FlyBase Gene Report: Dmel\Vrp1

FB2025_05 , released December 11, 2025

FB2025_05 , released December 11, 2025

Gene: Dmel\Vrp1

General Information

Symbol

Dmel\Vrp1

Species

D. melanogaster

Name

Verprolin 1

Annotation Symbol

CG13503

Feature Type

protein_coding_gene

FlyBase ID

FBgn0243516

Gene Model Status

Stock Availability

11 publicly available

Gene Summary

Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

sltr, D-WIP, solitary, wip, dWIP

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:22,106,107..22,122,562 [-]

Recombination map

2-98

RefSeq locus

NT_033778 REGION:22106107..22122562

Sequence

Get Decorated FASTA

Genomic Maps

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables actin filament binding

inferred from direct assay

(Kim et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables actin binding

inferred from electronic annotation with InterPro:IPR003124

(InterPro Project Members, 2004-)

enables small GTPase binding

inferred from biological aspect of ancestor with PANTHER:PTN008593182

(GO Reference Genome Project, 2011-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in behavioral response to ethanol

inferred from mutant phenotype

(Kong et al., 2010)

involved_in myoblast fusion

inferred from mutant phenotype

(Berger et al., 2008, Kim et al., 2007, Massarwa et al., 2007, Estrada et al., 2006)

involved_in positive regulation of actin filament polymerization

inferred from direct assay

(Kim et al., 2007)

involved_in regulation of actin filament polymerization

inferred from mutant phenotype

(Rotkopf et al., 2011)

involved_in spermatid development

inferred from mutant phenotype

(Rotkopf et al., 2011)

involved_in visceral muscle development

inferred from mutant phenotype

(Eriksson et al., 2010)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of actin filament polymerization

inferred from biological aspect of ancestor with PANTHER:PTN008593182

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Kim et al., 2007)

located_in filopodium tip

inferred from direct assay

(Berger et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN008593182

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Verprolin 1 (Vrp1) encodes the sole Drosophila homolog of the conserved Verprolin/WASp-interacting-protein family of actin regulators. It facilitates myoblast fusion in somatic muscles by recruiting the branched-actin polymerization machinery to sites of myoblast-myotube attachment and fusion. [Date last reviewed: 2019-03-21]

Summary (Interactive Fly)

facilitator of myoblast fusion - homolog of the conserved Verprolin/WASp Interacting Protein family of WASp-binding proteins - recruits the actin-polymerization machinery to sites of myoblast attachment and fusion

Interactive Fly

Gene Model and Products

Number of Transcripts

12

Number of Unique Polypeptides

7

Please see the JBrowse view of Dmel\Vrp1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A8DYL3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.51

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0071793

3823

751

FBtr0071791

3686

751

FBtr0071795

3345

751

FBtr0071794

3331

751

FBtr0071796

3263

761

FBtr0071792

3407

708

FBtr0113104

4017

852

FBtr0302295

3134

718

FBtr0302296

3410

809

FBtr0302297

3888

809

FBtr0302298

3216

708

FBtr0342980

3281

767

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0071706

76.4

751

11.89

FBpp0071704

76.4

751

11.89

FBpp0071708

76.4

751

11.89

FBpp0071707

76.4

751

11.89

FBpp0071709

77.6

761

11.99

FBpp0071705

71.2

708

11.98

FBpp0112017

86.3

852

11.96

FBpp0291501

72.5

718

12.08

FBpp0291502

81.1

809

12.05

FBpp0291503

81.1

809

12.05

FBpp0291504

71.2

708

11.98

FBpp0309744

78.3

767

11.94

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

751 aa isoforms: Vrp1-PA, Vrp1-PB, Vrp1-PC, Vrp1-PD

708 aa isoforms: Vrp1-PF, Vrp1-PK

809 aa isoforms: Vrp1-PI, Vrp1-PJ

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vrp1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.36

