FlyBase Allele Report: Hsap\SNCA[UAS.cFa]

General Information

Symbol

Hsap\SNCA^UAS.cFa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Feany

FlyBase ID

FBal0104766

Feature type

allele

Associated gene

Hsap\SNCA

Associated Insertion(s)

Carried in Construct

P{UAS-Hsap\SNCA.F}

Also Known As

UAS-α-synuclein, UAS-α-syn, UAS-Hsap/SNCA.F, UAS-αSyn, UAS-h[WT]αSyn, UAS-SNCA, syn^WT, α-syn^WT, UAS-Syn, UAS-h^wt-SNCA

Key Links

Transgenic product class

wild_type

(Feany and Bender, 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Feany and Bender, 2000)

Mutagen

in vitro construct

(Feany and Bender, 2000)

Progenitor genotype

Carried in construct

P{UAS-Hsap\SNCA.F}

Cytology

Description

UASt regulatory sequences drive expression of wild-type Hsap\SNCA.

(Feany and Bender, 2000)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\SNCA

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of synucleinopathy

CEA

(Alexopoulou et al., 2016, Chen et al., 2009, Auluck et al., 2005)

model of bowel dysfunction

CEA

(Olsen and Feany, 2019)

model of Lewy body dementia

CEA

(Olsen and Feany, 2019)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of Parkinson's disease 1

is ameliorated by Buffy^UAS.cQa

(M'Angale and Staveley, 2016)

is ameliorated by cn^KK101938

(Breda et al., 2016)

is exacerbated by anne^KK107621

(Dhanushkodi et al., 2023)

is exacerbated by Hsap\DNAJC13^{N855S.UAS.Tag:MYC}

(Yoshida et al., 2018)

is ameliorated by Hsap\ARSA^N352S.UAS

(Lee et al., 2019)

is ameliorated by Hsap\ARSA^UAS.cLa

(Lee et al., 2019)

is exacerbated by Hsap\GBA1^{L444P.UAS.Tag:MYC,Tag:polyHis}

(Maor et al., 2019)

is ameliorated by IP3K2^KK112292

(Di Leva et al., 2023)

is exacerbated by porin^JF03251

(M'Angale and Staveley, 2016)

is exacerbated by porin^KK107645

(M'Angale and Staveley, 2016)

is exacerbated by HtrA2^HM05030

(Chung et al., 2020)

is ameliorated by HtrA2^UAS.cYa

(Chung et al., 2020)

is ameliorated by Drp1^KG03815

(Krzystek et al., 2021)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Krzystek et al., 2021)

is ameliorated by Pink1^UAS.cYa

(Krzystek et al., 2021)

is ameliorated by park^UAS.cGa

(Krzystek et al., 2021)

is exacerbated by Avic\GFP^klar.LD.UASp

(Girard et al., 2021)

is exacerbated by CG7900^EY10020

(Girard et al., 2021)

is exacerbated by Lsd1^UAS.EGFP

(Girard et al., 2021)

is exacerbated by Lsd2^UAS.EGFP

(Girard et al., 2021)

is exacerbated by BI-1^GD1660

(M'Angale and Staveley, 2017)

is exacerbated by BI-1^KK100983

(M'Angale and Staveley, 2017)

is exacerbated by Gba1b^GD10253

(Abul Khair et al., 2018)

is exacerbated by Rop^A3

(Matsuoka et al., 2024)

is exacerbated by Rop^G27

(Matsuoka et al., 2024)

model of synucleinopathy

is ameliorated by Shark^UAS.cFa

(Chen et al., 2009)

is ameliorated by Usp8^HMS01898

(Alexopoulou et al., 2016)

exacerbates Huntington's disease

modeled by Hsap\HTT^GMR.Q120

(Winslow et al., 2010)

model of Parkinson's disease

is exacerbated by Atg6^GD11647

(M'Angale and Staveley, 2016)

is exacerbated by Pi3K59F^KK107602

(M'Angale and Staveley, 2016)

is ameliorated by Hsap\HSPA1L^UAS.cWa

(Auluck et al., 2002)

is exacerbated by Hsc70-4^K71S.UAS

(Auluck et al., 2002)

is ameliorated by Hsap\PRKN^UAS.cYa

(Yang et al., 2003)

is ameliorated by park^UAS.cHa

(Haywood and Staveley, 2004)

is ameliorated by Pink1^UAS.cTa

(Todd and Staveley, 2008)

is exacerbated by Gprk2^UAS.cCb

(Chen and Feany, 2005)

is ameliorated by Mmus\Rab1a^UAS.cCa

(Cooper et al., 2006)

is ameliorated by Rab11^UAS.EGFP

(Breda et al., 2015)

is ameliorated by Hsap\UBC^UAS.Tag:HA

(Lee et al., 2009)

is ameliorated by Hsap\UBC^{K63R.UAS.Tag:HA}

(Lee et al., 2009)

is ameliorated by Hsap\UBC^{K48.UAS.Tag:HA}

(Lee et al., 2009)

is exacerbated by HDAC6^KO

(Du et al., 2010)

is ameliorated by HDAC6^UAS.cDa

(Du et al., 2010)

is ameliorated by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

is ameliorated by Sin3A⁰⁸²⁶⁹

(Kontopoulos et al., 2006)

is exacerbated by Gba1a^GD6246

(Suzuki et al., 2015)

is exacerbated by Gal^GD936

(Suzuki et al., 2015)

is exacerbated by Vps35^GD11710

(Miura et al., 2014)

is ameliorated by chico¹

(Knight et al., 2014)

is exacerbated by Pgi^EY09730

(Knight et al., 2014)

is exacerbated by Tpi^GD10138

(Vicente Miranda et al., 2017)

is exacerbated by Glo1^KK109109

(Vicente Miranda et al., 2017)

is exacerbated by Debcl^UAS.Tag:HA

(M'Angale and Staveley, 2016)

is ameliorated by Debcl^JF02429

(M'Angale and Staveley, 2016)

is ameliorated by Hsap\HTRA2^UAS.cCa

(Chung et al., 2020)

ameliorates Parkinson's disease

modeled by Hsap\SNCAIP^UAS.cHa

(Hernández-Vargas et al., 2011)

exacerbates Parkinson's disease

modeled by Vps35^GD11710

(Miura et al., 2014)

exacerbates Kufor-Rakeb syndrome

modeled by anne^KK107621

(Dhanushkodi et al., 2023)

exacerbates developmental and epileptic encephalopathy 4

modeled by Rop^A3

(Matsuoka et al., 2024)

modeled by Rop^G27

(Matsuoka et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 3 )

FlyBase curator comment: "Parkinson's disease 1" is associated with human alpha-synuclein.

(Maor et al., 2019)

Nicotinamide significantly improves the climbing ability of Hsap\SNCA^Scer\UAS.cFa flies.

(Jia et al., 2008)

Geldanamycin (ChEBI:5292) protects against dopaminergic neuron loss in the DM clusters in Hsap\SNCA^Scer\UAS.cFa synucleinopathy model. Acts via Hsf, in Hsf⁴ flies, this protective function is lost.

