FlyBase Gene Report: Dmel\Cyp4g1

General Information

Symbol

Dmel\Cyp4g1

Species

D. melanogaster

Name

Cytochrome P450 4g1

Annotation Symbol

CG3972

Feature Type

protein_coding_gene

FlyBase ID

FBgn0010019

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. [Date last reviewed: 2020-01-16] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

T1, EG:165H7.1 , P450, ASC-T1, P-450-A

Key Links

Genomic Location

Cytogenetic map

1B4-1B4

Sequence location

X:467,057..469,335 [-]

Recombination map

1-0

RefSeq locus

NC_004354 REGION:467057..469335

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables long-chain fatty aldehyde oxidative decarbonylase activity

inferred from mutant phenotype

(Qiu et al., 2012)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables heme binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables iron ion binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables monooxygenase activity

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972, InterPro:IPR036396

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in cuticle hydrocarbon biosynthetic process

inferred from mutant phenotype

(Qiu et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYTOCHROME P450 - CYP4 CLAN

UNCLASSIFIED CARBON-CARBON LYASES

Protein Family (UniProt)

Belongs to the cytochrome P450 family. (Q9V3S0)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

long-chain fatty aldehyde oxidative decarbonylase activity
RHEA 83563:

Summaries

Gene Snapshot

Cytochrome P450-4g1 (Cyp4g1) encodes the terminal oxidative decarbonylase in cuticular hydrocarbon biosynthesis within oenocytes. [Date last reviewed: 2020-01-16]

Gene Group (FlyBase)

CYTOCHROME P450 - CYP4 CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP4 clan includes D. melanogaster CYP4, 311-313, 316 and 318 family genes. Few CYP4 enzymes have been characterized, though some CYP4 genes are inducible by xenobiotics. (Adapted from FBrf0248421.)
UNCLASSIFIED CARBON-CARBON LYASES -: This group comprises carbon-carbon lyases that do not classify under other groups in flybase.

Protein Function (UniProtKB)

May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.

(UniProt, Q9V3S0)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp4g1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V3S0)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp4g1-RA

FBtr0070099

NM_080292

2279

556

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyp4g1-PA

FBpp0070094

63.0

556

7.47

Q9V3S0

NP_525031

AAF45503

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

59 (kD)

(Sundseth et al., 1989)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V3S0

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4g1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyp4g1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.27

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism

Comment: maternal

(Chung et al., 2009)

embryonic stage 7 -- 16

embryonic/larval oenocyte

(Chung et al., 2009)

embryonic stage 13 -- 16

embryonic/larval oenocyte

(Fisher et al., 2012)

embryonic stage 16

ring gland

(Niwa et al., 2011)

embryonic/larval oenocyte

(Niwa et al., 2011)

third instar larval stage

embryonic/larval oenocyte

(Chung et al., 2009)

larval ring gland | restricted

(Niwa et al., 2011)

prothoracic gland | restricted

(Niwa et al., 2011)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

organism

Comment: induced after emergence

(Storelli et al., 2019)

Additional Descriptive Data

Cyp4g1 expression is induced after emergence and peaks at day 2.

(Storelli et al., 2019)

Cyp4g1 transcripts are present in equal levels in an insecticide resistant strain (91-R) and a susceptible strain (91-C).

(Waters et al., 1992)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval oenocyte

(Brodu et al., 2004)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Cyt-P450-A1 protein was found in all insecticide resistant and susceptible strains tested.

(Sundseth et al., 1989)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp4g1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp4g1

View exonic expression by tissue for Dmel\Cyp4g1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010019

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

30986/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010019

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010019

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010019

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3972

Flygut - An atlas of the Drosophila adult midgut

FBgn0010019

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cyp4g1

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp4g1

Transgenic constructs containing regulatory region of Cyp4g1

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene not disrupted in

Df(1)ase-1

(Gonzalez et al., 1989, Alonso and Cabrera, 1988, Campuzano et al., 1985)

Df(1)sc19

(Alonso and Cabrera, 1988)

In(1)sc^4Lsc^9R

(Alonso and Cabrera, 1988)

In(1)sc^8Lsc^4R

(Alonso and Cabrera, 1988)

In(1)y^3PLsc^8R

(Alonso and Cabrera, 1988)

