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Citation
Chen, K.F., Lowe, S., Lamaze, A., Krätschmer, P., Jepson, J. (2019). Neurocalcin regulates nighttime sleep and arousal in Drosophila.  eLife 8(): e38114.
FlyBase ID
FBrf0241819
Publication Type
Research paper
Abstract

Sleep-like states in diverse organisms can be separated into distinct stages, each with a characteristic arousal threshold. However, the molecular pathways underlying different sleep stages remain unclear. The fruit fly, Drosophila melanogaster, exhibits consolidated sleep during both day and night, with night sleep associated with higher arousal thresholds compared to day sleep. Here we identify a role for the neuronal calcium sensor protein Neurocalcin (NCA) in promoting sleep during the night but not the day by suppressing nocturnal arousal and hyperactivity. We show that both circadian and light-sensing pathways define the temporal window in which NCA promotes sleep. Furthermore, we find that NCA promotes sleep by suppressing synaptic release from a dispersed wake-promoting neural network and demonstrate that the mushroom bodies, a sleep-regulatory center, are a module within this network. Our results advance the understanding of how sleep stages are genetically defined.

PubMed ID
PubMed Central ID
PMC6415939 (PMC) (EuropePMC)
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference
    Alleles (59)
    Genes (13)
    Natural transposons (1)
    Insertions (7)
    Experimental Tools (3)
    Transgenic Constructs (49)