(Auluck et al., 2005)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior, with Scer\GAL4^elav.PLu

(Feany and Bender, 2000)

abnormal locomotor behavior, with Scer\GAL4^elav.PU

(Davies et al., 2014, Hillman et al., 2012)

abnormal locomotor behavior, with Scer\GAL4^GMR.PF

(Haywood and Staveley, 2004)

abnormal locomotor behavior, with Scer\GAL4^unspecified

(Hernández-Vargas et al., 2011)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016, M'Angale and Staveley, 2016)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PLu

(Siddique et al., 2016, Siddique et al., 2013, Siddique et al., 2013, Siddique et al., 2013)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

(Siddique et al., 2016)

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav-C155

(Breda et al., 2015, Lee et al., 2009)

abnormal locomotor behavior | adult stage, with Scer\GAL4^NP6510

(Riemensperger et al., 2013)

abnormal locomotor behavior | adult stage, with Scer\GAL4^ple.PF

(Breda et al., 2015)

abnormal locomotor behavior | adult stage | conditional, with Scer\GAL4^ple.PF

(Du et al., 2010)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016, Todd and Staveley, 2008)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav.PU

(Todd and Staveley, 2008)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017, Suzuki et al., 2015)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^GMR.PS

(Miura et al., 2014)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^C164

(Breda et al., 2015)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^ple.PF

(Breda et al., 2015)

abnormal memory | male | progressive

(McBride et al., 2010)

abnormal neuroanatomy, with Scer\GAL4^Ddc.PL

(Yang et al., 2003, Auluck et al., 2002)

abnormal neuroanatomy, with Scer\GAL4^elav.PLu

(Outeiro et al., 2007)

abnormal neuroanatomy, with Scer\GAL4^elav-C155

(Hernández-Vargas et al., 2011)

abnormal neuroanatomy, with Scer\GAL4^ple.PF

(Hernández-Vargas et al., 2011, Cooper et al., 2006)

abnormal neuroanatomy | adult stage, with Scer\GAL4^elav.PU

(Chen et al., 2009)

abnormal neuroanatomy | adult stage, with Scer\GAL4^GMR.PF

(Chen and Feany, 2005)

abnormal neuroanatomy | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^elav.PU

(Kontopoulos et al., 2006)

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^GMR.PU

(Du et al., 2010)

abnormal neuroanatomy | adult stage | conditional, with Scer\GAL4^ple.PF

(Du et al., 2010)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav.PLu

(Mohite et al., 2018)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav.PU

(Periquet et al., 2007, Chen and Feany, 2005)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav-C155

(Breda et al., 2015)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^ple.PF

(Breda et al., 2015, Knight et al., 2014)

abnormal neuroanatomy | progressive, with Scer\GAL4^elav-C155

(Suzuki et al., 2015)

abnormal neuroanatomy | progressive, with Scer\GAL4^ple.PF

(Botella et al., 2008)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

abnormal neurophysiology, with Scer\GAL4^unspecified

(Hernández-Vargas et al., 2011)

abnormal neurophysiology | third instar larval stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

decreased cell number, with Scer\GAL4^elav-C155

(Luan et al., 2015)

decreased cell number | adult stage, with Scer\GAL4^elav.PU

(Yoshida et al., 2018)

decreased cell number | adult stage | progressive, with Scer\GAL4^elav.PLu

(Mohite et al., 2018)

decreased cell number | adult stage | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

decreased cell number | adult stage | progressive, with Scer\GAL4^ple.PF

(Knight et al., 2014)

decreased cell number | nutrition conditional, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PU

(Celle et al., 2026)

decreased rate of flight behavior, with Scer\GAL4^da.PU

(Diaw et al., 2023)

increased cell death | larval stage, with Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

short lived, with Scer\GAL4^da.PU

(Diaw et al., 2023)

short lived, with Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016, M'Angale and Staveley, 2016, M'Angale and Staveley, 2016)

short lived, with Scer\GAL4^elav.PLu

(Siddique et al., 2013)

short lived, with Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

short lived, with Scer\GAL4^unspecified

(Hernández-Vargas et al., 2011)

short lived | adult stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

short lived | nutrition conditional, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

visible, with Scer\GAL4^GMR.PS

(Tue et al., 2012)

visible, with Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

visible | adult stage, with Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

visible | adult stage, with Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016, M'Angale and Staveley, 2016)

Phenotype Manifest In

cell body rind of adult lamina | adult stage | progressive, with Scer\GAL4^elav.PU

(Periquet et al., 2007)

dopamine neuron & adult brain, with Scer\GAL4^elav.PLu

(Feany and Bender, 2000)

dopaminergic neuron, with Scer\GAL4^Ddc.PL

(Lee et al., 2009, Yang et al., 2003, Auluck et al., 2002)

dopaminergic neuron, with Scer\GAL4^elav.PLu

(Mohite et al., 2018, Outeiro et al., 2007)

dopaminergic neuron, with Scer\GAL4^elav.PU

(Davies et al., 2014)

dopaminergic neuron, with Scer\GAL4^elav-C155

(Luan et al., 2015)

dopaminergic neuron, with Scer\GAL4^ple.PF

(Hernández-Vargas et al., 2011, Cooper et al., 2006)

dopaminergic neuron | adult stage, with Scer\GAL4^elav.PU

(Yoshida et al., 2018, Chen et al., 2009)

dopaminergic neuron | adult stage | progressive, with Scer\GAL4^elav.PU

(Periquet et al., 2007, Chen and Feany, 2005)

dopaminergic neuron | conditional, with Scer\GAL4^elav.PU

(Kontopoulos et al., 2006)

dopaminergic neuron | conditional, with Scer\GAL4^ple.PF

(Du et al., 2010)

dopaminergic neuron | progressive, with Scer\GAL4^elav-C155

(Suzuki et al., 2015)

dopaminergic neuron | progressive, with Scer\GAL4^ple.PF

(Knight et al., 2014, Botella et al., 2008)

dopaminergic PPL1 neuron | adult stage | progressive, with Scer\GAL4^elav-C155

(Breda et al., 2015)

dopaminergic PPL1 neuron | adult stage | progressive, with Scer\GAL4^ple.PF

(Breda et al., 2015)

dopaminergic PPM1 neuron | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

dopaminergic PPM2 neuron | adult stage, with Scer\GAL4^ple.PF

(Zhu et al., 2016)

dorso-lateral dopaminergic neuron, with Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

eye, with Scer\GAL4^GMR.PS

(Tue et al., 2012)

eye, with Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016, M'Angale and Staveley, 2016)

eye | adult stage, with Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

eye | adult stage, with Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

eye | heat sensitive, with Scer\GAL4^GMR.PU

(Davies et al., 2014)

eye photoreceptor cell | conditional, with Scer\GAL4^GMR.PU

(Du et al., 2010)

eye photoreceptor cell | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

lamina | adult stage | progressive, with Scer\GAL4^elav.PU

(Periquet et al., 2007)

larval brain | larval stage, with Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

mitochondrion | larval stage, with Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