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

embryonic stage 11

embryonic precursor cell of adult muscle

(Massarwa et al., 2007)

embryonic stage 11 -- 12

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

(Fisher et al., 2012)

visceral trunk mesoderm

(Eriksson et al., 2010)

embryonic stage 11 -- 14

embryonic somatic muscle cell

• cytoplasm

Comment: expressed in fusion-competent myoblasts at sites of fusion

(Kim et al., 2007)

embryonic visceral muscle cell

• cytoplasm

(Kim et al., 2007)

embryonic stage 12

fusion competent cell

(Massarwa et al., 2007)

embryonic stage 12 -- 14

somatic trunk mesoderm

(Eriksson et al., 2010)

embryonic stage 12 -- 15

embryonic myoblast

(Massarwa et al., 2007)

embryonic stage 13 -- 16

dorsal pharyngeal muscle cell

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

larval muscle system

(Fisher et al., 2012)

larval somatic muscle cell

(Fisher et al., 2012)

Additional Descriptive Data

Vrp1 is expressed in somatic and visceral muscle starting in embryonic stage 11 and persists in somatic muscle until the end of stage 14 when fusion is completed. It is observed in fusion-competent cells but not in founder cells. It is found within the cytoplasm, specifically at sites of fusion.

(Kim et al., 2007)

Vrp1 expressionis absent during early stages, and is first observed at stage 11 in mesodermal muscle precursors, resolving into myoblast-specific expression that peaks at stage 14, then diminishes and disappears by stage 16.

(Massarwa et al., 2007)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

muscle attachment site

(Eriksson et al., 2010)

larval somatic muscle cell

(Eriksson et al., 2010)

embryonic stage 11 -- 14

embryonic somatic muscle cell

• cytoplasm

Comment: expressed in fusion-competent myoblasts at sites of fusion

(Kim et al., 2007)

embryonic visceral muscle cell

• cytoplasm

(Kim et al., 2007)

fusion competent cell

(Eriksson et al., 2010)

visceral trunk mesoderm

(Eriksson et al., 2010)

embryonic stage 14

fusion competent cell

(Jin et al., 2011)

adult stage | male & spermatogenesis

(Rotkopf et al., 2011)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Vrp1 protein expression is specific to fusion competent cells, and is not expressed in muscle founder cells.

(Jin et al., 2011)

Vrp1-reactive antibody shows specific accumulation within head cyst cells, in close proximity to the sperm nuclear bundle.

(Rotkopf et al., 2011)

Vrp1 is strongly expressed in muscles. It is found in both embryonic visceral mesoderm and somatic muscle as well as muscle attachment sites. Expression in the visceral mesoderm is specific to fusion competent cells and it is not found in muscle founder cells.

(Eriksson et al., 2010)

Vrp1 is expressed in somatic and visceral muscle starting in embryonic stage 11 and persists in somatic muscle until the end of stage 14 when fusion is completed. It is observed in fusion-competent cells but not in founder cells. It is found within the cytoplasm, specifically at sites of fusion.

(Kim et al., 2007)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Kim et al., 2007)

located_in filopodium tip

inferred from direct assay

(Berger et al., 2008)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vrp1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Vrp1

View exonic expression by tissue for Dmel\Vrp1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0243516

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37521/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0243516

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0243516

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0243516

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13503

Flygut - An atlas of the Drosophila adult midgut

FBgn0243516

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Vrp1

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Vrp1

Transgenic constructs containing regulatory region of Vrp1

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

(Eriksson et al., 2010)

(Ryder, 2004.4.26)

(Kim et al., 2007, Ryder, 2004.4.26)

(Massarwa et al., 2007)

(Kim et al., 2007)

Gene partially disrupted in

(Massarwa et al., 2007)

Inferred from location ( 10 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

Vrp1^f06715

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Vrp1^GD8042

viable, with Scer\GAL4^pnr-MD237

Vrp1^GD8042

Sterility

Allele

Vrp1^KO

male sterile, with Scer\GAL4^A3.eya

Vrp1^KK111261

male sterile, with Scer\GAL4^Mef2.PR, Vrp1^S1946/Vrp1^D30

Vrp1^UAS.cMa

male sterile (with Vrp1^D30), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^S1946

male sterile (with Vrp1^S1946), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^D30