Gene disrupted in

Df(1)260-1

(Giebel et al., 1997, Duffy and Gergen, 1991)

Inferred from location ( 12 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die before end of pupal stage | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp4g1^GD3166

viable, with Scer\GAL4^Mef2.PR

Cyp4g1^GD3166

viable, with Scer\GAL4^pnr-MD237

Cyp4g1^GD3166

viable, with Scer\GAL4^tin.CΔ4

Cyp4g1^GD3166

Other Phenotypes

Allele

abnormal eclosion, with Scer\GAL4^Desat1.RE

Cyp4g1^KK105644

abnormal eclosion | male

abnormal starvation stress response | larval stage

Cyp4g1^Δ4

abnormal starvation stress response | larval stage, with Scer\GAL4^Desat1.PB

Cyp4g1^RNAi.UAS

abnormal stress response | adult stage, with Scer\GAL4^insc-Mz1407

Cyp4g1^NIG.3972R

increased mortality, with Scer\GAL4^Desat1.RE

Cyp4g1^KK105644

increased mortality | male

short lived, with Scer\GAL4^Desat1.RE

Cyp4g1^KK105644

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Cyp4g1^GD3166

some die during pupal stage | recessive

Phenotype manifest in

Allele

embryonic/larval oenocyte | larval stage

Cyp4g1^Δ4

embryonic/larval oenocyte | larval stage, with Scer\GAL4^Desat1.PB

Cyp4g1^RNAi.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\CYP4V2

6 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CYP7B1

1 of 14

Yes

Hsap\CYP8B1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CYP46A1

1 of 14

Hsap\CYP51A1

1 of 14

Yes

Hsap\PTGIS

1 of 14

Yes

Hsap\TBXAS1

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (41)

Rnor\Cyp4v3

6 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cyp7a1

1 of 14

Yes

Rnor\Cyp7b1

1 of 14

Yes

Rnor\Cyp8b1

1 of 14

Yes

Rnor\Cyp11b1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cyp26c1

1 of 14

Yes

Rnor\Cyp27a1

1 of 14

Rnor\Cyp27b1

1 of 14

Rnor\Cyp39a1

1 of 14

Yes

Rnor\Cyp51

1 of 14

Yes

Rnor\LOC680316

1 of 14

Yes

Rnor\LOC103692784

1 of 14

Yes

Rnor\Ptgis

1 of 14

Yes

Mus musculus (laboratory mouse) (46)

Mmus\Cyp4v3

6 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cyp7b1

1 of 14

Yes

Mmus\Cyp8b1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cyp27a1

1 of 14

Mmus\Cyp27b1

1 of 14

Mmus\Cyp39a1

1 of 14

Yes

Mmus\Cyp51

1 of 14

Yes

Mmus\Ptgis

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (27)

Xtro\XB980013

4 of 13

Yes

Xtro\cyp4b1.2

3 of 13

Yes

Xtro\cyp4f22

3 of 13

Yes

Xtro\cyp4v2.2

3 of 13

Xtro\XB5810926

3 of 13

Xtro\cyp19a1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cyp4v2.1

1 of 13

Xtro\cyp7a1

1 of 13

Yes

Xtro\cyp7b1

1 of 13

Yes

Xtro\cyp8b1.2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (34)

Drer\cyp4v7

6 of 14

Yes

Drer\cyp4v8

6 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cyp7a1

1 of 14

Yes

Drer\cyp7b1

1 of 14

Yes

Drer\cyp8b1

1 of 14

Yes

Drer\cyp8b2

1 of 14

Yes

Drer\cyp8b3

1 of 14

Yes

Drer\cyp19a1b

1 of 14

Yes

Drer\cyp24a1

1 of 14

Drer\cyp26a1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\si:ch211-113j14.1

1 of 14

Drer\si:dkey-91i10.3

1 of 14

Drer\zgc:136333

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (23)

Cele\cyp-29A2

5 of 14

Yes

Cele\cyp-29A3

5 of 14

Yes

Cele\cyp-29A4

5 of 14

Yes

Cele\cyp-31A2

5 of 14

Yes

Cele\cyp-31A3

5 of 14

Yes

Cele\cyp-32A1

5 of 14

Yes

Cele\cyp-32B1

5 of 14

Yes

Cele\cyp-37A1

5 of 14

Yes

Cele\cyp-37B1

5 of 14

Yes

Cele\cyp-42A1

5 of 14

Yes

4 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (91)