NMJ bouton | third instar larval stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

ommatidium, with Scer\GAL4^elav-C155

(Hernández-Vargas et al., 2011)

ommatidium, with Scer\GAL4^GMR.PF

(Chen and Feany, 2005, Haywood and Staveley, 2004)

ommatidium, with Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

ommatidium | adult stage, with Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

ommatidium | adult stage, with Scer\GAL4^GMR.PU

(Chen et al., 2009)

ommatidium | conditional, with Scer\GAL4^GMR.PU

(Du et al., 2010)

ommatidium | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

retina, with Scer\GAL4^GMR.PF

(Chen and Feany, 2005, Feany and Bender, 2000)

retina | progressive, with Scer\GAL4^GMR.long

(Yan et al., 2019)

retina | progressive, with Scer\GAL4^GMR.PF

(Todd and Staveley, 2008)

rhabdomere, with Scer\GAL4^GMR.PF

(Lee et al., 2009)

rhabdomere of eye photoreceptor cell | adult stage, with Scer\GAL4^GMR.PU

(Breda et al., 2015)

synaptic vesicle | third instar larval stage, with Scer\GAL4^elav-C155

(Breda et al., 2015)

Detailed Description

Statement

Reference

The expression of Hsap\SNCA^UAS.cFa under the control of Scer\GAL4^GMR.long leads to progressive retinal generation: while 1-day old adults show normal retinal morphology, 30-days old adults show severe defects, namely apparent loss of photoreceptor neurons along with vacuole formation.

(Yan et al., 2019)

The expression of Hsap\SNCA^UAS.cFa under the control of Scer\GAL4^elav.PLu does not affect lifespan or adult climbing activity, as compared to controls. There is a progressive decrease in the number of PPL2, but not PAL, PPM1/2, PPM3 or PPL1, dopaminergic neurons (observed in 30 days old, but not in 10days old, flies).

(Mohite et al., 2018)

Expressing Hsap\SNCA^UAS.cFa under the control of Scer\GAL4^GMR.PS does not significantly affect the number of ommatidia.

Expressing Hsap\SNCA^UAS.cFa under the control of Scer\GAL4^elav.PU leads to a significant decrease in the number of dopaminergic neurons, but does not have a major effect in climbing activity, as compared to controls.

(Yoshida et al., 2018)

The expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 leads to a significant and progressive decrease in adult locomotor capacity in negative geotaxis assays, and leads to a small but significant decrease in lifespan, as compared to controls.

(Vicente Miranda et al., 2017)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype in the adult eye.

(Alexopoulou et al., 2016)

Flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^Ddc.PL have a decreased lifespan and impaired climbing ability. Flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^GMR.PU have a rough eye phenotype.

(M'Angale and Staveley, 2016)

The expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU leads to a decrease in the number of ommatidia and disrupts the ommatidial array, as compared to controls. Expression under the control of Scer\GAL4^Ddc.PL leads to a significant decrease in longevity and to a progressive decrease in adult locomotor ability in climbing assays, as compared to controls.

(M'Angale and Staveley, 2016)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL results in decreased median adult lifespan and rapid age-progressive decline in climbing ability.

(M'Angale and Staveley, 2016)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU results in loss of climbing ability in adult flies.

(Siddique et al., 2016)

Adult flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu show decreased climbing ability and lower average activity compared to controls.

(Siddique et al., 2016)

Adult flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF fed with 1% glucose show a significantly lower survival rate and loss of dopaminergic neurons in the PPM1/2 cluster (other dopaminergic neuronal clusters - VUM, PAL, PPM3, PPL1 and PPL2 - are unaffected) but their locomotion (climbing ability) at 0-5 days post-eclosion is not impaired relative to wild-type.

(Zhu et al., 2016)

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 results in an increase in average amplitude of miniature excitatory junction potentials (mEJPs) at neuromuscular junctions of third instar larvae and the frequency distribution of mEJP amplitude sizes is significantly different compared to controls, the quantal content or the amplitude of evoked excitatory potentials (eEJPs) remains unchanged.

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 results in an increased size of synaptic vesicles and a shift in frequency distribution toward larger vesicles in both type 1b and 1s of neuromuscular junction boutons in third instar larvae compared to controls.

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of either Scer\GAL4^C164 or Scer\GAL4^ple.PF results in a decrease in the distance travelled per unit of time by third instar larvae in a crawling assay compared to controls.

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of either Scer\GAL4^C164 or Scer\GAL4^ple.PF results in loss of dopaminergic neurons of the PPL1 cluster in the brain of adult flies.

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control Scer\GAL4^GMR.PU results in loss of rhabdomeres in the eye of 30 day-old adults.

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 results in defects in climbing behavior in adults of various ages (10, 20 and 30 day-old).

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF results in defects in climbing behavior in adults of various ages (10, 20 and 30 day-old).

Ectopic expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 results in shortened lifespan of adult flies.

(Breda et al., 2015)

The expression of Hsap\SNCA^UAS.cFa under the control of Scer\GAL4^elav-C155 leads to loss of dopaminergic neurons, as assessed by the levels of TH, as compared to controls.

(Luan et al., 2015)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 exhibit a mild decline in climbing ability from 4 weeks after eclosion, compared with control flies. Fewer dopaminergic neurons are seen compared with controls.

(Suzuki et al., 2015)

Expression of Hsap\SNCA^Scer\UAS.cFa in the developing eye under the control of Scer\GAL4^GMR.PU induces a rough eye phenotype at 28[o]C.

(Davies et al., 2014)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF does not lead to any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but at 20 days post-eclosion, these flies show a significant decrease in neuron numbers in all dopaminergic neuron clusters.

(Knight et al., 2014)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PS does not result in any obvious eye phenotype or reduction in life span, but do exhibit a progressive defect in climbing ability.

(Miura et al., 2014)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF does not result in a loss of dopaminergic neurons in 55-day old flies.

(Navarro et al., 2014)

Exposure to C.asiatica extract for 24 days delays the loss of climbing ability seen in flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu in a dose-dependent manner. C.asiatica extract has no effect on the climbing ability of control flies. C. asiatica extract also delays the loss of activity pattern seen in Hsap\SNCA^Scer\UAS.cFa-expressing flies, and a similar effect is seen when the flies are fed dopamine.

(Siddique et al., 2014)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^NP6510 show an accelerated age-dependent decline in locomotor performance in a startle-induced negative geotaxis (SING) assay compared to controls.

(Riemensperger et al., 2013)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu exhibit a decrease in lifespan and a decrease in physical activity, as compared to controls.

(Siddique et al., 2013)

The climbing response in wild-type flies remains essentially unchanged over 21 days. From day 9 on, however, the response of flies expressing Scer\GAL4^elav.PLu>Hsap\SNCA^Scer\UAS.cFa is significantly lower than that of controls. When the climbing assay is performed after 21 days of exposure to various doses of Eucalyptus citriodora leaf extract, it is found that the loss of climbing ability in transgenic flies is significantly delayed in a dose dependent manner.

(Siddique et al., 2013)

Flies expressing Scer\GAL4^elav.PLu>Hsap\SNCA^Scer\UAS.cFa show lower performance 12 days after eclosion in a climbing assay compared with wild-type. An alginate-curcumin nanocomposite supplement in the diet of transgenic flies results in a significant delay in the loss of their climbing ability.