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Vrp1^GD8042

chemical sensitive

Vrp1^EY02177

decreased rate of movement | conditional

Vrp1^EY02177

visible, with Scer\GAL4^pnr-MD237

Vrp1^GD8042

Phenotype manifest in

Allele

actin cytoskeleton

Vrp1^S1946

actin filament, with Scer\GAL4^Mef2.PR, Vrp1^S1946/Vrp1^D30

Vrp1^UAS.cMa

actin filament (with Vrp1^D30)

Vrp1^KO

actin filament (with Vrp1^D30), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^S1946

actin filament (with Vrp1^KO)

Vrp1^D30

actin filament (with Vrp1^S1946), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^D30

actin filament & fusion competent cell

Vrp1^S1946

actin filament & muscle founder cell

Vrp1^S1946

dorsal acute muscle cell | embryonic stage

Vrp1^D30

dorsal pharyngeal muscle cell

Vrp1^D30

embryonic myoblast

embryonic somatic muscle cell

Vrp1^f06715

exocytic vesicle & fusion competent cell

Vrp1^S1946

fusion competent cell

head cyst cell, with Scer\GAL4^Mef2.PR, Vrp1^S1946/Vrp1^D30

Vrp1^UAS.cMa

head cyst cell (with Vrp1^D30)

Vrp1^KO

head cyst cell (with Vrp1^D30), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^S1946

head cyst cell (with Vrp1^KO)

Vrp1^D30

head cyst cell (with Vrp1^S1946), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^D30

larval somatic muscle cell, with Scer\GAL4^twi.PB

Vrp1^ΔC.UAS

mesonotum, with Scer\GAL4^pnr-MD237

Vrp1^GD8042

muscle founder cell

myoblast, with Scer\GAL4^twi.PB

Vrp1^ΔC.UAS

myoblast | embryonic stage

plasma membrane | embryonic stage

primordial germ cell | embryonic stage

Vrp1^S1946

primordial germ cell | embryonic stage (with Df(2R)Exel7170)

Vrp1^S1946

seminal vesicle

Vrp1^KO

seminal vesicle, with Scer\GAL4^A3.eya

Vrp1^KK111261

seminal vesicle, with Scer\GAL4^Mef2.PR, Vrp1^S1946/Vrp1^D30

Vrp1^UAS.cMa

seminal vesicle (with Vrp1^D30), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^S1946

seminal vesicle (with Vrp1^S1946), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^D30

Vrp1^KO

spermatid cyst, with Scer\GAL4^A3.eya

Vrp1^KK111261

spermatid cyst, with Scer\GAL4^Mef2.PR, Vrp1^S1946/Vrp1^D30

Vrp1^UAS.cMa

spermatid cyst (with Vrp1^D30)

Vrp1^KO

spermatid cyst (with Vrp1^D30), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^S1946

spermatid cyst (with Vrp1^KO)

Vrp1^D30

spermatid cyst (with Vrp1^S1946), with Scer\GAL4^Mef2.PR, Vrp1^UAS.cMa

Vrp1^D30

visceral muscle fiber | embryonic stage

Vrp1^D30

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

3 of 14

Yes

Yes

1 of 14

No

Yes

1 of 14

No

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

2 of 14

Yes

Yes

2 of 14

Yes

Yes

1 of 14

No

Yes

Mus musculus (laboratory mouse) (3)

4 of 14

Yes

Yes

2 of 14

No

Yes

2 of 14

No

Yes

Xenopus tropicalis (Western clawed frog) (2)

1 of 13

Yes

No

1 of 13

Yes

No

Danio rerio (Zebrafish) (4)

2 of 14

Yes

Yes

2 of 14

Yes

Yes

1 of 14

No

Yes

1 of 14

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

2 of 14

Yes

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP001886

7 of 12

Yes

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

4 of 13

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

2 of 12

Yes

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Vrp1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