Agam\AgaP_AGAP000877

7 of 12

Yes

6 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (92)

Atha\CYP704A2

6 of 13

Yes

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

Yes

Atha\CYP96A3

4 of 13

Yes

Atha\CYP96A4

4 of 13

Atha\CYP96A5

4 of 13

Atha\CYP96A8

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

Yes

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

Yes

Atha\CYP710A2

2 of 13

Atha\CYP710A3

2 of 13

Yes

Atha\CYP710A4

2 of 13

Yes

Atha\CYP711A1

2 of 13

Atha\AOS

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\BR6OX2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\ERG5

4 of 13

Yes

Scer\DIT2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\erg11

2 of 12

Yes

Spom\erg5

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyp4g1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (72)

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

5 of 13

4 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

sad

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

dib

1 of 13

shd

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

CYP4V2; cytochrome P450 family 4 subfamily V member 2

model of Bietti crystalline corneoretinal dystrophy

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYP4V2; cytochrome P450 family 4 subfamily V member 2

6 of 14

608614

BIETTI CRYSTALLINE CORNEORETINAL DYSTROPHY; BCD

Bietti crystalline corneoretinal dystrophy

CYP4A11; cytochrome P450 family 4 subfamily A member 11

4 of 14

601310

CYP4B1; cytochrome P450 family 4 subfamily B member 1

4 of 14

124075

CYP4F2; cytochrome P450 family 4 subfamily F member 2

4 of 14

604426

CYP4F3; cytochrome P450 family 4 subfamily F member 3

4 of 14

601270

CYP4F8; cytochrome P450 family 4 subfamily F member 8

4 of 14

611545

CYP4F11; cytochrome P450 family 4 subfamily F member 11

4 of 14

611517

CYP4F12; cytochrome P450 family 4 subfamily F member 12

4 of 14

611485

CYP4F22; cytochrome P450 family 4 subfamily F member 22

4 of 14

611495

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 5; ARCI5

autosomal recessive congenital ichthyosis 5

CYP4X1; cytochrome P450 family 4 subfamily X member 1

4 of 14

614999

CYP4A22; cytochrome P450 family 4 subfamily A member 22

3 of 14

615341

CYP4Z1; cytochrome P450 family 4 subfamily Z member 1

3 of 14

618953

CYP4Z2P; cytochrome P450 family 4 subfamily Z member 2, pseudogene

3 of 14

618954

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cyp4g1

suppressible

Cyp4g15

(Kefi et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57559

DroID - A comprehensive database of gene and protein interactions.

FBgn0010019

MIST (protein-protein) - An integrated Molecular Interaction Database

30986

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0

Cytogenetic map

1B4-1B4

Sequence location

X:467,057..469,335 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1B4-1B4

Limits computationally determined from genome sequence between P{EP}CG17896^EP1320&P{EP}EP1398 and P{EP}svr^EP356&P{EP}arg^EP452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

1B-1B

(Dunkov, 2000.6.29, Feyereisen and Dunkov, 1995.11.2)

1B1-1B1

(determined by in situ hybridisation)

(Maitra et al., 1996)

1B-1B

(determined by in situ hybridisation)

(Dunkov et al., 1996)

Experimentally Determined Recombination Data

Location

1-0

(FlyBase, 2016)

1-0.0

(Comeron et al., 2012)

(Feyereisen and Dunkov, 1995.11.2)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

36737

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01628}attP40

NIG-Fly

3972R-1

P{NIG.3972R}1

HMJ22311

y¹ v¹; P{TRiP.HMJ22311}attP40/CyO

HMS01628

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01628}attP40

VDRC

v102864

P{KK105644}VIE-260B

v30207

w¹¹¹⁸; P{GD3166}v30207

Genomic Clones (8)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (322)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0010019