(Siddique et al., 2013)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU results in a loss of climbing ability in adult flies. Addition of L-DOPA or GABA to the food of these flies restores their climbing ability. Addition of muscimol, a GABA[[A]] receptor agonist has no effect on the reduced climbing ability of Hsap\SNCA^Scer\UAS.cFa flies. However, the GABA[[B]] receptor agonist baclofen does repair climbing ability.

(Hillman et al., 2012)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PS results in a rough eye phenotype.

(Tue et al., 2012)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 leads to toxicity and ultrastructural abnormalities in ommatidia.

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF causes a significant reduction in the number of dopaminergic neurons.

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^unspecified causes decreased motility and premature death.

Flies over-expressing Hsap\SNCAIP^Scer\UAS.cHa under the control of Scer\GAL4^unspecified display abnormalities in their electroretinograms (ERG). The amplitude of the sustained component of the photoreceptor potential (PP) and the overshoot (OS) are affected. Treatment with L-Dopa/carbidopa reverts the effect of the over-expression of the transgene.

(Hernández-Vargas et al., 2011)

20 day old adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF show significant loss of dopaminergic (DA) neurons in both the dorsomedial, posteriomedial and dorsolateral 1 clusters (loss of DA neurons is not see in 10 day old adults of this genotype).

20 to 30 day old adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU show a neurodegenerative phenotype in the eyes, with less photoreceptor cells than normal and disruption of the ommatidia.

Adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF do not show noticeable defects in climbing ability until 20 days after eclosion.

Lewy body-like Hsap\SNCA positive inclusions are clearly observed in the brains of 10 and 20 day old adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF and the number and size of the inclusions gradually increases with age.

(Du et al., 2010)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^30Y leads to age-progressive short-term (60 min) memory loss (measured by assessing courtship behavior in adult males).

(McBride et al., 2010)

In 1-day, 5-day and 10-day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU, the number of dopaminergic neurons in the dorsomedial clusters is not significantly different from the number in controls. However, at 20 days, there is a marked loss of neurons.

Scer\GAL4^GMR.PU-mediated expression of Hsap\SNCA^Scer\UAS.cFa causes mild adult-onset retinal degeneration manifested by disruption of the normal arrangement of ommatidia.

(Chen et al., 2009)

Expression of Hsap\SNCA driven by Scer\GAL4^GMR.PF causes the degeneration of rhabdomeres in the eyes of Drosophila.

Transgenic flies expressing Hsap\SNCA driven by Scer\GAL4^elav-C155 show an age-dependent decline in negative geotactic locomotory response starting from 27 days after eclosion.

Expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^Ddc.PL results in a significant reduction in the number of dorsomedial cluster 1 dopaminergic neurons in the brain.

(Lee et al., 2009)

Flies expressing Hsap\SNCA^Scer\UAS.cFa in dopaminergic neurons under the control of Scer\GAL4^ple.PF develop an age-dependent neurodegeneration that can be detected at day 15, and continuously increases with age leading to a loss of about 20% of all dopaminergic neurons after 40 days. No loss of dopaminergic neurons is seen in age-matched wild type flies.

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF does not suppress the hypoxia-induced dopaminergic neuron degeneration seen in control flies.

(Botella et al., 2008)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL show a progressive decrease in climbing ability over time. This defect can be significantly improved by feeding with nicotinamide.

(Jia et al., 2008)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of either Scer\GAL4^Ddc.PL or Scer\GAL4^elav.PU prematurely develop age-related climbing defects. Lifespan is unaffected.

The retinas of three day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF are intact, whereas premature deterioration is observed at 30 days old.

(Todd and Staveley, 2008)

20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu show a marked loss of dopamine neurons in the dorsomedial cluster. If the flies are fed either AK-1 or AGK2 for the first 20 days of adult life, a dose-dependent rescue of this loss of neuron phenotype is seen.

(Outeiro et al., 2007)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU results in age-progressive loss of dopaminergic neurons in the adult brain and aged adult flies (20 days) display abnormal neuronal inclusions in the lamina cell cortex and neuropil.

(Periquet et al., 2007)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF results in loss of dopaminergic neurons in aged brains.

(Cooper et al., 2006)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU show a progressive loss of dorsomedial dopamine neurons in the brain. This neurodegeneration can be rescued by feeding the flies sodium butyrate or SAHA.

(Kontopoulos et al., 2006)

1 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU have a normal number of dorsomedial dopaminergic neurons, while 20 day old flies show a substantial loss of these neurons compared to wild type.

Adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF show mild retinal degeneration with vacuolisation and disruption of the normal arrangement of ommatidia.

(Chen and Feany, 2005)

When Hsap\SNCA^Scer\UAS.cFa is driven by Scer\GAL4^GMR.PF premature degeneration of the ommatidial architecture is seen in thirty day old flies. The external morphology of the eyes in unaffected. When Hsap\SNCA^Scer\UAS.cFa is driven by Scer\GAL4^Ddc.PL mutant animals prematurely lose their climbing ability.

(Haywood and Staveley, 2004)

20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL have a 50% reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain.

(Yang et al., 2003)

20 day old (but not 1 day old) flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL show marked loss of neurons in the dorsomedial (DM) dopaminergic clusters. Neuron loss is more variable in the dorsolateral (DL)-1 dopaminergic clusters, ranging from no loss of neurons to as much as 50% of neurons being lost. Inclusions are present in the dopaminergic neurons of flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL. These inclusions increase in size and number with age. Most inclusions are in the DL-1 and DL-2 clusters and they are only rarely seen in the DM clusters.

(Auluck et al., 2002)

Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu show a marked, age-dependent loss of dorsomedial dopaminergic neurons. Hsap\SNCA inclusions in the brain (detected by immunostaining) are seen in aged flies (the inclusions are first seen at 20-30 days of age). Most neuronal cytoplasmic inclusions are single, round and regular, although a few are more irregular. Neuritic Hsap\SNCA inclusions are also present in the brain and consist of both thread- and grain-like inclusions. Locomotor behaviour is grossly preserved in young flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PLu. These flies initially climb as well as wild-type flies, but over time they show a premature loss of climbing ability compared to control flies. Flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF show retinal degeneration that is detectable by 10 days, and marked at 30 days after eclosion.