WIPF1; WAS/WASL interacting protein family member 1

3 of 14

WISKOTT-ALDRICH SYNDROME 2; WAS2

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, anti tag western blot, anti tag coimmunoprecipitation

(Kim et al., 2007)

anti tag coimmunoprecipitation, anti tag western blot, pull down, experimental knowledge based, western blot

(Kaipa et al., 2013, Guruharsha et al., 2011, Jin et al., 2011, Kim et al., 2007)

anti tag coimmunoprecipitation, western blot, anti tag western blot

(Jin et al., 2011)

two hybrid, anti tag coimmunoprecipitation, western blot

(Kaipa et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Kaipa et al., 2013)

enhanceable

(Sens et al., 2010, Berger et al., 2008)

enhanceable

(Kaipa et al., 2013)

suppressible

(Massarwa et al., 2007)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Sens et al., 2010)

enhanceable

(Kaipa et al., 2013)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63141

DroID - A comprehensive database of gene and protein interactions.

FBgn0243516

MIST (genetic) - An integrated Molecular Interaction Database

37521

MIST (protein-protein) - An integrated Molecular Interaction Database

37521

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

protein_coding_gene

(Chen, 2006)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-98

Cytogenetic map

Sequence location

2R:22,106,107..22,122,562 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

58B8-58B9

Limits computationally determined from genome sequence between P{EP}CG6393^EP2457 and P{PZ}ari-2⁰⁷⁷⁶⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-98

(FlyBase, 2016)

2-103.7

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Aberrations including deletions of this gene Aberrations including duplications of this gene

43746

y¹ w^*; Mi{MIC}Vrp1^MI07644

56117

y¹ w^*; Mi{MIC}Vrp1^MI11078

15403

y¹ w^67c23; P{EPgy2}Vrp1^EY02177

78948

y¹ w^*; TI{CRIMIC.TG4.0}Vrp1^{CR00552-TG4.0}

36704

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01593}attP2

38201

y¹ sc^* v¹ sev²¹; P{TRiP.GL00640}attP40

23236

y¹ w^*; P{UAST-YFP.Rab1.S25N}mei-S332⁰⁴ Vrp1⁰⁴

13503R-1

v102253

P{KK111261}VIE-260B

v23888

w¹¹¹⁸; P{GD8042}v23888

v318860

PBac{fTRG01357.sfGFP-TVPTBF}VK00033

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (122)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0243516

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0243516

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Berger et al., 2008, Massarwa et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

EM analysis reveals abnormal accumulations of prefusion vesicles along the apposing membranes of adhering myoblasts in CG13503 mutant embryos, indicating a role of the actin cytoskeleton in targeting and fusion of these vesicles to proper sites on the plasma membrane.

(Chen, 2007)

Vrp1 is required for F-actin accumulation at sites of fusion in fusion-competent cells during muscle formation in the embryo.

(Kim et al., 2007)

CG13503, which is expressed specifically in myoblasts, associates with both the CG13503-Arp2/3 system, and with the myoblast fusion receptors kirre and sns, thereby recruiting the actin polymerization machinery to sites of myoblast attachment and fusion.

(Schejter et al., 2007)

Embryonic injection of dsRNA made from templates generated with primers directed against this gene results in a reduction in myoblast function, with an overall reduction and disorganisation of muscle fibers.

(Estrada et al., 2006)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R⁺ cells: reduced F-actin and altered cell shape.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: D-WIP CG13503

(Schejter, 2007.2.26)

Source for identity of: sltr CG13503

(Chen, 2007.2.26)

Source for identity of: Vrp1 CG13503

(Paunola et al., 2002)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (31)

Reported As

Symbol Synonym

CG13503

(McEachern et al., 2014, Abmayr and Pavlath, 2012, Ni et al., 2011.7.19, Eriksson et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Lebo et al., 2009, Chen, 2007.2.26, Kim et al., 2007, Massarwa et al., 2007, Schejter, 2007.2.26, Zhang et al., 2007, Estrada et al., 2006, Johansson et al., 2005)

