined by in situ hybridisation)

(Schäfer et al., 1999.3.29)

Experimentally Determined Recombination Data

Location

1-16

(FlyBase, 2016)

1-16.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Aberrations including deletions of this gene Aberrations including duplications of this gene

49800

w¹¹¹⁸; P{GMR34G05-GAL4}attP2

29340

y¹ v¹; P{TRiP.JF02502}attP2

11665

w^67c23 P{lacW}schlank^G0061/FM7c

11985

w^67c23 P{lacW}schlank^G0365/FM7c

F003238

M{UAS-schlank.ORF-CC}ZH-21F

F000075

M{UAS-schlank.ORF.3xHA.GW}ZH-86Fb

105376

y^* w^* P{GawB}schlank^NP7130 / FM7c

v41115

P{GD4653}v41115

v109418

P{KK108152}VIE-260B

v41114

w¹¹¹⁸; P{GD4653}v41114

v33896

w¹¹¹⁸; P{GD15550}v33896

v33897

w¹¹¹⁸; P{GD15550}v33897

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (203)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD18904

Other clones

DPiM_LD18904

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0040918

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0040918

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Sociale et al., 2018, Voelzmann and Bauer, 2011, Bauer et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Lag1 mutant show homozygous embryonic lethality, with ventral holes and germband extension/retraction problems.

(Bauer et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: Lag1 l(1)G0365 l(1)G0061 l(1)G0489

(Peter et al., 2002)

Source for merge of: CG15898 CG3576

(FlyBase, 1996-)

Additional comments

Source for merge of CG15898 CG3576 was a shared cDNA ( date:010720 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Source for identity of: Lag1 CG15898

(Bauer, 2002.3.22)

Nomenclature comments

Etymology

'schlank' means 'slim' in German - named as such because mutants show defects in larval growth and fat metabolism.

(Bauer et al., 2009)

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

CG15898

CG3576

(Kolkhof et al., 2017, Hosono et al., 2015, Jaspers et al., 2012, Ida et al., 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Peter et al., 2002)

CerS

(Voelzmann et al., 2016)

DLAG1

(Bauer et al., 2002)

DLag1

(Bauer et al., 2009)

Dlag1

(Bauer et al., 2005)

Iag1

(Saha et al., 2022)

Lag1

(Manning et al., 2012, Ida et al., 2009, Tan et al., 2009, Christensen et al., 2008.10.20, Bhutkar et al., 2007)

Schlank

(Yuan et al., 2024, Bittern et al., 2021, Waters et al., 2021, Bischof et al., 2018, Sociale et al., 2018, Kraut, 2011)

cerS

(Ziegler et al., 2025)

l(1)G0061

(Schäfer et al., 1999.3.29, Schäfer et al., 1999.6.15)

l(1)G0365

(Schäfer et al., 1999.8.12)

l(1)G0489

(Schäfer et al., 1999.12.2)

lag1

(Kuronen et al., 2009)

lon

(Bauer, 2001.12.10)

Name Synonyms

Longevity assurance gene 1

(Jaspers et al., 2012)

Psc

(Bauer et al., 2009)

Schlank

(Voelzmann et al., 2016)

longevity

(Bauer, 2001.12.10)

schlank

(Graves et al., 2020, Yin et al., 2018, Pepperl et al., 2013, Voelzmann and Bauer, 2011)

Secondary FlyBase IDs

FBgn0026692
FBgn0028312
FBgn0029852
FBgn0040141

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

50392

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W423

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W423

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W423

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0040918

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

50392/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0040918

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0040918

FlyMine - An integrated database for Drosophila genomics

FBgn0040918

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3576

MARRVEL_MODEL - MARRVEL (model organism gene)

50392

Linkouts

BioGRID - A database of protein and genetic interactions.

72669

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0040918

DroID - A comprehensive database of gene and protein interactions.

FBgn0040918

DRSC - Results frm RNAi screens

FBgn0040918

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0040918

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0040918

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3576

Flygut - An atlas of the Drosophila adult midgut

FBgn0040918

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0040918

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

50392

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Sphingolipid de novo biosynthesis

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

Sphingolipid de novo biosynthesis

References (100)