(Feany and Bender, 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has decreased cell number | adult stage phenotype, enhanceable by Hsap\DNAJC13^{N855S.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Glo1^KK109109, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Tpi^GD10138, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has short lived phenotype, enhanceable by Tpi^GD10138, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Vps28^GD7696, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible phenotype, enhanceable by Buffy^RNAi.UAS/Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage phenotype, enhanceable by Buffy^RNAi.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Buffy^RNAi.UAS, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy | progressive phenotype, enhanceable by Gba1a^GD6246, Scer\GAL4^elav-C155

(Suzuki et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Gba1a^GD6246, Scer\GAL4^elav-C155

(Suzuki et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Gal^GD936, Scer\GAL4^elav-C155

(Suzuki et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, enhanceable by Nedd4^GD5146, Scer\GAL4^elav.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has decreased cell number | adult stage | progressive phenotype, enhanceable by Pgi^EY09730/Pgi[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal neuroanatomy | adult stage | progressive phenotype, enhanceable by Pgi^EY09730/Pgi[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS has abnormal locomotor behavior | adult stage | progressive phenotype, enhanceable by Vps35^GD11710, Scer\GAL4^GMR.PS

(Miura et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal neuroanatomy | adult stage | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal locomotor behavior | adult stage | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has abnormal neuroanatomy | adult stage | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has visible phenotype, enhanceable by Pink1^UAS.cTa

(Todd and Staveley, 2008)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage | progressive phenotype, enhanceable by Gprk2^UAS.cCb, Scer\GAL4^elav.PU

(Chen and Feany, 2005)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal neuroanatomy phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has decreased cell number | adult stage phenotype, non-enhanceable by Hsap\DNAJC13^{wt.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has short lived phenotype, non-enhanceable by Glo1^KK109109, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by Pi3K59F^KK107602, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage | progressive phenotype, non-enhanceable by Atg6^GD11647, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Suppressed by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has increased cell death | larval stage phenotype, suppressible by park^UAS.cGa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has increased cell death | larval stage phenotype, suppressible by Pink1^UAS.cYa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible | adult stage phenotype, suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has visible phenotype, suppressible by Buffy^UAS.cQa/Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible by Debcl^JF02429, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage phenotype, suppressible by Debcl^JF02429, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has visible | adult stage phenotype, suppressible by Debcl^JF02429, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^C164 has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^C164

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal locomotor behavior | third instar larval stage phenotype, suppressible | partially by Rab11^UAS.EGFP, Scer\GAL4^ple.PF

(Breda et al., 2015)

FBal0156007:, Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal locomotor behavior | adult stage phenotype, suppressible | partially by Rab11^UAS.EGFP/Rab11^UAS.EGFP

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Scer\GAL4^elav-C155/Rab11^UAS.EGFP

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by Scer\GAL4^ple.PF/Rab11^UAS.EGFP

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neurophysiology | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal locomotor behavior | adult stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has short lived | adult stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal locomotor behavior phenotype, suppressible by Nedd4^UAS.Tag:MYC, Scer\GAL4^elav.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has decreased cell number | adult stage | progressive phenotype, suppressible by chico¹/chico[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal neuroanatomy | adult stage | progressive phenotype, suppressible by chico¹/chico[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS has visible phenotype, suppressible by Hsap\CRYAB^UAS.Tag:HA, Scer\GAL4^GMR.PS

(Tue et al., 2012)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal neuroanatomy phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^ple.PF

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^unspecified has short lived phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^unspecified

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^unspecified has abnormal locomotor behavior phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^unspecified

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has abnormal neuroanatomy phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^elav-C155

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has abnormal neuroanatomy | conditional | adult stage phenotype, suppressible by HDAC6^UAS.cDa, Scer\GAL4^GMR.PU

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage phenotype, suppressible by Shark^UAS.cFa, Scer\GAL4^elav.PU

(Chen et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\UBC^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\UBC^{K48.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior | adult stage phenotype, suppressible by Hsap\UBC^{K63R.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage | progressive phenotype, suppressible by Pink1^UAS.cTa, Scer\GAL4^Ddc.PL

(Todd and Staveley, 2008)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has abnormal neuroanatomy phenotype, suppressible by Mmus\Rab1a^UAS.cCa, Scer\GAL4^ple.PF

(Cooper et al., 2006)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal neuroanatomy | adult stage | conditional phenotype, suppressible by Sin3A⁰⁸²⁶⁹

(Kontopoulos et al., 2006)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior phenotype, suppressible by park^UAS.cHa, Scer\GAL4^GMR.PF

(Haywood and Staveley, 2004)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal neuroanatomy phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has abnormal neuroanatomy phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT suppressed by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has decreased cell number | adult stage phenotype, non-suppressible by Hsap\DNAJC13^{wt.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Hsap\UBC^{K48R.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Hsap\UBC^{K63.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Enhancer of

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Glo1^KK109109, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 is an enhancer of short lived phenotype of Glo1^KK109109, Scer\GAL4^elav-C155

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^elav-C155, Tpi^GD10138

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 is an enhancer of short lived phenotype of Scer\GAL4^elav-C155, Tpi^GD10138

(Vicente Miranda et al., 2017)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Scer\GAL4^ple.PF/Hsap\SNCA^UAS.cFa is an enhancer of decreased cell number | adult stage | progressive phenotype of Pgi^EY09730

(Knight et al., 2014)

Scer\GAL4^ple.PF/Hsap\SNCA^UAS.cFa is an enhancer of abnormal neuroanatomy | adult stage | progressive phenotype of Pgi^EY09730

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Scer\GAL4^GMR.PS, Vps35^GD11710

(Miura et al., 2014)

Scer\GAL4^elav-C155/Hsap\SNCA^UAS.cFa is an enhancer of abnormal neuroanatomy phenotype of Hsap\HTT^GMR.Q120

(Winslow et al., 2010)

Hsap\SNCA^UAS.cFa is an enhancer of visible phenotype of Scer\GAL4^GMR.PF

(Todd and Staveley, 2008)

Other

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL, anne^KK107621 has decreased cell number | adult stage phenotype

(Dhanushkodi et al., 2023)

Hsap\DNAJC13^{N855S.UAS.Tag:MYC}, Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has abnormal locomotor behavior | adult stage | progressive phenotype

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS, Vps35^GD11710 has visible | adult stage phenotype

(Miura et al., 2014)

Gprk2^UAS.cCb, Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has abnormal neuroanatomy | adult stage phenotype

(Chen and Feany, 2005)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | adult stage phenotype, enhanceable by Hsap\DNAJC13^{N855S.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye | adult stage phenotype, enhanceable by Vps28^GD7696, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Buffy^RNAi.UAS/Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has ommatidium phenotype, enhanceable by Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has eye | adult stage phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, enhanceable by Debcl^UAS.Tag:HA, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has dopaminergic neuron | progressive phenotype, enhanceable by Gba1a^GD6246, Scer\GAL4^elav-C155

(Suzuki et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron phenotype, enhanceable by Nedd4^GD5146, Scer\GAL4^elav.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic neuron | progressive phenotype, enhanceable by Pgi^EY09730/Pgi[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic neuron | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has ommatidium | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye photoreceptor cell | conditional phenotype, enhanceable by HDAC6^KO

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has eye phenotype, enhanceable by Pink1^UAS.cTa

(Todd and Staveley, 2008)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | adult stage | progressive phenotype, enhanceable by Gprk2^UAS.cCb, Scer\GAL4^elav.PU

(Chen and Feany, 2005)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, enhanceable by Hsc70-4^K71S.UAS, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has mitochondrion | larval stage phenotype, non-enhanceable by Hsap\MFN2^UAS.cDa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | adult stage phenotype, non-enhanceable by Hsap\DNAJC13^{wt.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, non-enhanceable by Nedd4^GD5146, Scer\GAL4^GMR.PU

(Davies et al., 2014)

Suppressed by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has mitochondrion | larval stage phenotype, suppressible by Drp1^KG03815