D-WIP

(Mukherjee et al., 2011, Rotkopf et al., 2011, Bulchand et al., 2010, Gildor et al., 2009, Massarwa et al., 2007, Massarwa et al., 2007, Richardson et al., 2007, Schejter, 2007.2.26, Schejter et al., 2007)

DWIP

(Martin, 2016)

DWiP

(Dubey et al., 2020)

DWip

(Bothe and Baylies, 2016, Bothe et al., 2014)

Dm_Vrp1

(Paunola et al., 2002)

Sltr

(Lee and Chen, 2019, Rodal et al., 2015, Abmayr and Pavlath, 2012)

Vrp1

(Collins et al., 2024, Lee et al., 2022, Teumer et al., 2019, Gene Disruption Project members, 2018-, Hamp et al., 2016, Sarov et al., 2016, Ashwal-Fluss et al., 2014, Popichenko et al., 2013, Abmayr and Pavlath, 2012, Japanese National Institute of Genetics, 2012.5.21, Friedman et al., 2011, Eriksson et al., 2010, Berger et al., 2008, Paunola et al., 2002)

WIP

(Lee and Chen, 2019, Dubey et al., 2016, Reed et al., 2012, Zoller and Schulz, 2012, Jin et al., 2011, Wolfstetter et al., 2009)

Wip

(Rout et al., 2022, Abmayr and Pavlath, 2012)

dWIP

(Rodal et al., 2015, Sens et al., 2010, Sens and Chen, 2008)

dwip

(Kim et al., 2021)

sltr

(Zhang et al., 2020, Duan et al., 2018, Deng et al., 2015, Kim et al., 2015, Duan et al., 2012, Jin et al., 2011, Bulchand et al., 2010, Sens et al., 2010, Berger et al., 2008, Chen, 2007, Chen, 2007.2.26, Kim et al., 2007, Chen, 2006)

solas

(Estrada et al., 2006)

vrp

(Álvarez-Fernández et al., 2015)

vrp1

(Dubois et al., 2016, Hamp et al., 2016, Kaipa et al., 2013, Bulchand et al., 2010, Berger et al., 2008)

wip

(Hamp et al., 2016, Haralalka et al., 2014, Rudolf et al., 2014, Kaipa et al., 2013, Hornbruch-Freitag et al., 2011, Berger et al., 2008)

Name Synonyms

CG13503

D-WASp-interacting protein

(Gildor et al., 2009)

Drosophila WIP

(Chen, 2007)

Solitary

(Bulchand et al., 2010)

Verprolin

(Reed et al., 2012, Eriksson et al., 2010, Kong et al., 2010)

Verprolin 1

(McEachern et al., 2014, Bulchand et al., 2010, Lebo et al., 2009)

Verprolin1

(Wolfstetter et al., 2009)

WASP-interacting protein

(Hornbruch-Freitag et al., 2011)

WASp Interacting Protein

(Schejter, 2007.2.26, Schejter et al., 2007)

WASp interacting protein

(Bulchand et al., 2010)

WASp-interacting protein

(Dubey et al., 2016)

solitary

(Jin et al., 2011, Sens and Chen, 2008, Chen, 2007, Chen, 2007.2.26, Kim et al., 2007, Chen, 2006)

veroprolin

(Reed et al., 2012)

verprolin

(Estrada et al., 2006, Paunola et al., 2002)

verprolin 1

(Schäfer et al., 2008)

Secondary FlyBase IDs

FBgn0034695
FBgn0086255

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 73 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

37521

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A8DYL3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A8DYL3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0243516

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

37521/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0243516

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0243516

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG13503

MARRVEL_MODEL - MARRVEL (model organism gene)

37521

Linkouts

BioGRID - A database of protein and genetic interactions.

63141

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0243516

DroID - A comprehensive database of gene and protein interactions.

FBgn0243516

DRSC - Results frm RNAi screens

FBgn0243516

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0243516

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0243516

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG13503

Flygut - An atlas of the Drosophila adult midgut

FBgn0243516

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

37521

MIST (protein-protein) - An integrated Molecular Interaction Database

37521

References (92)