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FB2025_04
,
released October 2, 2025
zinc finger - regulates cell identity in the peripheral nervous system - a binary genetic switch that acts to repress a multiple dendritic arbor and promote single-dendrite morphology - controls nociceptive behavior in sensory neurons
Please see the JBrowse view of Dmel\ham for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.45
Gene model reviewed during 6.32
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ham using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: weak expression
Comment: weak expression
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Comment: strong expression
Comment: strong expression
Comment: weak expression
Comment: weak expression
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JBrowse - Visual display of RNA-Seq signals
View Dmel\ham in JBrowse2-54
2-53.4
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dsRNA has been made from templates generated with primers directed against this gene. ham RNAi results in supernumerary class I neurons.
In ham mutant external sensory organs, the internal cell types (external sensory neuron and thecogen) are converted to external cell types via a cousin-cousin cell-fate respecification event.
Loss of ham function in hamlet mutant embryos results in a switch of neural fate; the ES neuron is transformed into an MD neuron.
ham acts as a binary genetic switch that acts to repress a multiple dendritic arbor (multidendritic neuron fate) and promotes single-dendrite morphology (external sensory neuron fate).
Mutants show altered cell fates in the external sensory organ lineage; the fate of the IIIb daughters is altered, with the sensory neuron being converted to a second multiple dendritic neuron and the glia being converted to a second trichogen.
Source for merge of: hamlet CG15907 CG31753
Source for merge of: CG10568 CG15906
"ham" does not correspond to "l(2)36Fd"; mutations in these two genes complement each other.
Annotations CG15907 and CG31753 merged as CG31753 (which corresponds to ham) in release 3.2 of the genome annotation.
Annotations CG10568 and CG15906 merged as CG31753 in release 3 of the genome annotation.
Source for merge of hamlet CG15907 CG31753 was sequence comparison ( date:021223 ).
The gene is named "hamlet" after the "To be or not to be" soliloquy in the Shakespeare play of the same name, as mutations of the gene appear to affect determination of cells descended from the IIB precursor of the external sensory organ precursor cell lineage.