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has mitochondrion | larval stage phenotype, suppressible by Drp1^UAS.cDa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has mitochondrion | larval stage phenotype, suppressible by Pink1^UAS.cYa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has larval brain | larval stage phenotype, suppressible by park^UAS.cGa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has larval brain | larval stage phenotype, suppressible by Pink1^UAS.cYa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long has ommatidium | progressive phenotype, suppressible | partially by Ire1^GD3071, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long has retina | progressive phenotype, suppressible | partially by Ire1^GD3071, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long has retina | progressive phenotype, suppressible | partially by Ire1^HMS03003, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.long has ommatidium | progressive phenotype, suppressible | partially by Ire1^HMS03003, Scer\GAL4^GMR.long

(Yan et al., 2019)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye | adult stage phenotype, suppressible by Usp8^HMS01898, Scer\GAL4^GMR.PU

(Alexopoulou et al., 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by Buffy^UAS.cQa/Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has eye | adult stage phenotype, suppressible by Debcl^JF02429, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium | adult stage phenotype, suppressible by Debcl^JF02429, Scer\GAL4^GMR.PF

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic PPL1 neuron | adult stage phenotype, suppressible by Scer\GAL4^elav-C155/Rab11^UAS.EGFP

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has rhabdomere of eye photoreceptor cell | adult stage phenotype, suppressible | partially by Rab11^UAS.EGFP, Scer\GAL4^GMR.PU

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has NMJ bouton | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has synaptic vesicle | third instar larval stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has dopaminergic PPL1 neuron | adult stage phenotype, suppressible by Rab11^UAS.EGFP, Scer\GAL4^elav-C155

(Breda et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, suppressible by Nedd4^UAS.Tag:MYC, Scer\GAL4^GMR.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron phenotype, suppressible by Nedd4^UAS.Tag:MYC/Scer\GAL4^GMR.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic neuron | progressive phenotype, suppressible by chico¹/chico[+]

(Knight et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS has eye phenotype, suppressible by Hsap\CRYAB^UAS.Tag:HA, Scer\GAL4^GMR.PS

(Tue et al., 2012)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic neuron phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^ple.PF

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has ommatidium phenotype, suppressible by Hsap\SNCAIP^UAS.cHa, Scer\GAL4^elav-C155

(Hernández-Vargas et al., 2011)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has ommatidium | conditional phenotype, suppressible by HDAC6^UAS.cDa, Scer\GAL4^GMR.PU

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye photoreceptor cell | conditional phenotype, suppressible by HDAC6^UAS.cDa, Scer\GAL4^GMR.PU

(Du et al., 2010)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | adult stage phenotype, suppressible by Shark^UAS.cFa, Scer\GAL4^elav.PU

(Chen et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\UBC^UAS.Tag:HA, Scer\GAL4^Ddc.PL

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by Hsap\UBC^UAS.Tag:HA, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by Hsap\UBC^{K48.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has rhabdomere phenotype, suppressible by Hsap\UBC^{K63R.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has retina | progressive phenotype, suppressible by Pink1^UAS.cTa, Scer\GAL4^GMR.PF

(Todd and Staveley, 2008)

Hsap\SNCA^UAS.cFa, Scer\GAL4^ple.PF has dopaminergic neuron phenotype, suppressible by Mmus\Rab1a^UAS.cCa, Scer\GAL4^ple.PF

(Cooper et al., 2006)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | conditional phenotype, suppressible by Sin3A⁰⁸²⁶⁹

(Kontopoulos et al., 2006)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has ommatidium phenotype, suppressible by park^UAS.cHa, Scer\GAL4^GMR.PF

(Haywood and Staveley, 2004)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Ddc.PL

(Yang et al., 2003)

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL has dopaminergic neuron phenotype, suppressible by Hsap\HSPA1L^UAS.cWa, Scer\GAL4^Ddc.PL

(Auluck et al., 2002)

NOT suppressed by

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Appl.G1a has mitochondrion | larval stage phenotype, non-suppressible by Hsap\MFN2^UAS.cDa, Scer\GAL4^Appl.G1a

(Krzystek et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^elav.PU has dopaminergic neuron | adult stage phenotype, non-suppressible by Hsap\DNAJC13^{wt.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU has eye | heat sensitive phenotype, non-suppressible by Nedd4^GD5146, Scer\GAL4^GMR.PU

(Davies et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-suppressible by Hsap\UBC^{K48R.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has rhabdomere phenotype, non-suppressible by Hsap\UBC^{K63.UAS.Tag:HA}, Scer\GAL4^GMR.PF

(Lee et al., 2009)

Enhancer of

Statement

Reference

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of photoreceptor neuron | adult stage phenotype of Lsd2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of lipid droplet | adult stage | increased number phenotype of Lsd2^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of lipid droplet | adult stage | increased number phenotype of CG7900^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of photoreceptor neuron | adult stage phenotype of CG7900^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of lipid droplet | adult stage | increased number phenotype of Lsd1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa/Scer\GAL4^GMR.PU is an enhancer of photoreceptor neuron | adult stage phenotype of Lsd1^UAS.EGFP, Scer\GAL4^ninaE.PT

(Girard et al., 2021)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS is an enhancer of ommatidium phenotype of Hsap\DNAJC13^{N855S.UAS.Tag:MYC}, Scer\GAL4^GMR.PS

(Yoshida et al., 2018)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of ommatidium phenotype of Atg6^GD11647, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU is an enhancer of ommatidium phenotype of Pi3K59F^KK107602, Scer\GAL4^GMR.PU

(M'Angale and Staveley, 2016)

Scer\GAL4^ple.PF/Hsap\SNCA^UAS.cFa is an enhancer of dopaminergic neuron | progressive phenotype of Pgi^EY09730

(Knight et al., 2014)

Scer\GAL4^elav-C155/Hsap\SNCA^UAS.cFa is an enhancer of rhabdomere of eye photoreceptor cell phenotype of Hsap\HTT^GMR.Q120

(Winslow et al., 2010)

Hsap\SNCA^UAS.cFa is an enhancer of eye phenotype of Scer\GAL4^GMR.PF

(Todd and Staveley, 2008)

Other

Statement

Reference

Hsap\SNCA^UAS.cFa, Scer\GAL4^Ddc.PL, anne^KK107621 has adult dopaminergic neuron | decreased number phenotype

(Dhanushkodi et al., 2023)

Gba1a^GD6246, Hsap\SNCA^UAS.cFa, Scer\GAL4^elav-C155 has retina phenotype

(Suzuki et al., 2015)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS, Vps35^GD11710 has ommatidium phenotype

(Miura et al., 2014)

Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PS, Vps35^GD11710 has interommatidial bristle phenotype

(Miura et al., 2014)

Gprk2^UAS.cCb, Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PF has retina phenotype

(Chen and Feany, 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Buffy^Scer\UAS.cQa suppresses the ommatidial defects (i.e ommatidial number and ommatidial array organization ) induced by the expression of either Pi3K59F^KK107602 or Atg6^GD11647 under the control of Scer\GAL4^GMR.PU.

The co-expression of Buffy^Scer\UAS.cQa respectively enhances and suppresses the Atg6^GD11647- Pi3K59F^KK107602-induced (expression driven by Scer\GAL4^Ddc.PL) decreased longevity and progressive decrease in adult locomotion.