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

GH02673
GH02806
GH03064
GH03653
GH04644
GH05014
GH05611
GH05773
GH05839
GH06263
GH06488
GH06534
GH07216
GH07595
GH07650
GH08141
GH08157
GH08514
GH08593
GH08932
GH09418
GH09563
GH10223
GH11207
GH11938
GH11942
GH13137
GH13284
GH13561
GH13651
GH14271
GH14353
GH14860
GH15604
GH15917
GH15982
GH16021
GH16091
GH16105
GH16462
GH16696
GH18703
GH20504
GH20633
GH21873
GH22070
GH22108
GH22195
GH22216
GH23140
GH23673
GH23894
GH27571
GH28328
GH28448
GH28732
GM01484
LP16908
LP20640
RE26628
RE27566
RE58530
RE65407

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0010019

Antibody Information

Laboratory Generated Antibodies

monoclonal

(Sundseth et al., 1989)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

The intronless Cyp4g1 gene is not a retrogene, as shown by the conserved synteny from Diptera to at least Hymenoptera.

(Feyereisen, 2020)

Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.

(Dunkov et al., 1996)

Corresponds to cytochrome P450 A1 cDNA of FBrf0057534.

(Feyereisen and Dunkov, 1995.11.2)

The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.

(Keogh et al., 1992)

Purification of Cyp4g1 and Cyp6a2 using techniques traditionally used for mammalian P-450.

(Sundseth et al., 1990)

Transcription unit defined during molecular analysis of the achaete-scute complex.

(Alonso and Cabrera, 1988)

Visualised as 59.3kD band on electrophoresis. Ubiquitous in all strains, irrespective of resistance to insecticides (Sundseth, Kennel and Waters, 1989). Monoclonal antibodies raised by Sundseth, Kennel and Waters (1989).

Relationship to Other Genes

Source for database merge of

Source for merge of: Cyp4g1 anon-WO0140519.102

(FlyBase, 1996-)

Additional comments

The Cyp4g1 gene may have been derived from the Cyp4ac1 gene by retroposition.

(Pan and Zhang, 2009)

Source for merge of Cyp4g1 anon-WO0140519.102 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

4g1

(Nelson, 2001.2.5)

ASC-T1

(Gomez-Skarmeta et al., 1995, Romani, 1994.12.12)

CG3972

(National Institute of Genetics Fly Stocks, 2023-, Çiçek et al., 2016, Cammarato et al., 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Benos, 2000.12.13)

CYP4G1

(Feyereisen, 2020, Qiu et al., 2012)

Cyp4G1

(Sato and Yamamoto, 2020)

Cyt-P450-A1

EG:165H7.1

(Benos et al., 2001, Benos, 2000.12.13)

P-450

(Danielson et al., 1995)

P-450-A

(Sundseth et al., 1990, Waters and Nix, 1988)

P450

(Arking, 1998, Zakharenko and Zakharov, 1998, Frolich and Wurgler, 1991)

P450-A

(Sundseth et al., 1989)

P450A

(Brodu et al., 2004)

(Long et al., 2000, Modolell and Campuzano, 1998, Campuzano and Modolell, 1992, Alonso and Cabrera, 1988, Campuzano et al., 1985)

anon-WO0140519.102

cyp4g1

(Wu et al., 2022, Sharma et al., 2011, Al-Anzi et al., 2009)

scγ

(Long et al., 2000)

Name Synonyms

Achaete-scute Complex transcript 1

Cytochrome P450 4g1

(Shafer, 2025, Pedersen et al., 2010)

Cytochrome P450 A1

Cytochrome P450-4g1

(Zhan et al., 2013, Cammarato et al., 2011, Kühnlein, 2010)

cytochrome P450

(Chung et al., 2009)

Secondary FlyBase IDs

FBgn0011757
FBgn0023539
FBgn0044782

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 44 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

30986

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V3S0

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V3S0

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V3S0

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0010019

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

30986/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0010019

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0010019

FlyMine - An integrated database for Drosophila genomics

FBgn0010019

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3972

MARRVEL_MODEL - MARRVEL (model organism gene)

30986

Linkouts

BioGRID - A database of protein and genetic interactions.

57559

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0010019

DroID - A comprehensive database of gene and protein interactions.

FBgn0010019

DRSC - Results frm RNAi screens

FBgn0010019

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyp4g1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0010019

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0010019

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3972

Flygut - An atlas of the Drosophila adult midgut

FBgn0010019

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0010019

MIST (protein-protein) - An integrated Molecular Interaction Database

30986

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (122)

The following external sites may use different assemblies or annotations than FlyBase.

-0.27

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