(M'Angale and Staveley, 2016)

Xenogenetic Interactions

Statement

Reference

Co-expressing Hsap\SNCA^UAS.cFa with Hsap\DNAJC13^{wt.UAS.Tag:MYC} under the control of Scer\GAL4^GMR.PS does not significantly affect the number of ommatidia.

Co-expressing Hsap\SNCA^UAS.cFa with Hsap\DNAJC13^{N855S.UAS.Tag:MYC}, but not with Hsap\DNAJC13^{wt.UAS.Tag:MYC}, under the control of Scer\GAL4^elav.PU leads to a significant, age-dependent decrease in climbing activity.

(Yoshida et al., 2018)

The co-expression of Hsap\SNCA^Scer\UAS.cFa with either Glo1^KK109109 or Tpi^GD10138 under the control of Scer\GAL4^elav-C155 leads to a significant and progressive decrease in adult locomotor capacity (in negative geotaxis assays) and a significant decrease in lifespan; these are more severe than the respective single expressions, with the exception that the decreased lifespan induced by the Hsap\SNCA^Scer\UAS.cFa, Tpi^GD10138 co-expression is only more severe than the Tpi^GD10138 single expression condition.

(Vicente Miranda et al., 2017)

The rough eye phenotype characteristic for adult flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU is restored by co-expression of Usp8^HMS01898 and worsened further by co-expression of Vps28^GD7696.

(Alexopoulou et al., 2016)

Co-expression of Buffy^{dsRNA.Scer\UAS} enhances shortened lifespan in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^Ddc.PL. Co-expression of Buffy^Scer\UAS.cQa suppresses shortened lifespan and impaired climbing ability in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^Ddc.PL.

Co-expression of Buffy^{dsRNA.Scer\UAS} enhances the rough eye phenotype seen in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^GMR.PU. Co-expression of Buffy^Scer\UAS.cQa suppresses the rough eye phenotype seen in flies with expression of Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^GMR.PU.

(M'Angale and Staveley, 2016)

The co-expression of either Hsap\SNCA^Scer\UAS.cFa and Pi3K59F^KK107602 or Hsap\SNCA^Scer\UAS.cFa and Atg6^GD11647 under the control of Scer\GAL4^GMR.PU, leads to a decrease in the number of ommatidia and consequent disruption of the ommatidial array, both of which are more severe than upon each single expression conditions.

The decreased longevity, but not the progressive decrease in adult locomotion, induced by the expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL is enhanced by the co-expression of either Pi3K59F^KK107602 or Atg6^GD11647.

(M'Angale and Staveley, 2016)

The reduced adult lifespan and poor climbing ability characteristic for adult flies expressing Hsap\SNCA^Scer\UAS.cFa (with the Scer\GAL4^Ddc.PL driver) as well as the morphological eye defects and ommatidial disarray (using the Scer\GAL4^GMR.PF driver) are significantly improved by co-expression of Debcl^JF02429 RNAi, while co-expression of Debcl^{Scer\UAS.T:Ivir\HA1} further worsens the phenotypes.

(M'Angale and Staveley, 2016)

Co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} suppresses increased mEJP and eEJP amplitudes and increased quantal content as well as increased synaptic vesicle size at boutons at the NMJs in third instar larvae expressing Hsap\SNCA^Scer\UAS.cFa driven by Scer\GAL4^elav-C155

The defective crawling behavior (decrease in distance travelled per unit of time) characteristic for third instar larvae expressing Hsap\SNCA^Scer\UAS.cFa under the control of either Scer\GAL4^C164 or Scer\GAL4^ple.PF can be suppressed by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} using the Scer\GAL4^C164 driver and partially suppressed when the Scer\GAL4^ple.PF driver is used.

The loss of dopaminergic PPL1 neurons in the adult brain characteristic for flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of either Scer\GAL4^elav-C155 or Scer\GAL4^ple.PF can be reversed by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} using either of the two drivers.

The decrease in the number of rhabdomeres in the adult eye observed in flies expressing Hsap\SNCA^Scer\UAS.cFa under the control Scer\GAL4^GMR.PU can be partially restored by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP}.

The defects in climbing behavior seen in adult flies or various ages (10, 20 and 30 day-old) expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 can be suppressed by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP}.

The defects in climbing behavior seen in adult flies or various ages (10, 20 and 30 day-old) expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF are suppressed by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP} in 30 day-old flies only.

The shortened lifespan characteristic for adult flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 can be reversed by co-expression of Rab11^{Scer\UAS.T:Avic\GFP-EGFP}.

(Breda et al., 2015)

Expression of Gba1a^GD6246 enhances the reduction in climbing activity and loss of dopaminergic neurons seen in flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155.

The eyes of flies co-expressing Hsap\SNCA^Scer\UAS.cFa and Gba1a^GD6246 under the control of Scer\GAL4^GMR.PS exhibit retinal thinning. No thinning is seen when either transgene is expressed alone.

Expression of Gal^GD936 enhances the reduction in climbing activity seen in flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155.

(Suzuki et al., 2015)

Co-expression of Nedd4^{Scer\UAS.T:Hsap\MYC} suppresses the rough eye phenotype induced by expression of Hsap\SNCA^Scer\UAS.cFa in the developing eye under the control of Scer\GAL4^GMR.PU.

Knockdown of Nedd4, through expression of Nedd4^GD5146 does not affect the rough eye phenotype induced by Hsap\SNCA^Scer\UAS.cFa in the developing eye under the control of Scer\GAL4^GMR.PU.

Co-expression of Nedd4^{Scer\UAS.T:Hsap\MYC} prevents the climbing deficit associated with neuronal Hsap\SNCA^Scer\UAS.cFa expression (both constructs under the control of Scer\GAL4^elav.PU.

Knockdown of Nedd4, through expression of Nedd4^GD5146, significantly worsens the climbing deficits found upon Hsap\SNCA^Scer\UAS.cFa expression (both constructs under the control of Scer\GAL4^elav.PU).

Knockdown of Nedd4, through expression of Nedd4^GD5146, combined with expression of Hsap\SNCA^Scer\UAS.cFa, in the nervous system (under the control of Scer\GAL4^elav.PU) leads to a significant reduction in the number of ple-positive neurons in the dorsomedial cluster when compared to controls.

Co-expression of Nedd4^{Scer\UAS.T:Hsap\MYC} prevents Hsap\SNCA^Scer\UAS.cFa-induced dopaminergic cell loss.

(Davies et al., 2014)

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF in chico¹/+ mutants does not lead to any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but chico¹/+ suppresses the dopaminergic neuron loss seen in 20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF.

Expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF in Pgi^EY09730/+ mutants does not lead to any significant difference in the number of dopaminergic neurons in newly eclosed adult males, but these flies show enhanced dopaminergic neuron loss seen at 20 days old as compared to either Pgi^EY09730/+ mutants or flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF.

(Knight et al., 2014)

Co-expression of Vps35^GD11710 and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PS leads to a small reduction in size of each ommatidium along with loss of interommatidial bristles, as compared to controls; and leads to a more severe progressive climbing defect, as compared to expression of either single allele alone.

(Miura et al., 2014)

The rough eye phenotype caused by expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PS is suppressed by co-expression of Hsap\CRYAB^{Scer\UAS.T:Ivir\HA1}.

(Tue et al., 2012)

Co-expression of Hsap\SNCAIP^Scer\UAS.cHa and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav-C155 suppresses the ommatidium phenotype resulting from the expression of either transgene alone.

Co-expression of Hsap\SNCAIP^Scer\UAS.cHa and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF increases the number of dopaminergic neurons compared with wild-type or the expression-phenotype of either transgene alone.

Flies co-expressing Hsap\SNCAIP^Scer\UAS.cHa and Hsap\SNCA^Scer\UAS.cFa via Scer\GAL4^unspecified show reduction in age-associated motility and mortality very similar to that of wild-type controls.

(Hernández-Vargas et al., 2011)

HDAC6^KO enhances the loss of dopaminergic (DA) neurons caused by expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF; the neuron degeneration phenotype is apparent at 10 days after eclosion in the double mutant flies, and 20 days after eclosion it is more severe than that seen in the Hsap\SNCA^Scer\UAS.cFa, Scer\GAL4^ple.PF single mutants.

HDAC6^KO enhances the retinal degeneration phenotype seen in adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU.

Co-expression of HDAC6^Scer\UAS.cDa suppresses the retinal degeneration phenotype seen in adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU.

HDAC6^KO enhances the climbing ability defect caused by expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF; defects are seen 10 days after eclosion in the double mutant flies (defects are not seen until 20 days after eclosion in Hsap\SNCA^Scer\UAS.cFa, Scer\GAL4^ple.PF single mutants) and the defects at 20 days after eclosion are more severe in the double mutants.

HDAC6^KO decreases the number of Lewy body-like Hsap\SNCA positive inclusions seen in the brains of adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF such that no inclusions are seen in 10 day old flies and the number of inclusions seen in 20 days old flies is reduced.

(Du et al., 2010)

Coexpression of shark^Scer\UAS.cFa significantly rescues the neurotoxicity of Scer\GAL4^elav.PU-mediated Hsap\SNCA^Scer\UAS.cFa expression.

(Chen et al., 2009)

Co-expression of Hsap\UBC^{Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^GMR.PF significantly suppresses the neurodegenerative process induced by Hsap\SNCA^Scer\UAS.cFa.

Co-expression of Hsap\UBC^{K48.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^GMR.PF significantly suppresses the neurodegenerative process induced by Hsap\SNCA^Scer\UAS.cFa.

Co-expression of Hsap\UBC^{K63R.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^GMR.PF significantly suppresses the neurodegenerative process induced by Hsap\SNCA^Scer\UAS.cFa.

Co-expression of Hsap\UBC^{K48R.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^GMR.PF does not suppresses the neurodegenerative process induced by Hsap\SNCA^Scer\UAS.cFa.

Co-expression of Hsap\UBC^{K63.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^GMR.PF does not suppresses the neurodegenerative process induced by Hsap\SNCA^Scer\UAS.cFa.

Co-expression of Hsap\UBC^{Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^elav-C155 in transgenic flies significantly suppresses the Hsap\SNCA^Scer\UAS.cFa-induced motor impairment.

Co-expression of Hsap\UBC^{K48.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^elav-C155 in transgenic flies significantly suppresses the Hsap\SNCA^Scer\UAS.cFa-induced motor impairment.

Co-expression of Hsap\UBC^{K63R.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^elav-C155 in transgenic flies significantly suppresses the Hsap\SNCA^Scer\UAS.cFa-induced motor impairment.

Co-expression of Hsap\UBC^{K48R.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^elav-C155 in transgenic flies does not suppresses the Hsap\SNCA^Scer\UAS.cFa-induced motor impairment.

Co-expression of Hsap\UBC^{K63.Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^elav-C155 in transgenic flies does not suppresses the Hsap\SNCA^Scer\UAS.cFa-induced motor impairment.

Co-expression of Hsap\UBC^{Scer\UAS.T:Ivir\HA} driven by Scer\GAL4^Ddc.PL suppresses the Hsap\SNCA^Scer\UAS.cFa-induced loss of dorsomedial cluster 1 dopaminergic neurons in the brain.

(Lee et al., 2009)

Expression of Pink1^Scer\UAS.cTa completely suppresses the premature loss of climbing ability seen when Hsap\SNCA^Scer\UAS.cFa is expressed under the control of Scer\GAL4^Ddc.PL. The lifespan of these flies is similar to controls.

Expression of Hsap\SNCA^Scer\UAS.cFa enhances the rough eye phenotype seen in Scer\GAL4^GMR.PF/+ flies at 29[o]C. Approximately 50% of the eye area contains fused or enlarged ommatidia. Co-expression of Pink1^Scer\UAS.cTa suppresses this phenotype, returning the proportion of eye fusion to the level seen when Scer\GAL4^GMR.PF is expressed alone. The retinal deterioration seen in 30 day old flies is suppressed.

(Todd and Staveley, 2008)

The loss of dopaminergic neurons that is seen in the brains of flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^ple.PF is suppressed by co-expression of Mmus\Rab1^Scer\UAS.cCa.

(Cooper et al., 2006)

Sin3A⁰⁸²⁶⁹ rescues the progressive loss of dorsomedial dopamine neurons in the brain seen in flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU.

(Kontopoulos et al., 2006)

Co-expression of Gprk2^Scer\UAS.cCb enhances the loss of dorsomedial dopaminergic neurons which is seen in adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^elav.PU, with cell loss being seen in 10 day old double mutant flies.

Co-expression of Gprk2^Scer\UAS.cCb and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PF results in marked cell loss in the retina as early as 10 days of age.

(Chen and Feany, 2005)

The reduction in the number of dopaminergic neurons in the dorsomedial clusters of the brain seen in 20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL is suppressed by coexpression of Hsap\PARK2^Scer\UAS.cYa.

(Yang et al., 2003)

The loss of dorsomedial dopaminergic neurons seen in 20 day old flies expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL is suppressed by co-expression of Hsap\HSPA1L^Scer\UAS.cWa, although there is no change in the number, morphology or distribution of inclusions seen in the dopaminergic neurons. Co-expression of Hsc70-4^{K71S.Scer\UAS} accelerates the loss of dopaminergic neurons caused by expression of Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL; neuronal loss is apparent in 1 day old flies expressing both Hsc70-4^{K71S.Scer\UAS} and Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL whereas neuronal loss in flies overexpressing only Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^Ddc.PL occurs by 10 to 20 days.

(Auluck et al., 2002)

Complementation and Rescue Data

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Mutant

Wild-type

Stocks (1)

Bloomington

8146

w^*; P{UAS-Hsap\SNCA.F}5B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Hsap\SNCA^Scer\UAS.cFa

Hsap\SNCA^UAS.cFa

Syn^WT

(Alexopoulou et al., 2016)

syn^WT

(Kontopoulos et al., 2006)

α-syn^WT

(Periquet et al., 2007)

αSyn^WT

(Yan et al., 2019)

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Feany

(Feany and Bender, 2000)

Secondary FlyBase IDs

References (92)

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